Item | Information |
---|---|
CAS RN | 999-81-5 |
Chemical Name | (2-Chloroethyl)trimethylammonium chloride |
Substance ID | m-nite-999-81-5_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no -0-0- structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available (Melting point: 236degC) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
In two tests with rats, we compared the LD50 values for male and female rats. Then for the lower of these groups we compared the LD50 values between the two tests, and selected the lower of the two. Based on the value LD50 = 450.0 mg/kg (Agricultural Chemical Registration Data) which was the lower value of the data from the two tests, the substance was classified as Category 4. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was set as the outside of Category based on rat LD50 >5000mg (Agricultural Chemical Registration Data). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
Warning |
- | - | It was set as Category 5 based on rat LC0 = 3.05mg/L and LC10-20 = 5.2mg/L (Agricultural Chemical Registration Data). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Category 3 |
Warning |
- | - | Skin reactions against rabbits is only slight erythema with non-scraping part and scratch part, and a stimulative reaction has a statement that it disappeared within 72 hours. It was set as category 3 since weak skin irritations was admitted also in skin sensitivity test (Agricultural Chemical Registration Data). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
Based on the description that the redness in the conjunctiva and dropsy were observed slightly to the rabbit eye, and recovered within four days (EU Agricultural Chemical Registration Data), it was classified into Category 2B. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Not classified |
- |
- | - | Skin sensitization was carried out the outside of Category by the maximization method using a guinea pig based on the description (Agricultural Chemical Registration Data) that it is negative. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | There is no data of human multi generation epidemiology, an multi generation mutagenicity test, and a germ cell in vivo mutagenicity test, and there is the description it is negative in the somatic cell test in vivo mutagenicity test (small core test using mouse) (EU Agricultural Chemical Registration Data). So it is classified as the out of the Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Not classified |
- |
- | - | In carcinogenicity tests in rat and mouse, based on the description that generating of treatment-related increased tumor was not observed in each examination (Agricultural Chemical Registration Data), it was out of the Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Not classified |
- |
- | - | Although gigantocellularis were acknowledged by the testis of F3 male child in the three-generation reproduction study using a rat, it seems that there is no relation with administrations. Both parent and fetal animals did not have the other effects of this. In the teratogenic study using rats and rabbits, teratogenic was not acknowledged by highest dose as which general toxicity is regarded by parent animals (Agricultural Chemical Registration Data). Based on the above information, it was carried out the outside of Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 2 (systemic, nervous system) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
It was considered as Category 2 (systemicity, nervous system) based on the description (Agricultural Chemical Registration Data) that creeping, eye haemorrhages, spasms, collapse, diarrhea, tremors, conrtraction, salivation, and bloody tears etc., at dose (450-1012mg/kg) within the range of guidance value in Category 2 in rats and mouse were observed. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Not classified |
- |
- | - | Because of the description of few toxic effects with dosage higher than the guidance value range of Category 2 in the subacute toxicity study with rats during 90 days, and of the mention of no toxic effect with dosage in the chronic toxicity study with rats for two years (Agricultural Chemical Registration Data), it was judged out of Categories. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified in Category 2 from 7-day EC50 (growth) = 2.6 mg/L for higher aquatic plants (Lemna gibba) (EPA AQUIRE: 2018, EPA Pesticide Ecotoxicity Database (1992)). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
It was classified in Category 1 due to being not rapidly degradable and 7-day NOEC (frond number) = 0.04 mg/L for higher aquatic plants (Lemna gibba) (NLM HSDB: 2018, EPA Pesticide Ecotoxicity Database (1992)). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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