NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	82560-54-1
Chemical Name	Benfuracarb
Substance ID	m-nite-82560-54-1_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Classification not possible	- -	-	-	Although there is information on a flash point of > 100 deg C (GESTIS (Accessed Jan. 2019)), the classification is not possible due to unknown test methods.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	We compared the rat LD50s in male (110mg/kg) and female (105mg/kg)in the oral administration test (Agricultural Chemical Registration Data). Based on the lower of these two values, the substance was classified as Category 3.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was set as the outside of Category. Based on rat LD50 >2000mg/kg in the dermal toxicity tests, and the description that there is no death (Agricultural Chemical Registration Data).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	It was set as Category 2 based on rat LC50 = 0.15mg/L (Agricultural Chemical Registration Data) in the inhalation exposure test (dust and mists).	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Not classified	- -	-	-	In the skin irritation test of rabbits, it carried out the outside of Category based on the statement that skin irritation is not admitted (Agricultural Chemical Registration Data).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In the eye irritation tests using a rabbit, mild redness of a conjunctiva and mild to moderate swelling were observed. And it disappeared within 24 to 48 hours after applying eyedrop (Agricultural Chemical Registration Data). So it was set as Category 2B.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Not classified	- -	-	-	In the skin sensitization test by guinea pig, it carried out the outside of Category based on the statement (Agricultural Chemical Registration Data) that sensitizing was not admitted.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	There is no result of human multi generation epidemiology, multi generation mutagenicity test, and germ cell in vivo mutagenicity test. And there is the description that it is negative result in all of the somatic cell in vivo mutagenicity test (chromosome aberration test using rat bone marrow cells and the small core test using mouse PCE stem cell) (Agricultural Chemical Registration Data). So it is classified as the out of the Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Not classified	- -	-	-	In the carcinogenicity tests using a mouse, it carried out the outside of Category based on the statement (Agricultural Chemical Registration Data) that tumor production and increased by medication were not seen.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Since a reduced viability index in pups at the dose that caused general toxicity in parental animals was observed in (1) and (2) and adverse effects on fertility were observed in (2), it was classified in Category 1B. It was classified based on the new information source. [Evidence Data] (1) It was reported that, in a two-generation reproduction toxicity study with rats dosed by feeding (GLP, 30 to 300 ppm), in parental animals, reduced body weight gain and decreased food consumption in P males and females and decreased adrenal weight in females were observed at or above the intermediate dose, and reduced body weight gain (males and females) and decreased food consumption (females) in F1 were observed at the high dose (300 ppm), but no adverse effects on fertility were observed; while in pups, reduced body weight gain in F1 and F2 males and females was observed at or above the intermediate dose and reduced viability index was observed at the high dose in F1 (viability index on postnatal day 4: 86.3%, viability index on postnatal day 14: 89.9%, viability index on postnatal day 21: 89.9%) and in F2 (viability index on postnatal day 4: 92.2%, no statistically significant difference but considered to be the effect of administration of the test substance) (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2019)). (2) It was reported that, in a two-generation reproduction toxicity study with rats dosed by feeding (GLP, 25 to 400 ppm), in the high-dose (400 ppm) group in which reduced body weight gain (about 10%) and increased food consumption (around 20%) in parental animals were observed, decreased male fertility, decreased number of live pups (viability index on postnatal day 4: 41.6% (92/221), viability index on postnatal day 21: 68.5% (63/92)), and lower pup weight (only F1) were observed (EFSA (2009), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2019)). [Reference Data, etc.] (3) It was reported that, in a developmental toxicity study with female rats dosed by gavage (GLP, 2 to 40 mg/kg/day, days 6 to 19 of gestation), at the highest dose (40 mg/kg/day) that caused maternal toxicity (1/24 death, reduced body weight gain, tremor), slight effects such as decreased body weight and delayed ossification were observed in fetuses (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2019), EFSA (2009)). (4) It was reported that, in a developmental toxicity study with female rabbits dosed by gavage (GLP, 5 to 15 mg/kg/day, days 7 to 29 of gestation), in dams, two deaths were observed at the intermediate dose (10 mg/kg/day) and three deaths and reduced body weight gain were observed at the high dose (15 mg/kg/day); while in fetuses, only decreased body weight was observed at the high dose (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2019), EFSA (2009)). (5) In the EU, it was classified in Repr. 2 (EU CLP Classification Results (Accessed Dec. 2021)).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	It was considered as Category 1(nerve systems) based on the description (Agricultural Chemical Registration Data ) that in mice and rats at the dose within the range of guidance value in Category 1 (more than 64mg/kg), entire body shivering, salivation, proneness position accompanied by dacryorrhea and a clonic convulsion, respiration depressed, protrusion of eyeballs, corneal reflex fall, and bloody tears were observed.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Since in mouse test, NOAEL=47.1-62.7 mg/kg is in the guidance value range of Category 2 (10-100 mg/kg), and although there is a description that toxic symptoms, such as decreased weight gain and accompanied decrease of organ weight, tranquility, piloerection and eyelid ptosis are observed in 162-222 mg/kg outside the range (Agricultural Chemical Registration Data), it cannot be classified only according to these data.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 48-hour EC50=0.0099 mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity was Category 1, and supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (BCF=90 (Agricultural Chemical Registration Data, 1989))).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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