Item | Information |
---|---|
CAS RN | 95-83-0 |
Chemical Name | 4-chloro-o-phenylenediamine |
Substance ID | m-nite-95-83-0_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible since no data are available though it contains chemical groups (haloanilines) associated with self-reactive properties in the molecule. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 degC) substances are not available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Positive results were reported in the mouse ear swelling test (NTP IMM 89029 (Access on Jun. 2009)). However, according to the description of this test method in the GHS document, it was not authorized in OECD and could be used as a first stage in the assessment of skin sensitization potential. Therefore, classification could not be determined only by this test result. Since there were no other test reports, the substance was classified as "Classification not possible" due to lack of data. As relevant information, o-Phenylenediamine, an analog of the substance, was classified as "Group 3" by Japan Society for Occupational Health (Recommendations of Occupational Exposure Limits (2010)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
The substance was classified as Category 2 based on the positive results in the micronucleus test and chromosome aberration test using the bone marrow of mice intraperitoneally administered (in vivo mutagenicity test in somatic cells) (NTP DB (Access on Jun. 2009)). As relevant information, negative results in the sister chromatid exchange test using bone marrow cells of mice intraperitoneally administered (in vivo genotoxicity test in somatic cells) (NTP DB (Access on Jun. 2009)) were reported. As for in vitro studies, positive results in the Ames test (NTP DB (Access on Jun. 2009)) and in the chromosome aberration test were reported (NTP DB (Access on Jun. 2009), Mutagenicity Test Data of Existing Chemical Substances based on the toxicity investigation system of the Industrial Safety and Health Law (1996)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
The substance was classified as Category 2 based on the carcinogenicity criteria of "Group 2B" in IARC (IARC suppl. 7 (1987)) and "Group 2B" in Japan Society for Occupational Health (JSOH) (Recommendations for allowable concentrations, Japan Society for Occupational Health (JSOH) (2005)). As relevant information, in the observation after 18 weeks and 28 weeks observation periods following 78-week dietary administration to rats and mice, significant increases in the incidence of bladder tumors and occurrence of neoplastic nodules in the liver and forestomach tumors considered as associated with the administration of this substance in rats, as well as a significant increase in the incidence of hepatocellular carcinomas in mice, were reported (NTP TR 63 (1978)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In the 8-week feeding studies with rats and mice, it was reported that although all animals in both species fed 3% died, no compound-related organ lesions were observed up to the dietary concentration of 1.4% (converted dose level as that of 13-week studies: 420 mg/kg/day for rats, 1260 mg/kg/day for mice), beyond the guidance values (IARC 27 (1982)). Therefore, "Not classified" was applicable for oral route, however, no data were available for the other routes to classify. In conclusion, "Classification not possible" was justified as the classification of this hazard class. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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