NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	923-26-2
Chemical Name	2-Hydroxypropyl methacrylate
Substance ID	m-nite-923-26-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified	- -	-	-	A flash point of 101 degrees C [closed cup] (IUCLID (2000)) is above 93 degrees C.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group present in the molecule associated with a self-reactive property (unsaturated bond), but the classification is not possible due to no data. Besides, there is the information that a marketed product contains 100 to 200 mg/L hydroquinone monomethyl ether (polymerization inhibitor) as a stabilizer (Verschueren (4th, 2001)). And there is the information about methacrylate esters that "they are stabilized by adding hydroquinone or pyrogallol." (HSDB (2002)). And there is the information that "inhibitor of polymerization: 200 ppm hydroquinone. Typical inhibitor level: 1200ppm monomethyl ether hydroquinone" for this substance (HSDB (2002)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for liquid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	An organic compound does not contain fluorine or chlorine but contains oxygen which is not chemically bonded to elements other than carbon or hydrogen.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	From an LD50 value of >2000 mg/kg bw and no death in rats (OECD TG 401; GLP) (English abstract of Report on Toxicity Tests of Chemical Substances, MHLW (Access on Aug. 2011)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	After the application of a drop of an undiluted isomer mixture containing 80 % of this substance to three rabbit eyes, slight irritation, conjunctivitis, keratitis, and corneal opacity within 1 hour and purulent conjunctivitis and iritis on the next day were observed. Slight recoveries were observed in 2 animals during a 7-day observation period, but keratitis and corneal opacity remained. (SIDS (2007)) It is conceivable that more than seven days are necessary for recovery from above results. It was classified in Category 2A by taking R36 in EU classification (EC-JRC (ESIS) (Access on July. 2011)) into consideration.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	According to a skin disease survey about acrylate compounds by Finnish Institute of Occupational Health, positive responses to this compound were observed in 15 out of 124 patients with occupational exposure in the 1990s. (SIDS (2007)) On the other hand, a 38-year-old female patient sensitized to a glue containing 2 components of an acrylic compound showed a positive response to this substance in a patch test. (SIDS (2007)) Furthermore, in a survey of 93 dental technicians with suspected occupational skin disease, 50% was diagnosed with allergic contact dermatitis and 16 humans showed positive responses to this substance. (SIDS (2007)) And 1619 patients were suspected of occupational contact dermatitis in the 1990s and 2 out of 9 patients sensitized to acrylate resin showed positive responses to this substance in a patch test in the occupational exposures. (SIDS (2007)) Because including above reports, there are many epidemiological survey reports and case reports showing allergic dermatitis by this substance or an acrylic compound including this substance (DFGMAK-Doc.16 (2001), SIDS (2007)), it was classified in Category 1. Besides, it is classified in R43 in EU classification (EC-JRC (ESIS) (Access on July. 2011)), and an acrylic compound is listed as allergic substance in Contact Dermatitis (Frosch) (Contact Dermatitis (4th Ed. (2006)), corresponding to List 1).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as in vitro tests, despite a negative in an Ames test (OECD TG 471 and 472, GLP) (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Aug. 2011)), positives in a chromosomal aberration test using Chinese hamster cultured cells (CHL/IU) (OECD TG 473, GLP) (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Aug. 2011)) and a gene mutation test using L5178Y mouse lymphoma cells (SIDS (2007)) were reported.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In a combined repeated oral dose toxicity test with reproductive developmental toxicity test in rats (OECD TG 422, GLP), effects of the test substance on sexual function and fertility such as copulation index, a number of pregnant animals, length of gestation, fertility index, implantation index, and birth index were not observed. A number of pups born, delivery index, a number of live pups born, live birth index, and viability index on lactation day 4 were not different from those in a control group. And effects on newborn were not observed. (English abstract of Report on Toxicity Tests of Chemical Substances, MHLW (Access on Aug. 2011)) But, the classification is not possible because data on effects on fetal development including teratogenicity were insufficient.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	As a result of a single oral dose toxicity test in rats (OECD TG401; GLP), it is reported that salivation right after administration in 2000 mg/kg group in males was only observed, but abnormal clinical signs in groups of 500 and 1000 mg/kg in both males and females or necropsy abnormality in all groups in males and females were not observed. (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Aug. 2011)) It corresponds to "Not classified" in an oral route, but, it was classified as "Classification not possible" in specific target organ toxicity (single exposure) because effects in other routes (dermal, inhalation) are unknown due to no data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a combined repeated oral dose toxicity test with reproductive/developmental toxicity test in rats (OECD TG 422, GLP), it is reported that two males and one female died and symptoms of salivation, a decrease in locomotor activity, and ptosis in 1000 mg/kg group were observed, and a NOEL was 300 mg/kg bw/day above a range of Category 2 in Guidance values (10 to 100 mg/kg bw/day) (converted to a 90-day equivalent: males 163, females 123 mg/kg bw/day). (English abstract of Report on Toxicity Tests of Chemical Substances, MHLW (Access on Aug. 2011)) Therefore, it corresponds to "Not classified" in an oral route, but, it was classified as "Classification not possible" in specific target organ toxicity (repeated exposures) because effects in other routes (dermal, inhalation) are unknown due to no data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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