Item | Information |
---|---|
CAS RN | 97-74-5 |
Chemical Name | Tetramethylthiuram monosulfide |
Substance ID | m-nite-97-74-5_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not an aerosol product. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Classification not possible |
- |
- | - | The Classification is not possible because there are no data based on a prescribed test though there is information that it is a "Combustible solid" (GESTIS (Access on Nov. 2010)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It was classified as "Not classified" because it can be judged not to ignite at normal temperatures from an ignition point of 315 degrees C. (NITE Chemical Risk Information Platform (Access on Nov. 2010)) (KANTO CHEMICAL CO., INC. reagent catalog) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for solid substances with a melting point of 140 degrees C or lower. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | An organic compound that does not contain oxygen, fluorine, or chlorine. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | An organic compound that does not contain -O-O- structure. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No established test method suitable for solid substances. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
All reported four data (1320 mg/kg, 900 mg/kg, 620-869 mg/kg, and 918-1300 mg/kg) (IUCLID (2000)) on an LD50 value for rats correspond to Category 4. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Lack of data. Besides, a test using one male or one female rabbit per one dose in which no death was observed up to 2000 mg/kg (IUCLID (2000)) was not used as a basis for the classification, because not appropriate was commented on the test. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | From an irritation score of 0.7/8.0 as a result of a test applied to rabbit skin for 24 hours which reported "slightly irritating" (IUCLID (2000)), it was classified as "Not classified." | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | Slight to moderate conjunctival redness and lots of exudates observed in a test applied 0.1 g to rabbit eyes recovered within 72 hours. From "slightly irritating" reported as a result and an irritation score of 4/110 (equivalent to AOI) (IUCLID (2000)), it was classified as "Not classified." |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
A repeated insult patch test of 50 human volunteers concluded that this substance was a sensitizing substance (IUCLID (2000)). And there are several reports that a patch test of ambulatory patients having a skin disease and workers of factories such as rubber industry having dermatitis indicates a positive reaction to this substance (IUCLID (2000), HSDB (2003)). Furthermore, it is listed as a sensitizing substance in Contact Dermatitis (Frosch) (4th, 2006). Therefore, it was classified in Category 1. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | On the basis of a negative result in a chromosome aberration test by oral administration to rats (an in vivo somatic cell mutagenicity test: GLP compliance), it was classified as "Not classified." Besides, a micronucleus test by intraperitoneal administration to Chinese hamsters (an in vivo somatic cell mutagenicity test), which reported statistically significant increase of polychromatophilic erythrocyte with micronucleus (IUCLID (2000)), was not used as a basis for the classification due to a slight increase, a few animals, and low test evaluation (IUCLID (2000)). In addition, both of an Ames test and a gene mutation test using Chinese hamster V79 cells and mouse lymphoma L5178Y cells reported negatives as in vitro tests (IUCLID (2000)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | A 19-month oral administration test using two strains mice did not show carcinogenicity. (IUCLID (2000)) But the result was from only one animal species (mice) and the test was not based on test guidelines. Therefore, it was classified as "Classification not possible" due to lack of data. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No teratogenicity observed up to a dose of 100 mg/kg bw/day in a developmental toxicity test by subcutaneous administration in an organogenetic period of two strains mice (IUCLID (2000)) was data of subcutaneous administration and unknown details. In addition, there are no data on effects on a sexual function and fertility. Therefore, it was classified as "Classification not possible" due to lack of data. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | In a single oral administration test using rats, toxic symptoms of anorexia, hypoactivity, a collapse, and on an autopsy, pneumonemia, discoloration of a liver, and gastrointestinal inflammation were observed, and an LD50 value of 1320 mg/kg was reported. (IUCLID (2000)) But a dosage of manifestation is unknown and specification of target organs is difficult. Because the data are from List 2, it was classified as "Classification not possible" due to lack of data. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Significant decreases of a red blood count and an amount of hemoglobin, and as a slight change of organs, mild widespread swelling in liver cells and renal uriniferous tubule epithelium by 4-week repeated oral administration of 26 mg/kg/day to female rats (90-day correction: 8mg/kg/day) were reported (IUCLID (2000)). The dose is equivalent to Category 1 in guidance values. But the test was only female and one dose. And there were no other supportive data. Therefore, it was classified as "Classification not possible." |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 96-hour EC50 = 1 mg/L for algae (Chlorella pyrenoidosa) (AQUIRE, 2012). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 because it is non-rapidly degradable (BIOWIN) and 60-day LOEC = 0.01 mg/L for fish (Oncorhynchus mykiss) (AQUIRE, 2012). If acute toxicity data are used for trophic levels for which chronic toxicity data are not available, then it is classified in Category 1 because it is non-rapidly degradable (BIOWIN) and 96-hour EC50 = 1 mg/L for algae (Chlorella pyrenoidosa) (AQUIRE, 2012). From the above results, it was classified in Category 1. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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