NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	8006-61-9
Chemical Name	Gasoline
Substance ID	m-nite-8006-61-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	UNRTDG No. 1203, Class: 3	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Category 2 because of its flash point: -45degC, initial boiling point: 39degC, and UNRTDG Class: 3, PGIII	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified	- -	-	-	Classified in UNRTDG No. 1203, Class: 3	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Flash point: about 300degC (>70degC)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	UNRTDG Class: 3 No.1203	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified	- -	-	-	UNRTDG No. 1203 Class: 3	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified	- -	-	-	UNRTDG No. 1203 Class: 3	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to liquid substances with boiling point of >55degC are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was set as the outside of Category based on that rat oral LD50 value (14063mg/kg (ATSDR (1995))) was 5000mg/kg or more.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	It became the Category 4 to outside of Category from rabbit percutaneous LD50 values (> 2000mg/kg, > 3750mg/kg (IUCLID (2000)). but it cannot be classified since it cannot be decided.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	It is Category 3 - out of Category based on rat inhalation LC50 value (>5.2 mg/L (IUCLID (2000))), it was cannot be decided and so cannot be classified.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	The result obtained in 4 hour contact test of the agents on rabbit skin irritation with Draize's method (Draize score 4.8 (IUCLID (200)), it was classified as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	By a statement that an eye is stimulated by gasoline vapor exposures in humans(ACGIH (2001)) and based on not irritating in rabbit eye irritation test (ATSDR (1995)), it was set as Category 2B.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Not classified	- -	-	-	Since a result that the guinea pig test proved no sensitization has been obtained[ ATSDR (1995) ].)., it was put ouyside of the Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	It gave negative in dominant lethality test using the mouse (IUCLID (2000)), and it also gave negative in the rat marrow cell in vivo chromosomal aberration test (IARC 45 (1989)). Therefore we classified it as Out Of Category based on the technical guideline.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	It was set as 2 based on the carcinogenic segment A3 by ACGIH (1996).	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Not classified	- -	-	-	Any significant reproductive toxicity has not been observed in the two generation reproduction studies with exposing for two weeks before mating to male/female rat and during pregnancy (IUCLID (2000)). Moreover, teratogenicity has not been observed in the teratogenicity test that followed OECD TG414 (IUCLID (2000)). Therefore, it was placed out of classification. [Special notes] In addition, increase in cleft palates and the number of survived litters has been observed in reproductive toxicity studies of mice, but this was the result at the highest dose with mother animals lethality reached 44%, while no statement of reproductive toxicity at any lower rate is found. Therefore, since the increase in cleft palates and fetal mortality is considered to have been caused of the toxicity against maternal animals, it is not used as referrence for this classification.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (lung, kidney), Category 3 (narcotic effects)	Danger Warning	H370 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	There is the description that the amount of the oral ingestion and the inhalation exposure in the high concentration in human causes pneumonitis (PATTY (5th, 2001)), disorders of kidney (ATSDR (1995)), and it is classified into Category 1 (respiratory tract, kidney). Moreover, it is classified into Category 3 (anaesthetic) by the description that there are a coma and anaesthetic by inhalation exposure to humans (PATTY (5th, 2001), ATSDR (1995)).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (nerve), Category 2 (blood vessels)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	It was classified to as Category 1 (nerve) based on the statement that C4-C7 hydrocarbon in gasoline may cause the sensitization of a cardiac muscle, acute central inhibition, and a respiratory insufficientry in humans (PATTY (5th, 2001)). It was classified to as Category 2 (vascular) because that vascular atrophy and a necrosis are observed in the rat long-term inhalation study (PATTY (5h, 2001)). In addition, the nephrotoxicity to the male rat observed in the repetitive atmospheric exposure test of the gasoline using a rat is a symptoms peculiar to a male rat, and it is not applied to humans. (IUCLID(2000))	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Category 1	Danger	H304	P301+P310 P331 P405 P501	Category 1 because of "human beings cause aspiration pneumonia by an oral ingestion of gasoline." (HSDB, 2004)	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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