NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7803-55-6
Chemical Name	Ammonium metavanadate
Substance ID	m-nite-7803-55-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (crystalline powder) at room temperature (Merck (14th, 2006))	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (crystalline powder) at room temperature (Merck (14th, 2006))	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (crystalline powder) at room temperature (Merck (14th, 2006))	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (crystalline powder) at room temperature (Merck (14th, 2006))	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified	- -	-	-	Non flammable (PATTY (5th, 2001))	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (crystalline powder) at room temperature (Merck (14th, 2006))	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified	- -	-	-	Non flammable (PATTY (5th, 2001))	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Non flammable (PATTY (5th, 2001))	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Although it contains a metal (V), its water solubility is 0.48 g/100 g (20 degC) (Lange (16th, 2005)) and it is considered that the substance doesn't react strongly with water.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (crystalline powder) at room temperature (Merck (14th, 2006))	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Classification not possible	- -	-	-	Inorganic compounds containing oxygen, which is chemically bonded to the elements other than carbon and hydrogen. Since no test results are available, classification is not possible.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on the rat LD50 values of 218 mg/kg (male), 141 mg/kg (female), and 160 mg/kg (DFGMAK-Doc. 25 (2009), original literature: Monatshefte fur Chenmie (1994)), the substance was classified as Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the rat LD50 value of > 2500 mg/kg (DFGMAK-Doc. 25 (2009), original literature: Monatshefte fur Chenmie (1994)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 or "Not classified" in the UN-GHS classification).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (crystalline powder) at room temperature (Merck, 14th (2006))	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on the rat LC50 values of 2.61 mg/L/4hrs (male) and 2.43 mg/L/4hrs (female) (DFGMAK-Doc. 25 (2009), original literature: Monatshefte fur Chenmie (1994)), the substance was classified as Category 4. According to the description, the test was carried out with dust, therefore the criterion values for dust/mist were adopted for the classification.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Category 1B	Danger	H340	P308+P313 P201 P202 P280 P405 P501	Based on the positive results in the dominant lethal test by oral administration to rats (in vivo heritable mutagenicity test in germ cells) (DFGMAK-Doc. 25 (2009)), it was classified as Category 1B. In other data, there were positive results in the chromosome aberration test and the micronucleus test using mouse bone marrow cells (in vivo mutagenicity test in somatic cells) (CICAD 29 (2001)). As relevant information, as for in vitro tests, positive results (PATTY, 5th (2001)) and negative results (ATSDR DRAFT (2009)) in the Ames test, negative results in the chromosomal aberration test using human lymphocytes (CICAD 29 (2001)), positive results in the chromosomal aberration test using Chinese hamster ovary cells (CICAD 29 (2001)), and positive results in the micronucleus test using human lymphocytes (CICAD 29 (2001)) were reported.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In the study, male rats, which were received test substance at the dose level of 20mg/kg bw/day via drinking water for 70 days, were mated with untreated females. In treated males, the weight of testes, epididymides, prostate and seminal vesicles was significantly lower than in control animals. The mating index and the fertility index were also reduced. In addition, in the study, females which were received at the dose level of 20mg/kg bw/day via drinking water from 14 days prior to mating through mating and during pregnancy and lactation period up to 21 days after birth, the estrous cycle was disturbed, the fertility, the number of implantation sites and the number of viable fetuses per animal were markedly reduced (DFGMAK-Doc. 25 (2009)). In both studies, reduced body weights and developmental disability in the offspring during perinatal and weaning period, skeletal and visceral anomalies, malformations (e.g. anophthalmia or microphthalmia) in partial offspring were observed. Although the incidence of the morphological defect was not significant in statistics, it was higher in the administering group. For parent animal's general toxicity, details were not found except that there was no influence in the weight gain. Therefore, the substance was classified as Category 2.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system, nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	One case report was reported. One worker, exposed to dust of this substance over 6 hours while shovelling dry powder into a bin, developed headache in the interior region of orbit, lacrimation, dry mouth, and green discoloration of the tongue within 2 hours of commencing work. On the third day after exposure, he developed wheezing, dyspnea, a cough, thereafter he revealed a small amount of hemoptysis over the following 2 weeks, of which dyspnea persisted for about 1 month (CICAD 29 (2001)). Moreover, it was also described in the other literature that in subjects with an acute occupational exposure to the dust of the mixture of vanadium pentaoxide and sodium metavanadate containing this substance, it was reported that a rhinitis with a sneezing or coughing, and an itching or burning sensation in the throat were seen as mild symptoms, irritation of the upper respiratory tract, bronchitis with expiratory dyspnea and bronchospasm as moderate symptoms, and in severe case bronchitis and bronchopneumonia were seen (PATTY, 5th (2001)). Based on these, the classification was determined as Category 1 (respiratory system). As the other remarkable symptoms, disorders of nervous system containing severe neurotic states or tremor of fingers and hands were described (PATTY, 5th (2001)). In the animal studies, neurophysiological effects containing disturbances of the central nervous system were reported following acute exposure by oral administration of dogs and rabbits to vanadium oxide and salts (IARC 86 (2006)), and acute toxic signs containing reduced motility extending to apathy, paralysis of hind legs, decreased sensitivity to pain and lacrimation were described as common symptoms exposed to vanadium compounds in rats (DFGMAK-Doc. 25 (2009)). Therefore, the classification was additionally determined as Category 1 (nervous system).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory system)	Danger	H372	P260 P264 P270 P314 P501	No information was available for human case exposed to the substance itself. It was reported, however, that workers who were occupationally exposed to dust mixtures of the substance and vanadium pentaoxide caused signs of coughing and irritation of the mucous membrane of the respiratory tract (DFGMAK-Doc. 4 (1992)), and was reported in several reports that workers exposed to vanadium dusts occupationally revealed the symptoms as follows: bronchitis, bronchospasm, persistent cough, irritating symptoms of nasal mucosa, wheezing, rale, coarse crackles, greenish tongue, and dyspnea or palpitation at higher concentrations. In addition, the risk of occurrence of pulmonary emphysema was pointed out. (JSOH, Recommendations for allowable concentrations, vol. 45 (2003)). Thus, the classification was determined as Category 1 (respiratory system). Besides, regarding the toxicity studies on experimental animals using this substance, a significant increase in leukocyte counts was observed in 4-week drinking study with rats (PATTY, 5th (2001)), and decreases in erythrocyte number and hematocrit value in males were reported in another 4-week drinking study with rats (CICAD 29 (2001)). However, details of these findings were unknown due to limited study design as well as no histopathological evidence.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	Classified into Category 3 from its 96h-LC50 = 13.5 mg/L for fish (Fundulus heteroclitus) (AQUIRE, 2011).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	Classified into Category 3 since its acute toxicity is Category 3 and data on rapid degradation are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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