Item | Information |
---|---|
CAS RN | 79-77-6 |
Chemical Name | Ionone |
Substance ID | m-nite-79-77-6_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified |
- |
- | - | From flash points of 127 deg C [closed-cup] (SIDS (Access on Dec. 2012)) and 110 deg C [test method; unknown] (Gangolli (2nd, 1999)), it was judged to be above 93 deg C. Therefore, it was classified as "Not classified." | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule, but it was judged to be Type G from the information: nicht explosionsgefaehrlich aufgrund der chemischen Struktur (IUCLID (2000)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 270 deg C (SIDS (Access on Dec. 2012)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" in the Classification JIS (Category 5 in UN GHS classification or "Not classified") because no deaths were seen at or below 2,000 mg/kg/day in a 5-day repeated oral administration test with rats (doses: 500, 1,000, 2,000, 4,000, 8,000 mg/kg bw/day) (SIDS (Access on Dec. 2012)). Besides, there is a report on an LD50 value for rats of 4590 mg/kg/day for an isomer mixture containing 40% of this substance (beta-ionone) and 60% alpha-ionone (SIDS (Access on Dec. 2012)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | It was classified as "Not classified" because scores for erythema and edema were 0 at all observation time points, and it was not irritating in a test by a 4-hour semi-occlusive application of 0.5 mL of undiluted this substance to the rabbit skin (OECD TG 404, GLP) (SIDS (Access on Dec. 2012)). Besides, it is reported that a 24-hour patch test on an isomer mixture containing 40% of this substance (beta-ionone) and 60% alpha-ionone did not produce skin reactions in 11 humans (SIDS (Access on Dec. 2012)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | It was classified as "Not classified" because it is reported that slight irritation was seen in a test in which 0.1 mL of undiluted this substance was applied to the rabbit eye (OECD TG 405, GLP), but the average score for 24, 48, and 72 hours was corneal opacity: 0.1, iritis: 0.2, conjunctival redness: 1.0, chemosis: 0.1, and all irritation reactions disappeared within 72 hours (SIDS (Access on Dec. 2012)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | It is reported that it was not sensitizing in a skin sensitization test with guinea pigs (a maximization test) (SIDS (Access on Dec. 2012)), but because it was a limited test in five animals in test groups (OECD guideline requires at least 10) and four in the control group, and it is questionable to classify it as "Not classified." Therefore, it was classified as "Classification not possible" due to lack of data. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | It was classified as "Not classified" based on a negative result in a micronucleus test with bone marrow cells after intraperitoneal administration to mice (OECD TG 474, GLP) (in vivo somatic cell mutagenicity test) (SIDS (Access on Dec. 2012)). Besides, as for in vitro tests, it was reported to be negative in an Ames test (SIDS (Access on Dec. 2012)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a developmental toxicity test by oral administration to rats on gestational days 6-19 (doses: 25, 100, 400 mg/kg/day), salivation immediately after administration at or above 100 mg/kg/day and a significant decrease in mean body weights at 400 mg/kg/day were observed as general toxicity in parent animals, but there were no effects on gestational parameters, developmental toxicity, or teratogenicity (SIDS (Access on Dec. 2012)), and it was considered that this substance had no adverse effects on the development of offspring. On the other hand, in a two-generation reproductive test by oral administration to rats, there were no significant differences in maternal animals, offspring, and offspring from F1-generation after 3-time parturition, and no fertility effects were found (USEPA/HPV (2004)), but a test dose was 8-10 mg/kg/day, which was very low and only one, and was insufficient to check adverse effects on sexual function/fertility. Therefore, it was classified as "Classification not possible" due to lack of data. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | After oral administration of an isomer mixture containing 40% of this substance and 60% alpha-ionone (LD50 value: 4,940 mg/kg), deaths occurred between 4 hours and 4 days, and toxic signs of depression and tremors were reported (SIDS (Access on Dec. 2012)), but further details are unknown. Therefore, it was classified as "Classification not possible" due to lack of data. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In a 90-day diet administration test with rats (OECD TG 408, GLP, doses: 100, 1,000, 10,000 ppm (7.5, 77.5, 760.5 mg/kg bw/day)), the target organs were reported to be the liver, kidney, and thyroid. However, as for the liver, hypertrophy of hepatocytes was observed, which was regarded as an adaptive change to increase the metabolizing or excretory capacity (SIDS (Access on Dec. 2012)), and as for the kidney, the formation of alpha-2-micro globulin was confirmed immunohistochemically, which was a specific phenomenon in male rats and not extrapolated to other animal species (SIDS (Access on Dec. 2012)). Therefore, the effects on the liver and kidney do not indicate adverse effects in humans. On the other hand, thyroid effects were found at doses above the upper limit of the guidance value range (SIDS (Access on Dec. 2012)). From the above, no adverse effects were seen within the guidance value range, but effects around the upper limit (100 mg/kg/day) of the guidance value range are unclear. Furthermore, due to no data in the other routes, it was classified as "Classification not possible" for this hazard class. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified in Category 2 from 48-hour EC50 = 3.7 mg/L for crustacea (Daphnia magna) (SIAR, 2004). | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (BIOWIN) and 72-hour ErC10 = 7.1 mg/L for algae (Desmodesmus subspicatus) (SIAR, 2004). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained (crustacea, fish), then it is classified in Category 2 due to being not rapidly degradable and 48-hour EC50 = 3.7 mg/L for crustacea (Daphnia magna) (SIAR, 2004). By drawing a comparison between the above results, it was classified in Category 2. |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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