NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	8003-34-7
Chemical Name	Pyrethrins and Pyrethroids
Substance ID	m-nite-8003-34-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Classification not possible	- -	-	-	Classification not possible due to lack of data on the compounds (expert judgment required because Pyrethrin containing diene structure of the target for the chemical groups with explosive properties present is only a part of a Pyrethrum structure).	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Flash point: >60degC and <=93degC	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	Although only the pyrethrin, which is a part of component, has a grouping relevant to explosiveness, there is no data as a mixture. [special notes] Although pyrethrin has the diene systems which is the target of the atom group relevant to explosive, this is not the structure applicable to all the composition ingredients of PIRETORAMU. So it requires expert judgment about aforementioned results.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Calculated based on the following data: Rat LD50 value: 200mg/kg, 1870mg/kg, 273mg/kg, 796mg/kg (ACGIH 7th, 2001), and 1030mg/kg (ATSDR, 2003). Since the calculated values was 337.7mg/kg, it was classified to category 4.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Category 4 because of "SPECIES: Rat; ENDPOINT: LC50(4hr.); VALUE: 3.4mg/L"(ATSDR, 2003)	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 3	- Warning	-	-	It was referred to as Category 3 from description that slight skin irritations were acknowledged in employment evidence of exposure on ATSDR (2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	We classified it as Category 2B based on the description that mild irritation was acknowledged when applied to the eyes of the laboratory animals (ATSDR (2003)).	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	Although ATSDR (2003) and ACGIH (7th, 2001) had descriptions of one case which developed hypersensitivity pneumonitis by inhalation exposure, we could not find other case reports, therefore we presupposed that we could not classify it for the insufficiency of data since it was not concluded that sensitizing property for respiratory organ was positive.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Since two or more case reports of contact dermatitis was found in ACGIH (7th, 2001), we classified it as Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Not classified	- -	-	-	Not classified because of "A4" (ACGIH, 7th, 2001)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	It was considered as Category 2 based on the description that in the oral administration examination during the pregnancy rabbit indicated to ATSDR (2003), although it was unknown about the general toxicity of parent animals, increase in postimplantation loss was observed.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	From description in ACGIH (7th, 2001) that transient spasm was seen in the child whom oral ingestion was given, and from description in ACGIH (7th, 2001) and ATSDR (2003) that the tremor was seen by the oral administration using rats and an inhalation exposure test, it was judged that it had transient effect to the nervous system. So it was set as Category 3 (anesthetic actions).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 2 (nervous system, blood, respiratory organs)	Warning	H373	P260 P314 P501	Based on the description that the effects on the nervous system were observed with the dose a little exceeding the guidance value range of Category 2 in the oral study using the dog (ACGIH (7th, 2001)), and based on the description that the effects on the blood were observed with the dose of the guidance value range of Category 2 in the oral study using the dog (ATSDR (2003)), and based on the description that the effects on the respiratory system was observed with the concentration of the guidance value range of Category 2 in the inhalation exposure test using the rat (ATSDR (2003)), therefore we classified it as Category 2 (nervous systems, blood, respiratory systems).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96-hour LC50=0.14ppb of Crustacea (Mysid shrimp) (AQUIRE, 2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=6.15 (PHYSPROP Database, 2005)), it was classified into Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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