NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	98-86-2
Chemical Name	Acetophenone
Substance ID	m-nite-98-86-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	A flash point is 77 deg C (closed cup) (GESTIS (Access on June 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 535 deg C (GESTIS (Access on June 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Four data of LD50 values for rats of 900 mg/kg, 900 mg/kg, 3,000 mg/kg, and 3,200 mg/kg are reported (all from PATTY (6th, 2012)). Two of these correspond to Category 4 while the other two correspond to "Not classified" (Category 5 in the UN GHS classification). By adopting the category with higher hazard, it was classified in Category 4.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a reported LD50 value of > 20 mL/kg (> 20,600 mg/kg from a specific gravity of 1.03) for guinea pigs (PATTY (6th, 2012)), it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data. There is a report that there were no death cases in a test in which rats were exposed by inhalation to the saturated vapour (approx. 430 ppm, 2.11 mg/L) of this substance for 8 hours (PATTY (6th, 2012), ACGIH (7th, 2009)). However, the category could not be specified on the basis of this data alone. Therefore, it was classified as "Classification not possible." Besides, since the exposure concentration was lower than 90% of the saturated vapor pressure concentration (524 ppm), a reference value in the unit of ppm was applied as vapour with little mist.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on a description that this substance is irritating to the skin (PATTY (6th, 2012), HSDB (Access on June 2017)), it was classified in Category 2. The category was revised based on information obtained in this survey.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Based on a description that severe irritation was observed in an evaluation 24 hours after an application of this substance in an eye irritation test with rabbits (PATTY (6th, 2012)), it was classified in Category 2A. Besides, this substance was classified as "Eye Irrit. 2" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Although it was reported that both of two skin sensitization tests with guinea pigs (the modified Draize method and the maximization method) were negative (PATTY (6th, 2012), ACGIH (7th, 2009)), it was classified as "Classification not possible" because no data were obtained in humans. The category was changed from the previous classification since the contents of information sources were reviewed.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There were no in vivo data. As for in vitro, a bacterial reverse mutation test was negative (IRIS (1988), PATTY (6th, 2012)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	No test data was available in either humans or experimental animals. However, since the EPA classified it in Group D (IRIS (1988)), it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	When this substance was administered by gavage to female rats from 14 days prior to mating to day 3 of lactation, in maternal animals, as toxic symptoms, urine stains, a decrease in locomotor activity, pale skin, rough fur, etc. at or above 225 mg/kg/day, and unsteady gait at 750 mg/kg/day were observed. As for effects on the pups, a decrease in the live birth index and decreased number of alive pups by day 4 of lactation were observed (ACGIH (7th, 2009), Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)). From the above, it was classified in Category 2 for this hazard class since effects on the next generation were observed at the dose where maternal toxicity occurred.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	With regard to humans, it is described that this substance was used as an anesthetic in the 19th century (ACGIH (7th, 2001)). As for experimental animals, central nervous system depression was reported to be a toxic symptom in a single oral dose test with rats (ACGIH (7th, 2009), PATTY (6th, 2012)). As for the inhalation route, it was reported that in a test with mice to evaluate the irritation potential of this substance, when a decline in the respiration rate following short-duration (5 minutes) inhalational exposure to the vapor was measured, an RD50 value was 500 mg/m3 (ACGIH (7th, 2009), PATTY (6th, 2012)). From the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects). Besides, it was reported that in a test with mice, administration by subcutaneous or intravenous injection showed hypnotic effects, and in intraperitoneal administration, clear hypnotic effects were observed at 400-500 mg/kg (ACGIH (7th, 2009)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	No information on humans is available. As for experimental animals, in a 17-week repeated toxicity test with rats dosed by feeding, no effects were observed even at 1% (0.845% due to volatilization (423 mg/kg/day)) exceeding the guidance value range for Category 2 (Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009), ACGIH (7th, 2009), IRIS (1988), PATTY (6th, 2012)). Also, it is reported that a 4-week repeated toxicity test with rats dosed by gavage, hyaline droplet nephrosis in the males at or above 75 mg/kg/day (converted guidance value: 23 mg/kg/day) within the guidance value range for Category 2, urine stains and salivation at or above 225 mg/kg/day (converted guidance value: 70 mg/kg/day), and a low value of body weights, reduced forelimb grip strength, a decrease in locomotor activity, and unsteady gait at 750 mg/kg/day (converted guidance value: 233 mg/kg/day) exceeding the guidance value range for Category 2 were reported (Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009), ACGIH (7th, 2009)). Other than these, it was reported that in a 14-day inhalation toxicity study with mice exposed to the vapor, no effects on the trachea were observed at 300 ppm (converted guidance value: 0.23 mg/L) within the guidance value range for Category 2 (PATTY (6th, 2012)). From the above, effects on the nervous system were reported, but these were observed at a dose exceeding the guidance value range for Category 2. Therefore, it was classified as "Classification not possible." Besides, since new information sources were used, the classification result was changed from the previous classification.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	From 96-hour LC50 = 162 mg/L for fish (Pimephales promelas) (ECETOC TR91: 2003), it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. Due to being rapidly degradable (readily biodegradable, a degradation rate by BOD: 64.7% (J-CHECK, 1977)), no bioaccumulation (LogKow: 1.58 (PHYSPROP Database: 2017)), and "Not classified" in acute toxicity, it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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