Item | Information |
---|---|
CAS RN | 79-24-3 |
Chemical Name | Nitroethane |
Substance ID | m-nite-79-24-3_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | There is a chemical group associated with explosive properties (nitro group) present in the molecule, and oxygen balance of -94 is higher than the criteria, -200. However, it is classified in Class 3 (UN2842) in UNRTDG, not in Class 1 in the higher precedence. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 3 based on a flash point 28 deg C (closed cup) (ICSC (2013)). Besides, it is classified in Class 3, PG III (UN2842) in UNRTDG. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with explosive properties (nitro group) present in the molecule. However, it is classified in Class 3 (UN2842) in UNRTDG and does not correspond to the hazards of the highest precedence, self-reactive substances and mixtures. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 410 deg C (ICSC (2013)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on a report of an LD50 value of 1,625 mg/kg for rats (DFGOT vol. 19 (2003)), it was classified in Category 4. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Category 4 |
Warning |
H332 | P304+P340 P261 P271 P312 |
There are reports that in a 6-hour inhalation test with rats, no toxic symptoms were observed at 2,200 ppm (converted 4-hour equivalent value: 2,694 ppm), and all animals died at 13,000 ppm (converted 4-hour equivalent value: 15,921 ppm) (DFGOT vol. 19 (2003), ACGIH (7th, 2001)), therefore, the LC50 value was assumed to be >2,694 ppm and <15,921 ppm. Based on this assumed LC50 value, it was classified in Category 4. Besides, since both exposure concentrations in the inhalation test were lower than 90% of the saturated vapour concentration (20,533 ppm), the reference value in units of ppm was applied as a vapour without a mist. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | There is a report that after application of 0.5 mL the undiluted liquid of this substance, although only slight erythema was observed, this substance was deemed a nonirritant (HSDB (Access on August 2014)). In addition, there is a description that this substance was weakly irritating to rabbits (DFGOT vol. 19 (2003)). From the above results, it was classified as "Not classified" (Category 3 in UN GHS classification). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
There is a description that this substance was weakly irritating to the conjunctiva in rabbits (DFGOT vol. 19 (2003)). It is concluded that it was weakly irritating to the mucosa in the DFGOT vol. 19 (2003). In addition, after application of 0.1 mL undiluted liquid of this substance to rabbits, lacrimation was observed (HSDB (Access on August 2014)), however, no change in the eyes which could fall under the classification criteria of irritation was observed. From the above, based on "weak irritation," it was classified in Category 2B. By reviewing the information, the category was revised. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a report that in a Draize test with guinea pigs, no sensitization was observed (HSDB (Access on August 2014)), however, it was judged to be insufficient data for classification because details, etc. were unknown. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a mouse bone marrow micronucleus test (DFGOT vol. 19 (2003), PATTY (6th, 2012), HSDB (Access on August 2014)). As for in vitro, it was negative in bacterial reverse mutation tests (DFGOT vol. 19 (2003), PATTY (6th, 2012), NTP DB (Access on September 2014), HSDB (Access on August 2014)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | There are reports that no carcinogenicity was observed in a 2-year inhalation exposure test with rats in DFGOT vol. 19 (2003), PATTY (6th, 2012), SIAP (2010). Since it was a result of a carcinogenicity test with only one species, classification was not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is a report that in a teratogenicity test with mice through the inhalation route, neither toxic effects on dams nor teratogenic, embryotoxic or fetotoxic effects were observed (DFGOT vol. 19 (2003)). However, this is a test with only one dose where no toxic effects on dams were observed. This was not used for classification due to lack of reliability. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (blood system), Category 3 (respiratory tract irritation, narcotic effects) |
Danger Warning |
H370 H335 H336 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance had respiratory tract irritation and narcotic effects. In humans, there are reports of vomiting, stomach irritation, sleepiness, breathlessness, lethargy, cyanosis and methemoglobinemia in 2 infants who ingested this substance (DFGOT vol. 19 (2003), PATTY (6th, 2012), HSDB (Access on August 2014)). As for experimental animals, there are reports of lacrimation, dyspnea and rales in guinea pigs and rabbits by inhalation exposure at or above 1,500 mg/m3 (1.5 mg/L) (DFGOT vol. 19 (2003)), of cerebral edema and congestion in guinea pigs and rabbits by the inhalation exposure (no description of concentration) (HSDB (Access on August 2014)), and of ataxia and convulsions in rats by the oral administration of 1,256 mg/kg (SIAP (2010)). From the above, since it was considered that it had effects on the hemal system, respiratory tract irritation and narcotic effects, it was classified in Category 1 (hemal system), Category 3 (respiratory tract irritation, narcotic effects). Besides, since the finding on rats by oral administration was described only in SIAP, and the source of information could not be followed, it was not adopted for classification. Additionally, the findings of cerebral edema and congestion were not adopted for classification because of no description of concentrations. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | As for humans, there was information by acute exposure but not by repeated exposure. As for experimental animals, in a carcinogenicity test in which rats were exposed to this substance by inhalation at up to 200 ppm for 2 years (7 hours/day, 5 days/week), no abnormalities in hematological and biochemical parameters, and in histopathological examination were observed, and a NOEL was estimated to be 200 ppm (DFGOT vol. 19 (2003), PATTY (6th, 2012)). By assuming the state of the substance inhaled is a vapour and converting the concentration of 200 ppm to the guidance value, the converted value (0.72 mg/L/6 hours) was within the range of Category 2, but it was unknown whether effects will appear at the upper limit concentration of Category 2. Since there was no other available information for classification, classification was not possible due to lack of data. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified in Category 2 from 72-hour ErC50 = 6 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2010). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
Reliable chronic toxicity data were not obtained. It was classified in Category 2 due to being not rapidly degradable (a 28-day degradation rate < 0.1% (SIDS, 2010)), and 72-hour ErC50 = 6 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2010). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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