NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	84-65-1
Chemical Name	9,10-Anthraquinone
Substance ID	m-nite-84-65-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	There is information that it is combustible (ICSC (J) (2005)), but the classification is not possible due to no data in the prescribed test.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 650 deg C (ICSC (J) (2005)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Both an LD50 value of 5 g/kg for mice (NTP TR 494 (2005)) and an LD50 value of > 5,000 mg/kg for rats from List 2 information (IUCLID (2000)) correspond to "Not classified."	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on an LD50 value of > 5,000 mg/kg for rats (IUCLID (2000)) and an LD50 value of > 3,000 mg/kg for rabbits (IUCLID (2000)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	An LC50 value by 4-hour exposure of > 1.327 mg/L for rats (IUCLID (2000)) corresponds to Category 4 or "Not classified," but the category cannot be determined. Therefore, it was classified as "Classification not possible." Besides, because the test concentration was higher than the saturated vapour pressure concentration, it was regarded as a test on dust.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	It was classified as "Not classified" because it was not irritating in a skin irritation test with rabbits (OECD TG 404) (IUCLID (2000)). Besides, it is also reported that it was not irritating in another test by a 24-hour semi-occlusive application of 500 microL or 0.5 g to the rabbit skin (IUCLID (2000)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It was classified in Category 2B based on the result that it was slightly irritating in an eye irritation test with rabbits (OECD TG 405) (IUCLID (2000)). Besides, it was not irritating in another test in which 100 microL or 0.1 g was applied to the rabbit eye (IUCLID (2000)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	It is reported that it was not sensitizing in a skin sensitization test with guinea pigs (Intracutaneus Test), which gave a negative result (IUCLID (2000)). However, because it was from List 2 information, and the test method was not the one approved by OECD, it was classified as "Classification not possible."	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on negative results in micronucleus tests with bone marrow cells after oral or intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (NTP DB (Access on July 2012), IARC 101 (2012)). Besides, a positive result was obtained in a micronucleus test with peripheral blood after 14-week diet administration to mice (in vivo somatic cell mutagenicity test), but it is described that it may be due to increased erythropoiesis (NTP TR 494 (2005)). And as for in vitro tests, it is reported that it was negative or positive in Ames tests (NTP DB Study ID A40147 (2006)), positive in a micronucleus test with hamster embryo cells, negative in a chromosomal aberration test with CHO cells, and negative in a gene mutation test with L5178Y mouse lymphoma cells (IARC 101 (2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 2 because IARC classified it in Group 2B for carcinogenicity (IARC 101 (2012)). Besides, it is reported that in 2-year diet administration tests with rats and mice, there was some evidence of carcinogenicity in male rats based on increased incidences of renal tubule adenoma and transitional epithelial papilloma in the kidney and urinary bladder, and there was clear evidence of carcinogenicity in female rats based on increased incidences of renal tubule neoplasms (NTP TR 494 (2005)). On the other hand, it is reported that increased incidences of liver neoplasms were observed in both male and female mice, and there was clear evidence of carcinogenicity (NTP TR 494 (2005)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood, lung)	Warning	H373	P260 P314 P501	It was classified in Category 2 (blood, lung) because there is a report on changes in hematological profile (decreased hemoglobin level, decreased erythrocytes, decreased reticulocytes) and histopathological findings in the lung (emphysema, atelectasis, cellular proliferation, perivascular hyperemia, and exudates in the alveolar lumen) at 0.0122 mg/L in a 4-month inhalation exposure test (5-6 hours/day) with rats (IUCLID (2000)). Besides, it corresponds to Category 1 judging from the guidance values, but it is List 2 data, and its test does not meet Decision criteria 1b3), so it was classified in Category 2 according to the GHS classification guidance for the Japanese government. On the other hand, as for the oral route, there is a report on responsive anemia, hematopoietic cell proliferation, liver hypertrophy, centrilobular hypertrophy of hepatocytes, nephropathy, etc. in 14-week diet administration tests with rats and mice (NTP TR 494 (2005)), but these were found at the high doses above the guidance value range, and the NOEL is unknown. In the oral route, there is also a report on decreased erythrocytes, centrilobular hypertrophy of hepatocytes, etc. in a 3-month diet administration test with rats and a 28-day oral administration test with rats (IUCLID (2000)), but the details are unknown, and these could not be used for classification.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 48-hour LC50 = 0.0942 mg/L for crustacea (Americamysis bahia) (Environmental Risk Assessment for Chemical Substances Vol. 1 (Ministry of the Environment, 2002)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (readily biodegradable, BOD: 52.3% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1975)), and 8-day NOEC < 0.01 mg/L for aquatic plants (Lemna gibba) (Environmental Risk Assessment for Chemical Substances Vol. 1 (Ministry of the Environment, 2002)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (readily biodegradable, BOD: 52.3% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1975)), and 48-hour LC50 = 0.0942 mg/L for crustacea (Americamysis bahia) (Environmental Risk Assessment for Chemical Substances Vol. 1 (Ministry of the Environment, 2002)). From the above results, it was classified in Category 1.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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