NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	90-12-0
Chemical Name	1-Methylnaphthalene
Substance ID	m-nite-90-12-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Based on a flash point of 82 degrees C (HSDB (Access on June 2015)), it was classified in Category 4.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an ignition point of 529 degrees C (HSDB (Access on June 2015))	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for liquid substances.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	It is an organic compound that does not contain oxygen, fluorine, or chlorine.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an organic compound that does not contain bivalent -O-O- structure in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Due to no data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	From a reported LD50 value of 1,840 mg/kg for rats (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012), HSDB (Access on June 2015)), it was classified in Category 4.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From a reported LDLo value of 7,500 mg/kg for rabbits (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)), it was classified as "Not classified." Based on the newly obtained data of "Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)," the category was revised.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, it is reported that toxicity effects were not observed after rats were exposed to the saturated vapour of a 2:1 mixture of 2-methylnaphthalene and this substance for 6 hours (IRIS Tox. Review (2003)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	It is reported that in a test using rabbits in 4-hour or 24-hour occlusive application of this substance, a 4-hour application group showed reversible weak redness and edema, and a 24-hour application group showed moderate to severe irritation (BUA 47 (1990)). Moreover, it is written that after application of a mixture of this substance and 2-methylnaphthalene to rabbit skin, it was irritating but not corrosive (IRIS Tox. Review (2003)). Besides, it is not specific information, but it is written that this substance is irritating to the skin without mentioning the extent of irritation (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); HSDB (Access on July 2015)). From the above, from the result that slight irritation was observed after 4-hour application, it was classified as "Not classified" (Category 3 in UN GHS classification).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	From the information that this substance is irritating to eyes (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); HSDB (Access on July 2015)), it was classified in Category 2. Besides, it is written that it was irritating but not corrosive after application of a mixture of this substance and 2-methylnaphthalene to rabbit eyes (IRIS Tox. Review (2003)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, it is reported that in a maximization test (OECD TG406, GLP compliance) using a commonly distributed product containing this substance (this substance 40%, 2-methylnaphthalene 60%), it was not sensitizing (BUA 240 (2005)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to lack of data. There are no in vivo data, and as for in vitro, a bacterial reverse mutation test, a chromosomal aberration test and a sister chromatid exchange test in human lymphocytes were all negative. (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); ACGIH (7th, 2007); ATSDR (2005); NTP DB (Access on August 2015))	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	In an 81-week diet administration test in mice, an increased incidence of bronchiolar/alveolar adenoma or adenocarcinoma was observed in males, but not in females. (ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); ATSDR (2005)) As the classification results in carcinogenicity by other organizations, only ACGIH classified carcinogenicity of this substance and its isomer, 2-methylnaphthalene as A4 (ACGIH (7th, 2007)). From the above, this substance was classified as "Classification not possible" in this hazard class.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with reproduction/developmental toxicity screening test in rats in gavage administration (OECD TG 422), increased liver weight was observed in both males and females at the highest dose of 250 mg/kg/day, but toxicity effects were not found in sexual function and fertility of parent animals and development of offspring by day 4 after birth. (Safety test results by Ministry of Economy, Trade and Industry (Access on August 2015)) However, it is not judged as "Not classified" only from this data which are screening test results. Beside this, it is reported that in a 81-week diet administration test in mice, effects were not observed in reproductive organs of males and females up to the dose corresponding to 143.7 mg/kg/day (ATSDR (2005); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)). From the above, the substance was classified as "Classification not possible" due to lack of data in this hazard class.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	This substance is irritating to the respiratory tract (ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); HSDB (Access on June 2015)). As for experimental animals, it is reported that the concentration that depressed the respiratory rate by 50% (RD50) was 129 mg/m3 (0.129 mg/L) in inhalation exposure in mice (ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)), which was judged to be a change in respiration by irritation. It is reported that decreased sensitivity to pain was assumed because a reaction time of licking paws to a heat stimulus increased in rats in inhalation exposure (0.25-0.41 mg/L) (ATSDR (2005), BUA 240 (2005)). This decreased sensitivity to pain was judged to be narcotic effects. From the above, the substance was classified in Category 3 (respiratory tract irritation, narcotic effects).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (lung)	Warning	H373	P260 P314 P501	As for experimental animals, in an 81-week oral administration toxicity test using mice, pulmonary alveolar proteinosis was observed at the doses of 71.6 mg/kg/day for males and 75.1 mg/kg/day for females. (ATSDR (2005); ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)) These doses were within a range of Category 2. Therefore, it was classified in Category 2 (lung). Besides, in a test in which mice were dermally administered a mixture of 1-methylnaphthalene and 2-methylnaphthalene twice a week for 30 weeks (total dose amount: 119 mg/kg) or 61 weeks (total dose amount: 30, 119 mg/kg), alveolar proteinosis was found in both at 119 mg/kg, and dead animals showed endogenous lipid pneumonia (lipoid pneumonia) which are thought to be a cause of death. (ATSDR (2005); ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012))	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 48-hour LC50 = 1.42 mg/L for crustacea (Daphnia magna) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012), it was classified in Category 2.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to being rapidly degradable (hardly degradable, a degradation rate by 28-day BOD = 2%, a degradation rate by HPLC = 0% (Official Bulletin of Economy, Trade and Industry, 2005)), 21-day NOEC (reproduction) = 0.223 mg/L for crustacea (Daphnia magna) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being rapidly degradable, and 96-hour LC50 = 5.66 mg/L for fish (Oryzias latipes) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012). From the above results, it was classified in Category 2.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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