Search Results - NITE-CHRIP (NITE Chemical Risk Information Platform)

Search Results

Excluding blank data Including blank data

Downloading the search results

General Information

General Information Data Description

CHRIP_ID	C004-707-28A	CAS RN	101-14-4
Chemical Substance Name	2,2'-Dichloro-4,4'-methylenedianiline
Molecular Formula	C13H12Cl2N2
Molecular Weight	267
SMILES	NC1=C(C=C(C=C1)CC2=CC(Cl)=C(C=C2)N)Cl
Structure

Synonym

Synonym Data Description

Synonym	3,3'-Dichloro-4,4'-diaminodiphenylmethane
	4,4'-Diamino-3,3'-dichlorodiphenylmethane
	4,4'-Methylenebis(2-chloroaniline) (MOCA)
	4,4'Methylenebis(2-chloroaniline)
	Benzenamine, 4,4'-methylenebis(2-chloro-)
	MBOCA
	Methylene-bis-ortho-chloroaniline
	MOCA
	MOCA; MBOCA

Nikkaji
- Information of Japan Chemical Substance Dictionary (Nikkaji) Data Description
  - Nikkaji Number
    J3.595E
    Detail to J-GLOBAL

Laws and Regulations in Japan

Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (Chemical Substances Control Law ; CSCL)

Japan CSCL: Priority Assessment Chemical Substances Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]

Registration Number	255	Date of Designation	2020/04/01
MITI Number	4-95, 4-96, 4-275
Chemical Substance Name	4,4'-Diamino-3,3'-dichlorodiphenylmethane (synonym: 4,4'-Methylenebis(2-chloroaniline))
Reason for Inclusion	Human Health
Remarks	-
Details	to J-CHECK

Japan CSCL: Canceled Priority Assessment Chemical Substances Data Description

Registration Number	73	Date of Cancellation	2017/03/30
MITI Number	4-95, 4-96, 4-275	Date of designation as a priority assessment chemical substance	2011/04/01
Chemical Substance Name	4,4'-Diamino-3,3'-dichlorodiphenylmethane (synonym: 4,4'-Methylenebis(2-chloroaniline))
Remarks	-
Remarks of Cancellation	It is redesignated as PACSs No. 255 on 2020/04/01
Details	to J-CHECK

Japan CSCL: Existing Chemical Substances Data Description Definition of the terms of Section 6 [PDF] Definition of the terms of Section 7 [PDF] Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]

MITI Number	4-95	Category	Section 4
Chemical Substance Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane
Remarks	-
Details	to J-CHECK
Remarks to Existing Chemical Substances of Industrial Safety and Health Act	Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law by June 29, 1979
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)

MITI Number	4-96	Category	Section 4
Chemical Substance Name	Poly (di-tetra) chloro-4,4'-diaminodiphenylmethane
Remarks	-
Details	to J-CHECK
Remarks to Existing Chemical Substances of Industrial Safety and Health Act	Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law by June 29, 1979
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)

MITI Number	4-275	Category	Section 4
Chemical Substance Name	o-Chloroaniline-formaldehyde condensation product
Remarks	-
Details	to J-CHECK
Remarks to Existing Chemical Substances of Industrial Safety and Health Act	Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law by June 29, 1979
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)

Japan CSCL: Type II Monitoring Chemical Substances (before amendment) Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]

Registration Number	6	Date of Designation in the Official Gazette	1987/10/17
MITI Number	4-95
Chemical Substance Name	4,4'-Diamino-3,3'-dichlorodiphenylmethane (synonym: 4,4'-Methylenebis(2-chloroaniline))
Remarks	-
Details	to J-CHECK

Japan CSCL: Type III Monitoring Chemical Substances (before amendment) Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]

Registration Number	76	Date of Designation in the Official Gazette	2008/03/21
MITI Number	4-95, 4-96, 4-275
Chemical Substance Name	4,4'-Diamino-3,3'-dichlorodiphenylmethane (synonym: 4,4'-Methylenebis(2-chloroaniline))
Remarks	-
Details	to J-CHECK

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	2,2'-dichloro-4,4'-methylenedianiline
Judgement of Biodegradation	Not readily biodegradable	Judgement of Bioconcentration	Low bioconcentration
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

Japan MHLW: Toxicity Test Results Data Description
- volume Number 12
  
  Tested Chemical Substance Name 4,4'-Methylenebis(2-chloroaniline)
  
  Details to J-CHECK

Japan MOE: Results of Eco-toxicity tests of chemicals Data Description
- Chemical Substance Name 4,4'-Methylenebis(2-chloroaniline)
  
  Details to J-CHECK

Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof(PRTR-SDS Law)

Japan: PRTR-SDS Law (until March 2023) Data Description Outline PRTR Law (METI site) Analysis of PRTR data

Classification	I	Cabinet Order Number	1-160
Cabinet Order Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	Releases Map (in Japanese) Atmospheric concentration Map (in Japanese)

Japan: PRTR-SDS Law (from April 2023) Data Description Outline PRTR Law (METI site)

JPSN(Japan PRTR-SDS Number)	160	Classification	Specified Class I	Cabinet Order Number	1-186
Cabinet Order Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	- -

Industrial Safety and Health Act (ISHA)

Japan ISHA: Chemical Substances Requiring Labeling and Delivery of Documents, etc. Data Description GHS compatible model label creation method (MH LW site : in Japanese) Risk assessment implementation support tool (MHLW site : in Japanese)

Cabinet Order Number	Attached table 9-242 of Cabinet order
Cabinet Order Name	3,3'-Dichloro-4,4'-diaminodiphenyl methane
Range of Application for Label (weight%)	>=0.1
Range of Application for SDS (weight%)	>=0.1

Japan ISHA: Chemical substances that cause skin disorders, etc. and other chemical substances that must be handled with impermeable protective equipment etc. based on special chemical regulations. Data Description Target substances list(MHLW site: in japanese)
- Substance Name 3,3'-Dichloro-4,4'-diaminodiphenylmethane
  
  Classification of Target Substances Special chemical regulations etc. Cutoff value(weight %) 1
  
  Details to the GHS Classification

Japan ISHA: Specified Chemical Substances Data Description Link to the Ordinance (JISHA site : in Japanese)

Category	Group-2 substances	Cabinet Order Number	Attached Table 3-2-19 of Cabinet order
Cabinet Order Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane
Range of Application (weight %)	>1
Remarks	Substances under special supervision / Specified Group-2 substances

The above information have been provided by the Ministry of Health, Labour and Welfare

Japan ISHA: Administrative Control Levels of Working Environment Evaluation Standards Data Description Working Environment Measurement (MHLW site : in Japanese)
- Registration Number
  17
  
  Kinds of substances 3,3' -Dichloro-4,4' -diaminodiphenyl methane
  
  Control Level 0.005mg/m3
  
  The above information have been provided by the Ministry of Health, Labour and Welfare

Air Pollution Control Act

Japan Air Pollution Control Law Data Description Air & Transportation (MOE site)

Classification	Substances that may be classified as Hazardous Air Pollutants	Cabinet Order Number	238 of Central Environment Council 9th Report (Appendix 1)
Cabinet Order Name	4,4'-Methylenebis(2-chloroaniline); 3,3'-Dichloro-4,4'-diaminodiphenylmethane

Laws and Regulations in Other countries

Recommendations on the transport of dangerous goods
- Dangerous Goods List (UN Number and Hazard class) Data Description
  - UN Number
    3077
    Class or Division 9
    
    Name and Description ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
    
    UN packing group III

Association of South-East Asian Nations(ASEAN)
- The ASEAN-Japan Chemical Safety Database (AJCSD).: Laws and Regulations Data Description
  - Detail to AJCSD

European Union (EU)

EC Inventory Data Description
- EC Number
  202-918-9
  
  EC Name 4,4'-methylenebis[2-chloroaniline]
  
  Description -
  
  Substance Infocard Infocard
  
  ECHA Name -

REACH: Substances of Very High Concern for Authorization (SVHC) Data Description

EC Number	202-918-9	Status	Authorisation List
Substance Name	2,2'-dichloro-4,4'-methylenedianiline (MOCA)
Intrinsic property	Carcinogenic (Article 57a)
Sunset Date	2017/11/22
Details	to ECHA site

EC Number	202-918-9	Status	Candidate List
Substance Name	2,2'-dichloro-4,4'-methylenedianiline
Reason for inclusion	Carcinogenic (Article 57a)
Date of inclusion	2011/12/19
Details	to ECHA site

EU: CLP Harmonised Classification Data Description To ECHA site

Index Number	612-078-00-9	EC Number	202-918-9
Chemical Name	2,2'-dichloro-4,4'-methylenedianiline; 4,4'-methylene bis(2-chloroaniline)
Classification	Carc. 1B / [Oral]Acute Tox. 4 * / Aquatic Acute 1 / Aquatic Chronic 1

US: Toxic Substances Control Act (TSCA)
- TSCA Inventory Data Description
  - TSCA Chemical Substance Name Benzenamine, 4,4'-methylenebis[2-chloro-
    
    DEF -
    
    UVCB -
    
    FLAG -
    
    ACTIVITY ACTIVE

China
- China: Catalog of Hazardous Chemicals 2015 Data Description
  - Number
    304
    
    Name 4,4'-Diamino-3,3'-dichlorodiphenylmethane
    
    Other Name -
    
    Remarks -

Korea

Korea: ARECs (K-REACH) / CCA; Hazardous Substance(s), Priority Control Substances Data Description
- Number
  98-1-479
  
  Category Toxic Substance(s)
  
  Chemical Substance Name 4,4'-Methylenebis(2-chloroaniline)
  
  Range of Application (%)
  >=0.1
  
  Number
  06-5-13
  
  Category Restricted Substance(s)
  
  Chemical Substance Name 4,4'-methylenebis(2-chloroaniline)
  
  Range of Application (%)
  >=0.1
  
  Number
  81
  
  Category Priority Control Substances
  
  Chemical Substance Name 4,4'-methylenebis[2-chloroaniline]

Korea: ARECs (K-REACH); Existing Chemical Substances Data Description

KE Number	KE-10102
Category	Existing Chemical Substances (Domestically distributed commercial purpose before February 2, 1991.)
Chemical Substance Name	4,4`-Methylene bis[2-chloroaniline]
Remarks	In the case of being hydrated, the resulting hydrate is also applicable.

Korea: ARECs (K-REACH); Others Data Description

Number	101
Category	Phase-in substance(s) subject to registration (by June 30, 2018)
Chemical Substance Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane
Note	The registration grace period is until June 30, 2018

Taiwan

Taiwan: TCCSCA/OSHA; Existing Chemical Substances Data Description
- English Name 4,4'-methylenebis[2-chloroaniline]
  
  Chinese Name -

Taiwan: TCCSCA; Toxic Chemicals Data Description

Listed No./Series No.	67/01
Toxicity Classify	1,2
English Name	4,4'-Methylenebis(2-chloroaniline)
Chinese Name	4,4'-亞甲雙(2-氯苯胺)
Control concentration standard (w/w%)	1
Large-scale handling standard(kg)	500

Chemical Hazard and Risk Information

GHS Classification Results
- NITE Japan-GHS Data Description
  - Edition version_2
    
    Chemical Substance Name 3,3'-Dichloro-4,4'-diaminodiphenylmethane
    
    Classification Result To the resut webpage To the Excel flie
- GHS Classification Results by the Japanese Government Data Description GHS Information
  - Year of implementation /renewal 2006 ID 130_H18_new
    
    Chemical Substance Name 3,3'-Dichloro-4,4'-diaminodiphenylmethane
    
    Classification Result To the resut webpage  To the Excel flie
    
    Year of implementation /renewal 2011 ID 23B5508
    
    Chemical Substance Name 3,3'-Dichloro-4,4'-diaminodiphenylmethane
    
    Classification Result To the resut webpage  To the Excel flie
    
    Year of implementation /renewal 2020 ID R02-B-031-MHLW, MOE
    
    Chemical Substance Name 3,3'-Dichloro-4,4'-diaminodiphenylmethane
    
    Classification Result To the resut webpage  To the Excel flie

MHLW:GHS Aligned Sample Label and SDS
- GHS Aligned Sample Label and SDS Data Description Information on GHS Aligned Sample Label and SDS (Workplace Safety Site)
  - Chemical Substance Name 3,3'-Dichloro-4,4'-diaminodiphenylmethane
    
    Sample Label to MHLW Website (in Japanese Only)
    
    Sample SDS to MHLW Website (in Japanese Only)

AIST: Relational Information System for Chemical Accidents Database(RISCAD)
- Relational Information System for Chemical Accidents Database(RISCAD) Data Description RISCAD (in Japanese)
  - Material ID 4956
    
    Name 3,3'-dichloro-4,4'diaminodiphenylmethane
    
    Material Information to RISCAD

Hazard and Risk Assessment Reports etc. in Japan

Chemical Substances Hazard Assessment Report / Initial Risk Assessment Report Data Description Guidance for Initial Risk Assessment ver.1 (in Japanese) Guidance for Initial Risk Assessment ver.2 (in Japanese)

Report Number	No.33
Assessed Chemical Substance Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane
Details	Hazard Assessment Report (in Japanese)	Date of publication/ renewal	2005/05
	Details Initial Risk Assessment Report (in Japanese)	Date of publication/ renewal	2005/11
	Details Summary of Initial Risk Assessment Report	Date of publication/ renewal	2010/05

Hazard Data Sheet for Chemical Substances Data Description
- Book Number
  2000-12
  Date of publication/ renewal 2002/10
  
  Assessed Chemical Substance Name 3,3'-Dichloro-4,4'-diaminodiphenylmethane
  
  Details Hazard Data Sheet (in Japanese)

CSCL: The Japan HPV Challenge Program Data Description
- Chemical Substance Name 3,3'-Dichloro-4,4'-diaminodiphenylmethane
  
  Details to J-CHECK

Hazard and Risk Assessment Reports etc. in Other Countries
- OECD: High Production Volume (HPV) Chemicals Data Description
  - Chemical Name 4,4'-methylenebis(2-chloroaniline)
    
    Details to OECD Existing Chemicals Database
- International Chemical Safety Cards (ICSC) Data Description
  - ICSC Number
    508
    
    ICSC Title 4,4'-Methylene bis(2-chloroaniline)
    
    Details to ILO site
- US Agency for Toxic Substances and Disease Registry (ATSDR): Toxicological Profiles Data Description
  - Profile Title 4,4'-Methylenebis(2-Chloroaniline) (MBOCA)
    
    Details to ATSDR site
    
    Date of Issue October 2017

Japan Society for Occupational Health (JSOH) Recommendation of Occupational Exposure Limits

JSOH: Occupational Exposure Limits Data Description

Substance Name	3,3'-Dichloro-4,4'-diaminodiphenyl-methane (MBOCA)
Occupational Exposure Limit (ppm)	-
Occupational Exposure Limit (mg/m3)	0.005
Details	Documentation in Japanese
Year of proposal	2012
Remarks	Skin absorption

JSOH: Occupational Exposure Limits Based on Biological Monitoring Data Description TableII-1
- Substance Name 3,3'-Dichloro-4,4'-diaminodiphenylmethane (MBOCA, MOCA)
  
  Details Documentation in Japanese
  
  Year of proposal 2023
  
  Remarks Provisional (year of proposal: 2023)

JSOH: Occupational Carcinogens Data Description

Substance Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane(MBOCA)
Carcinogenicity classification	2A
Details	Documentation in Japanese
Year of proposal	1993, (2012)
Remarks	Substance whose OEL is set based on non-caninogenic health effects. ( ) in the year of proposal indicates year of reconsideration resulting in no classification change.

Carcinogenicity Assessment

IARC: Carcinogenicity Assessment Data Description to IARC site

Volume	Sup 7, 57, 99, 100F	Volume publication year	2012
Agent Name	4,4'-Methylenebis(2-chloroaniline) (MOCA)
Group	1
Details	Sup 7 Vol.57 Vol.99 Vol.100F -
Additional information	NB Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

US NTP: Carcinogenicity Assessment Data Description to NTP site
- Chemical Substance Name 4,4'-Methylenebis(2-chloroaniline)
  
  Category
  RAHC
  
  NAME OR SYNONYM
  4,4ʹ-Methylenebis(2-chloraniline)
  
  Details to Substance Profile

European Union (EU): Carcinogenicity Assessment Data Description to ECHA site
- Substance Name 2,2'-dichloro-4,4'-methylenedianiline; 4,4'-methylene bis(2-chloroaniline)
  
  Category Code 1B

Test Data and Reports

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	2,2'-dichloro-4,4'-methylenedianiline
Judgement of Biodegradation	Not readily biodegradable	Judgement of Bioconcentration	Low bioconcentration
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

Japan MHLW: Toxicity Test Results Data Description
- volume Number 12
  
  Tested Chemical Substance Name 4,4'-Methylenebis(2-chloroaniline)
  
  Details to J-CHECK

Japan MOE: Results of Eco-toxicity tests of chemicals Data Description
- Chemical Substance Name 4,4'-Methylenebis(2-chloroaniline)
  
  Details to J-CHECK

volume Number	12
Tested Chemical Substance Name	4,4'-Methylenebis(2-chloroaniline)
Details	to J-CHECK

Substance Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane
Classification of Target Substances	Special chemical regulations etc.	Cutoff value(weight %)	1
Details	to the GHS Classification

Registration Number	17
Kinds of substances	3,3' -Dichloro-4,4' -diaminodiphenyl methane
Control Level	0.005mg/m3

UN Number	3077	Class or Division	9
Name and Description	ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
UN packing group	III

EC Number	202-918-9
EC Name	4,4'-methylenebis[2-chloroaniline]
Description	-
Substance Infocard	Infocard
ECHA Name	-

TSCA Chemical Substance Name	Benzenamine, 4,4'-methylenebis[2-chloro-
DEF	-
UVCB	-
FLAG	-
ACTIVITY	ACTIVE

Number	304
Name	4,4'-Diamino-3,3'-dichlorodiphenylmethane
Other Name	-
Remarks	-

Number	98-1-479
Category	Toxic Substance(s)
Chemical Substance Name	4,4'-Methylenebis(2-chloroaniline)
Range of Application (%)	>=0.1

Number	06-5-13
Category	Restricted Substance(s)
Chemical Substance Name	4,4'-methylenebis(2-chloroaniline)
Range of Application (%)	>=0.1

Number	81
Category	Priority Control Substances
Chemical Substance Name	4,4'-methylenebis[2-chloroaniline]

Edition	version_2
Chemical Substance Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2006	ID	130_H18_new
Chemical Substance Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2011	ID	23B5508
Chemical Substance Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2020	ID	R02-B-031-MHLW, MOE
Chemical Substance Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane
Classification Result	To the resut webpage To the Excel flie

Chemical Substance Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane
Sample Label	to MHLW Website (in Japanese Only)
Sample SDS	to MHLW Website (in Japanese Only)

Material ID	4956
Name	3,3'-dichloro-4,4'diaminodiphenylmethane
Material Information	to RISCAD

Book Number	2000-12	Date of publication/ renewal	2002/10
Assessed Chemical Substance Name	3,3'-Dichloro-4,4'-diaminodiphenylmethane
Details	Hazard Data Sheet (in Japanese)

ICSC Number	508
ICSC Title	4,4'-Methylene bis(2-chloroaniline)
Details	to ILO site

Profile Title	4,4'-Methylenebis(2-Chloroaniline) (MBOCA)
Details	to ATSDR site
Date of Issue	October 2017

Substance Name	2,2'-dichloro-4,4'-methylenedianiline; 4,4'-methylene bis(2-chloroaniline)
Category Code	1B