NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	-
Chemical Name	Powder cake (2) [composition: nitroglycerin/nitrocellulose/isopropyl alcohol = 60/23/17]
Substance ID	m-nite-nocas-0024_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Division 1.1	Danger	H201	P370+P372+P380+P373 P210 P230 P234 P240 P250 P280 P401 P501	It is rated as UN0433 and Division 1.1.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Since the substance is classified as an explosive, classification as a self-reactive substance is not applicable.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids.	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no bivalent -O-O- structure in the molecule	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	The LD50 for rats given to nitroglycerin is 100 mg/kg (Japanese Government's classification) and that for rats given to isopropyl alcohol is 3437 mg/kg (Japanese Government's classification). Based on these values, the LD50 for this compound was computed to be 127.3 mg/kg and was classified into Category 3.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Since no test results on nitroglycerin are available, classification is not possible (Japanese Government's classification). Nitrocellulose is classified into the "Not classified" category based on its LD50 of > 29200 (Japanese Government's classification). And LD50 of isopropyl alcohol is 4050 mg/kg. Giving a priority to the classification of nitroglycerin over that of other two components, this compound was classified into the "Classification not possible" category.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Since both nitroglycerin and nitrocellulose are classified into the "Classification not possible" category, this compound was classified into the "Classification not possible" category.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Since all components are classified into the "Classification not possible" category, this compound was classified into the "Classification not possible" category.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Since both nitroglycerin and nitrocellulose are classified into the "Classification not possible" category, this compound was classified into the "Classification not possible" category.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Because nitroglycerin and isopropyl alcohol are classified into Category 2A-2B, this compound was also classified into Category 2A-2B assuming the same cutoff values.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	Since all components are classified into the "Classification not possible" category, this compound was classified into the "Classification not possible" category.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Since nitroglycerin is classified into Category 1, this compound was classified into Category 1 assuming the same cutoff values.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Since nitrocellulose is classified into the "Classification not possible" category, this compound was also classified into the "Classification not possible" category.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	Since both nitroglycerin and nitrocellulose are classified into the "Classification not possible" category, this compound was classified into the "Classification not possible" category.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Because nitroglycerin and isopropyl alcohol are classified into Category 2, this compound was also classified into Category 2 assuming the same cutoff values.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (cardiovascular system, blood, central nervous system, kidney, systemic), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	Nitroglycerin is classified into Category 1 for its toxicity to the cardiovascular system and blood, and isopropyl alcohol is classified into Category 1 for its central nervous system, kidney, and systemic toxicity. Thus, assumining the same cutoff values, this compound was classified into Category 1 (cardiovascular system, blood, central nervous system, kidney, and systemic toxicity). Since both compounds, nitrocellulose and isopropyl alcohol, are classified into Category 3 for its respiratory irritation. Thus, assuming the same cutoff values, this compound was classified into Category 3 (respiratory tract irritation).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (cardiovascular system), Category 2 (liver, spleen)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	Since nitroglycerin is classified into Category 1 for its toxicity to the cardiovascular system, the substance was classified into Category 1 (cardiovascular system) assuming the same cutoff point. Isopropyl alcohol is classified into Category 2 for its toxicity to the blood vessel, liver, and spleen, this compound was classified into Category 2 (liver and spleen) (the blood vessel is included in Category 1 and excluded from Category 2).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	The toxic effect of Isopropyl alcohol (Category 2) is suspected to contribute to the toxicity of this compound. However, since kinematic viscosity of this compound is unknown, it was classified into the "Classification not possible" category.	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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