Item | Information |
---|---|
CAS RN | 95-57-8 |
Chemical Name | 2-Chlorophenol |
Substance ID | m-nite-95-57-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
Since the flash point by HSDB(2005) is 64degC(closed type), it was classified into Category 4. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 550degC (Merck KGaA data from March 2009)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | The test method suitable for liquid substances is not established. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Although it is an organic compound including oxygen and chlorine, not fluorine, these oxygen and chlorine have not chemically bound to any elements other than carbon and hydrogen. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | The organic compound not including peroxy group in molecule. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
There is description of LD50 value of 40 mg/kg and 670 mg/kg of the acute oral toxicity test employing a rat (6th volume (2008) of MOE risk assessment), with about 2,000 mg/kg (OECD TG 401, GLP) (Health, Labor and Welfare Ministry reports (Access on October 2008)). Since LD50 value of 2,000 mg/kg of OECD TG 401 and GLP based standard test falls within Category 4, and there exists much data in Category 4, it was classified into Category 4. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Category 4 |
Warning |
H312 | P302+P352 P362+P364 P280 P312 P321 P501 |
Since it was described as LD50 value 1,000-1,580 mg/kg (ATSDR (1999)) of the dermal administration test employing a rabbit, it was classified into Category 4. In addition, although it was described that LD50 value of the dermal administration test employing a rabbit was 740-2,670 mg/kg (HSDB (2005)), since it was the description about Phenol rather than this substance as a result of checking the primary reference (Toxicol.Appl.Pharmacol.42 (1977)), it is not adopted. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Since it was a liquid on the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
It is written that LC50 value of 4-hour inhalation exposure test employing rats (OECD TG 403) is 2.05 mg/L (equivalent 390 ppm) (IUCLID (2000)). Since saturated vapor pressure level of this substance (20degC) is 2,270 ppm, it was classified into Category 2 by applying the gas standard. It is written in ATSDR (1999) that there was no mortality with 908 ppm in 4-hour inhalation exposure test employing rats. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
For animals, "corrosion with severe skin damages such as erythema, dropsy, discoloration, etc."(ATSDR (1999)) has been described in the direct dosage study to skin of rabbits. For humans, "concern about occurrence of contact dermatitis" (HSDB (2005)) has been described. Therefore, it was classified into Category 1. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
It was classified as Category 1 based on descriptions that it is a skin corrosive substance and "strongly irritates eyes and causes redness, pain, and haze eyes when going into eyes" (the 6th volume of the MOE Risk Assessment (2008)), and that it is "corrosive" to eyes of rabbits (ATSDR (1999)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification is not possible since there is no data. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification is not possible since there is no data. In addition, there is a description of "concern about contact dermatitis" in humans (HSDB (2005)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Based on description of "negative" (IUCLID (2000)), in the body cell in vivo mutagenicity test (micronucleus tests employing a mouse), it was classified into "Not classified". It has been described that the body cell in vivo genotoxicity test (SCE test employing the mouse bone marrow cell) is "negative" (ATSDR (1999)) while the in vitro mutagenicity test (chromosome aberration test employing Chinese hamster culture cells (OECD TG 473, GLP)) is "positive" (Health, Labor and Welfare Ministry reports (Access on October 2008)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Since no evaluation by major international evaluation agencies is made, classification is not possible. In addition, it is described that "there is a tumor promotions effect", but "there is no proof that it has an effect of initiation" in the test employing mice or rats (EHC 93 (1989)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
Since it is described as follows in the drinking water administration study using rats, " Decrease in the number of fetuses per one litter and increase in the number of still birth of fetal animals were observed" (MOE Risk Assessment Vol.6 (2008) and there is a description as follows in the primary literature (Environ. Health Perspect. 46 (1982)), "There is no effect on the body weight increase and blood index such as the number of red blood cells, " it was classified in Category 1B. There is a description as follows in the drinking water administration study using rats, "No teratogenicity was found" (EHC 93 (1989)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system, central nervous system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
As for humans, the 6th volume (2008) of the MOE Risk Assessment which is the information sources of List1 has a description that "it strongly stimulates a respiratory tract, and causes a sense of exhaustion, a deep sleep, a spasm, inhalation then cough, shortness of breath, sore throats, etc. when oral ingestion is carried out. Lung edemas may be caused when an aerosol is inhaled," and HSDB (2005) which is the information source of List2 have a description of "the influence on a central nervous system, and lung dropsy" by acute exposures. Moreover, the inhalation exposure test employing rats (OECD TG403) showed "gross change of lung tissue" (IUCLID (2000)) within the limits of the guidance value of Category 1. As mentioned above, it was classified into Category 1 (the respiratory systems, central nervous systems). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Although in repeated oral administration test in rats "high level of liver weight, hypertrophy of hepatocytes, tremulousness, decrease in locomotor activity, and gait abnormality " (Ministry of Health, Labour and Welfare reports (Access on October 2008)) were found, they are effects out of the scope of the guidance value of Category 2. It is written in oral study in mice that "decrease in liver, lien and brain weight "was found, however, "there were no abnormality in morphology or organization" (ATSDR (1999)). Since there is no examination data based on other exposure paths, classification is not possible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Although the kinematic viscosity at 40degC is expected to be 14 mm2/s or less, the classification is not possible since the substance is not hydrocarbon. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified into Category 2 from 48 hours EC50=3.9mg/L of the crustacea (Daphnia magna) (Hazard Assessment Report (2008)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
Since acute toxicity was Category 2 and there were no rapid degradability (the decomposition by BOD: 0%(standard test method (2 weeks)) Existing Chemical Safety Inspections Data (1980))), it was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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