NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	88-75-5
Chemical Name	o-Nitrophenol
Substance ID	m-nite-88-75-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	Although it contains chemical groups (N-O) associated with explosive properties in the molecule, the substance is rated as Division 6.1(III) by UNRTDG (UN1663), and it does not correspond to the explosive of a higher rank.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Type G	- -	-	-	Although it contains chemical groups (N-O) associated with explosive properties in the molecule, the substance is rated as Division 6.1(III) by UNRTDG (UN1663), and it was estimated that the substance was classified into Type G.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified	- -	-	-	Since its autoignition temperature is 485 degC (Hommel (1996)), it is considered that the substance does not ignite at room temperature.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 degC) substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen which is chemically bonded to the element other than carbon or hydrogen. Since no test results are available, classification is not possible.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	This substance is a solid whose melting point is lower than 55 degC, since no test results are available, classification is not possible.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on the rat LD50 value of 2830 mg/kg bw (ATSDR (1992)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the rat LD50 value of > 5000 mg/kg bw (CICAD 20 (2000)), the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	In the rabbit test (OECD TG 404), slightly irritating was reported (CICAD 20 (2000)). In another rabbit test, application of 50 mg of test substance for 24 hours caused slightly irritating and irritation index was 1.4/8.0 (IUCLID (2000)). Based on these documents, the substance was classified as "Not classified" in the JIS classification (corresponding to Category 3 in the UN-GHS classification).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	The substance was classified as "Not classified" based on the documented case of "not irritating" resulted from rabbit test (OECD TG 405) (CICAD 20 (2000)). As relevant notes, in another rabbit test in which 30 mg of the test substance was applied, the substance was concluded to be a slight irritant, but the irritation index was under 15 (10.8/110) (IUCLID (2000)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Not classified	- -	-	-	The substance was classified as "Not classified" based on the documented case of "no skin-sensitizing effects" from Buehler test using guinea pig (OECD TG 406) (CICAD 20 (2000)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro mutagenicity test, negative results in the Ames test were reported (NTP DB (Access on Aug. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In the oral administration study using pregnant rats during the organogenetic period, slight but statistically significant increase in post-implantation losses and early resorption was observed at the dose levels at which transient, but dose-dependent decrease in body weight gain was observed in maternal animals (CICAD 20 (2000)). Therefore, the substance was classified as Category 2.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (blood)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	There was a description that aromatic amine compounds were generally known to cause methemoglobinemia in both humans and the experimental animals (ATSDR (2000)). In cats, the oral application of this substance at the doses ranging from 50 to 250 mg/kg resulted in a dose-dependent formation of methemoglobin (CICAD 20 (2000)). Since judging from the guidance values, the effective dose corresponded to Category 1, the substance was classified as Category 1 (blood). As relevant information, in the acute oral toxicity studies in rats and mice (LD50 values: 2830 - 5376 mg/kg bw for rats, 1300 - 2080 mg/kg bw for mice), clinical signs observed after treatment included dyspnea, ataxic gait, trembling, somnolence, apathy, and cramps. As for macroscopic findings, congestion in the liver and kidneys and ulcers in the stomach in high-dose rats (CICAD 20 (2000)). In the case of mice, although it was reported that clinical signs were observed at the dose levels of Category 2 of the guidance values and higher, the detail of both findings and dose levels was indistinct. (CICAD 20 (2000)). In addition, it was also reported that there were chiefly two patterns for methemoglobin formation, and rat/mouse/rabbit/guinea pig/monkey was less sensitive to methemoglobin formation and they generally could reduce induced methemoglobin more effectively than human/dog/cat (Blom, 2000). The cat was the most sensitive to methemoglobin formation, primarily because of different type of hemoglobin (EU-RAR Vol. 65 (2006)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In the 28-day repeated dose oral study in rats (OECD TG 407), no treatment-related changes were observed in histopathology for the main organs, and no significant toxic findings were noted up to the high dose level of 200 mg/kg/day (converted dose level as that of 90-day study: 62.2 mg/kg/day) except for the organ weight change of the adrenal glands (CICAD 20 (2000)). Moreover, in the 4-week inhalation study exposed to rats as vapors, no treatment-related effects in histopathology were detected except for squamous metaplasia of the epithelium lining the maxilloturbinates and nasoturbinates in the high dose group at 60 mg/m3 (converted value as that of 90-day study: 0.018 mg/L). In this study, no obvious effect was noted in the methemoglobin concentration determined after the 11th exposure (CICAD 20 (2000)). The results described above were obtained at the doses within the range of the guidance value. The effects in the dose near the upper limit of the guidance values were unknown. Therefore, the classification was concluded as "Classification not possible" due to insufficient data.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	Classified into Category 2 from its 72h-ErC50 = 6.0 mg/L for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2008).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (14d-BOD degradation rate = 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1978)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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