NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	87-56-9
Chemical Name	Mucochloric acid
Substance ID	m-nite-87-56-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (normal temperatures) (SIDS (2003))	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (normal temperatures) (SIDS (2003))	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (normal temperatures) (SIDS (2003))	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (normal temperatures) (SIDS (2003))	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	There is information that it is combustible (GESTIS (Access on June 2012)), but there are no data in the prescribed test method.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	The substance does not contain chemical groups associated with explosive properties but contains a chemical group associated with self-reactive properties (acrylic group), however, there are no data.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (normal temperatures) (SIDS (2003))	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (normal temperatures) (SIDS (2003))	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There is a report on five LD50 values for rats (400, 360, 300, 500, and 350 mg/kg) (SIDS (2003)), one corresponds to Category 3, and four correspond to Category 4. Therefore, it was classified in Category 4, to which most corresponded.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	There is a report on an LD50 value of > 200 mg/kg for rabbits (SIDS (2003)), but the category cannot be determined. Therefore, the classification is not possible.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (normal temperatures) (SIDS (2003))	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS based on an LC50 value for rats of > 5.1 mg/L (dust: 4-hour exposure) (SIDS (2003)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In a test by a 4-hour occlusive application of 0.5 g of an 80% aqueous solution of this substance to the skin of two rabbits (Test guidelines of the US Department of Transportation), the average scores after 4 hours, 1 day, 2 days, and 8 days were 3.5, 4, 4, 4, respectively for erythema, and 3, 3, 3, 1.5 for edema, and it was assessed to be corrosive (SIDS (2003)). Therefore, it was classified in Category 1.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	In a test in which 50 mg of this substance as a powder was applied to rabbits, the most severe symptom was an opacity of the complete cornea graded as opaque, this persisted on day 8 of the end of the test and was regarded as irreversible, and it was judged as highly corrosive (SIDS (2003)). Therefore, it was classified in Category 1.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	It is reported that one out of five animals became sensitized in a maximization test with guinea pigs (SIDS (2003)), but the test results are unclear, and no conclusion was drawn. And it is reported that it was not sensitizing in another skin sensitization test with guinea pigs (open epicutaneous test) (SIDS (2003)), but the test method was not the one approved by OECD. Because there was no other information to be the rationale for classification, it was classified as "Classification not possible."	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	In a test in which nuclear anomalies including micronuclei were measured using intestinal epithelial cells after oral administration to mice, an increase in anomalies was observed only in the duodenum, and it was suggested to be weakly genotoxic (SIDS (2003)). On the other hand, as for in vitro tests, there is a report on positive results in all of the various in-vitro mutagenicity tests such an Ames test, a mouse lymphoma test, an HGPRT test with CHO cells, a chromosomal aberration test with CHO cells, and a micronucleus test with V79 cells of Chinese hamsters (SIDS (2003)). Therefore, it was classified in Category 2.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	Data are lacking. Besides, it is reported that in a test in which 7-day-old mice of two different hybrid strains were orally administered for 18 months (by gavage until the age of 4 weeks followed by diet administration), there were no significant effects on mortality compared to the control group, and no significant increase in tumor rates was also observed (SIDS (2003)), but data are insufficient to use for classification because it is a test with only one dose and the limited number of animals, and the number of organs examined and target tumor categories were limited.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In a developmental toxicity test by oral administration to rats on gestational days 6-19 (OECD TG414: GLP), decreased food consumption and reduced weight gain were observed in maternal animals as general toxicity, but there were no signs of developmental toxicity or teratogenicity (SIDS (2003)). Therefore, it was judged to have no adverse effects on the development of offspring. However, because effects on sexual function and fertility are unknown due to no data, it was classified as "Classification not possible."	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (systemic)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In an oral administration test with rats, an LD50 value was 300-400 mg/kg, and atonia and ataxia were observed (SIDS (2003)). And in another test, all animals died at the high dose, and gasping and clonic convulsions were found as symptoms (SIDS (2003)). Furthermore, there is also a test in which excitement was found initially followed by labored breathing and reduced breathing frequency (SIDS (2003)). On the other hand, in an inhalation test, 4-hour exposure to 5.1 mg/L caused no deaths in rats, and clinical signs of preening, dyspnea, and salivation were seen (SIDS (2003)). From the above, after oral administration, symptoms were observed at doses corresponding to the guidance values for Category 2, but it was hard to specify the target organ. Therefore, it was classified in Category 2 (systemic toxicity).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Data are lacking. Besides, there is a description of findings such as loss of reflexes and an intermittent increase in excitability after 5-month inhalation exposure in rats and increased excitability after 4-month oral administration to rats, but neither was used for classification because both were regarded as insufficient data for assessment due to the test method being inappropriate or limited (SIDS (2003)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 48-hour EC50 = 13 mg/L for crustacea (Daphnia magna) (SIDS, 2005).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 3 because appropriate data on rapid degradability were not obtained, and it corresponds to Category 3 in acute toxicity for crustacea (SIDS, 2005).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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