Item | Information |
---|---|
CAS RN | 91-57-6 |
Chemical Name | 2-Methylnaphthalene |
Substance ID | m-nite-91-57-6_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not an aerosol product. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | Due to no data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an ignition point of 488 degrees C (GESTIS (Access on June 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for solid substances with a melting point of 140 degrees C or lower. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | It is an organic compound that does not contain oxygen, fluorine, or chlorine. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an organic compound that does not contain bivalent -O-O- structure in the molecule. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Although it is a solid with a melting point of 55 degrees C or lower, the classification is not possible because of no data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Four LD50 values of 1,630 mg/kg (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)), 4,310 mg/kg (males), 3,270 mg/kg (females) (IRIS Tox. Review (2003)), and 4,050 mg/kg (SIDS (2011)) were reported for rats. Because one corresponds to Category 4, and three correspond to "Not classified" (Category 5 in UN GHS classification), it was classified as "Not classified" (Category 5 in UN GHS classification) to which most of the data correspond. By adding data from Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012), SIDS (2011), the Category was revised. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | From a reported LD50 value (OECD TG 402) of > 2,000 mg/kg for rats (SIDS (2011)), and reported LD50 values of 6,130 mg/kg (males) and 4,790 mg/kg (females) for rabbits (IRIS Tox. Review (2003)), it was classified as "Not classified." By adding the data from SIDS (2011) and IRIS Tox. Review (2003), the Category was revised. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. Besides, it is reported that toxicity effects were not observed after rats were exposed to the saturated vapour of a 2:1 mixture of this substance and 1-methylnaphthalene for 6 hours (IRIS Tox. Review (2003)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | It is reported that in a test using rabbits in 4-hour or 24-hour occlusive application of this substance, a 4-hour application group showed reversible weak redness and edema, and a 24-hour application group showed moderate to severe irritation (BUA 47 (1990)). Moreover, it is written that after application of a mixture of this substance and 1-methylnaphthalene to rabbit skin, it was irritating but not corrosive (IRIS Tox. Review (2003)). Besides, it is not specific information, but it is written that this substance is irritating to the skin without mentioning the extent of irritation (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); HSDB (Access on July 2015)). From the above, from the result that slight irritation was observed after 4-hour application, it was classified as "Not classified" (Category 3 in UN GHS classification). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
From the information that this substance is irritating to eyes (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); HSDB (Access on July 2015)), it was classified in Category 2. Besides, it is written that it was irritating but not corrosive after application of a mixture of this substance and 1-methylnaphthalene to rabbit eyes (IRIS Tox. Review (2003)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, it is reported that in a maximization test (OECD TG406, GLP compliance) using a commonly distributed product containing this substance (this substance 60%, 1-methylnaphthalene 40%), it was not sensitizing (BUA 240 (2005)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. There are no in vivo data. As for in vitro, there are results of negative in a bacterial reverse mutation test and a chromosomal aberration test in cultured mammalian cells, and positive in a sister chromatid exchange test, but this substance was assessed to be not mutagenic in vitro (SIDS (2011); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); ACGIH (7th, 2007); IRIS Tox. Review (2003); ATSDR (2005); NTP DB (Access on August 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | In an 81-week diet administration test in mice, a statistically significant increase in an incidence of lung adenoma was observed in males of a low dose group, but it was not a dose-dependent change (ACGIH (7th, 2007), ATSDR (2005)). As the classification results in carcinogenicity by other organizations, EPA classified in "I (Inadequate to assess human carcinogenic potential)" in 1991 (IRIS Summary (Access on August 2015)), and ACGIH classified this substance and its isomer, 1-methylnaphthalene in "A4" in 2006 (ACGIH (7th, 2007)). From the above, this substance was classified as "Classification not possible" in this hazard class in accordance with the GHS classification guidance for the Japanese government. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, it is reported that in an 81-week diet administration test in mice, effects were not observed in reproductive organs of males and females up to the dose corresponding to 113.8 mg/kg/day (ATSDR (2005)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335 H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
This substance is irritating to the respiratory tract (ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); HSDB (Access on June 2015)). As for experimental animals, it is reported that the concentration that depressed the respiratory rate by 50% (RD50) was 67 mg/m3 (0.067 mg/L) in inhalation exposure in mice, and a change in respiration occurred, resulting from irritation (ACGIH (7th, 2007); SIDS (2011); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)). It is reported that decreased sensitivity to pain was assumed because a reaction time of licking paws to a heat stimulus increased in rats in inhalation exposure (0.35-0.53 mg/L) (ATSDR (2005), SIDS (2011), IRIS Tox. Review (2003), BUA 240 (2005)). This decreased sensitivity to pain was judged to be narcotic effects. From the above, the substance was classified in Category 3 (respiratory tract irritation, narcotic effects). |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (lung) |
Warning |
H373 | P260 P314 P501 |
As for experimental animals, in an 81-week diet administration toxicity test using mice, pulmonary alveolar proteinosis was observed at the doses of 54.3 mg/kg/day for males and 50.3 mg/kg/day for females. (ATSDR (2005); ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)) These doses were within a range of Category 2. Therefore, it was classified in Category 2 (lung). Besides, in a test in which mice were dermally administered a mixture of 1-methylnaphthalene and 2-methylnaphthalene twice a week for 30 weeks (total dose amount: 119 mg/kg) or 61 weeks (total dose amount: 30, 119 mg/kg), alveolar proteinosis was found in both at 119 mg/kg, and dead animals showed endogenous lipid pneumonia (lipoid pneumonia) which are thought to be a cause of death. (ATSDR (2005); ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)) |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
From 48-hour EC50 = 1.39 mg/L for crustacea (Daphnia magna) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012), it was classified in Category 2. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (BioWin), and 21-day NOEC (reproduction) = 0.233 mg/L for crustacea (Daphnia magna) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable, and for 96-hour LC50 = 1.456 mg/L fish (Oncorhynchus mykiss) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012). From the above results, it was classified in Category 2. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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