NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	9002-86-2
Chemical Name	Chloroethene polymer [polyvinyl chloride or PVC]
Substance ID	m-nite-9002-86-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	It is combustible, but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an ignition point of 600 degrees C (GESTIS (Access on June 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Due to no data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	It is an organic compound which does not contain oxygen or fluorine but contains chlorine, and the chlorine is not chemically bonded to the elements other than carbon or hydrogen.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an organic compound that does not contain bivalent -O-O- structure in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No established test method suitable for solid substances.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible. Besides, it is reported that mild irritation was observed in a skin irritation test using rats (PATTY (6th, 2012)). However, it was judged as insufficient data to be used for the classification due to unknown details such as application time.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible. There are no in vivo data, and as for in vitro, a bacterial reverse mutation test was negative (NTP DB (Access on July 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Many epidemiological studies in workers in inhalation exposure to dust of this substance were reported. It is written that workers exposed for over five years to the environment where levels measured as total dust (particles of 1 to 6 micro m constitute 4.5 to 30%) exceeded 10 mg/m3 more than 60% time to measure a work environment concentration were diagnosed of benign pneumoconiosis in X-ray examination, and mild pneumoconiosis (diagnosed by X-ray examination), respiratory symptoms, and slightly decreased pulmonary function were observed in workers exposed to particles of this substance as respirable dust at a 10 (mg/m3 x-years) concentration (ACGIH (7th, 2008)). However, there is no report clearly showing an increase of respiratory system tumors in exposure to this substance. Also in experimental animals, inhalation exposure (six hours/day, five days/week) to this substance (90% of particles were not larger than 1.5 micro m in diameter) in rats, guinea pigs, or monkeys at a 13 mg/m3 concentration for 22 months resulted in no lung tumor formation in any species. What found was the only existence of particles of this substance in alveolar macrophages (ACGIH (7th, 2008)). From the above, ACGIH classified in A4. Besides, IARC classified in Group 3 (IARC vol. 19, Suppl. 7 (1987)). Therefore, also in this evaluation, the substance was classified as "Classification not possible" in this hazard class.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	It is reported in ACGIH (7th, 2008) that Finnish female workers in occupational exposure to this substance did not show increased risk of spontaneous abortions, and that an increased odds ratio (2.3, 95% confidence interval: 1.0 to 5.1) for stillbirths or cases having infants with deaths after birth, malformations, or low birth weight was observed in a case-control study in Norwegian and Swedish female workers who were engaged in work handling this substance. However, other than these, there is neither report on reproductive effects in human by exposure to this substance nor reproductive/developmental toxicity information in experimental animals (ACGIH (7th, 2008), DFGOT vol. 2 (1991), PATTY (6th, 2012), HSDB (Access on June 2015)). Therefore, the classification is not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	Because this substance (dust) is irritating to the respiratory tract (HSDB (Access on June 2015)), it was classified in Category 3 (respiratory tract irritation).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	As for humans, it is written that in epidemiological studies in workers in inhalation exposure to dust of this substance, workers exposed for over five years to the environment where levels measured as total dust (particles of 1 to 6 micro m constitute 4.5 to 30%) exceeded 10 mg/m3 more than 60% time to measure a work environment concentration were diagnosed of benign pneumoconiosis in X-ray examination, and mild pneumoconiosis (diagnosed by X-ray examination), respiratory symptoms, and slightly decreased pulmonary function were observed in workers exposed to particles of this substance as respirable dust at a 10 (mg/m3 x-years) concentration as cumulative exposure (ACGIH (7th, 2008)). As for experimental animals, in a 22-month inhalation exposure test (an average diameter: 1.2 micro m) using rats, guinea pigs, or monkeys, phagocytosis of PVC by macrophages and benign pneumoconiosis (fibrosis, inflammation, deficits in pulmonary function, no cancer observed) were reported at 13 mg/m3 (0.013 mg/L). In a 15-week to 8-month inhalation toxicity test using rats (an average diameter: 1.31 micro m, 1.7 micro m), phagocytosis of PVC by macrophages, alveolar septal thickening, interstitial inflammation including the proliferation of connective tissue, and granulomatous foci characterized by the small nodular formation in the lung lymph nodes were reported at 8 to 12 mg/m3 (0.008 to 0.012 mg/L). On an oral route, it is reported that significant effects were not observed in a 2-year repeated oral administration toxicity test using rats did. Besides, it is reported that hyperplasia of the gastric mucosa was observed in a drinking water administration toxicity test using rats after ten months, but a period and amount of administration and so on were not described (ACGIH (7th, 2008)). Findings in the lung in animal tests were within the range of Category 1. As above, as effects of inhalation exposure to dust of this substance, there is the report of benign pneumoconiosis, respiratory symptoms, and slightly decreased pulmonary function in humans. On top of that, because effects on the lung were reported within the range of Category 1 in experimental animals using respirable-sized dust, ACGIH (7th, 2008) recommended a threshold limit value (TLV) of 1 mg/m3 for the respirable-sized fraction. Therefore, the substance was classified in Category 1 (respiratory organs).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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