NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	92-84-2
Chemical Name	Phenothiazine
Substance ID	m-nite-92-84-2_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Classification not possible	- -	-	-	No data by the designated test method are available though the information is available that the substance is "Combustible" (ICSC (J) (1998)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified	- -	-	-	Auto-ignition point is 470 degC (IUCLID (2000)) exceeding 70 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Containing no oxygen, fluorine or chlorine in the molecule	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on a LD50 value of 5000 mg/kg for rats (ACGIH (2001)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a LD0 value of ca. 9400 mg/kg for rabbits (IUCLID (2000)), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on no toxicity in rats exposed to the substance of 2000 mg/L (4-hour equivalence: 50 mg/L) for 1-hour (IUCLID (2000)), the substance was classified as "Not classified". Since the test concentration was higher than saturated vapour pressure concentration, the test was considered to be conducted for dust or mist.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Since there is a report that employees with skin irritation characterized by itching and reddening, developed a tolerance within a 1 to 4-week period following initial exposure (ACGIH (2001)), and the substance is classified as "Skin irr" by ACGIH, the substance was classified into Category 2. As relevant information, there are results of "not irritating" and "slightly irritating" in a rabbit and guinea pig test (IUCLID (2000)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	Based on a result of "not irritating" in a rabbit test (OECD TG405 (GLP)) (IUCLID (2000)), the substance was classified as "Not classified". As relevant information, photosensitization with direct sunlight was a result of exposure to the substance (ACGIH (2001)) and keratitis was also reported among workers handling the substance (ACGIH (2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Category 1B	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on a negative result in a rat bone marrow micronucleus test by oral administration (in vivo somatic cell mutagenicity test) (NTP DB (access on May. 2009)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (NTP DB (access on May. 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	The promotive effects of phenothiazine were examined in female rats. A mixture of the substance in combination with N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) administered to rats through their diet induced bladder tumors (IUCLID (2000)). Since no carcinogenicity test with phenothiazine itself is available, classification was not possible due to lack of data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Classification not possible	- -	-	-	Following feeding administration to pregnant rats during gestation, the percent of resorbed implants per litter increased and the viability of fetuses decreased in comparison with the control groups at dose levels in which general toxicity is not manifested in maternal animals (IUCLID (2000)). However, the data is insufficient because of its single dose test design and a lack of a report regarding whether the effects were significant. In rat and mice tests by oral administration during organogenesis period, no treatment-related effects on maternal general condition or fetal development including teratogenicity were observed in both species except for decreased body weight gain in rats (IUCLID (2000)). This data is also insufficient since there are no data for effects on sexual function and fertility by exposure before mating. Classification was not possible due to lack of sufficient data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 1 (liver, kidney, blood, nervous system, circulatory system), Category 3 (respiratory tract irritation)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	There is a report that accidental exposure of humans has caused hemolytic anemia and toxic hepatitis (HSDB (2005)). A second report indicates that oral exposure may cause hepatotoxicity, hemolytic anemia, abdominal cramps, tachycardia and renal damage (ACGIH (2001)). Additionally, cardiac arrest and sudden death were reported, and hypotension, dysrhythmias (especially ventricular tachycardia), CNS depression and coma may occur (HSDB (2005)). Based on the data, the substance was classified into Category 1 (liver, kidney, blood system, cardiovascular system, nervous system). In addition, since there are reports that the substance may cause respiratory system irritation in addition to skin irritation (HSDB (2005)) and that "can irritate the respiratory tract" (ICSC (J) (1998)), the substance was classified into Category 3 (respiratory tract irritation).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood)	Warning	H373	P260 P314 P501	In a 13-week feeding test in dogs, decreases in hemoglobin, hematocrit and erythrocyte count attributed to hemolytic action of the substance were observed at a dose of 2000 ppm (approximately 154 mg/kg/day). Microscopic evaluation revealed extramedullary hematopoiesis in the spleen, deposition of hemosiderin in the spleen, liver, kidney and bone marrow as well as changes or abnormalities in bone marrow cell and erythrocyte. In addition, slight deposition of hemosiderin in the liver and kidney and changes in bone marrow cells were also observed at a dose of 500 ppm (approximately 39 mg/kg/day) (IUCLID (2000)). In a 18-day feeding test in rats, changes in bone marrow accompanied by peripheral blood destruction were observed at concentration of 0.5% (approximately 250 mg/kg/day, 90-day equivalence: 50 mg/kg/day). In a 125-day feeding test in rats, decrease in blood hemoglobin concentration and increased hematopoiesis in the bone marrow were observed at a concentration of 0.3% (approximately 150 mg/kg/day) and higher. Since 500 ppm (approximately 39 mg/kg/day) in the 13-week feeding test in dogs and 0.5% (approximately 250 mg/kg/day, 90-day equivalence: 50 mg/kg/day) in the 18-day feeding test in rats are within the guidance value range for Category 2, the substance was classified into Category 2 (blood system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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