Latest GHS Classification Results by the Japanese Government (edited by NITE)
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 98-83-9 |
| Chemical Name | alpha-Methylstyrene |
| Substance ID | m-nite-98-83-9_v1 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | To Guidance List |
| UN GHS document (External link) | To UN GHS document |
| FAQ（GHS classification results by the Japanese Government） | To FAQ |
| List of Information Sources (Excel file) | List of Information Sources |
| List of Definitions/Abbreviations | Definitions/Abbreviations |
| Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
| Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
| OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
|---|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 6 | Flammable liquids | Category 3 |
 Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of 46 deg C (closed cup) (GESTIS (Access on July 2015)), it was classified in Category 3. Besides, it is classified in Class 3, PG III (UN 2303) in UNRTDG. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (olefins) present in the molecule, but because it is classified in Class 3, PG III (UN 2303) in UNRTDG, it does not correspond to hazard class of the highest precedence, self-reactive substances and mixtures. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 574 deg C (HSDB (Access on July 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 17 | Desensitized explosives | - |
- |
- | - | - | - | - |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
|---|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | There are a total of three reports of LD50 values for rats of 4,900 mg/kg in 2 cases (PATTY (6th, 2012), NTP TR 543 (2007), Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), SIDS (2002), DFGOT Vol. 15 (2001)) and 4,900-5,900 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and all data correspond to "Not classified." Besides, since the 2 cases correspond to Category 5 in UN GHS classification, it was classified as "Not classified" (Category 5 in UN GHS classification). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a report of an LD50 value of 14,560 mg/kg for rabbits (SIDS (2002)), it was classified as "Not classified." | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | Based on a report of an LCLo value (6 hours) of 3,000 ppm (converted 4-hour equivalent value: 4,500 ppm (21.78 mg/L)) for rats (SIDS (2002)), it was classified as "Not classified." Besides, the reference value of mist was applied because the LCLo value is higher than the saturated vapor pressure concentration (2,962 ppm). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 2 | Skin corrosion/irritation | Category 2 |
 Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
There is a report that moderate irritation was observed in a skin irritation test (standard Draize test) with rabbits (SIDS (2002)). From the above, based on the descriptions of the moderate irritation, it was classified in Category 2. Besides, after a 24-hour application of 0.5 mL of undiluted solution of this substance, severe erythema, edema, blistering, and skin corrosivity occurred after 24 hours, and the Draize score was 8.0 (maximum value 8.0) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), but this was not used for the classification because it was a 24-hour application test. This substance was classified as "Skin. Irrit. 2 H315" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
There is a report that in an eye irritation test with rabbits, after a 24-hour application of 0.1 mL of an undiluted solution of this substance, slight to moderate irritation was observed, but this resolved after 48 hours, and the Draize score was 8 (maximum value 110) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). For other eye irritation tests with rabbits, there is a report that moderate irritation was observed by an application of 86 mg of this substance (SIDS (2002)), and there is information that slight conjunctivitis was observed, but there was no corneal damage (NTP TR 543 (2007)). In addition, there are multiple descriptions that it was irritating to the eyes in humans (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), DFGOT Vol. 15 (2001)). From the above, it was classified in Category 2B based on the recovery after 48 hours in the animal test. Besides, this substance was classified as "Eye. Irrit. 2 H319" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there are reports of contact dermatitis and eczema in occupational exposure to this substance (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). However, since details on the exposure situation etc. were unknown, it was judged as insufficient information for the use in the classification. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Since a positive in-vivo micronucleus test was not a definitive finding, and all in-vitro tests were negative, classification was not possible according to the GHS classification guidance for the Japanese government. As for in vivo, in a micronucleus test with peripheral blood of female and male mice exposed by inhalation for 13 weeks, positive results in the females and negative results in the males were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), NTP TR 543 (2007)). However, among these, the positive findings in females were observed at a dose where 2 out of 10 animals died, 1.8-time higher induction than the control group (0.510% vs 0.913%) was shown in NCE, it was negative in PCE. In males, it was negative in both NCE and PCE. No difference in metabolism between the female and male mice was reported. Therefore, it is difficult to say that these findings were definitive evidence for micronucleus induction. There are no other in vivo test data. As for in vitro, one positive result was observed in a sister chromatid exchange test with mammalian cultured cells, but other tests, i.e. bacterial reverse mutation tests, mammalian cell chromosome aberration tests, sister chromatid exchange tests with human lymphocytes, etc. were negative (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), JECDB (Access on July 2015), SIDS (2002), Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), DFGOT Vol. 15 (2001), NTP TR 543 (2007)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 6 | Carcinogenicity | Category 2 |
 Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
There is no information on carcinogenicity in humans. As for experimental animals, in 2-year carcinogenicity studies with rats or mice by the inhalation route, in rats, dose-related increases in the incidence of renal tubule adenoma and carcinoma (combined) were observed in males, and in mice, increases in the incidence of hepatocellular adenoma or carcinoma (combined) were observed in both sexes (IARC 101 (2012), NTP TR 543 (2007), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and IARC classified it in Group 2B (IARC 101 (2012)). Other than this, there are no other classification results by other organizations. Therefore, it was classified in Category 2 for this hazard class. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats dosed by oral administration, at the high dose (1,000 mg/kg/day) where general toxic effects (decreased body weight gain, increased liver and kidney weight, thymus atrophy, etc.) were manifested significantly in parental animals, two maternal animals (2/10) failed to produce enough lactation due to the deterioration of the general conditions, resulting in the deaths of all the newborns within two days after delivery. Other than this, no effects on the sexual function and fertility of parental animals, the development of pups, and the index on growth up to 4 days after birth were observed, and the NOAEL for reproductive and developmental toxicity under this test condition is reported as 1,000 mg/kg/day (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), SIDS (2002), JECDB (Access on July 2015)). However, it is impossible to classify it as "Not classified" with only this result since this test is a screening test, and there is no data available for classification other than this. Therefore, it was classified as "Classification not possible" for this hazard class. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335 H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
This substance is irritating to the respiratory tract in humans (Environmental Risk Assessment for Chemical Substances Vol.2, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2003), Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), ACGIH (7th, 2010), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), DFGOT Vol. 15 (2001), HSDB (Access on August 2015)). As for experimental animals, a decrease in motor activity and staggering gait in oral administration (at doses exceeding Category 2) in rats, eyelid closure, coordination ataxia, and sensation loss in inhalation exposure (at the doses corresponding to Category 2) in rats, and decreased motor activity and convulsions in dermal application in rabbits (at doses exceeding Category 2) were reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). From the above, this substance is irritating to the respiratory tract and has narcotic effects, and it was classified in Category 3 (respiratory tract irritation, narcotic effects). New information was added, and the previous classification was reviewed. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver), Category 2 (respiratory organs, kidney) |
Danger Warning |
H372 H373 |
P260 P264 P270 P314 P501 |
As for humans, there is a report on liver dysfunction, vitamin B12 deficiency, and immunological change (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As for experimental animals, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG422) with rats, at 200 mg/kg/day (converted guidance value: male 95.6 mg/kg/day, female 91.1-100 mg/kg/day) within the range of Category 2, increased ALT, increases in absolute and relative weight of the liver and kidney, acidophilic change in hepatocytes, and vacuolation of the renal tubular epithelium (female) were observed (JECDB (Access on July 2015)). Atrophy and metaplasia of the olfactory epithelia in the nasal cavity, and atrophy or hyperplasia of the Bowman's glands were found at or above 75 ppm (converted guidance value: 0.27 mg/L) within the range for Category 2, and hyaline degeneration of the olfactory epithelia in the nasal cavity was seen at 150 ppm (converted guidance value: 0.53 mg/L) in a 14-week inhalation toxicity test with mice. Hyperplasia of basal cells of the olfactory epithelia was observed at 100 ppm (0.48 mg/L) within the range for Category 2 in a 2-year carcinogenicity test with rats by the inhalation route, and olfactory epithelial metaplasia and hyperplasia of the glands were observed at 100 ppm (0.48 mg/L) within the range for Category 2 in a 2-year carcinogenicity test with mice by the inhalation route (NTP TR 543 (2007)). From the above, effects on the liver were observed in humans, and as for experimental animals, effects on the nasal cavity, liver, and kidney were observed within the range for Category 2. Therefore, it was classified in Category 1 (liver), Category 2 (respiratory organs, kidney). Besides, in the previous classification, the effect on the kidney in rats was denied as a finding specific to male rats, but the kidney was adopted as the target organ this time since the effect on the kidney was also observed in female rats. In addition, effects on the liver observed in rats were denied as an adaptive response. However, in the same test, the effects on lipid metabolism such as disappearance of lipid droplets in hepatocytes, decreased triglycerides, fatty changes of the renal tubular epithelium in the kidney, and an increase in lipid droplets of adrenal zona fasciculata were suggested, and there are reports of findings in humans, therefore, the liver was adopted as the target organ. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 10 | Aspiration hazard | Category 1 |
Danger |
H304 | P301+P310 P331 P405 P501 |
Since it is a hydrocarbon, and the kinematic viscosity is calculated to be 1.03 mm2/sec (20 deg C) from the numerical data (viscosity: 0.940 mPa*s (20 deg C), density (specific gravity): 0.9106) listed on HSDB (Access on August 2015), it was classified in Category 1. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
|---|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
From 48-hour EC50 = 2.62 mg/L for crustacea (Daphnia magna) (Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005), Initial Risk Assessment (NITE, CERI, NEDO, 2008)), it was classified in Category 2. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
 - |
H411 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (non-biodegradable, a degradation rate by 14-day BOD = 0% (Official Bulletin of Ministry of International Trade and Industry, 1979)), and 72-hour NOEC = 0.3 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1996), Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable and 96-hour LC50 = 7.28 mg/L for fish (Oryzias latipes) (Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005), Initial Risk Assessment (NITE, CERI, NEDO, 2008)). From the above results, it was classified in Category 2. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
NOTE:
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