Item | Information |
---|---|
CAS RN | 91-17-8 |
Chemical Name | Decahydronaphthalene |
Substance ID | m-nite-91-17-8_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Classified into Category 3 since flash point 58 degC (closed-cup) (Merck (14th, 2006)) is >=23 degC and <=60 degC. The substance is classified into Class 3, PG III in UNRTDG (UN1147). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Auto-ignition point is 250 degC (Sax (11th, 2004)) exceeding 70 degC. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance does not contain oxygen, fluorine or chlorine. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on a LD50 value of 4170 mg/kg for rats (PATTY (5th, 2001)), the substance was classified into "Not classified" in JIS classification (correspond to Category 5 in GHS classification). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a LD50 value of 5900 mg/kg for rabbits (PATTY (5th, 2001)), the substance was classified as "Not classified". | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
LC50 values (4h) of 500 ppmV (PATTY (5th, 2001)) and 710 ppmV (NTP TR 513 (2005)) for rats correspond to Category 2 and Category 3, respectively. The category with higher hazard was adopted and the substance was classified into Category 2. Since the LD50 values are lower than 90% of saturated vapour pressure concentration (3026 ppm), the classification criteria of gas was adopted. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
Based on a result that the substance showed a strong irritant effect on the skin and caused necrosis by application to the skin of rabbits for 4-hour (OECD TG404), it was concluded to be corrosive with a skin primary irritation index of 7.5/8.0 (BUA 218 (1998)). The substance was classified into Category 1. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | Based on a result that in a rabbit eye irritation test (OECD TG405), no irritant effect on the cornea or iris was observed and the marked hyperemia and swelling of the conjunctiva had completely disappeared after 6 and 8 days, it was concluded that the substance was not irritating with an eye irritation index of 3.5/110 (BUA 218 (1998). The substance was classified as "Not classified". As relevant information, there is a report that dropping the substance on rabbit eyes caused no injury (HSDB (2004)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Skin sensitization | Not classified |
- |
- | - | Based on a result of "not-sensitizing" (positive ratio: 0%) in a guinea pig maximization test (OECD TG406) (BUA 218 (1998)), the substance was classified as "Not classified". | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Based on negative results in a mouse peripheral blood micronucleus test by 13-week inhalation exposure (in vivo somatic cell mutagenicity test) (NTP DB (aaccess on Nov. 2009)) and in an in vitro chromosomal aberration test using Chinese hamster lung fibroblast cells ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Dec. 2000)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative reverse mutation tests using S. typhimurium ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Dec. 2009), NTP DB (access on Dec. 2009)) and a negative mouse lymphoma cell gene mutation test (BUA Report No.218 (1998)). [Based on expert's decision, weakly positive result for males in the mouse micronucleus test is considered not to be biologically significant because of slight increase (2 times control value) and negative result for females.] |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | In rat and mouse 2-year inhalation tests (NTP TR513 (2005)), survival of exposed groups was similar to that of the control groups and incidences of renal tubule adenoma and pheochromocytoma of the adrenal gland were significantly increased for male rats only. However, the development of these neoplasms was likely related to alpha2u-globulin nephropathy specific to male rats, which may not be applicable as an indication of human carcinogenicity. In addition to these findings, marginally increased incidences of hepatocellular and uterine neoplasms were observed in female mice. Classification was not possible based on the absence of sufficient information for judging the carcinogenicity. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a oral test in mice in which the substance was administered on days 6 - 13 of gestation, there were no effects in the offspring developmental parameters including birth weight, neonatal growth and survival to postnatal day 3 at dose levels producing maternal mortality (NTP TR513 (2005)). However, classification was not possible due to lack of data for effects on sexual function and fertility of parental animals. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
Based on reports that the vapour can irritate the respiratory system (BUA Report 269 (2006)) and that breathing the substance can irritate the nose and throat (HSFS (2002)), the substance was classified into Category 3 (respiratory tract irritation). As relevant information, there is a report that vapour exposures in guinea pigs or dropping on rabbit eyes caused cataracts (PATTY (5th, 2001), HSDB (2004)). Test conditions such as dose level or detailed results are unclear for both the guinea pig vapour and the rabbit eye reports. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver, respiratory organs) |
Danger |
H372 | P260 P264 P270 P314 P501 |
In mouse inhalation tests, incidences of centrilobular cytomegaly of the liver were increased in males exposed to 0.14 - 2.26 mg/L (vapour, 6h/day) for 14 weeks (NTP TR513 (2005)), and incidences of hepatocyte vacuolization of the liver were increased in females exposed to 0.028 - 0.283 mg/L for 90 days or 0.287 - 1.435 mg/L (24h/day) for 30 days (NTP TR513 (2005), BUA Report 218 (1998)). Since these effects were observed at dose levels within the guidance value range for Category 1, the substance was classified into Category 1 (liver). In rat and mouse inhalation tests, the exposure to 0.287 - 1.435 mg/L (6h/day) for 30 day caused concentration-dependent histopathological changes in the trachea, bronchi and alveoli (formation of hyaline droplet on the tracheal epithelium, loss or proliferation of cells, exudate, increased incidence of type II alveolar epithelial cells in tracheobronchial epithelium). Additionally, in a guinea pig inhalation test, exposure at the same concentration for the same period caused irritation to alveoli with multifocal pneumonia, alveolar wall thickening with exudate (NTP TR513 (2005), BUA Report 218 (1998)). Since these effects were observed at dose levels within the guidance value range for Category 1, the substance was classified into Category 1 (respiratory system). Based on effects in both liver and respiratory system, the substance was classified into Category 1 (liver, respiratory system). As relevant information, in rat tests, degeneration in renal tubules with alpha2u-globulin accumulation and hyaline droplet accumulation was observed in the kidney of male rats (NTP TR513 (2005)), however, the lesion was the alpha2u-globulin nephropathy specific to male rats which may not be considered as a human risk. Therefore, this result was not used as the basis of classification. Additionally, it was reported that excessive exposure to high concentrations caused numbness, nausea, headache, and vomiting in human (PATTY (5th, 2001). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Aspiration hazard | Category 1 |
Danger |
H304 | P301+P310 P331 P405 P501 |
Since the substance is a hydrocarbon with kinematic viscosity of 1.9 mm2/s (approx. 25 degC) and is noted that aspiration into the lung may result in chemical pneumonitis (ICSC (2004)), the substance was classified into Category 1. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
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