Item | Information |
---|---|
CAS RN | 917-69-1 |
Chemical Name | Cobalt(III) acetate |
Substance ID | m-nite-917-69-1_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is ionically bonded to the element other than carbon or hydrogen (Co) and does not contribute to oxidation. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Category 1A |
Danger |
H334 | P304+P340 P342+P311 P261 P284 P501 |
According to Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2015)), cobalt and its compounds are listed in Group 1 as occupational sensitizers to the airway. Therefore, this substance was classified in Category 1A. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Category 1A |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
According to Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2015)), cobalt and its compounds are listed in Group 1 as occupational sensitizers to the skin. Therefore, this substance was classified in Category 1A. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. No data are available for this substance, but it is reported that cobalt compounds with valence states of +3 were positive in bacterial reverse mutation tests (CICAD 69 (2009), Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
There is no test result for this substance itself. Cobalt and cobalt compounds are classified in Group 2B by IARC (IARC 52 (1991)), A3 by ACGIH (7th, 2001), Group 2B by Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (2015)) and R by NTP (NTP RoC (14th, 2016)). Therefore, this substance was classified in Category 2. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
Although there is no information on reproductive effects for this substance itself, information regarding soluble cobalt compounds was considered to be available. In a test in which cobalt chloride hexahydrate was fed to male rats (265 ppm: 20 mg Co/kg/day), moderate to severe congestion appeared in the testes after administration for 35 days, and significant effects on spermatogonial cells, spermatocytes and sperm cells were observed in addition to degenerative or necrotic changes in the testicular germinal epithelium and Sertoli cells after administration for 70 days (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). In a test where male mice administered cobalt(II) chloride in drinking water for 12 weeks were mated with unexposed females, the epididymal sperm count decreased and decreased survival of newborn pups at doses of 200 mg/L or higher, and the number of pregnant animals was reduced (declining fertility in males), testis weights were decreased, reduced testicular sperm counts and daily sperm production, and in a tissue observation of testes hypertrophy of the interstitial Leydig cells, congested blood vessels, degeneration of the spermatogonial cells, necrosis of the seminiferous tubules and interstitial tissue etc. were observed at doses of 400 mg/L or higher (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment) (2013), CICAD 69 (2006)). In another study in which pregnant rats were administered cobalt sulfate by gavage (gestation day 1 to 21), from 50 mg/kg/day, which is lower than the level of maternal toxicity expression (at 100 mg/kg/day, relative weight decrease of the liver, adrenal gland, or spleen were observed), fetuses were reported to have malformations (malformations of the cranium, spinal column, renal pelvis, renal tubule, ovary and testis) and it was also reported that in orally administered pregnant mice (gestation days 6 to 15) at 50 mg/kg/day, malformations of eyelids, kidneys, cranium, and spine occurred in fetuses (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). From the above, in soluble cobalt compounds, harmful effects on male genetic organs and consequent reduction in fertility by the oral route, and teratogenicity observed at dose levels without the maternal toxicity expression were reported. Since this substance is also a soluble cobalt compound, and it is considered that similar reproductive and developmental toxicity is likely to occur, this substance was classified in Category 1B. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system, gastrointestinal tract), Category 3 (respiratory tract irritation) |
Warning |
H371 H335 |
P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
No single exposure data for humans or experimental animals is available. This substance is described as soluble in water (CICAD 69 (2006)). In a single oral dose test on cobalt (II) dichloride (CAS RN 7646-79-9), which is a soluble cobalt salt, decreased spontaneous activity, depression of muscle tone, depression of respiration rate, effects on the gastrointestinal tract were reported at doses equivalent to Category 1 (ATSDR (2004)), and it was classified in Category 1 (central nervous system, gastrointestinal tract) in the GHS Classification (FY 2015). Also cobalt dichloride along with other soluble cobalt salts such as cobalt (II) sulfate, cobalt (II) dinitrate and cobalt (II) diacetate administered in acute oral dose tests using rats caused sedation, diarrhoea, tremors and convulsions prior to death, decrease in body temperature, increased heart rate, and piloerection at the highest dose (corresponds to Category 2), but no macroscopic alterations were observed in the most significant organs and most effects disappeared after 72 hours (SIAP (2014)). Furthermore, it is stated that cobalt (II) chloride, cobalt(II) sulfate, cobalt(II) nitrate, cobalt(II) acetate stimulate the respiratory tract (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). Together with the above information, it is considered that this substance also shows respiratory tract irritation in addition to the effects on the central nervous system and gastrointestinal tract as with other soluble cobalt salts. Therefore, this substance was classified in Category 2 (central nervous system, gastrointestinal tract) and Category 3 (respiratory tract irritation). |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, respiratory organs, cardiovascular system, thyroid, blood system), Category 2 (reproductive organs (male)) |
Danger Warning |
H372 H373 |
P260 P264 P270 P314 P501 |
It is described that this substance is soluble in water (CICAD 69 (2006)). No data regarding humans or experimental animals is available for this substance. As information for soluble cobalt compounds, in humans, it was reported that as disorders in overdose of cobalt chloride or cobalt sulfate used for the treatment of anemia, effects on the nervous system (anorexia, nausea, tinnitus, hearing loss, neuropathy) and thyroid (goiter and inhibition of thyroid gland iodine uptake) were observed and as a result of oral administration of cobalt chloride to volunteers, it was reported that erythroid haematopoiesis was enhanced and there were many complaints of headaches and abdominal discomfort as subjective symptoms (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), CICAD 69 (2006)). Also, as cobalt sulfate was added for the purpose of stabilizing the foam of beer, deaths due to cardiomyopathy were reported among heavy beer drinkers and myocardial damage action of cobalt was a concern (CICAD 69 (2006), ACGIH (7th, 2001)). By limiting the addition of cobalt, it is said that the occurrence of cardiomyopathy and the resulting deaths had disappeared (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment) (2013)). From the above, the nervous system, cardiovascular system, thyroid, and haemal system could be cited as the target organs for repeated exposures to soluble cobalt compounds, including this substance, in humans. As for experimental animals, in tests using rats administered by gavage for 7 months of cobalt dichloride, increase in red blood cell numbers and hemoglobin levels were observed at doses of 0.5 mg Co/kg/day or more (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), ATSDR (2004)). Blood effects were also observed in tests in which cobalt chloride hexahydrate was orally administered to rats for 8 weeks (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), ATSDR (2004)). In addition, in inhalation exposure tests on cobalt sulfate heptahydrate using rats or mice for 13 weeks or 2 years, inflammatory tissue changes in the respiratory organs were observed from the low concentration of 0.3 mg/m3 (0.11 mg/m3 as cobalt) in both rats and mice and also in the 13-week exposure test using rats, an influence in the blood (polycythemia, platelet count reduction, increased reticulocyte counts) was observed (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), CICAD 69 (2006)). Furthermore, it was reported that in a test in which male mice were given by drinking water 200 to 800 ppm of cobalt dichloride for 12 weeks, decrease in the weight of testes, decrease in the epididymal sperm count, reduced daily sperm production and necrosis of seminiferous tubules and interstitial tissue were observed at doses of 400 to 800 ppm (47 to 93 mg/kg/day, 21 to 42 mg/kg/day as cobalt) (converted guidance value: 19.6 to 39.2 mg/kg/day) (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), CICAD 69 (2006)). From the above, it was considered that the target organs of soluble cobalt compounds are the respiratory organs, haemal system, testis and the effects on testes and that on others correspond to Category 2 and category 1, respectively. Therefore, based on information regarding effects of repeated exposure of soluble cobalt compounds to humans and experimental animals, this substance was classified in Category 1 (the nervous system, respiratory organs, cardiovascular system, thyroid, haemal system) and Category 2 (the genetic organs (men)). |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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