NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	87-61-6
Chemical Name	1,2,3-trichlorobenzene
Substance ID	m-nite-87-61-6_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified	- -	-	-	Since it was classified into Class 6.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2321 (HSDB (2008)), it was classified into Not classified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	Since it was classified into Class 6.1 an PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2321 (HSDB (2008)), it was classified into Not classified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Although it is an organic compound including chlorine, not oxygen and fluorine, chlorine has bound only to carbon.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	The organic compound not including peroxy group in molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There is a description of 1,830 mg/kg (4th volume (2005) of the MOE risk assessment), DFGOT vol.3 (1992), >5,000 mg/kg (DFGOT vol.3 (1992)), and 756 mg/kg (HSDB (2004)) as LD50 value of the oral administration test employing a rat. The category to which multiple data corresponded was adopted and it was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	There is a description, "There is no irritation,"(DFGOT Vol.3 (1992)) in the 4-hour study where 500mg of this substance was administered into the skin of rabbits. On the other hand, there is a description, "moderately irritating in the skin" as an effect on human health in HSDB (2004). classification is not possible due to insufficiency of data, because there is no other datum.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	For animals, it has been described that "In the test where 100 mg of this substance was medicated to the conjunctival sac of a rabbits' eye lids, mild corneal opacity, moderate to severe redness and edema of the conjunctiva were seen in 2/3 rabbits, and such symptoms disappeared in 72 hours."(DFGOT vol.3 (1992)). For humans, there are descriptions of "In some people, a minimal eye irritation with 3 to 5 ppm may occur." in the clause of the human health effect of HSDB (2004) and of "An eye is irritated and redness and pain are found in the eye as acute symptoms." in MOE Risk Assessment, Volume 4 (2005)). As mentioned above, it was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Although there is a description of "slightly positive" by a body cell in vivo mutagenicity test (micronucleus tests which employed mouse erythrocyte) (DFGOT vol.3 (1992)), EU-RAR which is about isomer 1,2,4-trichlorobenzene (2003) described on this test that "a question lingers in the validity of positive finding since the test protocol is not so suitable"On the other hand, there is a description that the in vitro mutagenicity test (chromosome aberration test employing a chinese hamster cells and ames test employing salmonella typhimurium) was "negative" (CaPSAR (1993), NTP DB (Access on December 2008), and DFGOT vol.3 (1992)). As mentioned above, since there is not enough data for classifying, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	In the MOE Risk Assessment, vol. 4 (2005), it was reported that in a gavage oral administration study in 6-15 day pregnant rats, "a significant increase in liver weight and decreases in hemoglobin concentration and hematocrit value were observed in mother animals, but the number of fetuses, fetal weight and malformations in the skeleton and organs were not observed." HSDB (2004) also reported about the same study that "the abnormalities in the pregnancy results do not appear to be related to the exposure." Incidentally, in a gavage oral administration study in 6-15 day pregnant rats, it was reported that "liver and thyroid pathologies and decreases in hematocrit value and hemoglobin concentration were observed in mother animals. Slight osteogenic changes in fetuses were observed, but there were no severe malformations" (Patty (5th, 2001), DFGOT vol. 3 (1992)), and that "a teratogenic study showed no embryotoxicity and fetotoxicity" in DFGOT vol. 3 (1992). It is also reported in a 13-week feeding study in rats that "no effects on the weight of reproductive organs or on the tissues were observed in males and females" (MOE Risk Assessment, vol. 4 (2005)). However, since there is no data concerning effects on the reproductive functions and the data is insufficient classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 2 (gastrointestinal system), Category 3 (respiratory tract irritation)	Warning	H371 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	As for humans, The paragraph of the clinical effect of HSDB (2004) has descriptions that "headache, nasal drainage, cough, breathlessness, chest pain, bronchus spasm, and rarely upper airway swelling and acute lung injury may occur as results of inhalation exposure", that "cough after inhalation, tachypnea, and wheezes are common" and that "there is a possibility of nausea, vomiting, and diarrhea when oral ingestion is carried out." Moreover, the paragraph of human influence of the 4th volume (2005) of MOE Risk Assessment has a description that "an airway is stimulated, cough and pain in the throat were seen as acute symptoms, and stomachache, diarrhea, nausea, and vomiting were developed by oral ingestion." As mentioned above, it was classified into Category 2 (digestive system) and Category 3 (Respiratory tract irritation).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, thyroid)	Warning	H373	P260 P314 P501	It has been described that, in the 13-weeks mixed feed administration test employing rats, " the weight increase of liver and kidney in female, increase of hepatic cell capacity and anisokaryosis increase in male and female, follicle reduction in thyroid gland, increase of the height of a follicular cell, colloid density reduction."(MOE Risk Assessment, Volume 4 (2005)), CaPSAR (1993), Patty (5th, 2001), DFGOT vol.3 (1992)). Since these symptoms were seen within the range of the guidance value of Category 2, it was classified into Category 2 (liver, thyroid). In addition, for humans, although there are descriptions of "The woman who had immersed the work clothes in Chlorobenzenes and washed them for a long period of time had experienced the aplastic anemias."(MOE Risk Assessment, Volume 4 (2005)), Patty (5th, 2001) and of "Some worker of 28 workers who was exposed to Trichlorobenzenes complained headache, giddiness, deep sleep, and indigestion" (MOE Risk Assessment, Volume 4 (2005))), the isomer has not been identified and it is unknown whether it is the influence due to this substance, it is not adopted.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 48-hour EC50 = 0.458 mg/L for crustacea (Daphnia magna) (Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2009), Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2011)).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	It was classified in Category 1 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, METI, 1974)) and 21-day NOEC = 0.03 mg/L for crustacea (Daphnia magna) (SVHC Annex XV Report, 2010).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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