Item | Information |
---|---|
CAS RN | 78-94-4 |
Chemical Name | Methyl vinyl ketone |
Substance ID | m-nite-78-94-4_v2 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Category 2 |
Danger |
H225 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 2 based on a flash point of -7 deg C (closed cup) and a boiling point of 81 deg C (NFPA (14th, 2010)). Besides, a stabilized one is classified in Division 6.1, Subsidiary Risk 3 and 8, PG I in UNRTDG (UN1251). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties, an unsaturated bond, present in the molecule, but because a stabilized one is classified in Division 6.1, Subsidiary Risk 3 and 8 in UNRTDG (UN1251), and it is considered to be not applicable to self-reactive substances and mixtures, hazards of the highest precedence, and it was classified in Type G. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from an autoignition temperature of 491 deg C (NFPA (14th, 2010)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to liquid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 |
Danger |
H300 | P301+P310 P264 P270 P321 P330 P405 P501 |
[Rationale for the Classification] It was classified in Category 2 from (1), (2). [Evidence Data] (1) LD50 for rats: 23.1 mg/kg (ACGIH (7th, 2019), GESTIS (Access on April 2020), HSDB (Access on April 2020)) (2) LD50 for rats: 31 mg/kg (MAK (DFG) vol.9 (1998)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Category 1 |
Danger |
H310 | P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
[Rationale for the Classification] It was classified in Category 1 from (1). [Evidence Data] (1) LD50 for rabbits: about 10-50 microL/kg (about 8.3-41.5 mg/kg) (GESTIS (Access on April 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
[Rationale for the Classification] It was classified in Category 1 from (1), (2). Besides, because exposure concentrations are lower than 90% of the saturated vapor pressure concentration (200,016 ppm), the reference value in units of ppm was applied as a vapour without a mist. [Evidence Data] (1) LC50 for rats (4 hours): 7 mg/m3 (2.4 ppm) (ACGIH (7th, 2019), GESTIS (Access on April 2020)) (2) LC50 for rats (4 hours): 22.4 mL/m3 (22.4 ppm) (MAK (DFG) vol.9 (1998)) (3) Vapor pressure of this substance: 152 mmHg (25 deg C) (converted value for the saturated vapor pressure concentration: 200,016 ppm) (HSDB (Access on April 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
[Rationale for the Classification] It was classified in Category 1 from (1) - (4). [Evidence Data] (1) This substance is a severe skin, eye, and respiratory tract irritant in humans and one of the more potent irritants of mucous membranes, particularly of the eye and respiratory tract (ACGIH (7th, 2001)). (2) This substance has a strong irritative effect on mucous membranes, and skin contact leads to severe necrosis (MAK (DFG) vol.9 (1998)). (3) This substance has strong irritative and corrosive effects on the skin and mucosa and causes severe eye and lung damage (GESTIS (Access on April 2020), HSDB (Access on April 2020)). (4) In a test in which this substance (0.2 mL) was applied to the rabbit skin (application time: unknown), hyperemia and edema occurred after 1 hour, edema disappeared on day 2, but deep purulent ulcers developed, and 28-30 days were required for recovery (MAK (DFG) vol.9 (1998)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
[Rationale for the Classification] It was classified in Category 1 from (1) - (5). [Evidence Data] (1) This substance is a severe skin, eye, and respiratory tract irritant in humans and one of the more potent irritants of mucous membranes, particularly of the eye and respiratory tract (ACGIH (7th, 2001)). (2) This substance has a strong irritative effect on mucous membranes, and skin contact leads to severe necrosis (MAK (DFG) vol.9 (1998)). (3) This substance has strong irritative and corrosive effects on the skin and mucosa and causes severe eye and lung damage (GESTIS (Access on April 2020), HSDB (Access on April 2020)). (4) In a test in which a drop of this substance was applied to the rabbit eye, severe corneal degeneration and tissue damage on the eyelids occurred, resulting in loss of the eye (MAK (DFG) vol.9 (1998)). (5) This substance was classified in Category 1 in skin corrosion/irritation. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
[Rationale for the Classification] It was classified in Category 1 from (1) - (3). [Evidence Data] (1) This substance was reported to be a sensitizer based on the results of animal experiments (ACGIH (7th, 2001)). (2) It was reported to be positive in skin sensitization tests with guinea pigs (Polak method and an open epicutaneous test) (MAK (DFG) vol.9 (1998)). (3) This substance has a skin sensitizing potential (GESTIS (Access on April 2020), HSDB (Access on April 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There is no clear knowledge that it was positive in in-vivo or in-vitro from (1), (2), and the classification is not possible due to lack of data. [Evidence Data] (1) As for in vivo, there was an equivocal result in a micronucleus test with rats, and in a micronucleus test with mice, it was reported to be negative in females and equivocal in males (CEBS (Access on April 2020)). (2) As for in vitro, positive results were obtained in bacterial reverse mutation tests but only under special conditions or standard conditions but with S9 mix from hamsters (MAK (DFG) vol. 9 (1998), ACGIH (7th, 2001), CEBS (Access on April 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification was not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, respiratory organs, kidney) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
[Rationale for the Classification] Based on (1) to (6), it was classified in Category 1 (central nervous system, respiratory organs, kidney). [Evidence Data] (1) This substance has a strongly irritative effect on mucous membranes, particularly on those of the eyes and respiratory passages. This causes bronchopneumonia and acute pulmonary edema. In animal experiments, the main effect of the substance after oral or dermal administration was central nervous depression (apathy, coordination disorders, and paresis of the limbs). The main systemic effect of this substance was severe kidney damage (MAK (DFG) vol.9 (1998)). (2) As a result of inhalation exposure of rats and mice for 15 to 20 minutes to this substance at concentration of 41.3 mL/m3 (converted 4-hour equivalent value: 0.03 mg/L, within the range for Category 1), death, severe irritation of mucous membranes, dyspnea, central nervous system disorder, and hyperemia and edema of the internal organs and brain were observed (MAK (DFG) vol.9 (1998)). (3) As a result of inhalation exposure of rats, mice and guinea pigs for 60 minutes at concentration of 100 mL/m3 (converted 4-hour equivalent value: 0.15 mg/L, within the range for Category 1), death (half of rabbits, one-third of guinea pigs) and bronchopneumonia (no description of animal species) were observed (MAK (DFG) vol.9 (1998)). (4) As a result of oral administration to mice and rats at 10 to 60 mg/kg (within the range for Category 1), loss of appetite, dyspnea, ruffled fur, and paralysis of the limbs were observed (MAK (DFG) vol.9 (1998)). (5) As a result of oral administration to rabbits at about 17 mg/kg (within the range for Category 1), death, apathy, loss of appetite, irritation of the stomach mucosa, and damage of the kidney were observed. As a result of oral administration at about 9 to 13 mg/kg (within the range for Category 1), damage of the kidney was also reported (MAK (DFG) vol.9 (1998)). (6) As a result of single oral administration to cats at about 4 mg/kg or about 2.5 mg/kg (both within the range for Category 1), damage of the kidney was also reported (MAK (DFG) vol.9 (1998)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (respiratory organs). [Evidence Data] (1) As a result of inhalation exposure of rats for 13 weeks (6 hours/day, 5 days/week), lesions of the nasal cavity (such as hyperplasia of the respiratory epithelium) were observed at or above 0.5 ppm (converted guidance value: 0.001 mg/L, within the range for Category 1) (ACGIH (7th, 2019)). (2) As a result of inhalation exposure of mice for 13 weeks (6 hours/day, 5 days/week), a decrease in leukocyte counts (only males) was observed at or above 0.5 ppm (converted guidance value: 0.001 mg/L, within the range for Category 1), and lesions of the nasal cavity (squamous metaplasia of the transitional and respiratory epithelia) were observed at or above 2 ppm (converted guidance value: 0.004 mg/L, within the range for Category 1) (ACGIH (7th, 2019)) [Reference Data, etc.] (3) There was a statement that the main systemic effect of this substance was severe kidney damage (MAK (DFG) vol.9 (1998)). (4) It was reported that in an inhalation exposure test with rats dosed at 6.9 mL/m3 for 2.5 months (4 hours/day), symptoms of general intoxication as well as functional disorders of the liver and kidney were observed, but the details were unknown (MAK (DFG) vol.9 (1998)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Not classified |
- |
- | - | [Rationale for the Classification] Because it corresponds to Category 2 in UN GHS classification from (1) and (2), it was classified as "Not classified" according to the current GHS classification guidance for the Japanese government. [Evidence Data] (1) It is a ketone with a composition of no more than 13 carbon atoms. (2) From kinematic viscosity of 0.97 mm2/s at 21 deg C (calculated from viscosity of 0.807 mPa*s at 21 deg C (HSDB (Access on April 2020)) and density of 0.83 g/cm3 (GESTIS (Access on April 2020))), kinematic viscosity is <= 14 mm2/s at 40 deg C. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 48-hour EC50 = 0.24 mg/L for crustacea (Daphnia magna) (BUA 233, 2001). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Reliable chronic toxicity data were not obtained. It was classified in Category 1 because sufficient data on rapid degradability were not obtained, and it was classified in Category 1 in acute toxicity. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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