NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	99-54-7
Chemical Name	1,2-Dichloro-4-nitrobenzene
Substance ID	m-nite-99-54-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	Although the nitro group is included in chemical structure and the calculation value of oxygen balance is -96, it was classified into Not classified since it was classified into Class 6.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1578(ICSC, 1995)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified	- -	-	-	Although the nitro is included in chemical structure, it was classified into Not classified, since it was classified into Class 6.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1578(ICSC, 1995)) .	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 420degC (IUCLID,2000)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Classification not possible	- -	-	-	Although it is an organic compound including oxygen having chemically bound to elements other than carbon and hydrogen, classification is not possible due to lack of data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	The organic compound not including peroxy group in molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	From a description of 625 mg/kg of lower value among LD50 value of 625 mg/kg and 800 mg/kg (SIDS (2003)) in the oral administration test employing rats, it was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Since LD50 value of the dermal administration test employing rats was >2,000 mg/kg (SIDS (2003)), it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	Since the 24 hour skin irritation/corrosion test with rabbits (OECD TG 404, GLP) did not identify skin irritation (average scored values for erythema/crust and edema:0.2, 0.0) (SIDS (2003)), it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	From a description of "slightly irritating (the mean score values of corneal opacity / iritis / conjunctival redness / conjunctival edemas: 0/0.1/1.3/0.2) and it recovered in 72 hours" in the eye irritation/corrosion test (SIDS (2003)) employing rabbits (OECD TG 405, GLP), it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	It was classified into "Not classified" from descriptions that skin sensitization was not shown in the Maximization tests employing 20 guinea pig (OECD TG 406, GLP) and that skin sensitization was not shown in the test of eczema-like contact dermatitis in ten women (SIDS (2003)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	From the description that the body cell in vivo mutagenicity test (chromosome aberration test employing a rat bone marrow cell (GLP)) which used the commercial grade (85% of this substance and 15% of 1,2-dichloro-3-nitrobenzene) is negative and there is no proof of in vivo heredity toxicity in the dosage which does not show general toxicity (SIDS (2003)), it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Although it is 3B by German DFG classification (ACGIH (7th, 2001)), classification is not possible since no evaluation of other major international evaluation agencies such as IARC is made.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There is a description in the 20 day oral administration study using rats (OECD TG 407) that no effect was caused against male and female reproductive functions (SIDS (2003)). Since it is described that ureteral dilatations were observed in fetuses at the dose level of 30mg/kg where suppression of the body weight increase is found among mother animals in the developmental toxicity study (GLP), while a product of commercial grade (85% of this substance and 155 of 1,2-dichloro-3- nitrobenzene) was orally administered to rats for 6-15 days of pregnancy, it was classified in Category 2. Incidentally, It is described that no clear effect was recognized on the reproduction by parent animals and development of fetal animals even with the administration of the maxumum dose level of 100mg/kg with regard to 1,2-dichloro-3- nitrobenzene (Access on October 2008).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	It was classified into Category 3 (Narcotic effects) based on a description that inactivity, atrophy, and a coma were seen in the oral administration test of rats, and temporary inactivity is seen in dermal administration test of rabbits (SIDS (2003)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system, liver, kidney), Category 2 (spleen)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	In 4-month vapor inhalation exposure test in rats and mice (4 hours/day), increase in methemoglobin and Heinz body, decrease in the number of red blood cells and hemoglobin, and decrease in serum transaminase and liver catalase, etc. are described (SIDS (2003)). Moreover, it is written in 28-day oral administration test in rats (OECD TG 407, GLP) that there were increase in urea value, decrease in the number of red blood cells, drop in hematocrit, increase in relative liver weight, increase in MCV value, increase in reticulocyte, increase in lien weight, lien congestion, splenic extramedullary hematopoiesis, and hemosiderosis (SIDS (2003)). Since effects on the blood system, liver, kidney are found within the scope of the guidance value of Category 1, and effects on lien are found within the scope of the guidance value of Category 2, it was classified into Category 1 (blood system, liver, and kidney) and Category 2 (lien).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified into Category 2 from 72 hours EC50=2.5mg/L of the algae (Pseudokirchneriella subcapitata) (MOE eco-toxicity tests of chemicals (2004)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Since acute toxicity was Category 2 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (Existing Chemical Safety Inspections Data (1985)), it was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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