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General Information
- General Information
  - General Information Data Description
    - CHRIP_ID C004-684-33A CAS RN 127-19-5
      
      Chemical Substance Name N,N-Dimethylacetamide
      
      Molecular Formula C4H9NO
      
      Molecular Weight 87
      
      SMILES CC(N(C)C)=O
      
      Structure
- Synonym
  - Synonym Data Description
    - Synonym Acetic acid dimethylamide
      
      Dimethylacetamide
- Nikkaji
  - Information of Japan Chemical Substance Dictionary (Nikkaji) Data Description
    - Nikkaji Number
      J2.517H
      Detail to J-GLOBAL

Laws and Regulations in Japan

Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (Chemical Substances Control Law ; CSCL)

Japan CSCL: Existing Chemical Substances Data Description Definition of the terms of Section 6 [PDF] Definition of the terms of Section 7 [PDF] Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]

MITI Number	2-723	Category	Section 2
Chemical Substance Name	N,N-Dimethylacetamide
Remarks	-
Details	to J-CHECK
Remarks to Existing Chemical Substances of Industrial Safety and Health Act	Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law by June 29, 1979
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)

Japan CSCL: Type II Monitoring Chemical Substances (before amendment) Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]
- Registration Number
  1039
  Date of Designation in the Official Gazette 2010/04/01
  
  MITI Number
  2-723
  
  Chemical Substance Name N,N-Dimethylacetamide
  
  Remarks -
  
  Details to J-CHECK

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	N,N-dimethylacetamide
Judgement of Biodegradation	Readily biodegradable	Judgement of Bioconcentration	-
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof(PRTR-SDS Law)

Japan: PRTR-SDS Law (until March 2023) Data Description Outline PRTR Law (METI site) Analysis of PRTR data

Classification	I	Cabinet Order Number	1-213
Cabinet Order Name	N,N-Dimethylacetamide
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	Releases Map (in Japanese) Atmospheric concentration Map (in Japanese)

Japan: PRTR-SDS Law (from April 2023) Data Description Outline PRTR Law (METI site)

JPSN(Japan PRTR-SDS Number)	213	Classification	I	Cabinet Order Number	1-242
Cabinet Order Name	N,N-Dimethylacetamide
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	- -

Industrial Safety and Health Act (ISHA)

Japan ISHA: Chemical Substances Requiring Labeling and Delivery of Documents, etc. Data Description GHS compatible model label creation method (MH LW site : in Japanese) Risk assessment implementation support tool (MHLW site : in Japanese)
- Cabinet Order Number
  Attached table 9-284 of Cabinet order
  
  Cabinet Order Name N,N-Dimethylacetamide
  
  Range of Application for Label (weight%) >=1
  
  Range of Application for SDS (weight%) >=0.1

Japan ISHA: Carcinogenic Substances (Ordinance on Industrial Safety and Health) (subject to 30-year storage of work records, etc.) Data Description Lists of Target Substances (MHLW site : in Japanese)

GHS Classification Substance Name	N,N-Dimethylacetamide
Carcinogenicity in GHS classification	Category 1B	Range of Application (weight%)	>=0.1
Implementation	2023/4/1
Details	to the GHS Classification

Japan ISHA: Concentration standards for the prevention of health problems caused by chemical substances (Concentration standard value setting substance) Data Description Target substances list(MHLW site: in japanese)

Kinds of substances(Substance name)	N,N-Dimethylacetamide
Eight-hour concentration standard value	5ppm
Sampling Method	Solid adsorption method
Analytical Method	Gaschromatography
Implementation	2024/04/01

Japan ISHA: Chemical substances that cause skin disorders, etc. and other chemical substances that must be handled with impermeable protective equipment etc. based on special chemical regulations. Data Description Target substances list(MHLW site: in japanese)
- Substance Name N,N-Dimethylacetamide
  
  Classification of Target Substances Skin Absorbing Hazardous Substances Cutoff value(weight %) 0.1
  
  Implementation 2024/4/1
  
  Details to the GHS Classification

Japan ISHA: Guidelines for Carcinogenic Substances Data Description
- Name N,N-Dimethylacetamide
  
  Details to MHLW site (in Japanese)

Air Pollution Control Act
- Japan Air Pollution Control Law Data Description Air & Transportation (MOE site)
  - Classification Substances that may be classified as Hazardous Air Pollutants Cabinet Order Number
    98 of Central Environment Council 9th Report (Appendix 1)
    
    Cabinet Order Name N,N-Dimethylacetamide

Laws and Regulations in Other countries

Association of South-East Asian Nations(ASEAN)
- The ASEAN-Japan Chemical Safety Database (AJCSD).: Laws and Regulations Data Description
  - Detail to AJCSD
- The ASEAN-Japan Chemical Safety Database (AJCSD).: GHS-Related Information Data Description
  - Detail to AJCSD

European Union (EU)
- EC Inventory Data Description
  - EC Number
    204-826-4
    
    EC Name N,N-dimethylacetamide
    
    Description -
    
    Substance Infocard Infocard
    
    ECHA Name -
- REACH: Substances of Very High Concern for Authorization (SVHC) Data Description
  - EC Number 204-826-4 Status Candidate List
    
    Substance Name N,N-dimethylacetamide
    
    Reason for inclusion
    Toxic for reproduction (Article 57c)
    
    Date of inclusion
    2011/12/19
    
    Details to ECHA site
- EU: CLP Harmonised Classification Data Description To ECHA site
  - Index Number 616-011-00-4 EC Number 204-826-4
    
    Chemical Name N,N-dimethylacetamide
    
    Classification Repr. 1B / [Inh.]Acute Tox. 4 * / [Der.]Acute Tox. 4 *

US: Toxic Substances Control Act (TSCA)
- TSCA Inventory Data Description
  - TSCA Chemical Substance Name Acetamide, N,N-dimethyl-
    
    DEF -
    
    UVCB -
    
    FLAG -
    
    ACTIVITY ACTIVE

Korea

Korea: ARECs (K-REACH) / CCA; Hazardous Substance(s), Priority Control Substances Data Description
- Number
  2019-1-938
  
  Category Toxic Substance(s)
  
  Chemical Substance Name N,N-Dimethylacetamide
  
  Range of Application (%)
  >=0.3
  
  Number
  111
  
  Category Priority Control Substances
  
  Chemical Substance Name N,N-Dimethylacetamide

Korea: ARECs (K-REACH); Existing Chemical Substances Data Description

KE Number	KE-11114
Category	Existing Chemical Substances (Domestically distributed commercial purpose before February 2, 1991.)
Chemical Substance Name	N,N-DIMETHYLACETAMIDE
Remarks	In the case of being hydrated, the resulting hydrate is also applicable.

Korea: ARECs (K-REACH); Others Data Description
- Number 169
  
  Category Phase-in substance(s) subject to registration (by June 30, 2018)
  
  Chemical Substance Name N,N-Dimethylacetamide
  
  Note
  The registration grace period is until June 30, 2018

Taiwan
- Taiwan: TCCSCA/OSHA; Existing Chemical Substances Data Description
  - English Name N,N-dimethylacetamide
    
    Chinese Name -
- Taiwan: TCCSCA; Existing Chemical Substances Subject to Standard Registration Data Description
  - Stage/Serial No.
    1/28
    
    English Name N,N-Dimethylacetamide
    
    Chinese Name N,N-二甲基乙醯胺

Chemical Hazard and Risk Information

GHS Classification Results

NITE Japan-GHS Data Description
- Edition version_2
  
  Chemical Substance Name N,N-Dimethylacetamide
  
  Classification Result To the resut webpage To the Excel flie

GHS Classification Results by the Japanese Government Data Description GHS Information

Year of implementation /renewal	2006	ID	795_H18_new
Chemical Substance Name	Acetamide, N,N-dimethyl-
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2008	ID	1-213
Chemical Substance Name	N,N-Dimethylacetamide
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2013	ID	25B0050
Chemical Substance Name	N,N-Dimethylacetamide
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2018	ID	H30-C-012-MHLW
Chemical Substance Name	N,N-Dimethylacetamide
Classification Result	To the resut webpage To the Excel flie
Remarks	The reclassification result of only some hazard classes. As for the other classes, please see the result in FY2013, FY2008 and FY2006.

Year of implementation /renewal	2021	ID	R03-B-012-METI, MOE
Chemical Substance Name	N,N-Dimethylacetamide
Classification Result	To the resut webpage To the Excel flie

MHLW:GHS Aligned Sample Label and SDS
- GHS Aligned Sample Label and SDS Data Description Information on GHS Aligned Sample Label and SDS (Workplace Safety Site)
  - Chemical Substance Name N,N-Dimethylacetamide
    
    Sample Label to MHLW Website (in Japanese Only)
    
    Sample SDS to MHLW Website (in Japanese Only)

AIST: Relational Information System for Chemical Accidents Database(RISCAD)
- Relational Information System for Chemical Accidents Database(RISCAD) Data Description RISCAD (in Japanese)
  - Material ID 1203
    
    Name n,n-dimethylacetamide
    
    Material Information to RISCAD

Hazard and Risk Assessment Reports etc. in Japan
- ISHA: Risk Assessment Report Data Description to MHLW site (in Japanese)
  - Name N,N-Dimethylacetamide
    
    Initial Risk Assessment Report text/cover (in Japanese)
    
    Name N,N-Dimethylacetamide
    
    Measurement and Analysis Methods Exposure Assessment Sub-Study Group (Measurement and Analysis Methods, in Japanese)
- CSCL: The Japan HPV Challenge Program Data Description
  - Chemical Substance Name N,N-dimethylacetamide
    
    Details to J-CHECK

Hazard and Risk Assessment Reports etc. in Other Countries
- OECD: High Production Volume (HPV) Chemicals Data Description
  - Chemical Name Acetamide, N,N-dimethyl-
    
    Details to OECD Existing Chemicals Database
- International Chemical Safety Cards (ICSC) Data Description
  - ICSC Number
    259
    
    ICSC Title N,N-Dimethylacetamide
    
    Details to ILO site

Japan Society for Occupational Health (JSOH) Recommendation of Occupational Exposure Limits

JSOH: Occupational Exposure Limits Data Description

Substance Name	N,N-Dimethyl acetamide
Occupational Exposure Limit (ppm)	10
Occupational Exposure Limit (mg/m3)	36
Details	Documentation in Japanese
Year of proposal	1990
Remarks	Skin absorption

JSOH: Occupational Carcinogens Data Description
- Substance Name N,N-Dimethylacetamide
  
  Carcinogenicity classification 2B
  
  Details -
  
  Year of proposal 2019
  
  Remarks -

JSOH: Reproductive Toxicants Data Description
- Substance Name N,N-Dimethylacetamide
  
  Reproductive toxicant classification 2
  
  Details Summary
  
  Year of proposal 2014
  
  Remarks -

Carcinogenicity Assessment
- IARC: Carcinogenicity Assessment Data Description to IARC site
  - Volume 123 Volume publication year 2020 online
    
    Agent Name N,N-Dimethylacetamide
    
    Group 2B
    
    Details Vol.123 - - - -

Test Data and Reports

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	N,N-dimethylacetamide
Judgement of Biodegradation	Readily biodegradable	Judgement of Bioconcentration	-
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

ISHA: Carcinogenicity Test Results for Chemical Substances Data Description to MHLW site (in Japanese)
- Chemical Name N,N-Dimethylacetamide
  
  Summary Inhalation test results (in Japanese)

CHRIP_ID	C004-684-33A	CAS RN	127-19-5
Chemical Substance Name	N,N-Dimethylacetamide
Molecular Formula	C4H9NO
Molecular Weight	87
SMILES	CC(N(C)C)=O
Structure

Registration Number	1039	Date of Designation in the Official Gazette	2010/04/01
MITI Number	2-723
Chemical Substance Name	N,N-Dimethylacetamide
Remarks	-
Details	to J-CHECK

Cabinet Order Number	Attached table 9-284 of Cabinet order
Cabinet Order Name	N,N-Dimethylacetamide
Range of Application for Label (weight%)	>=1
Range of Application for SDS (weight%)	>=0.1

Substance Name	N,N-Dimethylacetamide
Classification of Target Substances	Skin Absorbing Hazardous Substances	Cutoff value(weight %)	0.1
Implementation	2024/4/1
Details	to the GHS Classification

Classification	Substances that may be classified as Hazardous Air Pollutants	Cabinet Order Number	98 of Central Environment Council 9th Report (Appendix 1)
Cabinet Order Name	N,N-Dimethylacetamide

EC Number	204-826-4
EC Name	N,N-dimethylacetamide
Description	-
Substance Infocard	Infocard
ECHA Name	-

EC Number	204-826-4	Status	Candidate List
Substance Name	N,N-dimethylacetamide
Reason for inclusion	Toxic for reproduction (Article 57c)
Date of inclusion	2011/12/19
Details	to ECHA site

Index Number	616-011-00-4	EC Number	204-826-4
Chemical Name	N,N-dimethylacetamide
Classification	Repr. 1B / [Inh.]Acute Tox. 4 * / [Der.]Acute Tox. 4 *

TSCA Chemical Substance Name	Acetamide, N,N-dimethyl-
DEF	-
UVCB	-
FLAG	-
ACTIVITY	ACTIVE

Number	2019-1-938
Category	Toxic Substance(s)
Chemical Substance Name	N,N-Dimethylacetamide
Range of Application (%)	>=0.3

Synonym	Acetic acid dimethylamide
	Dimethylacetamide

Number	169
Category	Phase-in substance(s) subject to registration (by June 30, 2018)
Chemical Substance Name	N,N-Dimethylacetamide
Note	The registration grace period is until June 30, 2018

Stage/Serial No.	1/28
English Name	N,N-Dimethylacetamide
Chinese Name	N,N-二甲基乙醯胺

Material ID	1203
Name	n,n-dimethylacetamide
Material Information	to RISCAD

Number	111
Category	Priority Control Substances
Chemical Substance Name	N,N-Dimethylacetamide

Edition	version_2
Chemical Substance Name	N,N-Dimethylacetamide
Classification Result	To the resut webpage To the Excel flie

Chemical Substance Name	N,N-Dimethylacetamide
Sample Label	to MHLW Website (in Japanese Only)
Sample SDS	to MHLW Website (in Japanese Only)

Name	N,N-Dimethylacetamide
Initial Risk Assessment Report	text/cover (in Japanese)

Name	N,N-Dimethylacetamide
Measurement and Analysis Methods	Exposure Assessment Sub-Study Group (Measurement and Analysis Methods, in Japanese)

ICSC Number	259
ICSC Title	N,N-Dimethylacetamide
Details	to ILO site

Substance Name	N,N-Dimethylacetamide
Carcinogenicity classification	2B
Details	-
Year of proposal	2019
Remarks	-

Substance Name	N,N-Dimethylacetamide
Reproductive toxicant classification	2
Details	Summary
Year of proposal	2014
Remarks	-

Volume	123	Volume publication year	2020 online
Agent Name	N,N-Dimethylacetamide
Group	2B
Details	Vol.123 - - - -