NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	82-68-8
Chemical Name	Pentachloronitrobenzene
Substance ID	m-nite-82-68-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Classification not possible	- -	-	-	There is a chemical group associated with explosive properties (nitro group) present in the molecule, oxygen balance of -94.8 is higher than the criteria of -200, and it may correspond to explosives. However, the classification is not possible due to no data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with explosive properties (nitro group) present in the molecule, but the classification is not possible due to no data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an organic compound which does not contain fluorine but contains chlorine and oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It contains no bivalent -O-O- structure in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There were 6 reports of LD50 values of 1,650 mg/kg (female), 1,710 mg/kg (male) (Environmental Risk Assessment for Chemical Substances Vol.1 (Ministry of the Environment, 2002), ACGIH (7th, 2001), JMPR (1995), NTP TR325 (1987), EHC 41 (1984)), 1,740 mg/kg (male) (PATTY (6th, 2012)), 2,140 mg/kg (male, female) (ACGIH (7th, 2001)), >5,000 mg/kg (male, female) (JMPR (1995)), and >30,000 mg/kg (ACGIH (7th, 2001), JMPR (1995), EHC 41 (1984)) for rats. Since three cases each corresponded to Category 4 and "Not classified," it was classified in Category 4 by adopting the category to which the smallest LD50 value corresponded, from a safer point of view.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a report of LD50 values of >4,000 mg/kg (PATTY (6th, 2012), ACGIH (7th, 2001), JMPR (1995), EHC 41 (1984)), and >5,000 mg/kg (JMPR (1995)) for rabbits, it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Although there was a report of an LC50 value (4 hours) of >1.7 mg/L for rats (JMPR (1995)), it could not be identified whether it was Category 4 or "Not classified," therefore, it was classified as "Classification not possible." Besides, since the LC50 value was higher than the saturated vapor concentration (0.0008 mg/L), the reference value as a mist was applied.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Not classified	- -	-	-	There is a description that no irritation was observed in a skin irritation test with rabbits (EHC (1984), JMPR (1995)). In addition, there is a report that no primary irritation was observed after application of this substance to 50 subjects (ACGIH (7th 2001), JMPR (1969)). From the above results, it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Not classified	- -	-	-	There is a description that in an eye irritation test with rabbits, eye discharge and blanching were observed and this was judged to be very slight irritation. The average eye irritation scores were 7/110 at 1 hour, 1.7/110 at 24 hours, and 0 at 48 hours (JMPR (1995)). From the above results, it was classified as "Not classified" based on the irritation scores.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	There are reports that in a skin sensitization test (modified Buehler method) with guinea pigs, positive reactions were observed in all treatment groups (0.5%, 2.5%, 5%) (JMPR (1995)), and that in a skin patch test in which 75% of this substance in water was applied to 50 people, positive reactions were observed in 13 people (ACGIH (7th, 2001), JMPR (1995)). In addition, there is a description that this substance was sensitizing (PATTY (6th, 2012), Environmental Risk Assessment for Chemical Substances Vol.1 (Ministry of the Environment, 2002)). From the above results, it was classified in Category 1. Besides, this substance was classified in "Xi; R43" in EU DSD classification and in "Skin Sens. 1 H317" in the EU CLP classification.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in dominant lethal tests with rats and mice (EHC 41 (1984), PATTY (6th, 2012)). As for in vitro, it was negative in bacterial reverse mutation tests, a gene mutation test, a sister chromatid exchange test and an unscheduled DNA synthesis test with cultured mammalian cells, and positive in a chromosome aberration test and a sister chromatid exchange test with cultured mammalian cells (NTP DB (Access on September 2014), ACGIH (7th, 2001), NTP TR325 (1987), PATTY (6th, 2012), HSDB (Access on August 2014), EHC 41 (1984)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Since it was classified in Group 3 by IARC Suppl. 7 (1987) and in A4 by ACGIH (7th, 2001), it was classified as "Classification not possible." The category was changed according to the revised GHS classification guidance for the Japanese government.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Not classified	- -	-	-	Effects on fertility were not observed even at doses where parental toxicity (suppressed body weight gain) was observed in a two-generation reproductive toxicity test with rats by the oral route (feeding) (JMPR (1995)). In addition, neither maternal toxicity nor reproductive toxicity was observed in a three-generation reproductive toxicity test with rats by the oral route (feeding) (PATTY (6th, 2012), ACGIH (7th, 2001), JMPR (1995), EHC 41 (1984)). In teratogenicity tests with rats, mice and rabbits by the oral route, even at doses where general toxicity or deaths were observed in maternal animals, no teratogenicity and no effects on the fetus were observed (PATTY (6th, 2012), Environmental Risk Assessment for Chemical Substances Vol.1 (Ministry of the Environment, 2002), ACGIH (7th, 2001), JMPR (1995), NTP TR 325 (1987), EHC 41 (1984)). From the above, it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 2 (blood system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	There are few human and experimental animal data on this substance. In humans, there was a report of decreased blood oxygen transporting ability and decreased function of the nervous system (Environmental Risk Assessment for Chemical Substances Vol.1 (Ministry of the Environment, 2002)). As for experimental animals, there is a report that in an experiment with cats, which have an unusually high sensitivity due to this low rate of methemoglobin reductase activity, methemoglobinemia and erythrocytes containing Heinz bodies were increased by a single oral administration at the high dose of 1,600 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.1 (Ministry of the Environment, 2002), ACGIH (7th, 2001), PATTY (6th, 2012)). Effects on hemal systems in cats were observed at doses within the range corresponding to Category 2. From the above, it was classified in Category 2 (hemal system).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver)	Danger	H372	P260 P264 P270 P314 P501	There are no hazardous findings by repeated exposure in humans. In experimental animals, in a study in which dogs were administered by feeding for 2 years, cholestatic hepatopathy at 180 ppm (equivalent to 4.5 mg/kg/day) corresponding to Category 1, increased relative liver weight and increased serum ALP activities at 1,080 ppm (equivalent to 27 mg/kg/day) were observed (IRIS (1987), ACGIH (7th, 2001), PATTY (6th, 2012), Environmental Risk Assessment for Chemical Substances Vol.1 (Ministry of the Environment, 2002)). US EPA selected this study as a key study to calculate the oral RfD value (IRIS (1987)). In addition, as for repeated oral administration to rats, there are descriptions that in a 13-week feeding study, increased relative liver weights were observed at 63.5 ppm (equivalent to 3.2 mg/kg/day: conversion was ppm value divided by 20) in males and at or above 635 ppm (equivalent to 32 mg/kg/day similarly as in the above) in females (ACGIH (7th, 2001), PATTY (6th, 2012), EHC 41 (1984)), and that in a 2-year feeding study, enlarged centrilobular hepatocytes at 100 ppm (equivalent to 5 mg/kg/day similarly as in the above), single-cell necrosis and fatty metamorphosis of hepatocytes with an increase in relative liver weight were observed at 400 ppm (equivalent to 20 mg/kg/day similarly as in the above) (JMPR (1995)). From the above, since effects on the liver were observed from the doses of Category 1 in both dogs and rats by the oral route, it was classified in Category 1 (liver). Besides, although the target organs of both the previous classification and this classification were "liver" based on the data different from those in the previous classification, Category "2" was raised to "Category 1" based on the guidance value.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 96-hour LC50 = 0.012 mg/L for crustacea (Mysidopsis bahia) (RED, 2006).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	It was classified in Category 1 due to being not rapidly degradable (a degradation rate by BOD: 1% (Environmental Risk Assessment for Chemical Substances Vol. 1 (Ministry of the Environment, 2002))), and NOEC = 0.020 mg/L for fish (Oryzias latipes) in an early life stage test (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2002)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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