NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	95-76-1
Chemical Name	3,4-Dichloroaniline
Substance ID	m-nite-95-76-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	Classification is not possible since detailed data are not available though the information is available that the substance is "Combustible solid, Flammability 1" (NFPA (13th, 2006)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	Its autoignition point is >= 260degC (ICSC (2000), NFPA (13th, 2006)), and thus is >= 70degC.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Its melting point is 72degC (Ullmanns (6th, 2003), Chapman (ver.16.1, 2008), HODOC (3rd, 1997), Lide (88th, 2008), ICSC (2000), NFPA (13th, 2006)). Test methods applicable to solid (melting point <= 140degC) substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing chlorine, which is chemically bonded only to carbon.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Its melting point is 72degC (Ullmanns (6th, 2003), Chapman (ver.16.1, 2008), HODOC (3rd, 1997), Lide (88th, 2008), ICSC (2000), NFPA (13th, 2006)). Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on the rat LD50 values (male: 570, 880, 510 and 545mg/kg bw; female: 530 and 470mg/kg bw) (EU-RAR (65, 2006), PATTY (5th, 2001)), the substance was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Of the rabbit LD50 of 300 and 631mg/kg bw (EU-RAR 65, 2006) documented, the value of 300mg/kg bw, which represents higher toxicity, was used as the basis to classify the substance into Category 3.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	LC50 values were >0.631 mg/L (OECD TG403) (EU-ARA (65, 2006)) and 3.3 mg/L (EU-ARA (65, 2006)) for rats exposed to the mist (aerosol) for 4-hour. Based on a definitive value of 3.3 mg/L, the substance was classified into Category 4.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	In Draize tests using rabbits, erythema of Grade 1 were observed, but the symptom was reversibly recoverable in 2 days and no edemas were detected (EU-RAR 65, 2006). Thus, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	In Draize tests using rabbits, moderate irritation to the conjunctivas and irises were observed. Although these symptoms disappeared after 14 days, angiogenesis of the cornea started in 7 days and was seen even after 14 days in 2 of 3 rabbits (EU-RAR65, 2006). Since the recovery took 14 days, the substance was classified into Category 2A.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Based on positive results (irritating) from skin sensitization tests using guinea pigs (maximization tests) (EU-RAR (65, 2006)), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Mouse micronucleus tests via oral and intraperitoneal administration using the bone marrow cells (in vivo mutagenicity tests) yielded negative results (EU-RAR (65, 2006)). Based on these results, the substance was classified into "Not classified". In addition, in vitro mutagenicity tests (both Ames tests and chromosomal aberration tests using human lymphocytes) yielded negative results (EU-RAR 65 (2006)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	In oral administration tests using pregnant rats (EU-RAR (65, 2006)), no adverse effects on embryos or fetuses were observed. However, since no data are available on reproductive toxicity of parental animals, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 1 (blood system), Category 2 (nervous system)	Danger Warning	H370 H371	P308+P311 P260 P264 P270 P321 P405 P501	In a 24-hour dermal test with rats (dose levels: 130 - 1500 mg/kg), cyanosis was observed in all treated groups. In a 4-hour inhalation test with rats, increased methaemoglobin was noted at a dose level of 2.8 mg/L (mist because of the substance's saturated vapour pressure concentration of 0.055 mg/L) (EU-RAR 65 (2006)). In addition, there are reports that acute intoxication in humans and animals is indicated by the symptoms of cyanosis, fatigue, dyspnoea, and muscle weakness (PATTY (5th, 2001)) and that like other chloroanilines, the primary toxic effect of the substance is methaemoglobin formation and acute intoxication is indicated by the symptoms of methaemoglobinemia (cyanosis), fatigue, dyspnoea, and muscle weakness (EU-RAR (2006)). Based on the data, the substance was classified into Category 1 (blood system). Additionally, based on a report that clinical signs at doses of 500 - 800 mg/kg included paralysis of the hind extremities (EU-RAR 65 (2006)), the substance was classified into Category 2 (nervous system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system)	Danger	H372	P260 P264 P270 P314 P501	In a 2-week inhalation test with rats (6 hour/day, 5 days/week), increased methaemoglobin level and accumulation of hemosiderin in the spleen were observed at dose levels of 45 mg/m3 (90-day equivalence: 0.007 mg/L) and higher. In a 6-month oral test with rats, increased methaemoglobin level was reported at a dose level of 20 mg/kg which is within the guidance value range for Category 2 (EU-RAR 65 (2006)). Based on the results in the 2-week inhalation test with rats, the substance was classified into Category 1 (blood system) (inhalation).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Since 48-hour EC50 = 0.55mg/L for crustaceans (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1995), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since its classification for acute toxicity is Category 1 and it is not rapidly degradable (non-biodegradable, BOD degradability: 0% (data from Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1979)), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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