Item | Information |
---|---|
CAS RN | 900-95-8 |
Chemical Name | Fentin acetate |
Substance ID | m-nite-900-95-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Classification not possible |
- |
- | - | It is combustible (a flash point of 185 plus or minus 5 deg C is described in Pesticide Manual (14th, 2006)), but the classification is not possible due to no data obtained with prescribed test methods. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is an agricultural chemical, and it is estimated that it does not spontaneously ignite in contact with air at normal temperatures. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because data of water solubility of about 9 mg/L (20 deg C) (HSDB (Access on July 2014)) were obtained, it is estimated that it does not react vigorously with water. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine), and the oxygen is chemically bonded to the element other than carbon or hydrogen (Sn). However, the classification is not possible due to no data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
There are seven reports of LD50 values of 136 mg/kg (males) and 136 mg/kg (EHC 15 (1980)), 140 mg/kg and 298 mg/kg (JMPR 827 (1991)), 140–298 mg/kg (CICAD 13 (1999)), 136-491 mg/kg (PIM 589 (1994)), and 491 mg/kg (males) (ACGIH (7th, 2001), EHC 15 (1980)) for rats. It was classified in Category 3, to which the larger number of values corresponds. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
There are four reports of LD50 values of 450 mg/kg (males) (EHC 15 (1980)), 450 mg/kg (PIM 589 (1994)), and > 2000 mg/kg (CICAD 13 (1999), JMPR 827 (1991)) for rats, and an LD50 value of approximately 125 mg/kg (PIM 589 (1994)) for rabbits. It was classified in Category 3, to which the larger number of values corresponds. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
There are reports of LC50 (4 hours) values of 0.044 mg/L (females) and 0.069 mg/L (females) for rats (JMPR 827 (1991)). It was classified in Category 1, to which the minimum value of LC50 corresponds. Besides, since LC50 values are higher than the saturated vapor concentration (3.17*10-4 mg/L), the reference value of the dust was applied. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | There are reports that no irritation was observed in tests where the substance was applied to rabbit skin (CICAD 13 (1999), JMPR 827 (1991)). On the other hand, it is suggested that this substance may be irritating (HSDB (Access on July 2014)). Based on the above results, this substance was considered to cause mild irritation and it was classified as "Not classified" (Category 3 in UN GHS classification). Besides, this substance is classified as "Xi; R38" in EU DSD classification, and "Skin Irrit. 2 H315" in EU CLP classification. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
Based on a report that in an eye irritation test with rabbits, the rabbits were slaughtered 72 hours after application because severe injury developed and this did not resolve (CICAD 13 (1999), JMPR 827 (1991)), it was classified in Category 1. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
Since there is a report that in a skin sensitization test (Buehler Test) with guinea pigs, sensitization was observed (CICAD 13 (1999)), it was classified in Category 1. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There are no in vivo data on this substance, and as for in vitro, it was negative in a chromosome aberration test with cultured mammalian cells, and positive in a micronucleus test and a sister chromatid exchange test with cultured mammalian cells (ATSDR (2005)). Besides, as for in vivo, there is a report that it was negative in a dominant lethal test with rodents for triphenyltin compounds (ACGIH (7th, 2001)). In addition, it was concluded in CICAD 13 (1999) that triphenyltin compounds were not genotoxic. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It is classified in A4 as organic tin compounds in ACGIH (7th, 2001). Therefore, it was classified as "Classification not possible." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
In a teratogenicity study by the oral route (unknown) with rats, at a dose (8 mg/kg/day) where maternal toxicities (decreased body weight gain, decreased food consumption, piloerection and bloody nose secretion) were observed, effects on reproduction or fetuses (abortion (10 cases), increased early and total intrauterine death, decreased number of implantations, total live fetuses, fetal body weight and crown/rump length, increased non-ossification or weak ossification of the sternebrae and distended ureter) were observed, and in a teratogenicity study by the oral route (gavage) with rabbits, at the dose (1.0 mg/kg/day) indicating maternal toxicity (mortality (1/15 cases), decreased water consumption, decreased food consumption), reproductive or developmental effects (abortion, premature delivery, intrauterine death, vaginal hemorrhages, decreased number of implantations, decreased number of live fetuses, decreased fetal weight, decreased crown/rump length, decreased placental weight, omphalocele, delayed ossification) were observed (JMPR (1991)). In addition, triphenyltin compounds were reported to have effects on reproduction and development in experimental animals (CICAD 13 (1999)). Since the effects on reproduction were observed at doses that caused maternal toxicity as described above, this substance was classified in Category 2. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, liver), Category 3 (respiratory tract irritation) |
Danger Warning |
H370 H335 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
In humans, effects on the central nervous system such as headache, nausea, vomiting, dizziness, vision disorders, visual disturbances, loss of consciousness, and photophobia are observed (CICAD 13 (1999), HSDB (Access on July 2014)). In addition, hepatic injury was observed, and enlarged liver and increased liver aminotransferase activity were reported (HSDB (Access on July 2014)). No data are available for experimental animals. Moreover, although it is not data on this substance itself, the possibility of respiratory tract irritation as an organotin compound is described (ATSDR (2005), ACGIH 7th (2001)). From the above, it was classified in Category 1 (central nervous system, liver) and Category 3 (respiratory tract irritation). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (immune system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
No findings on toxic effects for repeated exposure in humans are available. As for experimental animals, as a result of feeding 15 ppm of this substance to guinea pigs for 47 and 77 days, at a dose corresponding to Category 1 (corresponding to 1.5 mg/kg/day (converted guidance value: 0.73-1.28 mg/kg/day)), decreases in thymus weight, decreases in the number of plasma cells of the spleen and lymph nodes were observed. Also, by feeding for 104 days, inhibition of the immunological reaction against tetanus toxoids was shown (CICAD 13 (1999), JMPR (1991)). In many studies in which triphenyltin hydroxide, a hydrolyzate of this substance in vivo, was administered by feeding to mice, rats, or dogs for 13 to 104 weeks, from a dose corresponding to Category 1, a decrease in the number of white blood cells and the number of lymphocytes and fluctuation of the immunoglobulin fraction (decrease in IgG and IgA, increase/decrease in IgM) were observed (CICAD 13 (1999), JMPR (1991)). From the above, since suppressive effects on the immune system were definitely observed in several animal species by repeated oral administration of this substance and the metabolite, it was classified in Category 1 (immune system). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Insufficient data available. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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