NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	90-02-8
Chemical Name	Salicylaldehyde
Substance ID	m-nite-90-02-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	It corresponds to Category 4 from a flash point of 78 deg C [closed-cup] (NFPA (14th, 2010)) > 60 deg C and <= 93 deg C.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was reported that in a test by the administration to rats (OECD TG423, GLP), there were no deaths in six animals at 300 mg/kg, 3/3 animals died at 2000 mg/kg and the approximate lethal dose was 500 mg/kg (JECDB (Access on May 2012)). Therefore, it was classified in Category 4. Besides, the LD50 value for rats of 520 mg/kg separately reported (Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006)) also corresponded to Category 4.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	As for an LD50 value of 3,000 mg/kg for rabbits and an LD50 value of 600 mg/kg for rats (both RTECS (2006), the source: Food and Cosmetics Toxicology. Vol. 17, Pg. 903, 1979), it corresponds to "Not classified" for rabbits and Category 3 for rats. After confirming the description in the source, a more hazardous category for rats was adopted, and it was classified in Category 3.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	In a test in which 0.5 mL of undiluted this substance was applied to four rabbits for 4 hours (OECD TG 404, GLP), the scores for erythema and edema at 24, 48, and 72 hours after the removal of patches were within the range of 0.5-2 and 0-2.5, respectively for all animals, and the primary irritation index (PII) was 2.54 (ECETOC TR66 (1995)). Therefore, it was classified as "Not classified" in the Classification JIS (corresponding to Category 3 in UN GHS classification).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	It is described that this substance is considered to have a sensitizing potential in humans because, in humans, some skin sensitization studies and case reports demonstrated positive reactions to this substance in patch tests conducted in patients with contact dermatitis (SIAP (2011)). However, because the data details are not described, it was classified as "Classification not possible" due to lack of data.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on a negative result in a micronucleus test with bone marrow cells after oral administration to rats (in vivo somatic cell mutagenicity test) (JECDB (Access on May 2012)). Besides, as for in vitro tests, it is reported that an Ames test was negative (JECDB (Access on May 2012)), and a chromosomal aberration test with cultured Chinese hamster cells (CHL/IU) was positive (JECDB (Access on May 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (doses: 0, 2.5, 10, 40, 160 mg/kg/day) (OECD TG422, GLP), no effects on estrous cycle, copulation, fertilization, gestation period, and delivery were observed in either group, and for offspring, no treatment-related effects were seen in the number of live pups on day 0 of lactation, the number of stillbirths, sex ratio, delivery index, and live birth index, but all pups of two maternal animals died by day 4 of lactation in the 160 mg/kg dose group, and effects on survival/development of pups were suggested. Furthermore, in the 160 mg/kg dose group, there was a tendency toward an increase in pup deaths during a nursing period and a tendency toward a decrease in viability index on day 4 of lactation (JECDB (Access on May 2012)). Therefore, it was classified in Category 2. As effects in parent animals, a decrease in cytoplasmic lipid droplets in the liver in males at or above 40 mg/kg and a slight increase in glycogen deposits in hepatocytes in females were found. Besides, there is also a report that fetal deaths and an increase in malformations such as cleft lip and polydactyly were observed after subcutaneous administration of 400 mg/kg to rats on a gestational day 11 (Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (systemic)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In an acute toxicity test by oral administration to rats (OECD TG423, GLP), at 300 mg/kg, transient loose stools were seen, but the animals showed smooth weight gain, and necropsy at the end of a 14-day observation period revealed no macroscopic changes in the visceral organs. At 2,000 mg/kg, decreased locomotor activity, deep and slow respiration, diarrhea, and soiled perineal region were observed, 3/3 animals died within 24 hours after a dose, no macroscopic changes were found at necropsy, and the approximate lethal dose was reported to be 500 mg/kg (JECDB (Access on May 2012)). The dose range of the test corresponded to the guidance values for Category 2, but because it was hard to specify the target organ from the findings obtained, it was classified in Category 2 (systemic toxicity).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (doses: 0, 2.5, 10, 40, 160 mg/kg/day, converted guidance value: about 1.25, 5, 20, 80 mg/kg/day) (OECD TG422, GLP), in females, although one dam in the 40 mg/kg group died during delivery on day 22 of gestation and one dam in the 160 mg/ kg group died on day 22 of gestation, and there were no changes in general status. At the histopathological examination, there were no common findings related to deaths. As for other changes, a decrease in the degree and incidence of cytoplasmic lipid droplets in the liver was observed in males in the groups at or above 40 mg/kg, and in females, increased liver weights in the 160 mg/ kg group and a slight increase of glycogen deposits in hepatocytes at or above 40 mg/kg were found (JECDB (Access on May 2012)). From the above test, no serious adverse effects related to the administration of this substance were seen, but because effects near the upper limit of the guidance values for Category 2 are unknown, it was classified as "Classification not possible" due to lack of data. Besides, it is described that effects on the liver were considered to reflect an increase in glycogen deposits in hepatocytes (JECDB (Access on May 2012)), and it was judged as slight and not used for the rationale for classification.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 96-hour LC50 = 1.6 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2004)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	If chronic toxicity data are used, then it is classified in Category 3 due to being rapidly degradable (readily biodegradable (a degradation rate by BOD of salicylic acid, the degradation product: 88.1% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1976))), and 21-day NOEC = 0.13 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2004)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to being rapidly degradable (readily biodegradable (a degradation rate by BOD of salicylic acid, the degradation product: 88.1% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1976))), and a low bioaccumulation estimate (log Kow = 1.81 (PHYSPROP Database, 2009)), despite 96-hour LC50 = 1.6 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2004)). From the above results, it was classified in Category 3.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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