Item | Information |
---|---|
CAS RN | 87392-12-9 |
Chemical Name | 2-Chloro-N-(2-ethyl-6-methylphenyl)-N-[(S)-1-methoxypropan-2-yl]acetamide; S-Metolachlor |
Substance ID | m-nite-87392-12-9_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | |
Sample SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Classification not possible |
- |
- | - | No data available. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to liquid substances are not available. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) to (3), it was classified as "Not classified" (Category 5 in UN GHS classification). [Evidence Data] (1) LD50 (S-metolachlor (containing an S isomer at 80% or higher)) for rats (males): 3,270 mg/kg (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)) (2) LD50 (S-metolachlor (containing an S isomer at 80% or higher)) for rats (females): 2,580 mg/kg (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)) (3) In this hazard class for Metolachlor (racemate, CAS RN 51218-45-2) containing this substance (S isomer), it was classified as "Not classified" (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) LD50 (S-metolachlor (containing an S isomer at 80% or higher)) for rabbits: > 2,000 mg/kg (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)) (2) In this hazard class for Metolachlor (racemate, CAS RN 51218-45-2) containing this substance (S isomer), it was classified as "Not classified" (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) In this hazard class for Metolachlor (racemate, CAS RN 51218-45-2) containing this substance (S isomer), it was classified as "Classification not possible" (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) LC50 (S-metolachlor (containing an S isomer at 80% or higher), 4 hours) for rats: > 2.91 mg/L (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)) (2) In this hazard class for Metolachlor (racemate, CAS RN 51218-45-2) containing this substance (S isomer), it was judged as classification not possible (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) It was reported that, as for S-metolachlor (containing an S isomer at 80% or higher), in a skin irritation test with rabbits (NZW), slight irritation was observed (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)). (2) In this hazard class for Metolachlor (racemate, CAS RN 51218-45-2) containing this substance (S isomer), it was classified as "Not classified" (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) It was reported that, as for S-metolachlor (containing an S isomer at 80% or higher), in an eye irritation test with rabbits (NZW), slight irritation was observed (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)). (2) In this hazard class for Metolachlor (racemate, CAS RN 51218-45-2) containing this substance (S isomer), it was classified as "Not classified" (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) In this hazard class for Metolachlor (racemate, CAS RN 51218-45-2) containing this substance (S isomer), it was judged as classification not possible (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. [Evidence Data] (1) It was reported that, as for S-metolachlor (containing an S isomer at 80% or higher), in a skin sensitization test by the maximization method with guinea pigs, results were positive (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)). (2) In this hazard class for Metolachlor (racemate, CAS RN 51218-45-2) containing this substance (S isomer), it was classified in Category 1 (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) As for S-metolachlor (containing an S isomer at 80% or higher), results were negative in an in vivo micronucleus test, and there were no data in an in vitro test, but for metolachlor of a racemate, results were negative in an in vivo micronucleus test, and results were negative in a reverse mutation test and an in vitro UDS assay, and therefore, the Food Safety Commission of Japan considered that S-metolachlor had no significant genotoxicity to living organisms (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)). (2) In this hazard class for Metolachlor (racemate, CAS RN 51218-45-2) containing this substance (S isomer), it was classified as "Not classified" (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) As for the classification results by domestic and international organizations, there were no classification results for this substance, but as for the racemate and S-metolachlor (containing an S isomer at 80% or higher), the EPA classified these substances in NL (Not Likely to be Carcinogenic to Humans) (EPA Annual Cancer Report 2018 (Accessed Oct. 2020): classification in 2017). (2) For the S isomer, a carcinogenicity study was not conducted, but based on the comparison between the test results on the racemate and those on the S-metolachlor, it was considered that both had similar dynamics and metabolism, and their toxicological profile and the degree of toxicity were almost the same (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)). (3) The EPA initially classified this substance in Group C (possible human carcinogen) based on the increased incidence of liver tumors observed in female rats, but in the re-assessment in 2017, the EPA substantially adopted the findings by the mode of action analysis, clarified that the liver tumors caused in rats were due to cell proliferation by the activation of CAR (constitutive androstane receptor), and concluded that the findings were an extension of hepatocyte toxicity. Therefore, since hepatocellular proliferation did not occur in the regulation range of the chronic RfD (reference dose), the carcinogenicity classification of metolachlor (racemate)/S-metolachlor was changed to NL (US Federal Register Vol. 83, No. 55 (2018)). (4) In this hazard class for Metolachlor (racemate, CAS RN 51218-45-2) containing this substance (S isomer), it was classified as "Classification not possible" (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) to (4), it was classified as "Not classified." [Evidence Data] (1) Based on the comparison between the test results on the racemate and those on the S-metolachlor (containing an S isomer at 80% or higher), it was considered that both had similar dynamics and metabolism, and their toxicological profile and the degree of toxicity were almost the same (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)). (2) In a developmental toxicity study with rats dosed by gavage (days 6-15 of gestation) using S-metolachlor (containing an S isomer at 80% or higher) as the test substance, no developmental effects were observed in fetuses even at a dose at which maternal toxicity (reduced body weight gain, a decrease in food consumption, discomfort) were observed (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)). (3) In a developmental toxicity study with rabbits dosed by gavage (days 7-19 of gestation) using S-metolachlor (containing an S isomer at 80% or higher) as the test substance, in a group at a high dose at which maternal toxicity (reduced body weight, a decrease in food consumption) was significant, malformations were observed in fetuses from 1 litter, but were considered to be spontaneous or secondary effects of maternal toxicity. Decreased feces, no-excretion, or loose stool were observed in dams even at a middle dose, but no effects were observed in fetuses (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)). (4) In this hazard class for Metolachlor (racemate, CAS RN 51218-45-2) containing this substance (S isomer), it was classified as "Not classified" (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (central nervous system). [Evidence Data] (1) As for S-metolachlor (containing an S isomer at 80% or higher), in an acute oral toxicity test with rats and mice, effects on the central nervous system (decreases in exploratory behavior/locomotor activity/pain response/somersault reflex, mydriasis, tonic convulsions, etc.) were observed at doses for Category 1 (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)). (2) In this hazard class for Metolachlor (racemate, CAS RN 51218-45-2) containing this substance (S isomer), it was classified in Category 1 (central nervous system) (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) In a 28-day feeding administration test using S-metolachlor (containing an S isomer at 80% or higher) as the test substance, effects on the liver (increased relative weight, centrilobular hepatocyte hypertrophy, increased GGT (males only), etc.) were observed similarly as metolachlor (racemate, CAS RN 51218-45-2) at or above 3,000 ppm (within the range for Category 2) (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)). (2) In a 90-day oral toxicity test with rats and dogs dosed by feeding using S-metolachlor (containing an S isomer at 80% or higher) as the test substance, no clear organ toxicity was observed within the dose range for Category 1 and Category 2 (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2009)). (3) In this hazard class for Metolachlor (racemate, CAS RN 51218-45-2) containing this substance (S isomer), it was classified as "Classification not possible" (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) In this hazard class for Metolachlor (racemate, CAS RN: 51218-45-2) containing this substance (S-isomer), it was classified as "Classification not possible" (GHS Classification Results in FY2020). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
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