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General Information
- General Information
  - General Information Data Description
    - CHRIP_ID C004-661-75A CAS RN 67-66-3
      
      Chemical Substance Name Chloroform
      
      Molecular Formula CHCl3
      
      Molecular Weight 119
      
      SMILES ClC(Cl)Cl
      
      Structure
- Synonym
  - Synonym Data Description
    - Synonym FLON-20
      
      Formyl trichloride
      
      Methane trichloride
      
      Trichloromethane
- Nikkaji
  - Information of Japan Chemical Substance Dictionary (Nikkaji) Data Description
    - Nikkaji Number
      J2.366C
      Detail to J-GLOBAL

Laws and Regulations in Japan

Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (Chemical Substances Control Law ; CSCL)

Japan CSCL: Priority Assessment Chemical Substances Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]
- Registration Number
  8
  Date of Designation 2011/04/01
  
  MITI Number
  2-37
  
  Chemical Substance Name Chloroform
  
  Reason for Inclusion Human Health / Ecosystem
  
  Remarks -
  
  Details to J-CHECK

Japan CSCL: Existing Chemical Substances Data Description Definition of the terms of Section 6 [PDF] Definition of the terms of Section 7 [PDF] Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]

MITI Number	2-37	Category	Section 2
Chemical Substance Name	Methane,trichloro-
Remarks	-
Details	to J-CHECK
Remarks to Existing Chemical Substances of Industrial Safety and Health Act	Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law by June 29, 1979
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)

Japan CSCL: Type II Monitoring Chemical Substances (before amendment) Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]
- Registration Number
  3
  Date of Designation in the Official Gazette 1987/07/02
  
  MITI Number
  2-37
  
  Chemical Substance Name Chloroform
  
  Remarks -
  
  Details to J-CHECK

Japan CSCL: Type III Monitoring Chemical Substances (before amendment) Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]
- Registration Number
  161
  Date of Designation in the Official Gazette 2010/03/19
  
  MITI Number
  2-37
  
  Chemical Substance Name Chloroform
  
  Remarks -
  
  Details to J-CHECK

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	trichloromethane
Judgement of Biodegradation	Not readily biodegradable	Judgement of Bioconcentration	Low bioconcentration
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

Japan MOE: Results of Eco-toxicity tests of chemicals Data Description
- Chemical Substance Name Chloroform
  
  Details to J-CHECK

Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof(PRTR-SDS Law)

Japan: PRTR-SDS Law (until March 2023) Data Description Outline PRTR Law (METI site) Analysis of PRTR data

Classification	I	Cabinet Order Number	1-127
Cabinet Order Name	Chloroform
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	Releases Map (in Japanese) Atmospheric concentration Map (in Japanese)

Japan: PRTR-SDS Law (from April 2023) Data Description Outline PRTR Law (METI site)

JPSN(Japan PRTR-SDS Number)	127	Classification	I	Cabinet Order Number	1-151
Cabinet Order Name	Chloroform
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	- -

Industrial Safety and Health Act (ISHA)

Japan ISHA: Chemical Substances Requiring Labeling and Delivery of Documents, etc. Data Description GHS compatible model label creation method (MH LW site : in Japanese) Risk assessment implementation support tool (MHLW site : in Japanese)
- Cabinet Order Number
  Attached table 9-160 of Cabinet order
  
  Cabinet Order Name Chloroform
  
  Range of Application for Label (weight%) >=1
  
  Range of Application for SDS (weight%) >=0.1

Japan ISHA: Chemical substances that cause skin disorders, etc. and other chemical substances that must be handled with impermeable protective equipment etc. based on special chemical regulations. Data Description Target substances list(MHLW site: in japanese)
- Substance Name Chloroform
  
  Classification of Target Substances Special chemical regulations etc. Cutoff value(weight %) 1
  
  Details to the GHS Classification

Japan ISHA: Specified Chemical Substances Data Description Link to the Ordinance (JISHA site : in Japanese)

Category	Group-2 substances	Cabinet Order Number	Attached Table 3-2-11-2 of Cabinet order
Cabinet Order Name	Chloroform
Range of Application (weight %)	>1
Remarks	Substances under special supervision / Special organic solvent, etc.

The above information have been provided by the Ministry of Health, Labour and Welfare

Japan ISHA: Administrative Control Levels of Working Environment Evaluation Standards Data Description Working Environment Measurement (MHLW site : in Japanese)
- Registration Number
  11.2
  
  Kinds of substances Chloroform
  
  Control Level 3ppm
  
  The above information have been provided by the Ministry of Health, Labour and Welfare

Japan ISHA: Guidelines for Carcinogenic Substances Data Description
- Name Chloroform
  
  Details to MHLW site (in Japanese)

Poisonous and Deleterious Substances Control Act
- Japan Poisonous and Deleterious Substances Control Act Data Description Link to the Act (MOJ site)
  - Classification Deleterious Substances(Law) Law or Cabinet Order Number
    Attached Table 2-20 of the Law
    
    Law or Cabinet Order Name Chloroform

Air Pollution Control Act

Japan Air Pollution Control Law Data Description Air & Transportation (MOE site)

Classification	Volatile Organic Compounds (VOC)	Cabinet Order Number	Article 2-4 of Act
Cabinet Order Name	Any organic compound (excluding substances specified by a Cabinet Order as not being sources from which suspended particulate matter or oxidants are generated) that is in a gaseous state at the time of its emission or dispersal into the atmosphere.
VOC Emission Inventory Substance Code	62-01-03
VOC Emission Inventory Substance Name	Chloroform

Classification	Substances that may be classified as Hazardous Air Pollutants	Cabinet Order Number	58 of Central Environment Council 9th Report (Appendix 1)
Cabinet Order Name	Chloroform

Classification	Substances that may be classified as Hazardous Air Pollutants (Priority Action Substances)	Cabinet Order Number	7 of Central Environment Council 9th Report (Appendix 2)
Cabinet Order Name	Chloroform

Water Pollution Prevention Act
- Japan Water Pollution Control Law Data Description Water / Soil / Ground Environment (MOE site)
  - Classification Designated Substances Cabinet Order Number
    Article 3-3-20 of Cabinet order
    
    Cabinet Order Name Chloroform

Fire Service Act

Fire Service Act : Substances that inhibit firefighting activities Data Description

Number of cabinet order etc.	HM Ordinance Article 1-10 (6) Attached Table 2(6)
Substances	Chloroform
Stipulated quantity	200kg
Sources	Hazardous Materials Data Book 2nd edition, MHLW Website; Sample SDS

Laws and Regulations in Other countries

Recommendations on the transport of dangerous goods
- Dangerous Goods List (UN Number and Hazard class) Data Description
  - UN Number
    1888
    Class or Division 6.1
    
    Name and Description CHLOROFORM
    
    UN packing group III

International Convention on the Commodity Description and Coding Systems (HS Convention)

HS Code: Section VI “Products of the Chemical or Allied Industries" Data Description

Chapter	29	Chapter name	Organic chemicals
Heading	2903	Substance name (Heading)	Halogenated derivatives of hydrocarbons
HS Code	2903.13	Substance Name	Saturated chlorinated derivatives of acyclic hydrocarbons : Chloroform (trichloromethane)

Association of South-East Asian Nations(ASEAN)
- The ASEAN-Japan Chemical Safety Database (AJCSD).: Laws and Regulations Data Description
  - Detail to AJCSD
- The ASEAN-Japan Chemical Safety Database (AJCSD).: GHS-Related Information Data Description
  - Detail to AJCSD

European Union (EU)

EC Inventory Data Description
- EC Number
  200-663-8
  
  EC Name Chloroform
  
  Description -
  
  Substance Infocard Infocard
  
  ECHA Name -

EU: CLP Harmonised Classification Data Description To ECHA site

Index Number	602-006-00-4	EC Number	200-663-8
Chemical Name	chloroform; trichloromethane
Classification	Carc. 2 / Repr. 2 / [Inh.]Acute Tox. 3 / [Oral]Acute Tox. 4 / STOT RE 1 / Eye Irrit. 2 / Skin Irrit. 2

US: Toxic Substances Control Act (TSCA)
- TSCA Inventory Data Description
  - TSCA Chemical Substance Name Methane, trichloro-
    
    DEF -
    
    UVCB -
    
    FLAG -
    
    ACTIVITY ACTIVE

China
- China: Catalog of Hazardous Chemicals 2015 Data Description
  - Number
    1852
    
    Name Trichloromethane
    
    Other Name Chloroform
    
    Remarks -

Korea

Korea: ARECs (K-REACH) / CCA; Hazardous Substance(s), Priority Control Substances Data Description
- Number
  97-1-281
  
  Category Toxic Substance(s)
  
  Chemical Substance Name Chloroform
  
  Range of Application (%)
  >=10
  
  Number
  22
  
  Category Priority Control Substances
  
  Chemical Substance Name Chloroform

Korea: ARECs (K-REACH); Existing Chemical Substances Data Description

KE Number	KE-34076
Category	Existing Chemical Substances (Domestically distributed commercial purpose before February 2, 1991.)
Chemical Substance Name	Trichloromethane ; Chloroform
Remarks	In the case of being hydrated, the resulting hydrate is also applicable.

Korea: ARECs (K-REACH); Others Data Description

Number	15
Category	Phase-in substance(s) subject to registration (by June 30, 2018)
Chemical Substance Name	Trichloromethane; Chloroform
Note	The registration grace period is until June 30, 2018

Taiwan
- Taiwan: TCCSCA/OSHA; Existing Chemical Substances Data Description
  - English Name chloroform
    
    Chinese Name -
- Taiwan: TCCSCA; Toxic Chemicals Data Description
  - Listed No./Series No. 54/01
    
    Toxicity Classify 1
    
    English Name Chloroform
    
    Chinese Name 三氯甲烷
    
    Control concentration standard (w/w%) 50
    
    Large-scale handling standard(kg) 50

Chemical Hazard and Risk Information

GHS Classification Results

NITE Japan-GHS Data Description
- Edition version_2
  
  Chemical Substance Name Chloroform
  
  Classification Result To the resut webpage To the Excel flie

GHS Classification Results by the Japanese Government Data Description GHS Information

Year of implementation /renewal	2006	ID	24_H18_new
Chemical Substance Name	Chloroform
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2014	ID	- / R-094
Chemical Substance Name	Chloroform
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2015	ID	H27-B-050/C-086B_P
Chemical Substance Name	Chloroform
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2021	ID	R03-C-059-MHLW
Chemical Substance Name	Chloroform
Classification Result	To the resut webpage To the Excel flie
Remarks	The reclassification result of only physical and health hazard classes. As for environmental hazard classes, please see the result in FY2015.

MHLW:GHS Aligned Sample Label and SDS
- GHS Aligned Sample Label and SDS Data Description Information on GHS Aligned Sample Label and SDS (Workplace Safety Site)
  - Chemical Substance Name Chloroform
    
    Sample Label to MHLW Website (in Japanese Only)
    
    Sample SDS to MHLW Website (in Japanese Only)

AIST: Relational Information System for Chemical Accidents Database(RISCAD)
- Relational Information System for Chemical Accidents Database(RISCAD) Data Description RISCAD (in Japanese)
  - Material ID 280
    
    Name chloroform
    
    Material Information to RISCAD

Hazard and Risk Assessment Reports etc. in Japan

Chemical Substances Hazard Assessment Report / Initial Risk Assessment Report Data Description Guidance for Initial Risk Assessment ver.1 (in Japanese) Guidance for Initial Risk Assessment ver.2 (in Japanese)

Report Number	No.16
Assessed Chemical Substance Name	Chloroform
Details	Hazard Assessment Report (in Japanese)	Date of publication/ renewal	2008/03
	Details Initial Risk Assessment Report (in Japanese)	Date of publication/ renewal	2005/05
	Details Summary of Initial Risk Assessment Report	Date of publication/ renewal	2010/05

ISHA: Examples of Occupational Accidents Caused by Chemical Substances Data Description
- Name Chloroform
  
  Examples of Occupational Accidents to MHLW site (in Japanese)

Hazard Data Sheet for Chemical Substances Data Description
- Book Number
  96-13
  Date of publication/ renewal 1997/07
  
  Assessed Chemical Substance Name Trichloromethane
  
  Details Hazard Data Sheet (in Japanese)

CSCL: The Japan HPV Challenge Program Data Description
- Chemical Substance Name Trichloromethane
  
  Details to J-CHECK

Hazard and Risk Assessment Reports etc. in Other Countries
- OECD: High Production Volume (HPV) Chemicals Data Description
  - Chemical Name Chloroform
    
    Details to OECD Existing Chemicals Database
- International Chemical Safety Cards (ICSC) Data Description
  - ICSC Number
    27
    
    ICSC Title Chloroform
    
    Details to ILO site
- Concise International Chemical Assessment Documents (CICADs) Data Description
  - CICADs Number
    58
    
    CICADs Title Chloroform (CICADS 58, 2004)
    
    Details to IPCS site
- Environmental Health Criteria (EHC) Data Description
  - EHC Number
    163
    
    EHC Title Chloroform
    
    Details to IPCS site
- US Agency for Toxic Substances and Disease Registry (ATSDR): Toxicological Profiles Data Description
  - Profile Title Chloroform
    
    Details to ATSDR site
    
    Date of Issue September 1997
- US EPA: Integrated Risk Information System (IRIS) Data Description
  - Chemical Substance Name Chloroform
    
    Details to EPA site Last Revision 2001/10/19
- US EPA: Acute Exposure Guideline Levels (AEGLs) Data Description
  - Chemical Name Chloroform
    
    Status Final
    
    AEGL Values to EPA site
- EU: Risk Assessment Reports (RAR) Data Description
  - EC Number
    200-663-8
    Date 2009/11/27
    
    Report Title CHLOROFORM
    
    Details to ECHA site
- Advisory Committee on Existing Chemicals (BUA) Reports by the German Chemical Society Data Description
  - BUA Number
    1, 117, 210
    
    Substance Name Chloroform
    
    Related information to BUA site
- Canada: Priority Substances List (PSL) Data Description
  - Type of Priory Substances List PSL2
    
    Report Title Chloroform
    
    Details to Environment Canada site

Japan Society for Occupational Health (JSOH) Recommendation of Occupational Exposure Limits

JSOH: Occupational Exposure Limits Data Description
- Substance Name Chloroform
  
  Occupational Exposure Limit (ppm) 3
  
  Occupational Exposure Limit (mg/m3) 14.7
  
  Details Documentation in Japanese
  
  Year of proposal 2005
  
  Remarks Skin absorption

JSOH: Occupational Carcinogens Data Description

Substance Name	Chloroform
Carcinogenicity classification	2B
Details	Documentation in Japanese
Year of proposal	1986, (2005)
Remarks	( ) in the year of proposal indicates year of reconsideration resulting in no classification change.

Carcinogenicity Assessment
- IARC: Carcinogenicity Assessment Data Description to IARC site
  - Volume Sup 7, 73 Volume publication year 1999
    
    Agent Name Chloroform
    
    Group 2B
    
    Details Sup 7 Vol.73 - - -
- US EPA: Carcinogenicity Assessment Data Description to EPA site
  - Chemical Substance Name Chloroform
    
    Guideline: Category 1986 : B2
    
    Exporsure Route Inhalation route
    
    Details to Substance Profile
    
    Chemical Substance Name Chloroform
    
    Guideline: Category 1999 : L
    
    Exporsure Route Inhalation route
    
    Details to Substance Profile
    
    Chemical Substance Name Chloroform
    
    Guideline: Category 1999 : NL
    
    Exporsure Route Inhalation route
    
    Details to Substance Profile
- US NTP: Carcinogenicity Assessment Data Description to NTP site
  - Chemical Substance Name Chloroform
    
    Category
    RAHC
    
    NAME OR SYNONYM
    Chloroform
    
    Details to Substance Profile
- European Union (EU): Carcinogenicity Assessment Data Description to ECHA site
  - Substance Name chloroform; trichloromethane
    
    Category Code 2

Safety Summary of Japan(JCIA BIGDr)
- Safety Summary of Japan(JCIA BIGDr) Data Description
  - Substance Name Methane, trichloro-
    
    Detail to JCIA BIGDr

Test Data and Reports

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	trichloromethane
Judgement of Biodegradation	Not readily biodegradable	Judgement of Bioconcentration	Low bioconcentration
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

Japan MOE: Results of Eco-toxicity tests of chemicals Data Description
- Chemical Substance Name Chloroform
  
  Details to J-CHECK

ISHA: Carcinogenicity Test Results for Chemical Substances Data Description to MHLW site (in Japanese)
- Chemical Name Chloroform
  
  Summary Inhalation test results (in Japanese)

ISHA: Mutagenicity Test Results for Chemical Substances Data Description to MHLW site (in Japanese)
- Chemical Name Chloroform(Gas)
  
  Bacterial Test Negative/Positive
  
  CHL/IU Test -

US National Toxicology Program (NTP) : Long-Term Study Reports & Abstracts Data Description
- Report Number
  TR-000
  
  Report Title Report on the Carcinogenesis Bioassay of Chloroform (CASRN 67-66-3)
  
  Abstract to NTP site Full Text to NTP site

CHRIP_ID	C004-661-75A	CAS RN	67-66-3
Chemical Substance Name	Chloroform
Molecular Formula	CHCl3
Molecular Weight	119
SMILES	ClC(Cl)Cl
Structure

Synonym	FLON-20
	Formyl trichloride
	Methane trichloride
	Trichloromethane

Registration Number	8	Date of Designation	2011/04/01
MITI Number	2-37
Chemical Substance Name	Chloroform
Reason for Inclusion	Human Health / Ecosystem
Remarks	-
Details	to J-CHECK

Registration Number	3	Date of Designation in the Official Gazette	1987/07/02
MITI Number	2-37
Chemical Substance Name	Chloroform
Remarks	-
Details	to J-CHECK

Registration Number	161	Date of Designation in the Official Gazette	2010/03/19
MITI Number	2-37
Chemical Substance Name	Chloroform
Remarks	-
Details	to J-CHECK

Cabinet Order Number	Attached table 9-160 of Cabinet order
Cabinet Order Name	Chloroform
Range of Application for Label (weight%)	>=1
Range of Application for SDS (weight%)	>=0.1

Substance Name	Chloroform
Classification of Target Substances	Special chemical regulations etc.	Cutoff value(weight %)	1
Details	to the GHS Classification

Registration Number	11.2
Kinds of substances	Chloroform
Control Level	3ppm

Classification	Deleterious Substances(Law)	Law or Cabinet Order Number	Attached Table 2-20 of the Law
Law or Cabinet Order Name	Chloroform

Classification	Designated Substances	Cabinet Order Number	Article 3-3-20 of Cabinet order
Cabinet Order Name	Chloroform

UN Number	1888	Class or Division	6.1
Name and Description	CHLOROFORM
UN packing group	III

TSCA Chemical Substance Name	Methane, trichloro-
DEF	-
UVCB	-
FLAG	-
ACTIVITY	ACTIVE

English Name	chloroform
Chinese Name	-

EC Number	200-663-8
EC Name	Chloroform
Description	-
Substance Infocard	Infocard
ECHA Name	-

Number	97-1-281
Category	Toxic Substance(s)
Chemical Substance Name	Chloroform
Range of Application (%)	>=10

Number	22
Category	Priority Control Substances
Chemical Substance Name	Chloroform

Listed No./Series No.	54/01
Toxicity Classify	1
English Name	Chloroform
Chinese Name	三氯甲烷
Control concentration standard (w/w%)	50
Large-scale handling standard(kg)	50

Edition	version_2
Chemical Substance Name	Chloroform
Classification Result	To the resut webpage To the Excel flie

Chemical Substance Name	Chloroform
Sample Label	to MHLW Website (in Japanese Only)
Sample SDS	to MHLW Website (in Japanese Only)

Name	Chloroform
Examples of Occupational Accidents	to MHLW site (in Japanese)

Book Number	96-13	Date of publication/ renewal	1997/07
Assessed Chemical Substance Name	Trichloromethane
Details	Hazard Data Sheet (in Japanese)

CICADs Number	58
CICADs Title	Chloroform (CICADS 58, 2004)
Details	to IPCS site

Profile Title	Chloroform
Details	to ATSDR site
Date of Issue	September 1997

EC Number	200-663-8	Date	2009/11/27
Report Title	CHLOROFORM
Details	to ECHA site

BUA Number	1, 117, 210
Substance Name	Chloroform
Related information	to BUA site

Type of Priory Substances List	PSL2
Report Title	Chloroform
Details	to Environment Canada site

Substance Name	Chloroform
Occupational Exposure Limit (ppm)	3
Occupational Exposure Limit (mg/m3)	14.7
Details	Documentation in Japanese
Year of proposal	2005
Remarks	Skin absorption

Volume	Sup 7, 73	Volume publication year	1999
Agent Name	Chloroform
Group	2B
Details	Sup 7 Vol.73 - - -

Chemical Substance Name	Chloroform
Guideline: Category	1986 : B2
Exporsure Route	Inhalation route
Details	to Substance Profile

Chemical Name	Chloroform
Summary	Inhalation test results (in Japanese)

Chemical Name	Chloroform(Gas)
Bacterial Test	Negative/Positive
CHL/IU Test	-

Report Number	TR-000
Report Title	Report on the Carcinogenesis Bioassay of Chloroform (CASRN 67-66-3)
Abstract	to NTP site	Full Text	to NTP site