Item | Information |
---|---|
CAS RN | 94-36-0 |
Chemical Name | Dibenzoyl peroxide |
Substance ID | m-nite-94-36-0_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties present in the molecule. However, it is classified in Division 5.2 (UN3102) and the higher precedence Class 1 in UNRTDG. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified |
- |
- | - | It is classified as organic peroxides. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available (melting point 103-106 deg C (HSDB (Access on July 2013))). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (O). However, the classification is not possible due to no data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Type B |
Danger |
H241 | P370+P380+P375+P378 P210 P234 P235 P240 P280 P403 P410 P411 P420 P501 |
It was classified in Type B because it is classified in Division 5.2 (UN3102) in UNRTDG. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" based on LD50 of > 5,000 mg/kg for rats (SIDS (2004)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | It was classified as "Not classified" based on LC0 of > 24.3 mg/L (converted value: 19.0 mg/L) for rats (SIDS (2004)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | Data are showing that it is slightly or not irritating to the skin, and it is concluded that it was slightly irritating to the skin (SIDS (2004)). Therefore, this substance was considered to be minimally or slightly irritating to the skin, and it was classified as "Not classified" in the Classification JIS (Category 3 in UN GHS classification). "Not classified" in the Classification JIS (Category 3 in UN GHS classification) was specified according to the revised GHS classification guidance for the Japanese government. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
Irritation was observed at 24, 48, 72 hours after application to the eyes of rabbits (SIDS (2004)), and the grade of irritation depended on the test or test method. Furthermore, this substance is classified in "Xi; R36" in EU DSD classification and "Eye Irrit. 2 H319" in EU CLP classification. It was classified in Category 2 based on the above information. Besides, the classification was changed to Category 2 because the information on sub-categorization could not be obtained (the information that irritation in a Draize test with rabbits or human findings is mild and disappear within seven days). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
Skin sensitization was confirmed in the result of a maximization test in humans and epidemiological studies in occupational exposure (SIDS (2004)). It is classified in occupational skin sensitizers Group 2 in the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2012), and it is listed as a skin sensitizer by the Special Committee of the Japanese Society of Occupational and Environmental Allergy (2004). Furthermore, this substance is classified in "R43" in EU DSD classification and "Skin Sens. 1 H317" in EU CLP classification. It was classified in Category 1 based on the above information. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a dominant lethal test with mice (SIDS (2004), IARC 71 (1999), JECFA (2006)) and a micronucleus test with mouse erythrocytes (SIDS (2004)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test (SIDS (2004), JECFA (2006), NTP DB (Access on June 2013)) and a chromosomal aberration test with cultured mammalian cells (SIDS (2004), JECFA (2006), IARC 71 (1999)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it is classified in Group 3 in IARC (1999) and A4 in ACGIH (7th, 2001). The category was changed according to the revised GHS classification guidance for the Japanese government, and information was added. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | It is described that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats by oral administration (OECD TG 422), paternal animals showed decreased weights of the genetic organs and slight testis degeneration, but there were no fertility effects (mating, gestation), and minimum developmental effects (increased incidence of runts, decreased weight gain) were observed in offspring (SIDS (2004)). However, because it was impossible to classify it as "Not classified" from the results of the screening test, it was classified as "Classification not possible" due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
It was classified in Category 3 (respiratory tract irritation) because it is described that there was irritation of the nose and throat in humans (ACGIH (7th, 2001)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | It corresponds to "Not classified" in the oral route rats because effects on the reproductive organs of male and female were observed at the dose (1,000 mg/kg/day) above the guidance value range for Category 2 in a gavage administration test (OECD TG 422) (SIDS (2004)). However, because of no data on the other routes, it was classified as "Classification not possible" due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
From 48-hour EC50 = 0.07 mg/L for crustacea (Daphnia magna) (SIDS, 2004), it was classified in Category 1. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. It was classified in Category 1 in acute toxicity. However, it is rapidly degradable (a 28-day degradation rate by BOD = 84% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1981)), and low bioconcentration is estimated (LogPow = 3.46 (HSDB, 2013)). Therefore, it was classified as "Not classified." | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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