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General Information
- General Information
  - General Information Data Description
    - CHRIP_ID C004-663-13A CAS RN 123-91-1
      
      Chemical Substance Name 1,4-Dioxane
      
      Molecular Formula C4H8O2
      
      Molecular Weight 88
      
      SMILES C1COCCO1
      
      Structure
- Synonym
  - Synonym Data Description
    - Synonym 1,4-Diethylene dioxide
      
      1,4-Diethyleneoxide
- Notes on CAS RN
  - Notes on CAS RN Data Description
    - Notes The CAS RN before replacement had been CAS RN 54841-74-6.
- Nikkaji
  - Information of Japan Chemical Substance Dictionary (Nikkaji) Data Description
    - Nikkaji Number
      J2.502J
      Detail to J-GLOBAL

Laws and Regulations in Japan

Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (Chemical Substances Control Law ; CSCL)

Japan CSCL: Priority Assessment Chemical Substances Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]
- Registration Number
  80
  Date of Designation 2011/04/01
  
  MITI Number
  5-839
  
  Chemical Substance Name 1,4-Dioxane
  
  Reason for Inclusion Human Health
  
  Remarks -
  
  Details to J-CHECK

Japan CSCL: Existing Chemical Substances Data Description Definition of the terms of Section 6 [PDF] Definition of the terms of Section 7 [PDF] Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]

MITI Number	5-839	Category	Section 5
Chemical Substance Name	1,4-Dioxane
Remarks	-
Details	to J-CHECK
Remarks to Existing Chemical Substances of Industrial Safety and Health Act	Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law by June 29, 1979
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)

Japan CSCL: Type II Monitoring Chemical Substances (before amendment) Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]
- Registration Number
  8
  Date of Designation in the Official Gazette 1987/10/17
  
  MITI Number
  5-839
  
  Chemical Substance Name 1,4-Dioxane
  
  Remarks -
  
  Details to J-CHECK

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	1,4-dioxane
Judgement of Biodegradation	Not readily biodegradable	Judgement of Bioconcentration	Low bioconcentration
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

Japan MOE: Results of Eco-toxicity tests of chemicals Data Description
- Chemical Substance Name 1,4-Dioxane
  
  Details to J-CHECK

Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof(PRTR-SDS Law)

Japan: PRTR-SDS Law (until March 2023) Data Description Outline PRTR Law (METI site) Analysis of PRTR data

Classification	I	Cabinet Order Number	1-150
Cabinet Order Name	1,4-Dioxane
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	Releases Map (in Japanese) Atmospheric concentration Map (in Japanese)

Japan: PRTR-SDS Law (from April 2023) Data Description Outline PRTR Law (METI site)

JPSN(Japan PRTR-SDS Number)	150	Classification	I	Cabinet Order Number	1-173
Cabinet Order Name	1,4-Dioxane
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	- -

Industrial Safety and Health Act (ISHA)

Japan ISHA: Chemical Substances Requiring Labeling and Delivery of Documents, etc. Data Description GHS compatible model label creation method (MH LW site : in Japanese) Risk assessment implementation support tool (MHLW site : in Japanese)
- Cabinet Order Number
  Attached table 9-227 of Cabinet order
  
  Cabinet Order Name 1,4-Dioxane
  
  Range of Application for Label (weight%) >=1
  
  Range of Application for SDS (weight%) >=0.1

Japan ISHA: Chemical substances that cause skin disorders, etc. and other chemical substances that must be handled with impermeable protective equipment etc. based on special chemical regulations. Data Description Target substances list(MHLW site: in japanese)
- Substance Name 1,4-Dioxane
  
  Classification of Target Substances Special chemical regulations etc. Cutoff value(weight %) 1
  
  Details to the GHS Classification

Japan ISHA: Specified Chemical Substances Data Description Link to the Ordinance (JISHA site : in Japanese)

Category	Group-2 substances	Cabinet Order Number	Attached Table 3-2-18-3 of Cabinet order
Cabinet Order Name	1,4-Dioxyn
Range of Application (weight %)	>1
Remarks	Substances under special supervision / Special organic solvent, etc.

The above information have been provided by the Ministry of Health, Labour and Welfare

Japan ISHA: Administrative Control Levels of Working Environment Evaluation Standards Data Description Working Environment Measurement (MHLW site : in Japanese)
- Registration Number
  16.3
  
  Kinds of substances 1,4-Dioxane
  
  Control Level 10ppm
  
  The above information have been provided by the Ministry of Health, Labour and Welfare

Japan ISHA: Guidelines for Carcinogenic Substances Data Description
- Name 1,4-Dioxane
  
  Details to MHLW site (in Japanese)

Air Pollution Control Act
- Japan Air Pollution Control Law Data Description Air & Transportation (MOE site)
  - Classification Substances that may be classified as Hazardous Air Pollutants Cabinet Order Number
    71 of Central Environment Council 9th Report (Appendix 1)
    
    Cabinet Order Name 1,4-Dioxane

Water Pollution Prevention Act
- Japan Water Pollution Control Law Data Description Water / Soil / Ground Environment (MOE site)
  - Classification Harmful Substances Cabinet Order Number
    Article 2-28 of Cabinet order
    
    Cabinet Order Name 1,4-Dioxane
    
    Effluent Standards 0.5mg/L

Fire Service Act

Fire Service Act : Hazardous Materials Data Description

Number of cabinet order etc.	Article 2, Paragraph 7 of the Act, Appended Table 1, Category IV (2)
Category; Property	Category IV; Inflammable Liquids
Item	Class I petroleums
Property	Water soluble liquid
Designated quantity	400L
Sources	Hazardous Materials Disaster Information Support System, Hazardous Materials Data Book 2nd edition, MHLW Website; Sample SDS

Laws and Regulations in Other countries

Recommendations on the transport of dangerous goods
- Dangerous Goods List (UN Number and Hazard class) Data Description
  - UN Number
    1165
    Class or Division 3
    
    Name and Description DIOXANE
    
    UN packing group II

Association of South-East Asian Nations(ASEAN)
- The ASEAN-Japan Chemical Safety Database (AJCSD).: Laws and Regulations Data Description
  - Detail to AJCSD
- The ASEAN-Japan Chemical Safety Database (AJCSD).: GHS-Related Information Data Description
  - Detail to AJCSD

European Union (EU)

EC Inventory Data Description
- EC Number
  204-661-8
  
  EC Name 1,4-dioxane
  
  Description -
  
  Substance Infocard Infocard
  
  ECHA Name -

REACH: Substances of Very High Concern for Authorization (SVHC) Data Description

EC Number	204-661-8	Status	Candidate List
Substance Name	1,4-dioxane
Reason for inclusion	Carcinogenic (Article 57a) / Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) / Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
Date of inclusion	2021/07/08
Details	to ECHA site

EU: CLP Harmonised Classification Data Description To ECHA site
- Index Number 603-024-00-5 EC Number 204-661-8
  
  Chemical Name 1,4-dioxane
  
  Classification Flam. Liq. 2 / Carc. 1B / STOT SE 3 / Eye Irrit. 2
  
  Notes and conditions Note D

US: Toxic Substances Control Act (TSCA)
- TSCA Inventory Data Description
  - TSCA Chemical Substance Name 1,4-Dioxane
    
    DEF -
    
    UVCB -
    
    FLAG -
    
    ACTIVITY ACTIVE

China
- China: Catalog of Hazardous Chemicals 2015 Data Description
  - Number
    647
    
    Name 1,4-Dioxacyclohexane
    
    Other Name Dioxane; 1,4-Dioxane
    
    Remarks -

Korea

Korea: ARECs (K-REACH) / CCA; Hazardous Substance(s), Priority Control Substances Data Description
- Number
  2021-1-1083
  
  Category Toxic Substance(s)
  
  Chemical Substance Name 1,4-Dioxane
  
  Range of Application (%)
  >=0.1

Korea: ARECs (K-REACH); Existing Chemical Substances Data Description

KE Number	KE-10463
Category	Existing Chemical Substances (Domestically distributed commercial purpose before February 2, 1991.)
Chemical Substance Name	p-Dioxane
Remarks	In the case of being hydrated, the resulting hydrate is also applicable.

Korea: ARECs (K-REACH); Others Data Description

Number	164
Category	Phase-in substance(s) subject to registration (by June 30, 2018)
Chemical Substance Name	1,4-Diethylene dioxide; 1,4-Dioxane
Note	The registration grace period is until June 30, 2018

Taiwan
- Taiwan: TCCSCA/OSHA; Existing Chemical Substances Data Description
  - English Name 1,4-dioxane
    
    Chinese Name -
- Taiwan: TCCSCA; Toxic Chemicals Data Description
  - Listed No./Series No. 93/01
    
    Toxicity Classify 1
    
    English Name 1,4-Dioxane
    
    Chinese Name 1,4-二氧陸圜
    
    Control concentration standard (w/w%) 1
    
    Large-scale handling standard(kg) 50

Chemical Hazard and Risk Information

GHS Classification Results

NITE Japan-GHS Data Description
- Edition version_1
  
  Chemical Substance Name 1,4-Dioxane
  
  Classification Result To the resut webpage To the Excel flie

GHS Classification Results by the Japanese Government Data Description GHS Information

Year of implementation /renewal	2006	ID	125_H18_new
Chemical Substance Name	1,4-Dioxane
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2009	ID	21B3131
Chemical Substance Name	1,4-Dioxane
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2018	ID	H30-C-011-MHLW
Chemical Substance Name	1,4-Dioxane
Classification Result	To the resut webpage To the Excel flie
Remarks	The reclassification result of only some hazard classes. As for the other classes, please see the result in FY2009.

MHLW:GHS Aligned Sample Label and SDS
- GHS Aligned Sample Label and SDS Data Description Information on GHS Aligned Sample Label and SDS (Workplace Safety Site)
  - Chemical Substance Name 1,4-Dioxane
    
    Sample Label to MHLW Website (in Japanese Only)
    
    Sample SDS to MHLW Website (in Japanese Only)

AIST: Relational Information System for Chemical Accidents Database(RISCAD)
- Relational Information System for Chemical Accidents Database(RISCAD) Data Description RISCAD (in Japanese)
  - Material ID 1177
    
    Name 1,4-dioxane
    
    Material Information to RISCAD
    
    Accident Information to RISCAD

Hazard and Risk Assessment Reports etc. in Japan

Chemical Substances Hazard Assessment Report / Initial Risk Assessment Report Data Description Guidance for Initial Risk Assessment ver.1 (in Japanese) Guidance for Initial Risk Assessment ver.2 (in Japanese)

Report Number	No.13
Assessed Chemical Substance Name	1,4-Dioxane
Details	Hazard Assessment Report (in Japanese)	Date of publication/ renewal	2004/09
	Details Initial Risk Assessment Report (in Japanese)	Date of publication/ renewal	2005/05
	Details Summary of Initial Risk Assessment Report	Date of publication/ renewal	2010/05

ISHA: Examples of Occupational Accidents Caused by Chemical Substances Data Description
- Name 1,4-Dioxane
  
  Examples of Occupational Accidents to MHLW site (in Japanese)

Hazard Data Sheet for Chemical Substances Data Description
- Book Number
  97-13
  Date of publication/ renewal 1997/07
  
  Assessed Chemical Substance Name 1,4-Dioxane
  
  Details Hazard Data Sheet (in Japanese)

CSCL: The Japan HPV Challenge Program Data Description
- Chemical Substance Name 1,4-Dioxane
  
  Details to J-CHECK

Hazard and Risk Assessment Reports etc. in Other Countries
- OECD: High Production Volume (HPV) Chemicals Data Description
  - Chemical Name 1,4-Dioxane
    
    Details to OECD Existing Chemicals Database
- International Chemical Safety Cards (ICSC) Data Description
  - ICSC Number
    41
    
    ICSC Title 1,4-Dioxane
    
    Details to ILO site
- US Agency for Toxic Substances and Disease Registry (ATSDR): Toxicological Profiles Data Description
  - Profile Title 1,4-Dioxane
    
    Details to ATSDR site
    
    Date of Issue April 2012
- US EPA: Integrated Risk Information System (IRIS) Data Description
  - Chemical Substance Name 1,4-Dioxane
    
    Details to EPA site Last Revision 2013/09/20
- US EPA: Acute Exposure Guideline Levels (AEGLs) Data Description
  - Chemical Name 1,4-Dioxane
    
    Status Interim
    
    AEGL Values to EPA site
- EU: Risk Assessment Reports (RAR) Data Description
  - EC Number
    204-661-8
    Date 2002/10/16
    
    Report Title 1,4-dioxane
    
    Details to ECHA site
- Advisory Committee on Existing Chemicals (BUA) Reports by the German Chemical Society Data Description
  - BUA Number
    80, 114
    
    Substance Name 1,4-Dioxane
    
    Related information to BUA site
- Australia: Priority Existing Chemicals (PEC) Assessment Reports Data Description
  - PEC Number
    7
    Date June 1998
    
    Report Title 1,4-Dioxane
    
    Details to AICIS site

Japan Society for Occupational Health (JSOH) Recommendation of Occupational Exposure Limits

JSOH: Occupational Exposure Limits Data Description
- Substance Name 1,4-Dioxane
  
  Occupational Exposure Limit (ppm) 1
  
  Occupational Exposure Limit (mg/m3) 3.6
  
  Details Documentation in Japanese
  
  Year of proposal 2015
  
  Remarks Skin absorption

JSOH: Occupational Carcinogens Data Description

Substance Name	1,4-Dioxane
Carcinogenicity classification	2B
Details	Documentation in Japanese
Year of proposal	1986, (2015)
Remarks	( ) in the year of proposal indicates year of reconsideration resulting in no classification change.

Carcinogenicity Assessment
- IARC: Carcinogenicity Assessment Data Description to IARC site
  - Volume 11, Sup 7, 71 Volume publication year 1999
    
    Agent Name 1,4-Dioxane
    
    Group 2B
    
    Details Vol.11 Sup 7 Vol.71 - -
- US EPA: Carcinogenicity Assessment Data Description to EPA site
  - Chemical Substance Name 1,4-Dioxane
    
    Guideline: Category 2005 : L
    
    Exporsure Route Oral route, Inhalation route
    
    Details to Substance Profile
- US NTP: Carcinogenicity Assessment Data Description to NTP site
  - Chemical Substance Name 1,4-Dioxane
    
    Category
    RAHC
    
    NAME OR SYNONYM
    1,4-Dioxane
    
    Details to Substance Profile
- European Union (EU): Carcinogenicity Assessment Data Description to ECHA site
  - Substance Name 1,4-dioxane
    
    Category Code 1B

Test Data and Reports

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	1,4-dioxane
Judgement of Biodegradation	Not readily biodegradable	Judgement of Bioconcentration	Low bioconcentration
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

Japan MOE: Results of Eco-toxicity tests of chemicals Data Description
- Chemical Substance Name 1,4-Dioxane
  
  Details to J-CHECK

ISHA: Carcinogenicity Test Results for Chemical Substances Data Description to MHLW site (in Japanese)
- Chemical Name 1,4-Dioxane
  
  Summary Oral test results (in Japanese)

ISHA: Mutagenicity Test Results for Chemical Substances Data Description to MHLW site (in Japanese)
- Chemical Name 1,4-Dioxane
  
  Bacterial Test Negative
  
  CHL/IU Test -
  
  Chemical Name 1,4-Dioxane(Gas)
  
  Bacterial Test Negative
  
  CHL/IU Test -

US National Toxicology Program (NTP) : Long-Term Study Reports & Abstracts Data Description
- Report Number
  TR-80
  
  Report Title Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1)
  
  Abstract to NTP site Full Text to NTP site

CHRIP_ID	C004-663-13A	CAS RN	123-91-1
Chemical Substance Name	1,4-Dioxane
Molecular Formula	C4H8O2
Molecular Weight	88
SMILES	C1COCCO1
Structure

Registration Number	80	Date of Designation	2011/04/01
MITI Number	5-839
Chemical Substance Name	1,4-Dioxane
Reason for Inclusion	Human Health
Remarks	-
Details	to J-CHECK

Registration Number	8	Date of Designation in the Official Gazette	1987/10/17
MITI Number	5-839
Chemical Substance Name	1,4-Dioxane
Remarks	-
Details	to J-CHECK

Cabinet Order Number	Attached table 9-227 of Cabinet order
Cabinet Order Name	1,4-Dioxane
Range of Application for Label (weight%)	>=1
Range of Application for SDS (weight%)	>=0.1

Substance Name	1,4-Dioxane
Classification of Target Substances	Special chemical regulations etc.	Cutoff value(weight %)	1
Details	to the GHS Classification

Registration Number	16.3
Kinds of substances	1,4-Dioxane
Control Level	10ppm

Classification	Substances that may be classified as Hazardous Air Pollutants	Cabinet Order Number	71 of Central Environment Council 9th Report (Appendix 1)
Cabinet Order Name	1,4-Dioxane

Classification	Harmful Substances	Cabinet Order Number	Article 2-28 of Cabinet order
Cabinet Order Name	1,4-Dioxane
Effluent Standards	0.5mg/L

UN Number	1165	Class or Division	3
Name and Description	DIOXANE
UN packing group	II

EC Number	204-661-8
EC Name	1,4-dioxane
Description	-
Substance Infocard	Infocard
ECHA Name	-

Synonym	1,4-Diethylene dioxide
	1,4-Diethyleneoxide

Index Number	603-024-00-5	EC Number	204-661-8
Chemical Name	1,4-dioxane
Classification	Flam. Liq. 2 / Carc. 1B / STOT SE 3 / Eye Irrit. 2
Notes and conditions	Note D

TSCA Chemical Substance Name	1,4-Dioxane
DEF	-
UVCB	-
FLAG	-
ACTIVITY	ACTIVE

Listed No./Series No.	93/01
Toxicity Classify	1
English Name	1,4-Dioxane
Chinese Name	1,4-二氧陸圜
Control concentration standard (w/w%)	1
Large-scale handling standard(kg)	50

Number	647
Name	1,4-Dioxacyclohexane
Other Name	Dioxane; 1,4-Dioxane
Remarks	-

Number	2021-1-1083
Category	Toxic Substance(s)
Chemical Substance Name	1,4-Dioxane
Range of Application (%)	>=0.1

Edition	version_1
Chemical Substance Name	1,4-Dioxane
Classification Result	To the resut webpage To the Excel flie

Chemical Substance Name	1,4-Dioxane
Sample Label	to MHLW Website (in Japanese Only)
Sample SDS	to MHLW Website (in Japanese Only)

Material ID	1177
Name	1,4-dioxane
Material Information	to RISCAD
Accident Information	to RISCAD

Name	1,4-Dioxane
Examples of Occupational Accidents	to MHLW site (in Japanese)

Book Number	97-13	Date of publication/ renewal	1997/07
Assessed Chemical Substance Name	1,4-Dioxane
Details	Hazard Data Sheet (in Japanese)

Profile Title	1,4-Dioxane
Details	to ATSDR site
Date of Issue	April 2012

EC Number	204-661-8	Date	2002/10/16
Report Title	1,4-dioxane
Details	to ECHA site

BUA Number	80, 114
Substance Name	1,4-Dioxane
Related information	to BUA site

PEC Number	7	Date	June 1998
Report Title	1,4-Dioxane
Details	to AICIS site

Substance Name	1,4-Dioxane
Occupational Exposure Limit (ppm)	1
Occupational Exposure Limit (mg/m3)	3.6
Details	Documentation in Japanese
Year of proposal	2015
Remarks	Skin absorption

Volume	11, Sup 7, 71	Volume publication year	1999
Agent Name	1,4-Dioxane
Group	2B
Details	Vol.11 Sup 7 Vol.71 - -

Chemical Substance Name	1,4-Dioxane
Guideline: Category	2005 : L
Exporsure Route	Oral route, Inhalation route
Details	to Substance Profile

Chemical Name	1,4-Dioxane
Summary	Oral test results (in Japanese)

Chemical Name	1,4-Dioxane(Gas)
Bacterial Test	Negative
CHL/IU Test	-

Report Number	TR-80
Report Title	Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1)
Abstract	to NTP site	Full Text	to NTP site