NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	87-59-2
Chemical Name	2,3-Dimethylaniline
Substance ID	m-nite-87-59-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified	- -	-	-	A flash point of 96 deg C [closed-cup] (ICSC (J) (2007)) is 93 deg C.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 545 deg C (ICSC (J) (2007)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on LD50 values for rats of 930 mg/kg (Initial Risk Assessment Report 208 (NITE, CERI, NEDO, 2005)) and 933 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	It was classified in Category 3 based on an LD50 value of 500-1,000 mg/kg for guinea pigs (Initial Risk Assessment Report 208 (NITE, CERI, NEDO, 2005)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified in Category 2 because it is reported that severe irritation was observed in a 24-hour occlusive application test with guinea pigs (Hazard Assessment Report Ver. 1.0, No. 208 (CERI, NITE, 2005)), and it is described that this substance and its isomer mixture irritate the skin in humans and may cause erythema and pain on contact with the skin (Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Data are lacking. Besides, it is described that this substance and its isomer mixture may irritate the eye (Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006)), but no data are quoted, and the details are unknown.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Data are lacking. Besides, it was reported to be negative in a DNA synthesis inhibition test with the testis after oral administration to mice (in vivo germ cell genotoxicity test) (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)). And as for in vitro tests, Ames tests gave both positive (JECDB (Access on July 2012), NTP DB (Access on June 2012)) and negative results (Initial Risk Assessment Report 208 (NITE, CERI, NEDO, 2005)), and it was reported to be positive in a chromosomal aberration test with CHL/IU cells (JECDB (Access on July 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available. Besides, ACGIH classified it in A3 for carcinogenicity as mixed isomers.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	It is described that exposure at high levels of this substance could cause lowering of consciousness and formation of methemoglobin (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)), but no specific data are quoted, and the details are unknown. Therefore, the classification is not possible due to lack of data. Besides, as data on 3,5-dimethylaniline, the isomer, it is reported that in an oral administration test with rats, blood methemoglobin level exceeded 5% after administration of 145 mg/kg or above (the control group, 4.96%) and reached the maximum of 32.7% at 3 hours after administration of 580 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)), and effects on the blood were observed.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood, kidney, liver)	Warning	H373	P260 P314 P501	In a 28-day repeated dose toxicity test by oral administration to rats (Guidelines specified by the Chemical Substances Control Law, GLP), decreases in hemoglobin level, erythrocyte count, and hematocrit value and increased methemoglobin were observed at or above 60 mg/kg (converted guidance value: 18.7 mg/kg/day) corresponding to the guidance value range for Category 2, histopathological examination revealed increased deposits of hemosiderin in the spleen and increased hematopoiesis in the bone marrow, and these were considered to be increased hematopoiesis to compensate for anemia with methemoglobinemia (JECDB (Access on July 2012)). Therefore, it was classified in Category 2 (blood). And at 300 mg/kg (converted guidance value: 93.3 mg/kg/day) corresponding to the guidance value range for Category 2, an increase in urinary protein, increases in erythrocytes and leukocytes and an increase in small round epithelial cells in urinary sediment, and an increase in urea nitrogen were found, and histopathological examination showed basophilic changes in the renal tubules and mineralization of the inner medulla, increased incidence of eosinophilic bodies in the renal tubular epithelium in addition to papillary necrosis, dilatation of the renal tubules, and cellular infiltration in the cortical interstitium (JECDB (Access on July 2012)). Therefore, it was classified in Category 2 (kidney). Furthermore, it was classified in Category 2 (liver) because increases in activities of gamma-GTP and GPT, an increase in total cholesterol, hypertrophy of centrilobular hepatocytes, and bile duct proliferation at the histopathological examination were seen at 300 mg/kg, and these were considered to be slight hepatic disorders (JECDB (Access on July 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 48-hour EC50 = 8.9 mg/L for crustacea (Daphnia magna) (Environmental Risk Assessment for Chemical Substances Vol. 7 (Ministry of the Environment, 2009); Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003); ECETOC TR91, 2003).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, it was classified in Category 1 due to being not rapidly degradable (BOD: 3% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1990)), and 21-day NOEC = 0.1 mg/L for crustacea (Daphnia magna) (Environmental Risk Assessment for Chemical Substances Vol. 7 (Ministry of the Environment, 2009); Hazard Assessment Report (CERI, NITE, 2005)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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