Item | Information |
---|---|
CAS RN | 96-12-8 |
Chemical Name | 1,2-Dibromo-3-chloropropane |
Substance ID | m-nite-96-12-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
Category 4 because of its flash point: >60degC and <90degC | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | UNRTDG : it is classified into a class 6.1 (Toxic substances) and PG 2 or 3. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon (but not to other elements). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Containing no -0-0- structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Not classified |
- |
- | - | UNRTDG Class: 6.1 (Toxic substances), PG II or III | FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
Category 3 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 185 mg/kg; REFERENCE SOURCE: ATSDR (1992) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Category 4 |
Warning |
H312 | P302+P352 P362+P364 P280 P312 P321 P501 |
It was set as Category 4 based on rabbits dermal LD50 = 1400mg/kg (ATSDR (1992)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
It was classified as Category 2 based on rat inhalation LC50 = 154ppm (ATSDR (1992)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | When it was applied to the normal skin in rabbit test, there was no irritation, and since even when it was applied to the brushing skin, only very slight erythema was observed. Therefore, it was classified as out of Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
Mild irritation was acknowledged in the conjunctiva and the iris of the rabbit. But it recovered completely in one to two days (ATSDR (1992)). So it was set as Category 2B. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Category 1B |
Danger |
H340 | P308+P313 P201 P202 P280 P405 P501 |
The substance was classified as Category 1B. Based on the positive results from the in vivo multi-generation mutagenicity test using germ cells (the rat dominant lethal test (IARC 71(1999)), the in vivo mutagenicity test using germ cells (the chromosome aberration test using rat spermatogenic cells (IARC 71(1999)), and the in vivo mutagenicity tests in somatic cells (the mouse spot test, micronucleus test using mouse or rat bone-marrow cells (IARC 71(1999)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
Since the IARC classification is 2B, the Japanese industrial hygene academic Society classification is 2B, and the NTP classification is R, it was to category 2. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Category 1A |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
In humans, azoospermia and oligospermia are observed and the possibility of infertility is suggested (IARC 71 (1999), IRIS (2003)). Moreover, it is reported in a reference that although this is reproductive toxicity product to male and also it effects to infertility, it does not have an adverse effects on reproduction of male offspring (Chemically Induced Birth Defects-3rd edition), indirect correlation is observed between exposure and a sperm count (Catalog of Teratogenic Agents, 11th edition). Furthermore, it clearly describes "The spermatogenesis is inhibited in humans, and infertility is occured" (IARC 71 (1999)). Therefore, it was classified into Category 1A. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
In the rat inhalation study, since the respiratory irritation was reported (ATSDR (1992)), it was classified into Category 3 (respiratory irritant). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs, kidney, liver, central nervous system, blood system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
In the test of repetitive inhalation exposure to rats or mise, the influence on the respiratory systemssuch as a necrosis of a nasal cavity and a trachea, pulmonary emphysema, and pneumonia (IARC 71 (1999), ATSDR (1992)), the nephrosis in kidney and nephropathia (ATSDR (1992)), the necrosis in liver (ATSDR (1992)) , meningoencephalitis and brain necrosis (ATSDR (1992)), anemia, and atrophy of the spleen (ATSDR (1992)) are accepted in the equivalent concentration for the guidance value range of Category 1. It was referred to as Category 1 (respiratory system, kidney, liver, central nervous systems, and blood systems) based on these results. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
It was classified in Category 3 from 48-hour EC50 (immobile) = 19 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2018)). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable and 72-hour NOEC (growth rate) = 2.7 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2018)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable and 96-hour LC50 = 39 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2018)). From the above results, it was classified in Category 3. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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