NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN
Chemical Name	Synthetic mineral fiber (except for RCF)
Substance ID	m-nite-nocas-0010_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (normal temperature)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (normal temperature)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (normal temperature)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (normal temperature)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC (J) (2012)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (normal temperature)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC (J) (2012)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (J) (2012)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It is estimated that it does not react vigorously with water from the observation result of being insoluble in water (HSDB (Access on September 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (normal temperature)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen, but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (normal temperature)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (normal temperature)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there are descriptions that although there are cases of workers who were exposed while manufacturing or handling rock/slag wool and had itching on the skin due to the physical stimulation, it was a temporary symptom, and could be managed by appropriate work (ACGIH (7th, 2001)) and often disappeared with continued exposure (EHC 77 (1988), ATSDR (2004)). In addition, there is a description that physical stimulation was caused mainly when the diameter of this substance was 5 micrometers or more (ACGIH (7th, 2001), ATSDR (2004)). The category was changed by revising the information content.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Based on descriptions that transient eye irritation was observed in workers who had inadequate protective measures (ACGIH (7th, 2001)), and that this substance is irritating to the eyes (ATSDR (2004)), and that exposure during handling of this substance was associated with eye irritation (EHC 77 (1988)), it was classified in Category 2. Since there was no information on the degree of the stimulation and on the recovery period, it was not sub-categorized.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There is no in vivo data. As for in vitro, for the synthetic glass fiber (excluding RCF), glass wool, rock wool, and slag wool, there were negative or positive results in bacterial reverse mutation tests, chromosomal aberration tests and micronucleus tests with mammalian cultured cells, and sister chromatid exchange tests were negative (ATSDR (2004), EHC 77 (1988), IARC 81 (2002)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	IARC classified man-made vitreous fibers excluding RCF mainly into continuous glass filament, insulation wool, rock (stone) wool, slag wool, and special-purpose wool. Among these, as for continuous glass filament, insulation wool, and rock (stone) wool, evidence of carcinogenicity was insufficient in humans and limited in experimental animals, and as for slag wool, evidence of carcinogenicity was also limited in experimental animals, therefore, they were classified in Group 3 (IARC 81 (2002)). On the other hand, regarding the special-purpose wool including E-glass and 475-glass, in the tests with rats given by injection or implantation into the peritoneal cavity, intraperitoneal tumors were observed, and in the tests with rats or hamsters dosed intratracheally, lung tumors (both species) and mesothelioma (hamsters) were observed. Special-purpose wool was classified in Group 2B because there was sufficient evidence of carcinogenicity in experimental animals (IARC 81 (2002)). On the other hand, ACGIH classified continuous glass filament in A4, and insulation wool, rock (stone) wool, slag wool, and special-purpose wool were all classified in A3 (confirmed animal carcinogen) (ACGIH (7th, 2001)). However, it is considered that the evidence of carcinogenicity in experimental animals is weak (there was a positive data by the intraperitoneal administration, but it was negative on inhalation exposure). In addition, Japan Society For Occupational Health (JSOH) classified continuous glass filament, glass wool, rock wool, and slag wool in Group 3 (OEL Documentations (2003)). From the above, according to the classification results by IARC and JSOH, special-purpose wool were classified in Category 2, and continuous glass filament, insulation wool, rock (stone) wool, and slag wool were all classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	As for humans, there is a description that symptoms of upper respiratory tract irritation such as nosebleed, cough, laryngeal and pharyngeal pain were observed after acute exposures to continuous glass filament, glass wool, rock wool, or slag wool. However, it is described that they disappeared rapidly following the cessation of exposure (ATSDR (2004)). Therefore, it was classified in Category 3 (respiratory tract irritation).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	As for humans, it is described in EHC 77 (1988) that in some cross-sectional epidemiological studies, the possibility of the exposure-related effects of man-made mineral fibers (MMMF) on respiratory function was suggested; in a large-scale study, the prevalence of low profusion shadowing increased in chest radiographs of smokers with increasing lengths of employment in MMMF manufacturing; however, no consistent pattern of MMMF-related effects on the respiratory system has not been obtained from the cross-sectional studies to date. As for experimental animals, in tests in which rats were exposed by inhalation to rock wool (MMVF21) or slag wool (MMVF22) for 2 years, as for rock wool, within the guidance value range for Category 1, inflammation of the lung was observed at or above 3.1 mg/m3 (0.0031 mg/L), and mild pulmonary fibrosis was observed at or above 16 mg/m3 (0.016 mg/L). As for slag wool, although inflammation of the lung was observed at or above 3.1 mg/m3 (0.0031 mg/L) within the range of the guidance value for Category 1, pulmonary fibrosis was not observed even at the highest dose of 29.9 mg/m3 (0.03 mg/L) (ACGIH (7th, 2001), ATSDR (2004)). In addition, in a test in which rats were exposed by inhalation to glass wool (MMVF10, MMVF11) for 2 years, inflammation of the lung was observed at or above the dose (3.1 mg/m3 for MMVF10, 4.8 mg/m3 for MMVF11) within the range of the guidance value for Category 1. However, pulmonary fibrosis was not observed even at the highest dose (27.8 mg/m3 for MMVF10, 28.3 mg/m3 for MMVF11) (ATSDR (2004)). From the above, it was classified in Category 1 (respiratory organs).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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