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General Information

General Information
- General Information Data Description
  - CHRIP_ID C004-707-40A CAS RN 108-10-1
    
    Chemical Substance Name Methyl isobutyl ketone
    
    Molecular Formula C6H12O
    
    Molecular Weight 100
    
    SMILES CC(CC(C)C)=O
    
    Structure

Synonym

Synonym Data Description

Synonym	4-Methyl-2-pentanone
	4-Methyl-2-pentanone; Methyl isobutyl ketone
	4-methylpentan-2-one
	Hexone
	Isopropylacetone
	methylisobutyl ketone
	methylisobutyl ketone(2-methyl-4-pentanone)
	MIBK

Nikkaji
- Information of Japan Chemical Substance Dictionary (Nikkaji) Data Description
  - Nikkaji Number
    J2.861D
    Detail to J-GLOBAL

Laws and Regulations in Japan

Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (Chemical Substances Control Law ; CSCL)

Japan CSCL: Priority Assessment Chemical Substances Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]
- Registration Number
  116
  Date of Designation 2012/12/21
  
  MITI Number
  2-542
  
  Chemical Substance Name Methyl isobutyl ketone
  
  Reason for Inclusion Human Health
  
  Remarks -
  
  Details to J-CHECK

Japan CSCL: Existing Chemical Substances Data Description Definition of the terms of Section 6 [PDF] Definition of the terms of Section 7 [PDF] Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]

MITI Number	2-542	Category	Section 2
Chemical Substance Name	Alkyl(C=1-16) methyl ketone
Remarks	-
Details	to J-CHECK
Remarks to Existing Chemical Substances of Industrial Safety and Health Act	Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law by June 29, 1979
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	methylisobutyl ketone
Judgement of Biodegradation	Readily biodegradable	Judgement of Bioconcentration	-
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof(PRTR-SDS Law)

Japan: PRTR-SDS Law (from April 2023) Data Description Outline PRTR Law (METI site)

JPSN(Japan PRTR-SDS Number)	737	Classification	I	Cabinet Order Number	1-472
Cabinet Order Name	Methyl isobutyl ketone
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	- -

Industrial Safety and Health Act (ISHA)

Japan ISHA: Chemical Substances Requiring Labeling and Delivery of Documents, etc. Data Description GHS compatible model label creation method (MH LW site : in Japanese) Risk assessment implementation support tool (MHLW site : in Japanese)
- Cabinet Order Number
  Attached table 9-569 of Cabinet order
  
  Cabinet Order Name Methyl isobutyl ketone
  
  Range of Application for Label (weight%) >=1
  
  Range of Application for SDS (weight%) >=0.1

Japan ISHA: Chemical substances that cause skin disorders, etc. and other chemical substances that must be handled with impermeable protective equipment etc. based on special chemical regulations. Data Description Target substances list(MHLW site: in japanese)
- Substance Name Methyl isobutyl ketone
  
  Classification of Target Substances Special chemical regulations etc. Cutoff value(weight %) 1
  
  Details to the GHS Classification

Japan ISHA: Specified Chemical Substances Data Description Link to the Ordinance (JISHA site : in Japanese)

Category	Group-2 substances	Cabinet Order Number	Attached Table 3-2-33-2 of Cabinet order
Cabinet Order Name	Methyl isobutyl ketone
Range of Application (weight %)	>1
Remarks	Substances under special supervision / Special organic solvent, etc.

The above information have been provided by the Ministry of Health, Labour and Welfare

Japan ISHA: Administrative Control Levels of Working Environment Evaluation Standards Data Description Working Environment Measurement (MHLW site : in Japanese)
- Registration Number
  30.2
  
  Kinds of substances Methyl isobutyl ketone
  
  Control Level 20ppm
  
  The above information have been provided by the Ministry of Health, Labour and Welfare

Japan ISHA: Guidelines for Carcinogenic Substances Data Description
- Name Methyl isobutyl ketone
  
  Details to MHLW site (in Japanese)

Air Pollution Control Act

Japan Air Pollution Control Law Data Description Air & Transportation (MOE site)

Classification	Volatile Organic Compounds (VOC)	Cabinet Order Number	Article 2-4 of Act
Cabinet Order Name	Any organic compound (excluding substances specified by a Cabinet Order as not being sources from which suspended particulate matter or oxidants are generated) that is in a gaseous state at the time of its emission or dispersal into the atmosphere.
VOC Emission Inventory Substance Code	31-06-01
VOC Emission Inventory Substance Name	Methyl isobutyl ketone

Food Sanitation Act
- Food Sanitation Act: Table 2 in Appended table 1 of Specifications and Standards Notification; Additives Data Description The positive list system for food utensils, containers and packaging (MHLW)
  - Number
    1480
    
    Name methyl isobutyl ketone
    
    Use Limit by Synthetic Resin Group [%] 1;1 2;- 3;1 4;0.001 5;0.001 6;0.001 7;0.001

Fire Service Act

Fire Service Act : Hazardous Materials Data Description

Number of cabinet order etc.	Article 2, Paragraph 7 of the Act, Appended Table 1, Category IV (2)
Category; Property	Category IV; Inflammable Liquids
Item	Class I petroleums
Property	Non-water soluble liquid
Designated quantity	200L
Sources	Hazardous Materials Disaster Information Support System, Hazardous Materials Data Book 2nd edition, MHLW Website; Sample SDS

Laws and Regulations in Other countries

Recommendations on the transport of dangerous goods
- Dangerous Goods List (UN Number and Hazard class) Data Description
  - UN Number
    1245
    Class or Division 3
    
    Name and Description METHYL ISOBUTYL KETONE
    
    UN packing group II

International Convention on the Commodity Description and Coding Systems (HS Convention)

HS Code: Section VI “Products of the Chemical or Allied Industries" Data Description

Chapter	29	Chapter name	Organic chemicals
Heading	2914	Substance name (Heading)	Ketones and quinones, whether or not with other oxygen function, and their halogenated, sulphonated, nitrated or nitrosated derivatives
HS Code	2914.13	Substance Name	Acyclic ketones without other oxygen function : 4-Methylpentan-2-one (methyl isobutyl ketone)

Association of South-East Asian Nations(ASEAN)
- The ASEAN-Japan Chemical Safety Database (AJCSD).: Laws and Regulations Data Description
  - Detail to AJCSD
- The ASEAN-Japan Chemical Safety Database (AJCSD).: GHS-Related Information Data Description
  - Detail to AJCSD

European Union (EU)

EC Inventory Data Description
- EC Number
  203-550-1
  
  EC Name 4-methylpentan-2-one
  
  Description -
  
  Substance Infocard Infocard
  
  ECHA Name -

EU: CLP Harmonised Classification Data Description To ECHA site

Index Number	606-004-00-4	EC Number	203-550-1
Chemical Name	4-methylpentan-2-one;isobutyl methyl ketone
Classification	Flam. Liq. 2 / Carc. 2 / [Inh.]Acute Tox. 4 / STOT SE 3 / Eye Irrit. 2
Specific Conc. Limits, M-factors	inhalation: ATE = 11 mg/l (vapours)

US: Toxic Substances Control Act (TSCA)
- TSCA Inventory Data Description
  - TSCA Chemical Substance Name 2-Pentanone, 4-methyl-
    
    DEF -
    
    UVCB -
    
    FLAG -
    
    ACTIVITY ACTIVE

China
- China: Catalog of Hazardous Chemicals 2015 Data Description
  - Number
    1059
    
    Name 4-Methyl-2-pentanone
    
    Other Name Methyl isobutyl ketone; Isohexanone
    
    Remarks -

Korea

Korea: ARECs (K-REACH); Existing Chemical Substances Data Description

KE Number	KE-24725
Category	Existing Chemical Substances (Domestically distributed commercial purpose before February 2, 1991.)
Chemical Substance Name	4-Methyl-2-pentanone ; Methylisobutyl ketone, MIBK
Remarks	In the case of being hydrated, the resulting hydrate is also applicable.

Taiwan
- Taiwan: TCCSCA/OSHA; Existing Chemical Substances Data Description
  - English Name Methyl isobutyl ketone
    
    Chinese Name -
- Taiwan: TCCSCA; Toxic Chemicals Data Description
  - Listed No./Series No. 117/01
    
    Toxicity Classify 4
    
    English Name Methyl isobutyl ketone
    
    Chinese Name 甲基異丁酮
    
    Control concentration standard (w/w%) 1
    
    Large-scale handling standard(kg) -

Chemical Hazard and Risk Information

GHS Classification Results

NITE Japan-GHS Data Description
- Edition version_2
  
  Chemical Substance Name Methyl isobutyl ketone
  
  Classification Result To the resut webpage To the Excel flie

GHS Classification Results by the Japanese Government Data Description GHS Information

Year of implementation /renewal	2006	ID	974_H18_new
Chemical Substance Name	Methyl isobutyl ketone
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2009	ID	21B3061
Chemical Substance Name	Methylisobutylketone
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2014	ID	- / R-159
Chemical Substance Name	Methylisobutylketone
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2015	ID	H27-B-063/C-099B_P
Chemical Substance Name	Methyl isobutyl ketone
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2021	ID	R03-C-054-MHLW
Chemical Substance Name	Methyl isobutyl ketone
Classification Result	To the resut webpage To the Excel flie
Remarks	The reclassification result of only some hazard classes. As for the other classes, please see the result in FY2015.

MHLW:GHS Aligned Sample Label and SDS
- GHS Aligned Sample Label and SDS Data Description Information on GHS Aligned Sample Label and SDS (Workplace Safety Site)
  - Chemical Substance Name Methyl isobutyl ketone
    
    Sample Label to MHLW Website (in Japanese Only)
    
    Sample SDS to MHLW Website (in Japanese Only)

AIST: Relational Information System for Chemical Accidents Database(RISCAD)
- Relational Information System for Chemical Accidents Database(RISCAD) Data Description RISCAD (in Japanese)
  - Material ID 1785
    
    Name 4-methyl-2-pentanone
    
    Material Information to RISCAD

Hazard and Risk Assessment Reports etc. in Japan
- ISHA: Examples of Occupational Accidents Caused by Chemical Substances Data Description
  - Name Methyl isobutyl ketone
    
    Examples of Occupational Accidents to MHLW site (in Japanese)
- Hazard Data Sheet for Chemical Substances Data Description
  - Book Number
    99-23
    Date of publication/ renewal 2000/08
    
    Assessed Chemical Substance Name Methyl isobutyl ketone
    
    Details Hazard Data Sheet (in Japanese)
- CSCL: The Japan HPV Challenge Program Data Description
  - Chemical Substance Name 4-methylpentan-2-one
    
    Details to J-CHECK

Hazard and Risk Assessment Reports etc. in Other Countries
- OECD: High Production Volume (HPV) Chemicals Data Description
  - Chemical Name Methyl isobutyl ketone
    
    Details to OECD Existing Chemicals Database
- International Chemical Safety Cards (ICSC) Data Description
  - ICSC Number
    511
    
    ICSC Title Methyl isobutyl ketone
    
    Details to ILO site
- Environmental Health Criteria (EHC) Data Description
  - EHC Number
    117
    
    EHC Title Methyl isobutyl ketone
    
    Details to IPCS site
- US EPA: Integrated Risk Information System (IRIS) Data Description
  - Chemical Substance Name Methyl isobutyl ketone (MIBK)
    
    Details to EPA site Last Revision 2003/04/25

Japan Society for Occupational Health (JSOH) Recommendation of Occupational Exposure Limits
- JSOH: Occupational Exposure Limits Data Description
  - Substance Name Methyl isobutyl ketone
    
    Occupational Exposure Limit (ppm) 50
    
    Occupational Exposure Limit (mg/m3) 205
    
    Details Documentation in Japanese
    
    Year of proposal 1984
    
    Remarks -
- JSOH: Occupational Exposure Limits Based on Biological Monitoring Data Description TableII-1
  - Substance Name Methyl isobutyl ketone
    
    Details Documentation in Japanese
    
    Year of proposal 2007
    
    Remarks -
- JSOH: Occupational Carcinogens Data Description
  - Substance Name Methyl isobutyl ketone
    
    Carcinogenicity classification 2B
    
    Details -
    
    Year of proposal 2015
    
    Remarks -

Carcinogenicity Assessment
- IARC: Carcinogenicity Assessment Data Description to IARC site
  - Volume 101 Volume publication year 2013
    
    Agent Name Methyl isobutyl ketone
    
    Group 2B
    
    Details Vol.101 - - - -
- US EPA: Carcinogenicity Assessment Data Description to EPA site
  - Chemical Substance Name Methyl isobutyl ketone (MIBK)
    
    Guideline: Category 1999 : I
    
    Exporsure Route -
    
    Details to Substance Profile
- European Union (EU): Carcinogenicity Assessment Data Description to ECHA site
  - Substance Name 4-methylpentan-2-one;isobutyl methyl ketone
    
    Category Code 2

Safety Summary of Japan(JCIA BIGDr)
- Safety Summary of Japan(JCIA BIGDr) Data Description
  - Substance Name 2-Pentanone, 4-methyl-
    
    Detail to JCIA BIGDr

Test Data and Reports

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	methylisobutyl ketone
Judgement of Biodegradation	Readily biodegradable	Judgement of Bioconcentration	-
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

US National Toxicology Program (NTP) : Long-Term Study Reports & Abstracts Data Description

Report Number	TR-538
Report Title	Toxicology and Carcinogenesis Studies of Methyl Isobutyl Ketone (CASRN 108-10-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Abstract	to NTP site	Full Text	to NTP site

CHRIP_ID	C004-707-40A	CAS RN	108-10-1
Chemical Substance Name	Methyl isobutyl ketone
Molecular Formula	C6H12O
Molecular Weight	100
SMILES	CC(CC(C)C)=O
Structure

Registration Number	116	Date of Designation	2012/12/21
MITI Number	2-542
Chemical Substance Name	Methyl isobutyl ketone
Reason for Inclusion	Human Health
Remarks	-
Details	to J-CHECK

Cabinet Order Number	Attached table 9-569 of Cabinet order
Cabinet Order Name	Methyl isobutyl ketone
Range of Application for Label (weight%)	>=1
Range of Application for SDS (weight%)	>=0.1

Substance Name	Methyl isobutyl ketone
Classification of Target Substances	Special chemical regulations etc.	Cutoff value(weight %)	1
Details	to the GHS Classification

Registration Number	30.2
Kinds of substances	Methyl isobutyl ketone
Control Level	20ppm

Number	1480
Name	methyl isobutyl ketone
Use Limit by Synthetic Resin Group [%]	1;1 2;- 3;1 4;0.001 5;0.001 6;0.001 7;0.001

UN Number	1245	Class or Division	3
Name and Description	METHYL ISOBUTYL KETONE
UN packing group	II

EC Number	203-550-1
EC Name	4-methylpentan-2-one
Description	-
Substance Infocard	Infocard
ECHA Name	-

TSCA Chemical Substance Name	2-Pentanone, 4-methyl-
DEF	-
UVCB	-
FLAG	-
ACTIVITY	ACTIVE

Number	1059
Name	4-Methyl-2-pentanone
Other Name	Methyl isobutyl ketone; Isohexanone
Remarks	-

Listed No./Series No.	117/01
Toxicity Classify	4
English Name	Methyl isobutyl ketone
Chinese Name	甲基異丁酮
Control concentration standard (w/w%)	1
Large-scale handling standard(kg)	-

Material ID	1785
Name	4-methyl-2-pentanone
Material Information	to RISCAD

Edition	version_2
Chemical Substance Name	Methyl isobutyl ketone
Classification Result	To the resut webpage To the Excel flie

Chemical Substance Name	Methyl isobutyl ketone
Sample Label	to MHLW Website (in Japanese Only)
Sample SDS	to MHLW Website (in Japanese Only)

Name	Methyl isobutyl ketone
Examples of Occupational Accidents	to MHLW site (in Japanese)

Book Number	99-23	Date of publication/ renewal	2000/08
Assessed Chemical Substance Name	Methyl isobutyl ketone
Details	Hazard Data Sheet (in Japanese)

ICSC Number	511
ICSC Title	Methyl isobutyl ketone
Details	to ILO site

EHC Number	117
EHC Title	Methyl isobutyl ketone
Details	to IPCS site

Chemical Substance Name	Methyl isobutyl ketone (MIBK)
Details	to EPA site	Last Revision	2003/04/25

Substance Name	Methyl isobutyl ketone
Occupational Exposure Limit (ppm)	50
Occupational Exposure Limit (mg/m3)	205
Details	Documentation in Japanese
Year of proposal	1984
Remarks	-

Substance Name	Methyl isobutyl ketone
Carcinogenicity classification	2B
Details	-
Year of proposal	2015
Remarks	-

Volume	101	Volume publication year	2013
Agent Name	Methyl isobutyl ketone
Group	2B
Details	Vol.101 - - - -

Chemical Substance Name	Methyl isobutyl ketone (MIBK)
Guideline: Category	1999 : I
Exporsure Route	-
Details	to Substance Profile

Substance Name	4-methylpentan-2-one;isobutyl methyl ketone
Category Code	2