NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	99-08-1
Chemical Name	m-Nitrotoluene
Substance ID	m-nite-99-08-1_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	UNRTDG Class: 6.1	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified	- -	-	-	Flash point: >93degC, UNRTDG Class: 6.1	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified	- -	-	-	Classified in UNRTDG Class: 6.1	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Flash point: 440degC (Hommel, 1991 Card No.361a)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified	- -	-	-	UNRTDG Class: 6.1	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Not classified	- -	-	-	UNRTDG Class: 6.1	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Rat LD50 value: 1072mg/kg, 2000mg/kg and 2200mg/kg (IARC 65, 1996). Since the calculated value was 1187mg/kg, it was classified to category 4.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Rabbit LD50 value : >20000mg/kg (HSDB, 2005), rat LD50 value: >1157mg/kg (IUCLID, 2000, BUA 41, 1989). So category could not be specified, it cannot be classified due to insufficient data.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	There is only a data with rat LC50 (4 hours) value: >157ppm (equivalent 0.879mg/L) in HSDB (2005), Category cannot be specified due to data insufficiency.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	The category cannot be specified by only data that rat LC50 (1 hour) value: >2.417mg/L (4-hour equivalent 0.6043mg/L) ( IUCLID (2000), BUA 41 (1989)). And data is insufficient, it cannot be classified.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 3	- Warning	-	-	It was set as Category 3 from description that the skin was stimulated slightly (ICSC (J) (2000), HSDB (2005).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Based on the description that the skin is stimulated slightly (ICSC (J), (2000), and HSDB (2005)), it was set as Category 2B.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	Since there was a negative result with micronucleus test on rat and mouse red corpuscles which is an in vivo mutagenicity test using somatic cells (NTP DB, 2005), it was classified as out of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. The DFG classified this substance in Category 3. However, since the classification by the DFG was based on analogy of the analogous compound (4-nitrotoluene) and no evidence for this substance itself could be obtained in either epidemiological or animal experiments, it was not used for classification. [Reference Data, etc.] (1) As for the classification results by domestic and international organizations, the DFG classified it in Category 3 (DFG MAK (2007)), as is the case with 4-nitrotoluene (CAS RN 99-99-0) which is an isomer of this substance, based on the data of (2) and (3). In addition, the IARC classified it in Group 3 (IARC 65 (1996)). (2) 4-nitrotoluene and this substance have almost the same metabolic pathway and exhibit qualitatively and quantitatively similar effects (DFG MAK (2007)). (3) It was reported that, in a carcinogenicity study for 4-nitrotoluene used as a test substance with rats dosed by feeding for two years, a significant increase in the incidence of clitoral gland adenoma and/or carcinoma in females and a significant increase of subcutaneous fibroma and of subcutaneous fibroma or fibrosarcoma (combined) in males were observed at 2,500 ppm, and there was equivocal evidence of carcinogenic activity in males and some evidence of carcinogenic activity in females (NTP TR498 (2002)). (4) It was reported that, in a test for 4-nitrotoluene used as a test substance with B6C3F1 mice dosed by feeding for 105 or 106 weeks, an increase in the total incidences of bronchiolar/alveolar adenomas and carcinomas was observed in males at 5,000 ppm, and there was equivocal evidence of carcinogenic activity of this substance in males. Besides, as preneoplastic lesions related to lung neoplasms observed in males, alveolar bronchiolization and hyperplasia were observed in males and females (NTP TR498 (2002)).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	It was classified into Category 2 based on the description that testicular dysfunction, such as low sperm count etc., and the female abnormalities of estrous cycle were observed at the dose causing general toxicity, such as a low value of weight etc., in the feeding oral administration tests using the rat and mouse (ACGIH (7th, 2001) and IARC 65 (1996)) .	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 2 (blood)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	It was set as Category 2 (blood) from description in ICSC (J) (2000) that blood may be affected and methemoglobin may be produced.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 2 (immune system)	Warning	H373	P260 P314 P501	Based on the description that in the oral study using the mouse, the effects on the immune systems were observed with the dosage in the Category 2 guidance value range (NTP DB (2005) and PATTY (4th, 1994)), it was classified into Category 2 (immune systems).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 48-hour LC50 = 7.5 mg/L for crustacea (Daphnia magna) (EPA AQUIRE: 2018, NLM HSDB: 2018, Maas-Diepeveen, J. L. et al. (1986)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Chronic toxicity data were not obtained. It was classified in Category 2 because it is not rapidly degradable (not readily degradable, a degradation rate by BOD: 2% (J-CHECK, 1997)) and was classified in Category 2 in acute toxicity.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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