NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	78-40-0
Chemical Name	Triethyl phosphate
Substance ID	m-nite-78-40-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified	- -	-	-	Since it is assumed that 115 degC (240 degF) (open-cup) (HSDB (2006)) of flash points is estimated to be >= 93 degC for the closed-cup flash point test methods, The substance is classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Although this substance contains P-O in the molecule, it does not correspond to chemical groups associated with self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	Since its autoignition temperature is 454 degC (HSDB (2006)), it is considered that the substance does not ignite at room temperature.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Although this substance contains the metalloid (P), it is classified as "Not classified" because of the description of "when mixed with water is quite stable at room temperature" (HSDB (2006)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Classification not possible	- -	-	-	Although the substance is an organic compound containing oxygen which is chemically bonded to the elements other than carbon or hydrogen, due to lack of additional data, classification is not possible.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on the rat LD50 value of 1131 - 1600 mg/kg (SIDS (Access on Nov. 2010)), the substance was classified into Category 4.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the rat LD50 value of > 20 g/kg (PATTY, 5th (2001)), the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on the rat LC50 value of > 8.817 mg/L (SIDS (Access on Nov. 2010)), the substance was classified as "Not classified". The test concentration was higher than the saturated vapour pressure concentration (3.85 mg/L), criterion values for dusts and mists were adopted.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	Moderate irritation was noted in 1 of 3 tested animals in the animal experiment (OECD TG 404, GLP-compliant), but SIDS concluded that the substance was not a skin irritant in accordance with guideline (SIDS (Access on Nov. 2010)). The substance caused slight irritation to guinea pig, but caused non irritation to rabbit (BUA 37 (1989)). Based on these documents, the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	In the rabbit test, transient conjunctivitis was noted. In other rabbit test, corneal opacity, iritis and corneal coloration were noted (BUA 37 (1989)). Based on these documents, the substance was classified as Category 2. As relevant notes, in Draize tests using rabbits, instillation of 100 mg of substance caused moderate irritation (RTECS (2006), original literature: National Technical Information Service. OTS0528351), which was the "List 3" information source of GHS classification guidance for the Japanese government.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	Insufficient data were available. In the sensitization test using guinea pig, no sensitizing effect was reported (BUA 37 (1989)). However, it was the datum from the "List 2" information source designated in the GHS classification guidance for the Japanese government, and there was neither information on test methods nor positive rate.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	The classification was concluded as "Not classified" based on the negative results in the dominant lethal test using mice of 2 strains intraperitoneally administered (in vivo inheritable mutagenicity test in germ cells) (BUA 37 (1989)), chromosome aberration test using spermatogonia obtained from mice intraperitoneally administered (in vivo mutagenicity test in germ cells) (BUA 37 (1989)), and chromosome aberration test using bone marrow of mice (in vivo mutagenicity test in somatic cells) (SIDS (Access on Nov. 2010)). As relevant information, as for in vitro studies, negative results in the Ames test (NTB DB (1982)) and HPRT test using V79 cells were reported.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In the 2-generation feeding study in rats, which were administered from 92 days before mating to 120 days after mating for males, and to 150 days after mating for females, the litter size was reduced at the dose level (670 mg/kg/day) that did not induce general toxicity to parental animals (SIDS (Access on Nov. 2010)). Therefore, the substance was classified as Category 1B. However, there was a description that this experiment should be considered as a pilot study using few animals that suggested some adverse effects on the reproduction and development of rats (BUA 37 (1989)). Therefore, the substance was concluded as Category 2. As relevant information, the developmental toxicity study in rats showed no evidence of teratogenic potential up to the highest dose of 625 mg/kg/day (SIDS (Access on Nov. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system), Category 3 (narcotic effects)	Warning	H371 H336	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	There was a description stating that this substance was harmful and caused the narcotic effect, and showed obvious neurotoxicity (cholinesterase inhibition) without delayed neurotoxicity (SIDS (Access on Nov. 2010)). In various experiments on acute toxicity the following symptoms of poisoning were observed: narcosis, excitations followed by depression of central nervous system, loss of muscular coordination and quadriplegia, etc. (BUA 37 (1989)). Dogs treated with a single oral dose of 1070 mg/kg revealed lateral position, dyspnea, sedation, narcotic-like condition and twitching, then died on the day of administration. In addition, the other dogs received a single dose of 100 or 250 mg/kg caused sedation and slight tremor with inhibition of plasma cholinesterase (BUA 37 (1989)). As described above, in addition to Category 3 (narcotic effects), the classification was determined as Category 2 (nervous system) because neurotoxic signs occurred in dogs at the dose level equivalent to Category 2 of the guidance values.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	The NOAEL in the 28-day oral dose toxicity in rats was reported as 1000 mg/kg/day (converted dose level as that of 90-day study: 311 mg/kg/day) (SIDS (Access on Nov. 2010)). There were no adverse effects up to 5000 ppm (335 mg/kg/day) in the 92-day feeding study in rats, and there were also no serious toxicity at the concentration of 5000 ppm (330 mg/kg/day) in another 9-week feeding study in rats (BUA 37 (1989)). While in the inhalation study exposed 12 times to rats (5 hours/day, 5 days/week) at the concentration of 1.786 mg/L as an aerosol (converted concentration as that of 90-day study: 0.275 mg/L), lethargy, reduced sensitivity to noise, behavioral disturbances, etc. were observed, however, hematological and biochemical parameters were within the ranges of the control group and no pathological changes were determined macroscopically or microscopically (BUA 37 (1989)). Thus, no adverse effects were shown up to the doses beyond the guidance values in both oral and inhalation routes, which led to a conclusion as "Not classified". However, since data for inhalation route were provided from the "List 2" information source designated in the GHS classification guidance for the Japanese government and the effects in dermal route was unknown due to no information, the classification for specific target organ toxicity (repeated exposure) was determined as "Classification not possible".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Classified as "Not classified" since its toxicity to algae (Scenedesmus subspicatus) and crustacea (Daphnia magna) are > 100 mg/L (SIDS, 2002).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified as "Not classified" since its acute toxicity is "Not Classified" and it is not non-water soluble (water solubility: 500000 mg/L (SRC, 2009)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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