NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7790-84-3
Chemical Name	Cadmium sulfate 8/3hydrate
Substance ID	m-nite-7790-84-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified	- -	-	-	Nonflammable. (GESTIS-database on hazardous substancess of cadmium sulfate (anhydride) (Accessed on Apr.2006) has a statement that it is "nonflammable".))	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Nonflammable. (GESTIS-database on hazardous substancess (Accessed on Apr.2006) of cadmium sulfate (anhydride) has a statement that it is "nonflammable".)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Nonflammable. (GESTIS-database on hazardous substancess (Accessed on Apr.2006) of cadmium sulfate (anhydride) has a "nonflammable" statement.)	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Stable to water (readily soluble)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data. (According to the risk phrases in EU-Annex I (Access on Jun. 2005) for cadmium sulfate (anhydride), its oral toxicity is high.) * Because the data available for this substance is limited, also refer to the classification results of cadmium sulfate (anhydride) (ID No.0254, CAS No.10108-64-2) for each item related to its health hazards.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Data without. (In the risk phrases of EU-Annex I (Access on Jun.2005) of cadmium sulfate (anhydride), it is supposed that inhalation toxicity is very high.)	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 1B	Danger	H340	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Because in vivo data on this substance itself available for the classification were not obtained, information on the whole cadmium compounds (as cadmium ion, Cd2+) was used for evaluation. From (1), (2), positive reports in germ cells and somatic cells were obtained on water-soluble cadmium chloride. There is no information on water solubility of this substance, but because this substance is thought to be very soluble in water like the anhydrate, this substance was classified in Category 1B as the anhydrate was. The category was revised by considering knowledge on the whole cadmium compounds and water solubility of this substance. [Evidence Data] (1) It is reported that after administration of cadmium (mainly cadmium chloride), chromosomal aberrations in mouse spermatocytes and hamster oocytes and altered gene expression in mouse spermatid occurred (ATSDR (2012), IARC 58 (1993)). (2) It is reported that as the result of administrating cadmium chloride to mice, dose-dependent increases in the incidences of micronuclei, sister chromatid exchanges, and chromosomal aberrations were observed in the peripheral blood. Moreover, it is reported that increased single strand breaks in the DNA were observed in rats after administrating cadmium chloride (EU-RAR (2007), DFGOT Vol. 22 (2006), NICNAS IMAP (Accessed Dec. 2018)). [Reference Data, etc.] (3) It is reported that increases in the incidences of micronuclei and sister chromatid exchanges in peripheral lymphocytes were shown in workers occupationally exposed to cadmium (compound not specified) and that human lymphocytes from people inhabiting cadmium-polluted areas of China were found to have increased micronuclei rates and a higher frequency of chromosomal aberrations and severe aberration types. However, conflicting knowledge is also reported (ATSDR (2012)). (4) As for in vivo, a dominant lethal test by administrating cadmium (mainly cadmium chloride) was negative (ATSDR (2012), IARC 58 (1993), DFGOT Vol. 22 (2006)). (5) As for in vitro, it is reported that a bacterial reverse mutation test, a chromosomal aberration test and a sister chromatid exchange test in cultured mammalian cells (CHO) were positive (NICNAS IMAP (Accessed Jan. 2019)). (6) There is no information on water solubility of this substance, but that of the anhydrate is 772 g/L (20 deg C) (GESTIS (Accessed Feb. 2019)). (7) The anhydrate of this substance was classified in Muta. 1B in EU CLP.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	It is categorized into Category 1A as cadmium compounds (Group 1, Known to be human carcinogens, 1respectively) in IARC53 (1993), NTP RoC (11th, 2005) and industrial hygene academic society advice (2004), the classification (Carc.Cat.2) as cadmium compounds in IRIS(1992) and ACGIH-TLV(2004)(B1, A2, respectively) and as cadmium sulfate (anhydride) in EU-Annex I (Access on Jun.2005) are categorized into Category 1B. Since the newness etc. of sources of the both Category were almost equivalent, it was classified into Category 1A-1B. [Indication] 1A is recommended based on the safety, when the Category needs to subdivide.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	In California Proposition 65 (California EPA/OEHHA, 2005), it is registered as cadmium having reproductive toxicity in sire. It was set as Category 1B.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (kidney)	Danger	H372	P260 P264 P270 P314 P501	Although there is no data of this product, there is a description of an effect on kidneys caused by repeated exposure of cadmium compounds (ACGIH-TLV (2004) in Priority 1 document). Therefore, it was classified into Category 1 (kidney).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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