NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	811-97-2
Chemical Name	1,1,1,2-tetrafluoroethane
Substance ID	m-nite-811-97-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified	- -	-	-	Not combustible gas (Merck (14th, 2006))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified	- -	-	-	Classified into Not classified since the substance is classified into Division 2.2 in UNRTDG (UN3159) without the description on Subsidiary risk and ERG is 126, not 122 (Gases - Oxidizing (Including Refrigerated Liquids)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Low pressure liquefied gas	Warning	H280	P410+P403	Critical temperature is 101.05 degC (Merck (14th, 2006)) exceeding 65 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gaseous substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	Based on 4 hour exposure LC50 values of >500,000 ppm (ECETOC (2000)), 567,000 ppm (IRIS (2003)) and 289,000 ppmV (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 7 (2009)) for rats, the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on results of only slight signs of irritation (PATTY (5th, 2001)) or not irritating (ECETOC JACC No. 50 (2006)) in rabbit tests, the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	From results of only slight signs of irritation (PATTY (5th, 2001)) and not irritating (ECETOC JACC No. 50 (2006)) in rabbit tests, the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Not classified	- -	-	-	Based on a result that sensitization was not observed in a guinea pig maximization test (ECETOC JACC No.50 (2006), DFGOT vol. 13 (1999)), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on a negative result in an inhalation mouse dominant lethal test (in vivo heritable germ cell mutagenicity tests) and negative results in an inhalation mouse bone marrow micronucleus test and a chromosomal aberration test (in vivo somatic cell mutagenicity tests) (ECETOC JACC 50 (2006)), the substance was classified as "Not classified". As relevant information, from in vitro tests, there are reports of a negative Ames test and a negative chromosomal aberration test (ECETOC JACC 50 (2006)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Not classified	- -	-	-	In a chronic/carcinogenicity test in rats with inhalation for 104 weeks, treatment related effects were limited to the testis. Increases in testis weight and incidence of testicular Leydig cell hyperplasia and adenomas were observed (ECETOC JACC 50 (2006)). However, this benign tumor was observed in the control animals and is common in aged rats, and there were no other treatment related neoplastic lesions or non-neoplastic lesions. In a mouse test with inhalation for 106 week, there were no treatment related tumors (ECETOC JACC 50 (2006)). There are no tests other than inhalation exposure as the substance is a gas and its major exposure route is by inhalation. Based on no treatment related tumor finding in either rat or mouse test, the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Not classified	- -	-	-	Descriptions of no effect on reproductive performance or development of the offspring were reported in a rat reproductive test by inhalation (ECETOC JACC 50 (2006)) and no adverse effects were reported on fetal development including teratogenicity in both rat and rabbit developmental toxicity tests by inhalation during organogenesis period (ECETOC JACC 50 (2006)). Based on these findings, the substance was classified as "Not classified". Additionally, decreased maternal weight gain and fetal delayed ossification were observed in a rat inhalation test (ECETOC JACC 50 (2006)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	Based on reports that narcotic effect was observed in mice, rats and dogs by inhalation (ECETOC JACC 50 (2006)), the substance was classified into Category 3 (narcotic effects).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Not classified	- -	-	-	NOEL in a chronic/carcinogenicity test in rats with inhalation for 52 weeks (6 hr/day) was 1000 ppm (ECETOC JACC 52 (2006)). NOAEL in rat 90-day inhalation test (6 hr/day) was 5000 ppm (IRIS (2003). Results demonstrate no effects at the dose exceeding the upper limit (250 ppm) of the guidance value range for Category 2. From many reports of inhalation tests such as rat 28-day, rat 13-week, mouse 90-day, dog 3-month and dog 1-year, there were no reports or reports of effects at the dose within the guidance value range (<=250 ppm) (IRIS (2003), DFGOT vol.13 (1999), ECETOC JACC 50 (2006)). There are only inhalation exposure tests as the substance is a gas and its major exposure route is inhalation. Therefore the substance was classified as "Not classified". As relevant information, no exposure related adverse effects were reported in healthy volunteer tests (ECETOC JACC 50 (2006), Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 7 (2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Classified into Not classified from its 96h-LC50 = 450 mg/L for fish (Rainbow trout), 48h-EC50 = 980 mg/L for Crustacea (Daphnia magna) (CICAD 11, 1998).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified into Not classified since its acute toxicity is Not classified and it is not non-water soluble (estimated value of water solubility = 2040 mg/L (PHYSPROP Database, 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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