Item | Information |
---|---|
CAS RN | 97-90-5 |
Chemical Name | Ethylene dimethacrylate |
Substance ID | m-nite-97-90-5_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified |
- |
- | - | A flash point is 101.5 deg C (closed cup) (GESTIS (Accessed Sept. 2018)). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with self-reactive properties (ethylene group) present in the molecule, but the classification is not possible due to no data. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] Based on the data in (1), an LD50 value for rats, it was classified as "Not classified." [Evidence Data] (1) LD50 value for rats: 8,700 mg/kg (REACH registration dossier (Accessed Sept. 2018)) |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] Based on the data in (1), an LD50 value for rats, it was classified as "Not classified." [Evidence Data] (1) LD50 value for rats: >2,000 mg/kg (REACH registration dossier (Accessed Sept. 2018)) |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition) |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) There is a report that in an eye irritation test with rabbits (n=6), the Draize score was 0, and it was not irritating (REACH registration dossier (Accessed Sept. 2018)). [Reference Data, etc.] (2) There is also a report that it is irritating to the eyes (HSDB (2002)), but detail information is unknown. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Category 1B |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
[Rationale for the Classification] Based on (1)-(4), it was classified in Category 1. In addition, based on (5), it was classified in Category 1B. Besides, the category was changed from the previous classification by using new information sources. [Evidence Data] (1) Among dentists and dental assistants who handled dental materials containing this substance, sensitization reactions to this substance are reported in 8 of 9 of them with allergic contact dermatitis (MAK/BAT (1999)). (2) Sensitization reactions (Type IV) to this substance are reported in 15 of 35 dental technicians with occupational allergic contact eczema (MAK/BAT (1999)). (3) In case reports on patients with allergic contact dermatitis, the sensitizing potential of this substance was indicated in patch tests of this substance (MAK/BAT (1999)). (4) There is a report that moderate to severe sensitization was observed in a maximization test (n=10 animals/group) with guinea pigs (MAK/BAT (1999)). (5) There is a report that in a maximization test with guinea pigs, after induction of sensitization with 1%, 5% or 10% preparations (in olive oil) of this substance, sensitization reactions were observed in 4/7 animals (57%), 12/14 animals (86%) and 19/22 animals (86%) by re-application (MAK/BAT (1999)). [Reference Data, etc.] (6) Patch tests with various substances including this substance were conducted on 82 workers who are suspected to be sensitized by exposure to acrylic acid, and sensitization is reported in 11 subjects (13.4%), but the further details are unknown (MAK/BAT (1999)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1)-(4), it was classified as "Classification not possible" according to the GHS Classification Guidance for the Japanese Government. [Evidence Data] (1) As for in vivo, there is a report that it was negative in a micronucleus test with mice (REACH registration dossier (Accessed Sept. 2018)). (2) As for in vivo, there is a report that it was negative in an unscheduled DNA synthesis test with rat liver (REACH registration dossier (Accessed Sept. 2018)). (3) As for in vitro, there is a report that it was negative in a mouse lymphoma test (HSDB (2002)) (4) As for in vitro, there is a report that it was positive in a chromosomal aberration test with cultured human lymphocytes (REACH registration dossier (Accessed Sept. 2018)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) As for ethylene glycol (CAS RN 107-21-1), the ester hydrolysate of this substance, an oral carcinogenicity study with mice showed that there was no evidence of carcinogenicity (REACH registration dossier (Accessed Sept. 2018)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There are the data in (1) only and no reproductive test data. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) There is a report that in a developmental toxicity test in which rats of gestational days 6-20 were dosed by gavage, no developmental effect on the fetuses was observed at up to 500 mg/kg/day where maternal toxicities (deterioration of general condition, transient body weight loss and decreased food consumption) were manifested (REACH registration dossier (Accessed Sept. 2018), GESTIS (Accessed Sept. 2018)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Toxicity findings by which specific organs were regarded as target organs were not obtained from the results of available studies. Therefore, it was classified as "Classification not possible" for this hazard class. [Evidence Data] (1) In a single administration test with rats given this substance by gavage, doses used were extremely high, and there are no findings available for classification at doses up to the range of Category 2 (REACH registration dossier (Accessed Sept. 2018)). (2) In a single dermal application test of this substance with rats, only irritation effects at the application site were observed (REACH registration dossier (Accessed Sept. 2018)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] Based on the data in (1), it was classified in Category 1 (respiratory organs). Besides, it is described in the GHS Classification Guidance for the Japanese Government that in principle, tests for 14 days or longer should be adopted, but the result from the 13-day test was used for classification on the basis that effects on the lung were observed after the 13 days. [Evidence Data] (1) In a study in which rats were exposed by inhalation to this substance (estimated as a vapor) at 120 ppm (1,000 mg/m3, converted guidance value: 0.14 mg/L) within the range of Category 1 for 13 days, lethargy was observed during exposure, and changes in the lung (discoloration, thickening of the alveoli, and lymphatic reactions in the alveolar area) were observed at necropsy at the end of the exposure period (GESTIS (Accessed Sept. 2018)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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