NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	92-70-6
Chemical Name	beta-Hydroxynaphthoic acid
Substance ID	m-nite-92-70-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	There is the information that it is combustible (ICSC (2010) (J)), but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of > 400 deg C (ICSC (2010) (J)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on the reports of LD50 values for rats of 823 mg/kg and 1,040 mg/kg (SIDS (2005)), it was classified in Category 4.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	Based on a report that in an acute dermal toxicity test with guinea pigs, no lethality was found at 1,000 mg/kg, but death was at 2,000 mg/kg (SIDS (2005)), it is considered that the LD50 value should be in the range of 1,000-2,000 mg/kg (only one animal per dose was used in this study). Therefore, it was classified in Category 4.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There is a description that irritation of the skin and respiratory tract may be caused in workers (SIDS (2005)). In addition, there is a report that in a skin irritation test (OECD TG 404 compliant) with rabbits, very slight erythema and edema were observed 1 hour and 24 hours after application of this substance, but these completely resolved within 48 hours, and the primary skin irritation index was 0.3. Also, there is a description that application of this substance for 24 hours caused mild to moderate irritation in a skin irritation test with guinea pigs (both SIDS (2005)). Based on the description of a possibility to cause skin irritation to workers, it was classified in Category 2. The information was reviewed, and the category was changed.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Based on a report that in an eye irritation test (OECD TG 405 compliant) with rabbits, edema and conjunctival hyperaemia with secretions were observed 1 hour after application of this substance in all three animals, and conjunctivitis and corneal opacity, and iritis (one animal) were observed after 24-72 hours, with corneal erosion and vascularization observed in all animals after 7 days. These symptoms did not resolve until 14 days later at the end of the study (SIDS (2005)), it was classified in Category 1. The contents of the information source were reviewed, and the category was changed.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Based on the result of a positive rate of 66.7% (6/9) 48 hours after a challenge in a modified maximization test (OECD TG 406 compliant) with guinea pigs (SIDS (2005)), it was classified in Category 1. Besides, results are reported that no sensitization was found in another maximization test (OECD TG 406 compliant) with guinea pigs and in a human patch test (SIDS (2005)). However, it is stated that it is impossible to make a final evaluation because of the small number of cases in both tests, particularly in the human patch test (28 healthy subjects, 8 dermatitis patients) (SIDS (2005)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government. As for in vivo, a micronucleus test with mouse bone marrow cells was negative, and a chromosomal aberration test with bone marrow cells of Chinese hamsters was negative (JECDB (Access on June 2017), SIDS (2005)). As for in vitro, bacterial reverse mutation tests were negative, and a mammalian cell chromosome aberration test was positive (SIDS (2005)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a one-generation study with rats orally dosed, in addition to lower values in body weight, external malformations such as kinked tail, brachyury and microphthalmos, and internal malformations such as abnormal position of the testes, hypoplasia of the spleen and diaphragmatic hernia were observed in the fetuses at the high dose (200 mg/kg/day) where decreased body weight gain was observed in parental animals in both sexes (JECDB (Access on June 2017), SIDS (2005)). From the above, since the occurrence of malformations was observed in the offspring at the dose of general toxic effects in parent animals, it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 2 (systemic), Category 3 (respiratory tract irritation)	Warning	H371 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	In humans, it is described that irritation of the skin and respiratory tract may be caused in workers (SIDS (2005)). As for experimental animals, there is a report that in a single oral dose test with rats, hypoactivity, abdominal position, lateral position, and diarrhea were found at 315 mg/kg/day or above, and at 1,000-1,250 mg/kg, in addition to these symptoms, tachypnea and eyelid closure were observed, and at necropsy of death cases, dark coloration and light-colored spots of the liver and hyperemia of the gastrointestinal tract were observed. An LD50 value of 823 mg/kg is reported in this test (SIDS (2005)). The dose where symptoms were observed correspond to Category 2 in the GHS classification guidance for the Japanese Government, but target organs cannot be identified with these symptoms alone. From the information above, it was classified in Category 2 (systemic toxicity), Category 3 (respiratory tract irritation). By adding the information on the respiratory tract irritation in humans, the classification result was changed from the previous one.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (adrenal gland)	Warning	H373	P260 P314 P501	No information is available on humans. As for experimental animals, in a 28-day repeated oral dose toxicity test with rats, adrenal gland necrosis (one case) was observed in females at 60 mg/kg/day (converted guidance value: 18.7 mg/kg/day) within the guidance value range for Category 2, and at 300 mg/kg/day (converted guidance value: 93.3 mg/kg/day), increased water consumption, decreased phosphate level, increased bilirubin in the serum and urine in females and males, and increased liver weight and adrenal gland necrosis (one case) in females were observed (SIDS (2005)). From the above, it was classified in Category 2 (adrenal gland). Besides, the classification result was different from the previous classification since adrenal gland necrosis was adopted as an effect.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	From 48-hour EC50 (immobile) = 32.9 mg/L for crustacea (Daphnia magna) (OECD SIDS: 2004), it was classified in Category 3.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (non-biodegradable, a degradation rate by BOD: 19.9% (J-CHECK: 1980)), and 72-hour NOEC (rate method) = 6.8 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2017)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (non-biodegradable, a degradation rate by BOD: 19.9% (J-CHECK: 1980)), and 48-hour EC50 (immobile) = 32.9 mg/L for crustacea (Daphnia magna) (OECD SIDS: 2004). From the above results, it was classified in Category 3.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information