NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	80-51-3
Chemical Name	4,4'-Oxybisbenzenesulfonylhydrazide
Substance ID	m-nite-80-51-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	Although there is a chemical group associated with explosive properties (sulfonyl hydrazides) in the molecule, and oxygen balance of -116 is above the criteria, -200, it is classified in Division 4.1 in UNRTDG (UN 3226, self-reactive substance, solid, type D). It does not correspond to explosives, hazard class with the highest precedence.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	There is the information that it is not combustible (ICSC (J) (1998)) and combustible (ACGIH (7th, 2001)). Due to conflicting data, the classification is not possible.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Type D	Danger	H242	P370+P378 P210 P234 P235 P240 P280 P403 P411 P420 P501	There is a chemical group associated with explosive properties (sulfonyl hydrazides) in the molecule, and the name of the substance is clearly mentioned in Table 2.4.2.3.2.3 in UNRTDG , and it is classified in Division 4.1 in UNRTDG (UN 3226, self-reactive substance, solid, type D).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	Because it is classified in Division 4.1 in UNRTDG (UN 3226, self-reactive substance, solid, type D), it does not correspond to pyrophoric solids, hazard class with the highest precedence.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (S). However, the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	The following three items of data are reported as LD50 values for rats: 1,000 to 2,000 mg/kg (SIDS (2007)), > 2,000 mg/kg (JECDB (Access on June 2017)), and 2,300 mg/kg (ACGIH (7th, 2001)). One value corresponds to Category 4, another value corresponds to "Not classified" (Category 5 in UN GHS classification), and the third value corresponds to "Not classified" (Category 5 in UN GHS classification or "Not classified"). By adopting the category to which the largest number of cases corresponds, it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Although there is a report of an LD50 value of > 200 mg (ACGIH (7th, 2001)) for rabbits, it is not possible to specify the category to which the LD50 value corresponds only from this data, and the classification was not possible.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on the reports on skin irritation tests with rabbits that it was not irritating to the skin (ACGIH (7th, 2001)), and that it was slightly irritating to the skin (SIDS (2007)), it was classified "Not classified" (Category 3 in UN GHS classification).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Based on the reports on eye irritation tests with rabbits that it was slightly irritating to the eyes (ACGIH (7th, 2001)), and that it was irritating (SIDS (2007)), it was classified in Category 2B.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a mouse bone marrow micronucleus test was negative (ACGIH (7th, 2001), SIDS (2007)). As for in vitro, a bacterial reverse mutation test and a chromosomal aberration test with mammalian cultured cells were positive (JECDB (Access on June 2017), ACGIH (7th, 2001), SIDS (2007), HSDB (Access on June 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats by oral administration (OECD TG 422), and in a reproduction/developmental toxicity screening test with rats by oral administration (OECD TG 421), reproductive development effects were not observed at up to the dose of 45 mg/kg/day in the former and at up to the dose of 30 mg/kg/day in the latter (SIDS (2007), JECDB (Access on June 2017)). However, since these are the results of screening tests, it was not classified as "Not classified" for this hazard class, and it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	As for single oral dose tests with rats, there are reports that tiptoe gait, paralytic gait, etc. were observed at 1,000 mg/kg, which is equivalent to Category 2 (JECDB (Access on June 2017)), and that mild paralysis of hind limbs was also observed at the same 1,000 mg/kg (SIDS (2007)). Therefore, it was classified in Category 2 (nervous system).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (nervous system, blood system, liver, kidney)	Warning	H373	P260 P314 P501	No information on humans is available. As for experimental animals, it is reported that in a 28-day repeated oral dose toxicity test with rats dosed by gavage, a decrease in grip strength, an increase in protein in the urine, an increase in rod nucleus neutrophils, an increase in inorganic phosphorus, a decrease in glucose, and an increase in kidney weights, etc. were observed at or above 30 mg/kg/day (converted guidance value: 9.3 mg/kg/day) within the guidance value range for Category 1, and decreases in hematocrit value and hemoglobin level, increases in reticulocytes and segmented leukocytes, a decrease in lymphocytes, increases in total cholesterol, triglycerides and urea nitrogen, a decrease in chlorine, an increase in the liver weight, perilobular fatty changes, centrilobular hypertrophy of hepatocytes, increased microgranuloma in the liver, fatty degeneration of the proximal tubular epithelium in the kidney, degeneration of nerve fibers in the sciatic nerve, extramedullary hematopoiesis and congestion in the spleen, and atrophy of muscle fibers in the gastrocnemius muscles were observed at or above 100 mg/kg/day (converted guidance value: 31.1 mg/kg/day) within the guidance value range for Category 2, a paralytic gait, diarrhea, deterioration of general conditions, fatty degeneration of the proximal tubular epithelium in the kidney, a decrease in hematopoietic capacity and congestion in the femoral bone marrow, decreases in secretory granules and atrophic changes in the organs and tissues of the whole body were observed at 200 mg/kg/day (converted guidance value: 62.2 mg/kg/day) (JECDB (Access on June 2017)). Besides, regarding the same study, the finding in the liver is not adopted as an effect for the target organ in SIDS (2007). In addition, it is reported that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats dosed by gavage (OECD TG 422), increases in spleen and kidney weights were observed in males at or above 15 mg/kg/day (converted guidance value: 7 mg/kg/day) within the guidance value range for Category 1, an increase in liver weight, decreased function in sensory and motor function tests in the open field were observed at 45 mg/kg/day (converted guidance value: 21 mg/kg/day), which is within the guidance value range for Category 2 (SIDS (2007)). From the above, effects on the nervous system, liver, spleen, haemal system, and kidney were observed. As for the effect on the nervous system, only a decrease in grip strength was seen at the dose within the guidance value range for Category 1, and the pathological histology findings were observed at the dose within the guidance value range for Category 2. Therefore, it was classified in Category 2 (nervous system, haemal system, liver, kidney). By reconfirming the reference, the classification was changed.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 48-hour EC50 = 2.9 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2017), OECD SIDS: 2006), it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (non-biodegradable, a degradation rate by BOD: 2% (J-CHECK, 1994)), and 72-hour NOEC (rate method) = 0.059 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2017)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to being not rapidly degradable (non-biodegradable, a degradation rate by BOD: 2% (J-CHECK, 1994)), and 96-hour LC50 >6.6 mg/L for fish (Oryzias latipes) (limit test, Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2017), OECD SIDS: 2006). From the above results, it was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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