National Institute of Technology and Evaluation
Collecting and transmitting information required for total risk assessment and management of chemical substance mark NITE TOPChemical Management Field> NITE-CHRIP
 

NITE-CHRIP is a database provided information on Risk Assessments

and Laws & Regulations, etc., of chemical substances.

Search Results; Data Description/Search Results Page
The information related to selected substance is displayed in a tree format.
You can switch the display by clicking "Excluding blank data" or "Including blank data". By default, the excluding blank data will be displayed.
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Downloading the search results
If you click "Downloading the search results" link, the list of search results in TSV format (tab separated values format) will be downloaded.
General Information
General Information
CHRIP ID
The CHRIP ID is a unique number assigned to a chemical by NITE-CHRIP.
CAS Registry No.
The CAS Registry number is a unique number assigned to a chemical by the Chemical Abstracts Service, which is an organization of the American Chemical Society.
Chemical Substance Name
The Chemical Substance Name corresponding to a CAS Registry No. is displayed.
Molecular Formula
The molecular formula for a substance is displayed.
SMILES
SMILES for a substance is displayed. This SMILES is created by ChemDraw.
Structure
According to a CAS registry number entered, the 2-D depiction of the corresponding chemical structure will be displayed. A typical structure would be shown if the number retrieved multiple answers. Alternatively, a typical structure of the constituent in mixtures, etc. would be displayed if the number failed to specify a single chemical structure.
Synonym
Another name is displayed.
When another name is not registered in NITE-CHRIP, this item in itself is not displayed.
Information of Japan Chemical Substance Dictionary (Nikkaji)
Updated: 2019-07-31
"Japan Chemical Substance Dictionary (Nikkaji)" is the database of organic compounds of the search service J-GLOBAL, provided by the Japan Science and Technology Agency (JST). Nikkaji contains chemical name in Japanese and English, regulation number, CAS Registry Number, structural information and so on.
Nikkaji Number
A substance unique number in Nikkaji.
Detail
If you click on "to NikkajiWeb", you can link to Nikkaji on J-GLOBAL website.
Laws and Regulations in Japan
Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (Chemical Substances Control Law ; CSCL)
CSCL: Class I Specified Chemical Substances
Updated: 2018-10-10 (Public Notice 2018-02-21 : Enforced 2018-04-01)
Substances that are persistent, highly bioaccumulative and pose a risk of long-term toxicity to humans or predator animals at a higher trophic level, and that are specified in Article 1 of the Cabinet Order for Enforcement of the CSCL. If a substance corresponds to the "Class I Specified Chemical Substance", the following items are displayed.
Cabinet Order number
It is the number given to the substance when designated by the Cabinet Order as a Class I Specified Chemical Substance.
Date of Designation in the Official Gazette
It is the date when the substance was publicized in the Official Gazette.
Date of Enforcement by the Cabinet Order
It is the date when the substance was designated by the Cabinet Order as a Class I Specified Chemical Substance.
Chemical Substances Name
It is the name of the Class I Specified Chemical Substance designated by the Cabinet Order.
Remarks
If the scope of the CAS Registry Number (CAS RN) includes non-relevant materials, the conditions applicable to the CAS Registry Number (CAS RN) will be displayed.
Detail
If there is more information, link to the CSCL database (J-CHECK) will be displayed.
CSCL: Class II Specified Chemical Substances
Updated: 2017-03-21 (Public Notice 1990-09-12)
Substances that may pose a risk of long-term toxicity to humans or to flora and fauna in the human living environment, and that have been, or in the near future are reasonably likely to be, found in considerable amounts over a substantially extensive area of the environment. These substances are specified in Article 2 of the Cabinet Order for Enforcement of the CSCL.. If a substance corresponds to the "Class II Specified Chemical Substance", the following items are displayed.
Cabinet Order number
It is the number given to the substance when designated by the Cabinet Order as a Class II Specified Chemical Substance.
Date of Enforcement by the Cabinet Order
It is the date when the substance was designated by the Cabinet Order as a Class II Specified Chemical Substance.
Chemical Substances Name
It is the name of the Class II Specified Chemical Substance designated by the Cabinet Order.
Remarks
If the scope of the CAS Registry Number (CAS RN) includes non-relevant materials, the conditions applicable to the CAS Registry Number (CAS RN) will be displayed.
Detail
If there is more information, link to the CSCL database (J-CHECK) will be displayed.
CSCL: Monitoring Chemical Substances
Updated: 2018-04-17 (Public Notice 2018-04-02)
Substances that are persistent and highly bioaccumulative and whose long-term toxicity to humans or predator animals at higher trophic level is unclear. These substances are specified in accordance with paragraph (4) of Article 2 of the CSCL. If a substance corresponds to the "Monitoring Chemical Substance", the following items are displayed.
Registration Number
It is the serial number given to the substance when publicized in the Official Gazette as a Monitoring Chemical Substance.
Date of Designation in the Official Gazette
It is the date when the substance was publicized in the Official Gazette.
MITI Number
It is the number given to the substance in the Official Gazette. The initial number of MITI Numbers (*-****) shows the categories.
Chemical Substances Name
It is the name of the Monitoring Chemical Substance publicized in the Official Gazette.
Remarks
If the scope of the CAS Registry Number (CAS RN) includes non-relevant materials, the conditions applicable to the CAS Registry Number (CAS RN) will be displayed.
Detail
If there is more information, link to the CSCL database (J-CHECK) will be displayed.
CSCL: Priority Assessment Chemical Substances
Updated: 2019-04-16 (Public Notice 2019-04-01)
The substances whose long-term toxicity to humans or to flora and fauna in the human living environment is unclear, that have been found, or are expected to be found, in considerable amounts over a substantially extensive area of the environment. For the above reason, these substances are designated in accordance with paragraph (5) of Article 2 of the CSCL as chemicals that require a priority assessment to assess the risk they may pose. If a substance corresponds to the "Priority Assessment Chemical Substance", the following items are displayed.
Registration Number
It is the serial number given to the substance when publicized in the Official Gazette as a Priority Assessment Chemical Substance.
Date of Designation in the Official Gazette
It is the date when the substance was publicized in the Official Gazette.
MITI Number
It is the number given to the substances including Existing Chemical Substances, Newly Announced Chemical Substances, and others publicized in the Official Gazette. The initial number of MITI Numbers (*-****) shows the categories.
Chemical Substances Name
It is the name of the "Priority Assessment Chemical Substance" publicized in the Official Gazette.
Reason for Inclusion
Perspective for designating as a Priority Assessment Chemical Substance are displayed. Relevant perspectives of "human health effects" and/or "ecological effects" will be displayed.
Remarks
If the scope of the CAS Registry Number (CAS RN) includes non-relevant materials, the conditions applicable to the CAS Registry Number (CAS RN) will be displayed.
Detail
If there is more information, link to the CSCL database (J-CHECK) will be displayed.
CSCL: Newly Announced Chemical Substances (notified on and after April 1, 2011)
Updated: 2019-07-31 (Public Notice 2019-07-31)
Substances that were notified on and after April 1, 2011, as substances that are either newly manufactured in, or imported to, Japan and are not classified as Class I Specified Chemical Substances. Such substances are designated on and after 2017 as Newly Announced Chemical Substances (notified on and after April 1, 2011) in accordance with paragraph (4) of Article 4. In addition, the substances that were designated in accordance with paragraph (5) of Article 2 of the CSCL (Priority Assessment ChemicalSubstances) and later the designation was cancelled are included in this list.
These substances are designated as General Chemical Substances in accordance with paragraph (7) of Article 2 (excluding Priority Assessment Chemical Substances, Monitoring Chemical Substances and Class I/II Specified Chemical Substances). If a substance corresponds to the "Newly Announced Chemical Substances (notified on and after April 1, 2011)", the following items are displayed.
Registration Number
It is the serial number given to the substance when publicized in the Official Gazette as a Newly Announced Chemical Substances.
Date of Designation in the Official Gazette
It is the date when the substance was publicized in the Official Gazette.
MITI Number
It is the number given to the substances including Existing Chemical Substances, Newly Announced Chemical Substances, and others publicized in the Official Gazette. The initial number of MITI Numbers (*-****) shows the categories.
Category
MITI Numbers are classified into nine categories. One of the sections from Section 1 to Section 9 will be displayed.
Section 1
Inorganic Compounds
Section 2
Low Molecular Chain-Like Organic Compounds
Section 3
Low Molecular Carbo-Monocyclic Organic Compounds
Section 4
Low Molecular Carbo-polycyclic Organic Compounds
Section 5
Low Molecular Heterocyclic Organic Compounds
Section 6
Organic High Polymers Obtained by Addition Polymerization
Section 7
Organic High Polymers Obtained by Polycondensation
Section 8
Chemically Modified Starches, Oils and Fats, etc.
Section 9
Compounds of unknown structure, etc.
Chemical Substances Name
It is the name of the "Newly Announced Chemical Substance" publicized in the Official Gazette.
Remarks
If the scope of the CAS Registry Number (CAS RN) includes non-relevant materials, the conditions applicable to the CAS Registry Number (CAS RN) will be displayed.
Detail
If there is more information, link to the CSCL database (J-CHECK) will be displayed.
CSCL: Newly Announced Chemical Substances (notified by March 31, 2011)
Updated: 2019-04-16 (Public Notice 2016-07-29)
Substances that were notified by March 31, 2011, as substances that are either newly manufactured in, or imported to, Japan and are not classified as Class I Specified Chemical Substances, Type II Monitoring Chemical Substances or Type III Monitoring Chemical Substances. Such substances are designated by 2016 as Newly Announced Chemical Substances (notified by March 31, 2011)in accordance with paragraph (4) of Article 4.
These substances are designated as General Chemical Substances in accordance with paragraph (7) of Article 2 (excluding Priority Assessment Chemical Substances, Monitoring Chemical Substances and Class I/II Specified Chemical Substances). If a substance corresponds to the "Newly Announced Chemical Substances (notified by March 31, 2011)", the following items are displayed.
Registration Number
It is the serial number given to the substance when publicized in the Official Gazette as a Newly Announced Chemical Substances.
Date of Designation in the Official Gazette
It is the date when the substance was publicized in the Official Gazette.
MITI Number
It is the number given to the substances including Existing Chemical Substances, Newly Announced Chemical Substances, and others publicized in the Official Gazette. The initial number of MITI Numbers (*-****) shows the categories.
Category
MITI Numbers are classified into nine categories. One of the sections from Section 1 to Section 9 will be displayed.
Section 1
Inorganic Compounds
Section 2
Low Molecular Chain-Like Organic Compounds
Section 3
Low Molecular Carbo-Monocyclic Organic Compounds
Section 4
Low Molecular Carbo-polycyclic Organic Compounds
Section 5
Low Molecular Heterocyclic Organic Compounds
Section 6
Organic High Polymers Obtained by Addition Polymerization
Section 7
Organic High Polymers Obtained by Polycondensation
Section 8
Chemically Modified Starches, Oils and Fats, etc.
Section 9
Compounds of unknown structure, etc.
Chemical Substances Name
It is the name of the "Newly Announced Chemical Substance" publicized in the Official Gazette.
Remarks
If the scope of the CAS Registry Number (CAS RN) includes non-relevant materials, the conditions applicable to the CAS Registry Number (CAS RN) will be displayed.
Detail
If there is more information, link to the CSCL database (J-CHECK) will be displayed.
Remarks to Existing Chemical Substances of Industrial Safety and Health Act
On the basis of the public notice of February 5, 1979, chemicals that have been published pursuant to the provisions of the CSCL by June 29, 1979, and the chemicals listed in Japanese Pharmacopoeia eighth amendment (1971), are also treated as existing chemical substances for ISHA. For those substances, "Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law on by June 29, 1979" will be displayed.
Details to Existing Chemical Substances of Industrial Safety and Health Act
If there is more information relating to Industrial Safety and Health Act, link to the website of Ministry of Health, Labour and Welfare will be displayed.
CSCL: Existing Chemical substances
Updated: 2019-07-31 (Public Notice 1974-05-14)
Substances that were manufactured or imported for business purpose at the time of the promulgation of the CSCL (excluding substances that were manufactured or imported for testing and research purposes and those that were manufactured or imported for use as reagents), and whose names were published pursuant to the CSCL (chemical substances were listed in the list of Existing Chemical Substances).
Under the current CSCL, substances are designated as General Chemical Substances in accordance with paragraph (7) of Article 2 (excluding Priority Assessment Chemical Substances, Monitoring Chemical Substances and Class I/II Specified Chemical Substances). If a substance corresponds to the "Existing Chemical substances", the following items are displayed.
MITI Number
It is the number given to the substances including Existing Chemical Substances, Newly Announced Chemical Substances, and others publicized in the Official Gazette. The initial number of MITI Numbers (*-****) shows the categories.
Category
MITI Numbers are classified into nine categories. One of the sections from Section 1 to Section 9 will be displayed.
Section 1
Inorganic Compounds
Section 2
Low Molecular Chain-Like Organic Compounds
Section 3
Low Molecular Carbo-Monocyclic Organic Compounds
Section 4
Low Molecular Carbo-polycyclic Organic Compounds
Section 5
Low Molecular Heterocyclic Organic Compounds
Section 6
Organic High Polymers Obtained by Addition Polymerization Definition of the terms of Section 6 (in Japanese)[PDF:48KB]
Section 7
Organic High Polymers Obtained by Polycondensation Definition of the terms of Section 7 (in Japanese)[PDF:114KB]
Section 8
Chemically Modified Starches, Oils and Fats, etc.
Section 9
Pharmaceutical compounds, etc.
Chemical Substances Name
It is the substance name listed in the List of Existing Chemical Substances (the Official Gazette).
Remarks
If the scope of the CAS Registry Number (CAS RN) includes non-relevant materials, the conditions applicable to the CAS Registry Number (CAS RN) will be displayed.
Detail
If there is more information, link to the CSCL database (J-CHECK) will be displayed.
Remarks to Existing Chemical Substances of Industrial Safety and Health Act
On the basis of the public notice of February 5, 1979, chemicals that have been published pursuant to the provisions of the CSCL by June 29, 1979, and the chemicals listed in Japanese Pharmacopoeia eighth amendment (1971), are also treated as existing chemical substances for ISHA. For those substances, "Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law on by June 29, 1979" will be displayed.
Details to Existing Chemical Substances of Industrial Safety and Health Act
If there is more information relating to Industrial Safety and Health Act, link to the website of Ministry of Health, Labour and Welfare will be displayed.
CSCL: Type II Monitoring Chemical Substances (before amendment)
Updated: 2019-04-16 (Public Notice 2011-03-22)
Substances that are suspected to have a long-term toxicity to humans, and that were published before April 1, 2011, as being Designated Chemical Substances or Type II Monitoring Chemical Substances. Designated Chemical Substances that were published by March 2, 2005, are displayed as Type II Monitoring Chemical Substances (before amendment), in order for them to be considered Type II Monitoring Chemical Substances in NITE-CHRIP.
Under the current CSCL, these substances are designated as General Chemical Substances in accordance with paragraph (7) of Article 2 (excluding Priority Assessment Chemical Substances, Monitoring Chemical Substances and Class I/II Specified Chemical Substances). If a substance corresponds to the "Type II Monitoring Chemical Substances (before amendment) ", the following items are displayed.
Registration Number
It is the serial number given to the substance when publicized in the Official Gazette as a Type II Monitoring Chemical Substance.
Date of Designation in the Official Gazette
It is the date when the substance was publicized in the Official Gazette.
MITI Number
If there is a MITI number for the substance, the number will be displayed.
Chemical Substances Name
It is the name of the Type II Monitoring Chemical Substance publicized in the Official Gazette.
Remarks
If the scope of the CAS Registry Number (CAS RN) includes non-relevant materials, the conditions applicable to the CAS Registry Number (CAS RN) will be displayed.
Detail
If there is more information, link to the CSCL database (J-CHECK) will be displayed.
CSCL: Type III Monitoring Chemical Substances (before amendment)
Updated: 2019-04-16 (Public Notice 2011-03-22)
Type III Monitoring Chemical Substances (before amendment) are substances that may interfere with the survival and/or growth of flora and fauna, and that were published before April 1, 2011, as Type III Monitoring Chemical Substances.
Under the current CSCL, these substances are designated as General Chemical Substances in accordance with the provisions of paragraph (7) of Article 2 (excluding Priority Assessment Chemical Substances, Monitoring Chemical Substances and Class I/II Specified Chemical Substances). If a substance corresponds to the "Type III Monitoring Chemical Substances (before amendment) ", the following items are displayed.
Registration Number
It is the serial number given to the substance when publicized in the Official Gazette as a Type III Monitoring Chemical Substance.
Date of Designation in the Official Gazette
It is the date when the substance was publicized in the Official Gazette.
MITI Number
If there is a MITI number for the substance, the number will be displayed.
Chemical Substances Name
It is the name of the Type III Monitoring Chemical Substance publicized in the Official Gazette.
Remarks
If the scope of the CAS Registry Number (CAS RN) includes non-relevant materials, the conditions applicable to the CAS Registry Number (CAS RN) will be displayed.
Detail
If there is more information, link to the CSCL database (J-CHECK) will be displayed
CSCL: Chemical Substances exempted from notification of manufacturing/import amount
Updated: 2019-04-16 (Public Notice 2019-03-29)
It is the substance that were publicized in the Official Gazette as a chemical substance for which it is not found necessary to conduct an assessment as prescribed in paragraph (5) of Article 2 of the CSCL. If a substance corresponds to the "Chemical Substances exempted from notification of manufacturing/import amount ", the following items are displayed.
Category
Category of the substance that were publicized in the Official Gazette as a "Chemical Substances exempted from notification of manufacturing/import amount" One of the sections from Section 1 to Section 9 will be displayed.
Section 1
Inorganic Compounds
Section 2
Low Molecular Chain-Like Organic Compounds
Section 3
Low Molecular Carbo-Monocyclic Organic Compounds
Section 4
Low Molecular Carbo-polycyclic Organic Compounds
Section 5
Low Molecular Heterocyclic Organic Compounds
Section 6
Organic High Polymers Obtained by Addition Polymerization
Section 7
Organic High Polymers Obtained by Polycondensation
Section 8
Chemically Modified Starches, Oils and Fats, etc.
Section 9
Pharmaceutical compounds, etc.
MITI Number
MITI number of the substance will be displayed.
Date of Designation in the Official Gazette
It is the date of "current substance list" was publicized as "Chemical Substances exempted from notification of manufacturing/import amount" in the Official Gazette.
Chemical Substances Name
It is the name of the substance corresponding to the MITI Number.
Remarks
If the scope of the CAS Registry Number (CAS RN) includes non-relevant materials, the conditions applicable to the CAS Registry Number (CAS RN) will be displayed.
Detail
If there is more information, link to the CSCL database (J-CHECK) will be displayed.
CSCL: Chemical Substances not regarded as a New Chemical Substances
Updated: 2019-07-31
It refers to substances, that are considered as "not regarded as a new chemical substance" based on the notice, "Implementation of the Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc." published in joint names by the Director General, Pharmaceutical and Food Safety Bureau, Ministry of Health, Labour and Welfare, the Director General, Manufacturing Industries Bureau, Ministry of Economy, Trade and Industry and the Director General, Environmental Policy Bureau, Ministry of the Environment on March 31, 2011.
In case the related chemical substances are Monitoring Chemical Substances or Priority Assessment Chemical Substances, please refer to "3 Manufacture, etc. of Class I Specified Chemical Substances, Class II Specified Chemical Substances, Monitoring Chemical Substances, Priority Assessment Chemical Substances, and General Chemical Substances" of the above-mentioned notice.
If a substance corresponds to the "Chemical Substances not regarded as a New Chemical Substances", the following items are displayed.
Classification
The term "Not Regarded as a New Chemical Substance" will be displayed.
Related Class Reference Number in The Gazette List
MITI-Number of the referenced materials will be displayed.
Remarks
If the scope of the CAS Registry Number (CAS RN) includes non-relevant materials, the conditions applicable to the CAS Registry Number (CAS RN) will be displayed.
Detail
If there is more information, link to the CSCL database (J-CHECK) will be displayed.
Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof
Updated: 2019-03-19 (Promulgated 2008-11-21)
The Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof, was enacted in 1999 to promote the voluntary improvements of the management of chemical substances by business operators and prevent impediments to the preservation of the environment.

Class I Designated Chemical Substances are chemical substances that may harm human health, interfere with the survival and/or growth of flora and fauna, or deplete the ozone layer, and that are considered to be persistent over a substantially extensive area of the environment in terms of their physical/chemical properties and the amounts manufactured, imported, and used. These substances are designated in accordance with Article 1 of the Cabinet Order for Enforcement of the Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof, based on paragraph (2) of Article 2 of the same Act.

Class II Designated Chemical Substances are chemical substances that may have the same requirements as Class I Designated Chemical Substances as a result of increases in the amounts manufactured, imported, or used. These substances are designated in accordance with Article 2 of the Cabinet Order for Enforcement of the Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof, based on paragraph (3) of Article 2 of the same Act.

The designation for Class I and Class II Designated Chemical Substances were revised by Cabinet Order on November 21, 2008.
* Former Designated Chemical Substances: 354 Class I substances; 81 Class II substances (Published : March 29, 2000)
* Currently Designated Chemical Substances: 462 Class I substances ; 100 Class II substances (Revised : November 21, 2008)

When the regulated substance of notification is metal etc., you need to convert into elements. Please refer to examples of metal compounds.
Classification
Either of the followings is displayed.
I
It refers to Class I Designated Chemical Substances. Anyone handling Class I Designated Chemical Substances in business is required to notify the quantities of these substances released to the environment (PRTR), etc. and to provide the information on properties and handling of these substances (Safety Data Sheet; SDS) when transferring or providing these substances (and/or products containing these substances) to the third parties.
II
It refers to Class II Designated Chemical Substances. Anyone handling Class II Designated Chemical Substances in business is required to provide the Safety Data Sheet (SDS) when transferring or providing these substances (and/or products containing these substances) to the third parties.
Specified Class I
It refers to Specified Class I Designated Chemical Substances. These are the substances designated as those with carcinogenicity to human among Class I Designated Chemical Substances. Notifying the released quantities of these substances is required more strictly than that of Class I Designated Chemical Substances.
Cabinet Order No.
It is the number assigned to each substance designated by the Cabinet Order.
Cabinet Order Name
It is the name of substance designated by the Cabinet Order.
Remarks
You can see the examples list of metal compounds.
Basis of selection
You can see the hazard data which is the bases of selection. (in Japanese)
Annual release amounts
It is the sum of the reported release amount and the estimated release amount.
Please refer to "Information on PRTR" on our website for detail data.
Link
There are links for Releases Map and Atmospheric concentration Map. (in Japanese)
Industrial Safety and Health Act (ISHA)
ISHA: Existing Chemical Substances / Newly Announced Chemical Substances
Updated: 2019-07-31 (Public Notice 2019-03-27)
Existing Chemical Substances of Industrial Safety and Health Act are listed separately in the following two types.

(1) ISHA: Existing Chemical Substances: Pursuant to the provisions of the Industrial Safety and Health Act Enforcement Order Supplementary Provisions of Article 9.2, it is the chemical substance which Minister of Labour has published its name and ISHA number, etc. with the Official Gazette as the chemical substance which had been 'manufactured or imported' in the country before June 29, 1979.

(2) ISHA: Newly Announced Chemical Substances: Pursuant to the provisions of the Industrial Safety and Health Act Article 57.3.3, it is the chemical substance which the Minister of Health, Labour and Welfare has published its name and ISHA number, etc. with the Official Gazette as a new chemical substance. (Since June 30, 1979 new chemical substances of the Act have been registered and published in the Official Gazette as the Newly Published Chemical Substances).
Note: On the basis of the public notice of February 5, 1979, chemicals that have been published pursuant to the provisions of the CSCL until June 29, 1979, and the chemicals listed in Japanese Pharmacopoeia eighth amendment (1971), are also treated as existing chemical substances for ISHA. This information is mentioned in the " Remarks to Existing Chemical Substances of Industrial Safety and Health Act " in the section of the CSCL.
ISHA: Chemical Substances Prohibited to Manufacturing, etc.
Updated: 2018-06-05 (Public Notice 2018-04-06)
Article 55 of the Law states that substances specified in paragraph (1) of Article 16 of the Cabinet Order, which are deemed to be substances that inflict serious damage on the health of workers, shall not be manufactured, imported, transferred, provided or used.
Cabinet Order Number
It is the number assigned to each substance designated by Article 16 of the Cabinet Order.
Cabinet Order Name
It is the name of the substances designated by Article 16 of the Cabinet Order.
Range of Application (weight %)
The range of content (% by weight) of regulated substances in preparations, etc. that are subject to the regulation.
ISHA: Chemical Substances Requiring Permission for Manufacture, etc.
Updated: 2018-06-05 (Public Notice 2018-04-06)
Paragraph (1) of Article 56 of this Act states that a person who intends to manufacture any of the substances specified in item 1 of Attached Table 3 in Article 17 of the Cabinet Order, which are deemed to have the possibility of inflicting serious damage on the health of workers, shall obtain advance permission from the Minister of Health, Labour and Welfare.
Cabinet Order Number
It is the number assigned to each substance designated by Article 17, attached table 3, item 1 of the Cabinet Order.
Cabinet Order Name
It is the name of the substances designated by Article 17, attached table 3, item 1 of the Cabinet Order.
Range of Application (weight %)
The range of content (% by weight) of regulated substances in preparations, etc. that are subject to the regulation.
ISHA: Chemical Substances Requiring Labeling and Delivery of Documents, etc.
Updated: 2019-06-04 (Public Notice 2018-04-06)
Paragraph (1) of Article 57 of the Act states that any of the chemical substances specified in Article 18 or item 1 of Attached Table 3 in Article 17 of the Cabinet Order, which are deemed to have the possibility of inflicting serious damage on the health of workers at the time of their transfer or provision, shall be indicated in the name of the substance, the ingredients or other such details provided on the container or package.

Paragraph (1) of Article 57-2 of the Act states that businesses are required to provide documents (SDSs) to their clients when transferring or providing any of the chemical substances specified in item 1 of Attached Table 3 in Article 17 or Attached Table 9 in Article 18-2 of the Cabinet Order, which are deemed to have the possibility of inflicting serious damage on the health of workers at the time of their transfer or provision.

By the revisions of the Cabinet Order (*1) and the Ministerial Ordinance (*2) of the Act concerning Labeling, etc., the substances and the cut-off values have been revised and a labeling obligation for solid-form substances has been removed.

By the same revisions of the Cabinet Order (*1) and the Ministerial Ordinance (*2) of the Act concerning Delivery of Documents, etc., the cut-off values for several substances have been revised.
Those values have been enforced from June 1, 2016. The substances for Labeling have been the same as those for Delivery of Documents.
(*1) Cabinet Order No. 250 of June 10, 2015
(*2) Ministerial Ordinance No. 115 of June 23, 2015
Cabinet Order Number
It is the number assigned to each substance designated by Article 17, attached table 3, item1 or Article1 8 and 18-2, attached table 9 of the Cabinet Order.
Cabinet Order Name
It is the name of the substances designated by Article 17, attached table 3, item 1 or Article 18 and 18-2, attached table 9 of the Cabinet Order.
Range of Application (weight %)
The range of content (% by weight) of regulated substances in preparations, etc. that are subject to the regulation.
ISHA: Dangerous Substances
Updated: 2014-09-11
Article 6 of the "Enforcement Order of Industrial Safety and Health Act" (hereinafter referred to as the "Cabinet Order") defines "the work subject to the appointment of an Operation Chief" in order to prevent industrial accidents, pursuant to the provision of Article 14 of the Industrial Safety and Health Act. Regulated, dangerous, or toxic substances are listed in the appended tables of the Cabinet Order.
The substances that are listed in Appended Table 1 of the Cabinet Order are called Dangerous Substances. When a substance corresponds to a Dangerous Substance, one of the following classifications, "explosive substances", "combustible substances", "oxidizing substances", "inflammable substances", or "flammable gases" is displayed in the column "Category", and the Cabinet Order number and Cabinet Order name will be displayed in the respective columns.
ISHA: Specified Chemical Substances
Updated: 2019-02-05 (Public Notice 2017-04-27)
The substances that are listed in Appended Table 3 of the Cabinet Order are called Specified Chemical Substances. When a substance corresponds to a Specified Chemical Substance, one of the following classifications, "Group-1 substances", "Group-2 substances", or "Group-3 substances" is displayed in the column "Category", and the Cabinet Order number and Cabinet Order name will be displayed in the respective columns. The range of content (% by weight) of regulated substances in preparations, etc. is displayed in the column " Range of Application (weight %)".
ISHA: Lead etc. / Tetraalkyl lead etc.
Updated: 2018-06-05
"Lead, etc." are defined, in Appended Table 4 of the Cabinet Order, as substances that are subject to regulated lead operations. When a substance corresponds to "Lead, etc.", "Ordinance on Prevention of Lead Poisoning" is displayed in the column "Relevant Ordinance etc.", and "Lead, etc." is displayed in the column "Cabinet Order Name". In the column "Remarks", "lead, lead alloys, lead compounds and mixtures of these substances with others" is displayed. It should be noted that the lead compounds are specified by the Minister of Health, Labour and Welfare, and have been announced in the Official Gazette.

"Tetraalkyl lead, etc." is defined, in Appended Table 5 of the Cabinet Order, to comprise substances that are subject to regulated tetraalkyl lead operations. When a substance corresponds to tetraalkyl lead compounds, "Ordinance on Prevention of Tetraalkyl Lead Poisoning" is displayed in the column "Relevant Ordinance etc.", and "Tetraalkyl lead, etc." is displayed in the column "Cabinet Order Name". In the column "Remarks", "tetra methyl lead, tetra ethyl lead, monomethyl,triethyl lead, dimethyl,diethyl lead and trimethyl,monoethyl lead, and also anti-knocking agents containing the said substances" is displayed.
ISHA: Organic Solvent Poisoning
Updated: 2014-12-17 (Public notice 2014-08-20)
The substances that are listed in Appended Table 6-2 of the Cabinet Order. When a substance corresponds to organic solvents, one of the following, "First-class organic solvents, etc.", "Second-class organic solvents, etc.", or "Third-class organic solvents, etc." is displayed in the column "Category", and the Cabinet Order number and Cabinet Order name will be displayed in the respective columns.
ISHA: Administrative Control Levels of Working Environment Evaluation Standards
Updated: 2019-02-05 (Public Notice 2017-04-27)
These are the concentrations provided in the attached table of "Working Environment Evaluation Standards" (Notification of the Ministry of Health, Labor, and Welfare).
ISHA: Guidelines for Carcinogenic Substances
Updated: 2018-03-20 (Announced 2014-10-31)
These are the substances which are likely to cause cancer or other serious health impairment to workers. The public guidelines for the businesses that manufacture or handle these substances are made to prevent the damage of workers' health caused by the said chemical substances based on paragraph (3) of Article 28 of the Act.
In the production and handling of these substances, businesses are required to take measures, such as reducing workers' exposure, work environment measurement, industrial health education, record keeping and Labeling and Deliver of SDS, etc.
The guidelines are published on the "Workplace Safety Site", the homepage of the MHLW.
Name
It is the substance name published in the Guidelines for Carcinogenicity Substances on the "Workplace Safety Site".
Details
NITE-CHRIP links to the "Workplace Safety Site" and you can see the guidelines.(in Japanese)
ISHA: Strong Mutagenic Chemical Substances
Updated: 2019-07-31 (Announced 2019-06-25)
These are the substances for which strong mutagenicity was recognized by the hazard investigation conducted based on Article 58 of the ISHA for Existing Chemical Substances in addition to Article 57-4 of the Act for Notified Chemical Substances. The substance names are announced in the Notification based on the Act.
In the production and handling of these substances, businesses are required to take measures, such as reducing workers' exposure, work environment measurement, industrial health education, Labeling and Deliver of SDS, etc. and record keeping, according to "Guidelines for Preventing Health Impairment by Chemical Substances with Mutagenicity Recognized", Labor Standards Bureau Notification No. 312, dated May 17, 1993 (Please see here : in Japanese).
Classification
Existing Chemical Substances or Notified Chemical Substances is shown.
Name
It is the name described in an attached sheet of the notification.
Date of Notification
It is the date published the notification and the number allocated to the substance in the attached sheet.
Poisonous and Deleterious Substances Control Act
Updated: 2019-07-31 (Public Notice 2019-06-19)
The Poisonous and Deleterious Substances Control Act was enacted in 1950 to carry out the controls on poisonous and deleterious substances that are needed to ensure health and hygiene.

Poisonous and Deleterious Substances are judged to be poisonous and deleterious based on knowledge regarding animals and people in the Criteria for Poisonous and Deleterious Substances. These substances are specified in paragraph (1) of Article 2 (Poisonous Substances), paragraph (2) of Article 2 (Deleterious Substances) and paragraph (3) of Article 2 (Specified Poisonous Substances) of the Act or in Article 1 (Poisonous Substances), Article 2 (Deleterious Substances) and Article 3(Specified Poisonous Substances) of the Cabinet Order for Designation of the Poisonous and Deleterious Substances Control Act.
Classification Law Cabinet Order
Poisonous Substances Attached Table 1 Article 1
Deleterious Substances Attached Table 2 Article 2
Specified Poisonous Substances Attached Table 3 Article 3
Classification
Either of the followings is displayed. Some substances may correspond to plural classifications.
Poisonous Substances These are defined as substances which may cause severe damage to human physiological function. In some case there are specific exceptions according to poisonous substances content and others.
Deleterious Substances These are defined as substances which may cause relatively light damage to human physiological function. In some case there are specific exceptions according to deleterious substances content and others.
Specified Poisonous Substances These are extremely poisonous among poisonous substances and are defined as substances which have high possibility of the harm for the person depending on the direction for uses.
Law or Cabinet Order Number
It is the number given to each substance designated by the Act or the Cabinet Order.
Law or Cabinet Order Name
It is the name of the substance designated by the Act or the Cabinet Order.
Poisonous and Deleterious Substances Control Act: Substances Excluded from Organic Cyanide Compounds
Updated: 2019-07-31 (Public Notice 2019-06-19)
These are the substances that are excluded from "Organic cyanide compounds and preparations containing it" specified in item 32 of paragraph (1) of Article 2 (Deleterious Substances) of the Cabinet Order for designation of the Poisonous and Deleterious Substances Control Act.
Classification
"Deleterious Substances/Exception(Cabinet order)" is displayed.
Cabinet Order Number
It is the number given to each substance designated by the Cabinet Order.
Name
It is the name of the substance designated by the Cabinet Order.
Act on Prohibition of Chemical Weapons and Control, etc. of Specific Chemicals
Updated: 2018-10-10 (Public Notice 2012-02-08)
The purpose of the Act, which aims to ensure appropriate implementation of the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on their Destruction, and the International Convention for the Suppression of Terrorist Bombings, is to prohibit the manufacture, possession, provision, and acceptance of chemical weapons, control the manufacture and use of specific chemicals, and implement other necessary measures.

Specific Chemicals are substances that are likely to be used for the manufacture of chemical weapons, are specified in the Cabinet Order for Enforcement of the Act on the Prohibition of Chemical Weapons and the Control, etc. of Specific Chemicals (hereinafter the "Cabinet Order"), and are specified in the 3rd or 4th column of the 1st section in the Appended Table of paragraph (1) of Article 3 of the Cabinet Order, based on paragraph (3) of Article 2 of the Act. These substances are regulated with regard to the following: permission for their manufacture and use; approval for their import; and restrictions on their possession and their transfer/acceptance; their conveyance; and their destruction.
In Japan, certain salts of Specific Chemicals are also regulated as Specific Chemicals based on the notice of Minister of Economy, Trade and Industry (METI) dated on April 1, 2010. (Only available in Japanese)

Class I Designated Chemicals are Chemicals designated in the Cabinet Order (hereinafter "Designated Chemicals") that are unlikely to be used for anything other than the manufacture of chemical weapons and that are specified in the 3rd or 4th column of the 2nd section in the Appended Table of paragraph (3) of Article 3 of the Cabinet Order, based on paragraph (5) of Article 2 of the Act. Notification of the scheduled and actual manufacturing,etc. quantity, the actual import/export quantity, etc., is required.

Class II Designated Chemicals are Designated Chemicals other than Class I Designated Chemicals that are specified in the 3rd or 4th column of the 3rd section in the Appended Table of paragraph (2) of Article 3 of the Cabinet Order, based on paragraph (5) of Article 2 of the Act. Notification of the scheduled and actual manufacturing quantity, the actual import/export quantity, etc., is required.

NITE-CHRIP provides information about Specific Chemicals, Class I Designated Chemicals and Class II Designated Chemicals designated by the Cabinet Order but no information about "Organic Chemicals" specified in Article 4 of the Cabinet Order based on paragraph (1) of Article 29 of the Act.
Please see the METI's website (only in Japanese) in details: see "Precautions for using Table 2" on the website.
Classification
Either of the following is displayed.
Specific Chemicals (Toxic chemicals or Precursors) Specific Chemicals shall mean toxic chemicals or materials from which toxic chemicals are made (precursors).
Class I Designated Chemicals (Toxic chemicals or Precursors) First-class designated chemicals shall mean toxic chemicals or materials from which toxic chemicals are made (precursors).
Class II Designated Chemicals (Toxic chemicals or Precursors) Second-class designated chemicals shall mean toxic chemicals or materials from which toxic chemicals are made (precursors).
Cabinet Order Number
It is the number given to each substance designated by the Cabinet Order.
Cabinet Order Name
It is the name of the substance designated by the Cabinet Order.
Act on the Protection of the Ozone Layer through the Control and Other Measures on Specified Substances and Other Substances
Updated: 2018-10-10 (Public Notice 2018-08-10)
The Act on the Protection of the Ozone Layer through the Control of Specified Substances and Other Measures was enacted in 1988 to fulfill the obligations and decisions of the contracting parties to the Vienna Convention for the Protection of the Ozone Layer (adopted in 1985) and the Montreal Protocol on Substances that Deplete the Ozone Layer (adopted in 1987). This Act stipulates regulations concerning the manufacture of the Specified Substances, control of their discharge and rationalization of their use, etc.

Based on the "Kigali Revision" of the Montreal Protocol, the Revised Ozone Layer Protection Act specifies measures to be taken to protect the ozone layer while considering the potential impact on climate. These measures include the addition of "alternatives to specified substances" as substances that are subject to manufacturing regulation. The specific types of such alternatives are specified by Orders, according to the Kigali Revision.

Specified Substances are substances that deplete the Ozone Layer and are specified in the Appended Table 1 of paragraph (1) of Article 1 of the Order for Enforcement of the Act.

Alternatives to Specified Substances (ozone-depleting substances) as substances that seriously exacerbate global warming, are specified in the Appended Table 2 of paragraph (1) of Article 1 of the Order for Enforcement of the Act.

NITE-CHRIP provides information on Specified Substances and Alternatives designated by the Act Enforcement Ordinance Concerning the Protection of the Ozone Layer through the Control and Other Measures on Specified Substances and Other Substances.
Type of Substances
Either of the following is displayed.
Group I in Annex A of the Protocol Attached Table 1-1 of Cabinet Order (A-I)
Group II in Annex A of the Protocol Attached Table 1-2 of Cabinet Order (A-II)
Group I in Annex B of the Protocol Attached Table 1-3 of Cabinet Order (B-I)
Group II in Annex B of the Protocol Attached Table 1-4 of Cabinet Order (B-II)
Group III in Annex B of the Protocol Attached Table 1-5 of Cabinet Order (B-III)
Group I in Annex C of the Protocol Attached Table 1-6 of Cabinet Order (C-I)
Group II in Annex C of the Protocol Attached Table 1-7 of Cabinet Order (C-II)
Group III in Annex C of the Protocol Attached Table 1-8 of Cabinet Order (C-III)
Group I in Annex E of the Protocol Attached Table 1-9 of Cabinet Order (E-I)
Group II in Annex F of the Protocol Attached Table 2-1 of Cabinet Order (F-I)
Group II in Annex F of the Protocol Attached Table 2-2 of Cabinet Order (F-II)
Cabinet Order Number
It is the number given to each substance designated by the Cabinet Order.
Cabinet Order Name
It is the name of the substance designated by the Cabinet Order.
Ozone-Depleting Potential
It is the value designated for each Specified Substance by the Cabinet Order, and it is also one of the indices to show the degree of influence on the ozone layer. It indicates the relative value of ozone depletion per 1kg of each compound, where the total amount of ozone depleted by 1 kg of CFC-11 is set to 1.
Global Warming Potential
It is the value designated for each Alternative by the Cabinet Order, and it is also one of the indices to show the global warming potential. It indicates the relative value of the global warming potential, expressed in CO2 equivalents.
Air Pollution Control Act
Updated: 2018-12-04 (Public Notice 2016-09-26)
The Air Pollution Control Act was enacted in 1968 to preserve the atmospheric environment. This Act stipulates that pollutants discharged by plants and factories must, depending on the scale and type of facility, meet the emission standards for each substance that is discharged.

Substances that are subject to this Act are "Soot and Smoke", "Mercury and Its Compounds", "Toxic Substances", "VOC (Volatile Organic Compounds) Exclusion Substances", "Designated Particulates", "Automobile Exhaust Gases", "Specific Substances", "Designated Substances", and "Hazardous Air Pollutants".

NITE-CHRIP provides information on chemical substances defined by Act, the Cabinet Order and the Central Environment Council Report as follows.
Classification
Either of the followings is displayed. One substance may correspond to two or more classifications.
Soot and Smoke Soot and Smoke mean sulfur oxides generated by the combustion of fuel or other items; soot and dust generated by the combustion of fuel or other items or by the use of electricity as a source of heat; and substances that are generated as a result of combustion, synthesis, decomposition, or other processes (excluding mechanical processes), that are likely to harm human health or living conditions. Emission standards shall be prescribed for each facility and in each prefecture.
                                Soot and Smoke (Hazardous Substances) Soot and Smoke (Hazardous Substances) mean substances that are generated as a result of combustion, synthesis, decomposition, or other processes (excluding mechanical processes), that are likely to harm human health or living conditions, and that are specified by a Cabinet Order. Emission standards shall be prescribed for each facility and in each prefecture.
Volatile Organic Compound (VOC) Volatile Organic Compound means any organic compound (excluding substances specified by a Cabinet Order as not being sources from which suspended particulate matter or oxidants are generated) that is in a gaseous state at the time of its emission or dispersal into the atmosphere. Emissions standards shall be prescribed as the maximum permissible limits for each type and size of the facilities. VOC stands for Volatile Organic Compound.
VOC Excluded Substances VOC Excluded Substances are specified by a Cabinet Order as not being sources from which suspended particulate matter or oxidants are generated.
Specified Particulates Specified Particulates mean asbestos and any other substance specified by a Cabinet Order that is likely to harm human health. Site Boundary Standards and Activity Standards shall be prescribed by an Ordinance of the Ministry of the Environment as standards for the methods for Activities That Emit, etc. Specified Particulates are done.
Mercury and Its Compounds To ensure accurate and smooth implementation of the Minamata Convention on Mercury, emissions of "mercury and its compounds" associated with the business activities of factories and workplaces is controlled.
Hazardous Air Pollutant (/Priority Chemicals) Hazardous Air Pollutant means any substance that is likely to harm human health if ingested continuously and that is a source of air pollution (excluding Soot and Smoke (limited to the items listed under Article 2, paragraph (1), items (i) and (iii) of Act) and Specified Particulates).
This is a candidate list of Hazardous Air Pollutant reported by the Central Environment Council. The State needs to implement risk assessment on these substances, and local public entities need to determine the status of the pollution, and business operators need to determine the status of the emission and control the emission. Among them, substances requiring priority measures in particular are listed as Priority Chemicals.
Hazardous Air Pollutant (Designated Substance) Designated Substance is a hazardous air pollutant specified by Cabinet Order as one whose emission and dispersal must be urgently controlled in order to prevent damage to human health. Standards for Controlling Designated Substances shall be established for controlling the emission and dispersal of each type of Designated Substance and each type of Facilities That Emit Designated Substances and shall be made public.
Automobile Exhaust Automobile Exhaust means substances likely to harm human health or living conditions, that are generated during the operation of an automobile among the automobiles; and among the motorized bicycles, and specified by a Cabinet Order.
Specified Substance Specified Substance is specified by a Cabinet Order as likely to harm human health or the living environment. Any person who has in place Specified Facilities that substances generated in the process of synthesis, decomposition, or other chemical processes of substances, include the Specified Substance shall, when a breakdown, damage, or other accident occurs at the Facilities That Generate Soot and Smoke or at the Specified Facilities and a large quantity of Soot and Smoke or a Specified Substance has been emitted into the atmosphere, immediately take emergency measures in response to said accident, and shall endeavor to carry out restoration promptly.
Cabinet Order Number
It is the number assigned to each substance designated by Cabinet Order (or Act or Report).
Cabinet Order Name
It is the name of the substance designated by Cabinet Order (or Act or Report).
Water Pollution Control Act
Updated: 2018-06-05 (Public Notice 2015-09-18)
The Water Pollution Control Act was enacted in 1970 to prevent the pollution of public water supplies and underground water. Discharges into public water supplies by plants and factories are categorized so as to indicate the effluent standards of Harmful Substances and the state of water contamination. The establisher of the factories or the workplaces which have Specified Facilities (*1) or Designated Facilities (*2) must, in the event of suspicion of harmfulness pertaining to human health or living environment by damage of those facilitfes and occurrence of other accidents, take emergency measures etc.
(*1) facilities which discharge polluted water or waste liquid, etc.
(*2) facilities which store or use Harmful Substances, or manufacture, store, use or treat Designated Substances

Based on item (1), paragraph (2) of Article 2 of this Law, Harmful Substances are substances specified in Article 2 of the Cabinet Order for Enforcement of the same Law, such as cadmium, that pose a risk of damage to human health.
Based on paragraph (4) of Article 2 of this Law, Designated Substances are substances specified in Article 3-3 of the same Cabinet Order, other than Harmful Substances and oil prescribed in paragraph (5) of Article 2 of this Law that are suspicious of harmfulness to human health or living environment by being discharged to the Public Water Areas in large quantities.

NITE-CHRIP provides information on the Harmful Substances and Designated Substances defined by the Cabinet Order.
Cabinet Order Number
It is the number assigned to each substance designated by Article 2 of the Cabinet Order (Harmful Substances) and Article 3-3 of the Cabinet Order (Designated Substances).
Cabinet Order Name
It is the name of the substance designated by Article 2 of the Cabinet Order (Harmful Substances) and Article 3-3 of the Cabinet Order (Designated Substances).
Effluent Standards
Effluent Standards are threshold limit values (amount of Harmful Substances contained in effluents) that stipulate the effluent standards in Appended Table 1 of Article 1 of the Ministerial Ordinance based on paragraph (1) of Article 3 of the Water Pollution Control Law.
Soil Contamination Countermeasures Act
Updated: 2019-04-16 (Public Notice 2018-09-28)
The Soil Contamination Countermeasures Act was enacted in 2002 to ascertain the state of soil contamination by Designated Hazardous Substances and stipulate preventative measures for human health hazards arising from such contamination.
Designated Hazardous Substances are substances that may pose a hazard to human health when contained in soil, as designated in Article 1 of the Ordinance for Enforcement of this Act, based on paragraph (1) of Article 2 of the same Act.

The Soil Leachate Standards regulate the amount of Designated Hazardous Substances that may be eluted into soil when water is added, as specified in paragraph (1) of Article 31 of the Ordinance for Enforcement of this Act, based on item (1) of paragraph (1) of Article 6 of the same Act.

The Soil Concentration Standards regulate the amount of Designated Hazardous Substances that may be contained in soil, as specified in paragraph (2) of Article 31 of the Ordinance for Enforcement of this Act, based on item (1), paragraph (1) of Article 6 of the same Act.

NITE-CHRIP provides information on the Designated Hazardous Substances defined by the Cabinet Order and the standards defined by the Ordinance for Enforcement.
Classification
Designated Hazardous Substances are classified into 3 classes by the Ordinance of the Ministry of the Environment, depending on the nature of the substances.
Class 1 Designated Hazardous Substances: Volatile Organic Compounds
Class 2 Designated Hazardous Substances: Heavy Metals, etc.
Class 3 Designated Hazardous Substances: Agricultural Chemicals, etc. (Agricultural Chemicals & PCB)
Cabinet Order Number
The number assigned to each hazardous substance designated by Article 1 of the Cabinet Order.
Cabinet Order Name
The name of the hazardous substance designated by Article 1 of the Cabinet Order.
Soil leachate standard
The soil leachate standards are determined for the Risk of ingestion of groundwater. The standards are prescribed in the Ordinance of the Ministry of the Environment.
Soil concentration standard
The soil concentration standards are determined for the risk of direct ingestion of the soil. The standards are prescribed in the Ordinance of the Ministry of the Environment.
Act on the Control of Household Products Containing Harmful Substances
Updated: 2019-03-19 (Public Notice 2015-07-09)
The Act on the Control of Household Products Containing Harmful Substances was enacted in 1973 to facilitate the protection of public health by applying regulations that are required from the standpoint of ensuring the health and hygiene of household products containing harmful substances. This Act stipulates standards for harmful substances and designated household products to be subject to regulation.

The harmful substances to be subject to regulation are mercury compounds and other substances that may pose a risk to human health and that are specified in the Cabinet Order designating the substances specified in paragraph (2) of Article 2 of this Act, based on paragraph (2) of Article 2 of the same Act.

Designated household products are household products that, from the standpoint of health and hygiene, have been designated in the Appended Table, etc., of Article 1 of the Ordinance for Enforcement of the Act, based on paragraph (1) of Article 4 of the same Act.

NITE-CHRIP provides information on harmful substances provided for by Cabinet Order of Article 2, paragraph (2) of the Act on the Control of Household Products Containing Harmful Substances.
Cabinet Order Number
It is the number assigned to each substance designated by Cabinet Order.
Cabinet Order Name
It is the name of the substance designated by Cabinet Order.
Applicable Household Goods
Designated household products are household products that have been designated in the Appended Tables, etc., of Article 1 and Article 2 of the Ordinance for Enforcement of the Act, based on paragraph (1) and (2) of Article 4 of the Act.
Standards
The standards of the designated household for the harmful substances are stipulated by Article 1 and 2 of the Ordinance for Enforcement of the Act. The standards include test methods, test equipment, test conditions and so on.
Laws and Regulations in Other countries
Dangerous Goods List (UN Number and Hazard class)
Updated: 2019-4-16 (Revised 2017, 20th Edition)
These Recommendations have been developed by the United Nations Economic and Social Council's Committee of Experts on the Transport of Dangerous Goods in the light of technical progress, the advent of new substances and materials, the exigencies of modern transport systems and, above all, the requirement to ensure the safety of people, property and the environment. The recommendations concerning the transport of dangerous goods are presented in the form of "Model Regulations on the Transport of Dangerous Goods", which are presented as annex to this document.

NITE-CHRIP provides information on UN Number, Class or division, Name and description listed in the Dangerous Goods List in "Model Regulations ".
UN Number
It refers to a four-digit number assigned to the article or substance listed in the Dangerous Goods List. The UN number is in principle assigned serially in the established order as dangerous goods, and there is no specific meaning to the number itself. If a substance has a UN number, it can be judged as a hazardous material. Because of some missing UN number, some numbers are not in serial.
Class or division
The article or substance is assigned to one of nine classes according to the hazard as shown below, and some of these classes are subdivided into divisions.
Class 1 Explosives
Division 1.1 Substances and articles which have a mass explosion hazard
Division 1.2 Substances and articles which have a projection hazard but not a mass explosion hazard
Division 1.3 Substances and articles which have a fire hazard and either a minor blast hazard or a minor projection hazard or both, but not a mass explosion hazard
Division 1.4 Substances and articles which present no significant hazard
Division 1.5 Very insensitive substances which have a mass explosion hazard
Division 1.6 Extremely insensitive articles which do not have a mass explosion hazard
Class 2 Gases
Division 2.1 Flammable gases
Division 2.2 Non-flammable, non-toxic gases
Division 2.3 Toxic gases
Class 3 Flammable liquids
Class 4 Flammable solids; substances liable to spontaneous combustion; substances which, on contact with water, emit flammable gases
Division 4.1 Flammable solids, self-reactive substances, solid desensitized explosives and polymerizing substances
Division 4.2 Substances liable to spontaneous combustion
Division 4.3 Substances which in contact with water emit flammable gases
Class 5 Oxidizing substances and organic peroxides
Division 5.1 Oxidizing substances
Division 5.2 Organic peroxides
Class 6 Toxic and infectious substances
Division 6.1 Toxic substances
Division 6.2 Infectious substances
Class 7 Radioactive material
Class 8 Corrosive substances
Class 9 Miscellaneous dangerous substances and articles, including environmentally hazardous substances
Name and description
It refers to proper shipping names designated by uppercase characters, which may be followed by additional descriptive text designated by lowercase characters. In addition, the abbreviation N.O.S. stands for "Not otherwise specified".
Stockholm Convention on Persistent Organic Pollutants (POPs)
Updated: 2019-02-05 (Effective 2018-12-18)
Please see POPs homepage.

The Stockholm Convention on Persistent Organic Pollutants (POPs) is a convention enacted in 2001 to serve as an international framework for the reduction, elimination, etc., of the release of POPs into the environment. It came into effect in 2004.

The POPs convention stipulates the abolishment of production and use, the reduction of discharge and a proper processing etc. of persistent organic pollutants that pose a risk of longrange transport, persistent in the environment, bioaccumulative and the toxicity to humans and other environmental organisms that are all severe.

NITE-CHRIP provides information on names, etc. listed in the Convention about substances listed in Annex A, B and/or C.
Annex
One of the following Annex is displayed.
A The substances listed in Annex A, of which each Party needs to eliminate the production, use and import/export (with specific exceptions).
B The substances listed in Annex B, of which each Party needs to restrict the production, use and import/export (with acceptable purposes and specific exemptions).
C The substances listed in Annex C, of which each Party needs to reduce or eliminate the releases from unintentional production.
Chemical Substance Listed in Annex
The name of the chemical substance in Annex is displayed.
Rotterdam Convention on the Prior Informed Consent Procedure for Certain Hazardous Chemicals and Pesticides in International Trade (PIC)
Updated: 2017-10-03 (Effective 2017-09-15)
Please see PIC website.

The Rotterdam Convention on the Prior Informed Consent (PIC) Procedure for Certain Hazardous Chemicals and Pesticides in International Trade is a convention that specifies a procedure for PIC between the contracted parties so as to prevent unrestricted exports to developing countries of hazardous chemical substances and pesticides (whose use is prohibited or strictly restricted in developed countries). This convention was adopted in 1998 and came into effect in Japan in 2004.

NITE-CHRIP provides the announced information on chemicals in "The export approval of the chemical substance" based on Export Trade Control Order about chemicals listed in Annex III to the Convention, which are subject to the PIC procedure.
Category
This refers to the use category for chemicals listed in Annex III to the Convention. Either of the followings is displayed.
Pesticide pesticide
Severely hazardous pesticide formulation a chemical formulated for pesticidal use that produces severe health or environmental effects observable within a short period of time after single or multiple exposure, under conditions of use.
Industrial industrial chemical
Name of Chemical in Annex III
The name of the chemical in Annex III is displayed.
Association of South-East Asian Nations(ASEAN)
ASEAN-Japan Chemical Safety Database (AJCSD) : Laws and Regulations
Updated: 2016-10-04
The ASEAN-Japan Chemical Safety Database (AJCSD) is a database co-developed by ASEAN countries and Japan based on an agreement reached by the ASEAN Economic Ministers and METI Economic and Industrial Cooperation Committee (AMEICC) Working Group on Chemical Industry (WG-CI). NITE is the operator of the AJCSD, and made it fully operational on April 28, 2016.

“The AJCSD: Laws and Regulations” contains regulatory information on chemical substances provided directly by the governments of ASEAN countries (Cambodia, Indonesia, Laos, Malaysia, Myanmar, the Philippines, Thailand, and Vietnam).

If ASEAN chemical regulatory information exists in the AJCSD, the following item is displayed.
Detail
If you click on “to AJCSD”, you will be able to find the corresponding data in the AJCSD.
European Union (EU)
EC Inventory
Updated: 2018-07-31 (Published 2017-08-11)
The EC inventory was announced by the European Commission Joint Research Centre in 2008. It is a list of chemical substances and consists of the three following lists

(a) European Inventory of Existing Commercial Chemical Substances (EINECS)
・EC Number (2xx-xxx-xx, 3xx-xx-xx)
EINECS is a list of about 100,000 chemical substances distributed in the European Union (EU) market between 1971/01/01 and 1981/09/18, and it was compiled in accordance with the Dangerous Substances Directive 67/548/EEC.

(b) European List of Notified Chemical Substances (ELINCS)
・EC Number (4xx-xxx-xx)
ELINCS is a list of about 5,000 Notification of New Substances (NONS) commercially available in the European Union (EU) market between 1981/09/18 and 2008/05/31 and it was compiled in accordance with the Dangerous Substances Directive (the 7th amendment to Directive 67/548/EEC of 1993).

(c) No Longer Polymers (NLP)
・EC Number (5xx-xxx-xx)
The definition of polymers was changed by Council Directive 92/32/EEC amending Dangerous Substances Directive 67/548/EEC adopted in 1992, and some substances previously considered to be polymers and excluded from regulation have become considered no longer polymers (NLP). The NLP lists such substances that were commercially available in the European Union (EU) market between 1981/09/18 and1993/10/31

NITE-CHRIP provides information on substances listed in this inventory.
EC Number
It is the number of the substance listed in EC Inventory.
EC Name
The substance name in EC Inventory is displayed.
Description
EC Name is described in detail.
REACH : Substances of Very High Concern for Authorisation
Updated: 2019-07-31 (Authorisation List : Announced 2017-06-14 / Candidate List : Announced 2019-07-16)
Substances of Very High Concern (SVHC) are substances selected by EU member countries or the European Chemicals Agency (ECHA), based on REACH Regulations, from among substances with the following properties:

(a) Carcinogenic, category 1A or 1B (Regulation (EC) No 1272/2008)
(b) Mutagenic, category 1A or 1B (Regulation (EC) No 1272/2008)
(c) Toxic for reproduction/development, category 1A or 1B (Regulation (EC) No 1272/2008)
(d) PBT (Persistent, Bio-accumulative and Toxic)
(e) vPvB (very Persistent and very Bio-accumulative)
(f) Other substances that have been found to have a significant effect on human health or the environment based on scientific evidence and that pose the same level of concern as (a) to (e)

SVHC are added to the Authorisation List of Annex XIV of the REACH Regulations and are subject to authorisation. Substances included in the Candidate List are SVHC candidates that will ultimately be registered in the Authorisation List.

NITE-CHRIP provides information on chemical substance names, etc in "Authorisation List" of Annex XIV of the REACH Regulation and "Candidate List" published on the ECHA website.
EC number
It is the code that is assigned to chemical substances within the European Union.
Status
Status means the followings.
Authorisation List : The substance listed in the Authorisation List
Candidate List : The substance listed in the Candidate List table of SVHC
Substance name
It is the substance name listed in the Authorisation List and / or the Candidate List table.
Details
If you click on "to ECHA site", you can see the information on the substance list published in ECHA website.
EU: CLP Harmonised Classification
Updated: 2019-07-31 (published 2018-10-05: ATP13)
European Union (EU) : CLP harmonized classification and dangerous substances are listed in Table 3 in Annex VI of CLP Regulation "Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures". The CLP Regulation aligns the European Union system of classification chemical substances and mixtures to GHS "the Globally Harmonized System of Classification and Labelling of Chemicals".
NITE-CHRIP provides this information on CLP harmonized classification and dangerous substances in Table 3 in Annex VI of CLP Regulation.

Designations * and **** in classification and remarks are defined as follows:
・* : For certain hazard classes, including acute toxicity and STOT repeated exposure, the classification according to the criteria in Directive 67/548/EEC does not correspond directly to the classification in a hazard class and category under this Regulation. The designation * can also be found in the column ‘Specific concentration Limits and M-factors’ where it indicates that the entry concerned has specific concentration limits under Directive 67/548/EEC for acute toxicity.
・**** : For some entries the correct classification for physical hazards could not be established because sufficient data were not available for the application of the classification criteria in this Regulation. The entry might be assigned to a different (also higher) category or even another hazard class than indicated. The correct classification shall be confirmed by testing. The entries with physical hazards that need to be confirmed by testing are indicated by **** in Table 3.
Index Number
The Index number for each substance is in the form of a digit sequence of the type ABC-RST-VW-Y. ABC corresponds to the atomic number of the most characteristic element or the most characteristic organic group in the molecule.
EC Number
It is the number of the substance listed in EC Inventory.
Name
It is the name of International Chemical Identification listed in Table 3.
Classification
The classification for each entry is based on the criteria set out in Annex I and is presented in the form of a code representing the hazard class and the category or categories/divisions/types within this hazard class.
Remarks
In case specific concentration limits or M-factor have been harmonised, these are given in Table 3.
TSCA: Inventory
Updated: 2018-03-19 (Issued 2019-02-19)
The US Toxic Substances Control Act (TSCA) was enacted in 1976 to prevent, through regulation, chemical substances and mixtures that pose unreasonable risks from having an adverse effect on human health and the environment

TSCA : List of Existing Chemical Substances is a list of chemical substances manufactured, imported, or processed in the United States that is prepared by the US Environmental Protection Agency (US EPA) in accordance with the TSCA. Any chemical substance not included in this list is regarded as a New Chemical Substance and subject to Premanufacture Notice (PMN) regulations.

NITE-CHRIP provides information on chemical substances displayed in the newest list (eliminating the parts insisted as secret by manufacturers)

Please see EPA website for more information .
TSCA Chemical Substance Name
The substance name (CAS registry name in principle) in the Chemical Substances Inventory is displayed.
Remarks
If "ACTIVE" is marked in the TSCA Inventory, "ACTIVE" is displayed.
TSCA: Significant New Use Rules (SNUR)
Updated: 2019-07-31 (Effective 2019-06-24)
TSCA: Significant New Use Rules (SNUR) are rules used to regulate New Chemical Substances in accordance with item (2) of paragraph (a) of Article 5 of the TSCA for the purpose of applying regulations in conjunction with Consent Orders in the same way as they are applied for individuals other than the applicant.

Although a Consent Order cannot clearly assess the risk of a chemical substance, one is issued when there is a possibility of excessive risk to human health or the environment and when there is a possibility of a large release into the environment or human exposure. SNUR restrict manufacturing, etc., until an adequate amount of data have been collected for risk assessment. From the viewpoint of fairness, the goal of SNUR is to impose restrictions equivalent to those of Consent Orders on all business operators that deal with chemical substances.

NITE-CHRIP provides information on chemical substances listed in the promulgated rules based on item (2) of paragraph (a) of Article 5 of TSCA. To see the contents of an individual rule, please click here.

Please see EPA homepage for more information .
40 CFR part 721 Subpart E
The number shows the Section Number of SNUR listed in 40 CFR Part 721 Subpart E.
SNUR Chemical Substance Name
It is the name of chemical substance listed as a regulated chemical substance in SNUR. For the case where a SNUR chemical substance is described by a generic name, "generic" is added at its name' s tail.
TSCA: Regulation of hazardous chemical substances and mixtures
Updated: 2019-07-31 (Effective 2019-05-28)
TSCA : Regulation of hazardous chemical substances and mixtures applies to cases where, based on the provisions of Article 6 of TSCA, there is sufficient valid evidence to conclude that the manufacture, import, processing, distribution, and disposal of these substances and their mixtures, or any combination thereof, pose or may pose an unreasonable risk of harm to human health or the environment.

In consideration of the possibility using alternatives that would impose the least burden on human health or the environment, the US Environmental Protection Agency (US EPA) applies appropriate risk reduction measures, such as prohibiting the manufacturing, processing and distributing of hazardous substances and their mixtures and imposing restrictions on the amount of such substances and their mixtures that can be manufactured, processed and distributed.

NITE-CHRIP provides information on chemical substances targeted for Article 6 of TSCA. among chemical substances listed in the existing chemical substance inventory of TSCA. Please see EPA homepage for more information .
TSCA Section 6
The corresponding CFR number is displayed.
China: Catalog of Hazardous Chemicals 2015
Updated: 2017-04-18 (Public Notice 2015-02-27)
China: Catalog of Hazardous Chemicals compiles "hazardous chemicals" defined as highly toxic substances and other chemicals which are toxic, corrosive, explosive, flammable, or combustion-supporting and can do harm to people, facilities, or the environment under Article 3 of the Regulations on Safe Management of Hazardous Chemicals (State Council Decree 591). It was published by ten agencies: the State Administration of Work Safety; the Ministry of Industry and Information Technology; the Public Security authorities; the Ministry of Environmental Protection; the Transport Department; the Agricultural Department; the Ministry of Health; the Quality Supervision, Inspection and Quarantine Department; the Railway Department; and the Civil Aviation Department.

NITE translated information on the NRCC (National Registration Center for Chemicals) web site (http://www.nrcc.com.cn/Content/d66aa2b2-f764-4e4d-a5b2-c968e2bdff26) into English and shows it on NITE-CHRIP.

"Diluent type A" and "Diluent type B" in chemical names are defined as follows:
・Diluent type A; This means an organic liquid having a boiling point greater than 150 degC and compatible with organic peroxides.It can be used for desensitization of all kind of organic peroxides.
・Diluent type B; This means an organic liquid having a boiling point greater than 60 degC but not more than 150 degC and a flash point greater than 5 degC, and is compatible with organic peroxides. It can be used for desensitization of all kind of organic peroxides, but the boiling point should be at least 60 degC greater than self-accelerating decomposition temperature (SADT) for a 50 kg package.
Number
It is the number in the Catalog of Hazardous chemicals 2015.
Name
It is the English chemical name in the Catalog of Hazardous chemicals 2015 translated by NITE.
Other name
It is the English synonyms translated by NITE. It contains generic name etc.
Remarks
’Toxic’ is shown for highly toxic substances.
Korea: ARECs (K-REACH) / CCA; Hazardous Substance(s), Priority Control Substances
Updated: 2019-06-04 (Published 2019-04-19)
The Toxic Chemicals Control Act which had been a basic law on chemical substance control in Korea was reorganized into the "Act on the Registration and Evaluation, etc. of Chemical Substances (ARECs)" and the "Chemicals Control Act (CCA)". The ARECs is a law concerning the registration and the evaluation of new and existing chemical substances, and the designation of hazardous chemical substances. The CCA is a law concerning the control of hazardous chemical substances. It has been in force since January 1, 2015.

NITE-NITE-CHRIP provides information on Hazardous Substance(s) (Toxic Substance(s), Restricted Substance(s), Prohibited Substance(s) and Accident Precaution Chemical) and Priority Control Substances.
Number
The numbers are given in the tables of each category.
Range of Application (%)
The range of content (%) of regulated substances in preparations, etc. that are subject to the regulation.
Category
Any of the following is displayed.
Toxic Substance(s) Toxic Substance(s) is a chemical substance designated in CCA. The observance of the handling standard for hazardous substance based on the CCA and the declaration of the Minister of Environment on the occasion of import is requested (Article 20 of the CCA).
Restricted Substance(s) Restricted Substance(s) is a chemical substance designated in the ARECs and its handling is prohibited in the specific use. On the occasion of import the permission of the Minister of Environment is requested (Article 20 of the CCA) and on the occasion of export the approval of the Minister of Environment is requested (Article 21 of the CCA).
Prohibited Substance(s) Prohibited Substance(s) is a chemical substance designated in the ARECs and its handling is prohibited except reagents such as examination use (Article 18 of the CCA).
Accident Precaution Chemical Accident Precaution Chemical is a chemical substance designated in CCA. The observance of the management standard for Accident Precaution Chemicals (Article 40 of the CCA), making and submitting of the harm management plan and etc. (Article 41 of the CCA) are requested.
Priority Control Substances Priority Control Substances are chemical substances designated in the ARECs. Reporting for products containing Priority Control Substances (Article 32 of the ARECs) and provision of information on chemical substances in products (Article 35 of the ARECs) are required.
Chemical Substance Name
It is name of the chemicals designated on the attached table of the Notification on "the designation of Toxic Substances" and "the designation of Restricted Substance and Prohibited Substance", and the attached table 10 of the Enforcement Regulation of the CCA and the attached table of the Notification on "the designation of Priority Control Substances".
Korea: ARECs (K-REACH) ; Existing Chemical Substances
Updated: 2019-06-04 (Published 2019-05-08)
ARECs (K-REACH) requires any person who intends to manufacture or import at least one ton per year of an existing chemical substance to apply for registration of the chemical substance before he/she manufactures or imports. NITE-CHRIP provides information on both “Existing Chemical Substances (Domestically distributed commercial purpose before February 2, 1991.)” and “Existing Chemical Substances (Has undergone hazard review after February 2, 1991.)”.                 
Number
This is KE number given in the appendices of the notification on “Partial amendments to existing chemical substances”.
Category
Any of the following is displayed.
Existing Chemical Substances (Domestically distributed commercial purpose before February 2, 1991.) Chemical substances which were placed on Korean market before February 2, 1991 and notified by the Ministry of Environment. (ARECs; Article 2(3) A)
Existing Chemical Substances (Has undergone hazard review after February 2, 1991.) Chemical substances which have undergone the examination of toxicity under the former provisions or the provisions of this Act after February 2, 1991 and were announced by the Minister of Environment. (ARECs; Article 2(3) B)
Chemical Substance Name
This is the name of the chemical designated in the Notification on "Partial amendments to existing chemical substances".
Remarks
Information on hydrates, etc. will be displayed.
Korea: ARECs (K-REACH) ; Others
Updated: 2019-06-04 (Published 2018-12-28)
ARECs (K-REACH) requires any person who intends to manufacture or import at least one ton per year of an existing chemical substance to apply for registration of the chemical substance before he/she manufactures or imports. If he/she submit a notification, the registration period is extended based on the tonnage band or type of chemical substances. NITE-CHRIP provides information on “Phase-in substance(s) subject to registration”, “CMR Substances” and “Chemical substances exempted from registration or notification”.                 
Number
The numbers are given in the tables of each category.
Category
Any of the following is displayed.
Phase-in substance(s) subject to registration “Phase-in substance subject to registration” is a chemical substance designated under the ARECs among the existing chemical substances. The registration grace period expired on June 30, 2018.
CMR Substances “CMR substances” are chemical substances which may be or are concerned to be carcinogenic, mutagenic or toxic for reproduction to human beings or animals designated in the ARECs among existing chemical substances. The registration grace period is until December 31, 2021.
Chemical substances exempted from registration or notification These are chemical substances which are exempted from registration or notification designated in the ARECs. These include natural existing substances, etc. in Annex Ⅰ and glucose and starch, etc. in Annex Ⅱ
Chemical Substance Name
It is the name of the chemicals designated in the Notification on "Phase-in substance(s) subject to registration" and the Notification on "Existing chemical substances to be registered by 2021 which may be or are concerned to be carcinogenic, mutagenic or toxic for reproduction" and the Notification on "Chemical substances exempted from registration or notification".
Remarks
Information on hydrates will be displayed.
Note
Other information on the chemical substance will be displayed.
Taiwan: TCCSCA; Toxic Chemicals
Updated: 2019-07-31 (Published 2019-01-16)
Toxic and Concerned Chemical Substances Control Act (TCCSCA) was published in January 2019 as amended Toxic Chemical Substances Control Act (TCSCA) of 1986. The purpose of the TCCSCA is to prevent toxic and concerned chemical substances from polluting the environment and endangering human health, and to ensure toxic chemicals are only handled by authorized operators, and appropriately handled, transported and disposed.

The TCCSCA requires a company that handles toxic chemical substances to apply for with the relevant management measures according to the provisions of the Act.
Listed No./Series No.
Numbers assigned to each Toxic Chemical Substance under the TCCSCA.
Toxicity Classify
TCCSCA listed chemical substances as Class 1, Class 2, Class 3 or Class 4 toxic chemicals. Different handling activities of different classes of toxic chemical substances shall comply with to corresponding management requirements.
English Name
English Name of the Toxic Chemical Substance under the TCCSCA.
Chinese Name
Chinese Name of the Toxic Chemical Substance under the TCCSCA.
Control concentration standard
Toxic Chemical Substance which is contained the Control concentration standard value or more is the managed substance under the TCCSCA.
Large-scale handling standard
Substances classified Class 1, 2 and 3 are defined each Large-scale handling standard. Companies are required to obtain the permit (manufacture, import or sell them more than the standard), to obtain the registration (use, store and dispose of them more than the standard), or to obtain approval (less than the standard)
Note
If the Large-scale handling standard has a note, it is displayed. Only for Asbestos, the note is regarding the Control concentration standard.
Taiwan: TCCSCA; Existing Chemical Substances Subject to Standard Registration
Updated: 2019-07-31 (Announced 2019-03-11)
TCCSCA and its related regulations, Regulations of New and Existing Chemical Substances Registration (hereinafter referred to as Regulation), require any person who intends to manufacture or import at least 100 kg per year of an existing chemical substance to apply for registration of the chemical substance before he/she manufactures or imports.

Existing Chemical Substances Subject to Standard Registration are designated according to the circumstances of the registration of existing chemical substances based on the Regulation. Registrants manufacturing or importing any Existing Chemical Substances Subject to Standard Registration are required to apply for a more detailed registration from January 1, 2020. The grace period of the application is determined according to the handling volume, etc.
Stage/Series No.
Numbers assigned to each Existing Chemical Substance Subject to Standard Registration under the Regulation.
English Name
English Name of the Existing Chemical Substances Subject to Standard Registration under the Regulation.
Chinese Name
Chinese Name of the Existing Chemical Substances Subject to Standard Registration under the Regulation.
Chemical Hazard and Risk Information
GHS Classification Results by the Japanese Government
Updated: 2019-07-31 (Original Data Last Updated 2019-05-29)
This classification has been conducted in accordance with the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) by the Japanese government's GHS Classification Project since 2006. The data include the following: classification, symbol, signal word, and hazard statement.
Further information about the GHS including Japan's classification is available from the following link.
GHS Information
Year of implementation / renewal
The displayed number is a Japanese fiscal year, from April 1 to March 31 of the following year, and it means that the GHS classification of the substance was implemented or renewed in the year.
Chemical Substance Name
The displayed name is an English translated substance name used by the Japanese government GHS classification.
Classification Result
You can see the GHS classification results (HTML and Excel) of the substance.
Remarks
If several classification results of different years are available and one of the results is displayed with "latest" but limited to part of hazard classes, a supplemental explanation of how to refer the results will be shown.
AJCSD: GHS Classification Results/Sample SDS
Updated: 2016-07-29
The ASEAN-Japan Chemical Safety Database (AJCSD) is a database co-developed by ASEAN countries and Japan based on an agreement reached at ASEAN Economic Ministers and METI Economic and Industrial Cooperation Committee (AMEICC) Working Group on Chemical Industry (WG-CI). NITE is the operator of the AJCSD, and started its full operation from April 28, 2016.

“AJCSD: GHS Classification Results/Sample SDS“ contains GHS classification results of Malaysia and Myanmar as reference, and Sample SDSs provided by Japan.

If a substance has information on GHS in AJCSD, the following item is displayed.
Detail
If you click on “to AJCSD”, you will be able to find the corresponding data in the AJCSD.
Relational Information System for Chemical Accidents Database(RISCAD)
Updated: 2018-12-04
RISCAD is operated by the National Institute of Advanced Industrial Science and Technology (AIST).
AIST has been gathering chemical accidents of explosives, high-pressure gas, hazardous substances and chemical plants etc. These chemical accidents are organized in RISCAD.
Some accident data have links to the accident progress flowcharts that analyzed by the Progress Flow Analysis (PFA: Registered Trademark, No. 5580785) method, the hazards information of relevant chemical substances, and the chemical process flowcharts etc.
RISCAD can be utilized for an advance assessment of chemical substances before using/handling these substances, and a safety education on-site.
Material ID
It is the number of the substance listed in RISCAD.
Name
The substance name in RISCAD is displayed.
Material Information
If you click on "to RISCAD", you can link to the page of material information in RISCAD.
Accident Information
If you click on "to RISCAD", you can link to the page of accident information in RISCAD.
Hazard and Risk Assessment Reports etc. in Japan
Chemical Substances Hazard Assessment Report / Initial Risk Assessment Report
Updated:
  2009-06-30 (Issued 2009-03) (Chemical Substances Hazard Assessment Report) /
  2009-01-29 (Issued 2008-12) (Initial Risk Assessment Report) /
  2013-04-25 (Issued 2010-05) (Summary of Initial Risk Assessment Report)
Chemical Substances Hazard Assessment Reports are chemical substance assessment documents that are published following deliberations by experts. They are based on chemical substance safety information obtained from documents, reports, etc. There are three types:

1) Those prepared from the Technological Development of Chemical Substance Risk Assessment Methods project, which was undertaken as part of the Comprehensive Chemical Substance Assessment and Management Program commissioned by NEDO (New Energy and Industrial Technology Development Organization). These assessment reports are published following deliberations by the Management Committee & Review Committee Chemical Substance Council's Safety Assessment and Management Subcommittee.

2) Those originally prepared by NITE based on the Guidelines for Initial Risk Assessment Reports and the Preparation Manual for Initial Risk Assessment Reports that were used in the above-mentioned project. The content of these assessment reports is deliberated upon by the same committee as for the above-mentioned project.

3) Those prepared as a result of the following project commissioned by the Ministry of Economy, Trade and Industry (METI): Ensuring the Safety of Chemical Substances / Promotion of International Regulation Countermeasures, etc., 2008 (Survey regarding the Toxicity of Designated Chemical Substances specified in the Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof). These reports are published following deliberations by the Hazard Assessment Committee that was established during the conducting of the survey.

The Initial Risk Assessment Report is a report created based on the initial risk assessment methods developed by NEDO in its Chemical Substance Risk Assessment and Risk Assessment Method Development Project. These assessment methods are compiled in the Guidelines for Initial Risk Assessment Reports (theory of assessment) and the Preparation Manual for Initial Risk Assessment Reports (concrete steps for preparing assessment reports).
Report Number
If the Assessment Report No. is displayed, it means the Assessment Report of the substance is published.
Assessed Chemical Substance Name
The substance name appearing in the title of an assessment report is displayed.
Details
You can link to the Reports of the substance in PDF files as follows.
* Hazard Assessment Report (in Japanese)
* Initial Risk Assessment Report (in Japanese)
* Summary of Initial Risk Assessment Report (in English)
Date of publication/renewal when the Report(s) was/were released or updated are also displayed.
ISHA: Risk Assessment Report
Updated: 2018-06-05 (Issued 2018-04-20)
The Risk Assessment Report provides compilations of the results of risk assessments conducted by the "Risk Assessment Committee of Chemical Substances", which was established to assess risks to workers' health.
The reports are published on the "Workplace Safety Site", the homepage of the MHLW.
Name
It is the substance name published in the Risk Assessment Report on the "Workplace Safety Site".
Risk Assessment Report, Initial Risk Assessment Report, Full Risk Assessment Report
NITE-CHRIP links to the "Workplace Safety Site" and you can see the reports.(in Japanese)
ISHA: Examples of Occupational Accidents Caused by Chemical Substances
Updated: 2018-06-05 (Issued 2018-05-07)
Examples of occupational accidents caused by chemical substances are actual cases of accidents that occurred at workplaces. The occurrence situation, cause, countermeasures, etc. are summarized.
The examples are published on the "Workplace Safety Site", the homepage of the MHLW.
Name
It is the substance name published in the Examples of Occupational Accidents Caused by Chemical Substances on the "Workplace Safety Site".
Examples of Occupational Accidents
NITE-CHRIP links to the "Workplace Safety Site" and you can see the examples of occupational accidents.(in Japanese)
Hazard Data Sheet for Chemical Substances
Updated: 2006-09-04 (Issued 2006-06)
The Hazard Data Sheet for Chemical Substances is a chemical substance assessment report prepared between FY1996 and FY2001 under the commission of the Ministry of Economy, Trade and Industry (METI). These assessment reports were published following deliberations by the Management Committee & Review Committee Chemical Substances Council's Safety Assessment and Management Subcommittee on drafts that were prepared by the Chemicals Evaluation and Research Institute (CERI) based on chemical substance safety information obtained through bibliographic surveys, etc.
Book Number
The No. in front of a hyphen indicates the year (A.D.) of the acceptance by the council.
Date of publication/renewal
This is the month and year when the book was released. As for the updated sheet, the latest refix date is displayed.
Assessed Chemical Substance Name
The substance name appearing in the title of the book is displayed.
Details
You can link to the book in PDF file.(in Japanese)
CSCL: The Japan HPV Challenge Program
Updated:2017-06-06
Japan HPV Challenge Program is a joint initiative of the Japanese Government and industry to facilitate the collection of safety information for High Production Volume (HPV) chemicals. This program was carried out by the Ministry of Health, Labor and Welfare (MHLW); the Ministry of Economy, Trade and Industry (METI); and the Ministry of the Environment (MOE).
Chemical Substance Name
Name of the High Priority Chemicals (Target chemicals) of Japan HPV Challenge Program
Detail
Hazard and Risk Assessment Reports etc. in Other Countries
OECD : High Production Volume (HPV) Chemicals
Updated: 2016-04-07 (Confirmed 2016-04)
OECD : High Production Volume (HPV) Chemicals are chemicals produced in at least one OECD member country in quantities that exceeds 1,000 tons per year. These substances are subject to safety inspections and their names are listed in the candidate list for the HPV Chemicals Program. Under this program, which began in 1992, developed countries in the OECD collect exposure and hazard data for HPV chemical substances and conduct initial risk assessments.
The name of the program was changed to the Cooperative Chemical Assessment Programme in 2011, and the range of substances subject to safety inspections was expanded from HPV Chemicals to include all chemical substances.

NITE-CHRIP provides information of high production volume (HPV) chemicals that the OECD Existing Chemicals Database tracks.

You can see original reports by searching CAS No., etc. on the homepage of the Database.
Chemical Name
The displayed name of the substance is confirmed as HPV by OECD Existing Chemicals Database.
Details
You can link to the OECD Existing Chemicals Database.
International Chemical Safety Cards (ICSC)
Updated:2018-07-31 (Original Data Last Updated 2017-11)
The International Chemical Safety Cards (ICSC) project is an International Program on Chemical Safety (IPCS) undertaking carried out jointly by the World Health Organization (WHO) and the International Labor Office (ILO) with the cooperation of the European Commission (EC). The purpose of these cards is to provide information on chemical substances by evaluating their risk to human health and the environment.

These cards provide concise compilations of important information pertaining to human health and the safety of chemical substances used in factories, agriculture and construction sites, and other places of work. Although the documents are not legally binding, they are prepared using standard terminology compiled through the collection and verification of data pertaining to health and safety by internationally recognized experts.

The full text of the ICSC is available on the IPCS or ILO websites.
ICSC Number
If the ICSC Number is displayed, it means ICSC of the substance is published.
ICSC Title
The title (substance name etc.) of ICSC is displayed.
Details
If you click on "to ILO site", you can link to ICSC on the ILO website.
Concise International Chemical Assessment Documents (CICADs)
Updated: 2018-07-31 (Original Data Last Updated 2013 : No.1-78)
Concise International Chemical Assessment Documents (CICADs) are assessment documents prepared by various countries, regions, and international organizations or assessment reports prepared and published by the International Program on Chemical Safety (IPCS) based on Environmental Health Criteria (EHC). CICADs provide information that is important for risk assessment.

The framework for CICADs is as follows.
(1) Aim to perform concise, internationally useful risk assessments based on assessment results provided by each government.
(2) Guarantee reliability and efficiency by conducting external critical discussions effectively.
(3) Proactively apply the latest risk assessment theories with a view to achieving an internationally harmonized approach.

CICADs are published by IPCS, and the full text of the document is available on the IPCS websites.
CICADs Number
If the CICADs Number is displayed, it means CICADs of the substance is published.
CICADs Title
The title (substance name etc.) of the CICADs is displayed.
Details
If you click on "to IPCS site", you can link to CICADs on the IPCS or WHO website.
Environmental Health Criteria (EHC)
Updated: 2014-12-17 (Original Data Last Updated 2014-11)
Environmental Health Criteria (EHC) is a chemical substance risk assessment document prepared by the International Program on Chemical Safety (IPCS). Chemical substances that are candidates for assessment include the following: household chemical substances; atmospheric air, water, and food pollutants; cosmetics; food additives; natural toxicants; heavy chemicals; and agrochemicals. Pharmaceuticals are excluded.

The main focus for EHC is as follows:
* The source of exposure to humans or the environment; transfer, distribution and changes within the environment; environmental concentrations and exposure to humans; pharmacokinetics and metabolism in the human body.
* The evaluation of effects on organisms in the environment; effects on humans; risks to human health; and effects on the environment.

EHC is published in a book by WHO. The full text of the document is also available on the IPCS websites.
EHC Number
If an EHC Number is displayed, it means EHC of the substance is published.
EHC Title
The title (substance name etc.) of EHC is displayed.
Details
If you click on "to IPCS site", you can link to EHC on the IPCS or WHO website.
US Agency for Toxic Substances and Disease Registry (ATSDR) : Toxicological Profiles
Updated: 2019-06-04 (Original Data Last Updated 2019-04-19)
The US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles are toxicological profiles prepared by the ATSDR for toxic substances observed within the National Priority List (NPL) areas. These toxic substances are ranked based on how frequently they are observed within the NPL areas, their toxicity and the potential for human exposure.
Profile Title
The title (substance name etc.) of the Profile is displayed.
Details
If you click on "to ATSDR site", you can link to the Profile of the substance on the ATSDR website.
US Environmental Protection Agency : Integrated Risk Information System (IRIS)
Updated: 2019-02-05 (Original Data Last Updated 2018-12-27)
The US EPA Integrated Risk Information System (IRIS) is operated by the EPA (Environmental Protection Agency) in the United States. It is a program used to assess the effects of environmental pollution on human health.

The IRIS database compiles and provides information (the oral reference dose and reference concentration for chronic inhalation exposure for non-carcinogenicity and other hazardous properties; oral slope factors for carcinogen; and oral or inhalation unit risk, etc.) on the effects of an individual chemical substance on human health.
The chemicals used as pesticides have not been re-assessed by IRIS program. These archived data of the substances are available in the 「List by Archived」.
Chemical Substance Name
The substance name in the IRIS is displayed.
Details
If you click on "To EPA site", you can link to the information on the substance in the IRIS on the EPA website.
EU: Risk Assessment Reports (RAR)
Updated: 2016-11-29 (Original Data Last Updated 2014-11)
European Union (EU) : Risk Assessments are conducted in accordance with European Parliament and Council Regulation (EC) 1907/2006 concerning REACH. The Risk Assessment Report (EU : RAR) is published in the European Chemicals Agency (ECHA).

These risk assessments are based on a priority list of substances that are deemed to be a potential threat to human health and the environment. Data is collected and risk assessments carried out on High Production Volume (HPV) Chemicals (chemicals produced or imported in quantities of over 1,000 tons per year) and Low Production Volume (LPV) Chemicals (chemicals produced or imported in quantities of between 10 to 1,000 tons per year) from 1990 to 1994. The full text of the report is available on the ECHA websites.
EC Number
The EC Number is displayed if the assessment information on the substance is published as an assessment report on the ECHA website.
Date
This is the date when the report was released. As for the updated report, the latest date is displayed.
Report Title
The title (substance name etc.) of the assessment report is displayed.
Details
If you click on "to ECHA site", you can link to the page of “Information from the Existing Substances Regulation (ESR)" published on the ECHA website.
Advisory Committee on Existing Chemicals (BUA) Reports by the German Chemical Society
Updated: 2009-05-28 (Original Data Last Updated 2008-12-02)
Published by the GDCh (Gesellschaft Deutscher Chemiker; German Chemical Society), the Advisory Committee on Existing Chemicals (BUA) Reports are assessment documents prepared by BUA (Beratergremium fur umweltrelevante Alstoffe), a body established as an advisory committee for the GDCh in 1982 to support the German government's efforts to perform risk assessments for existing chemicals. The BUA Reports are used within the German government as the basis for legislation regulating chemical substances that are hazardous to the environment and human health. In 1997, the BUA was renamed the GDCh Advisory Committee on Existing Chemicals (its abbreviation remains "BUA"), and it ceased its activities in 2007.
BUA Number
If the BUA Number is displayed, it means the assessment of the substance has been published by BUA.
Substance Name
The Chemical substance name of the assessment report is displayed.
Related information
If you click on "to BUA site", you can link to the GDCh website.
Canada: Priority Substances List (PSL)
Updated: 2018-06-05 (Original Data Last Updated 2013-06-21)
The Priority Substances List (PSL), which was established in accordance with the Canadian Environmental Protection Act (CEPA), is a list of substances that need to be subjected on a priority basis to a comprehensive and detailed risk assessment by Environment Canada and Health Canada in accordance with the CEPA, which took effect in 1991.
The chemical substances that appear on this list are evaluated by Environment Canada and Health Canada, and any substances that are judged to be hazardous are published on a Toxic Substances List and risk management measures are enforced.
Type of Priory Substances List
PSL1 (First Priority Substances List) ; PSL1 was published in 1989 and included 44 substances.
PSL2 (Second Priority Substances List) ; PSL2 was published in December 1995 and included 25 substances.
Report Title
The title (substance name etc.) of the assessment report is displayed.
Details
If you click on "to Environment Canada site", you can see the information on the substance list published in Canada website.
Australia : Priority Existing Chemicals (PEC) Assessment Reports
Updated: 2019-06-04 (Original Data Last Updated 2019-05-07)
Australia's Priority Existing Chemicals (PEC) Assessment Reports are assessment reports on chemical substances that are already being used within Australia and that have been declared by the National Industrial Chemicals Notification and Assessment Scheme (NICNAS) to be Priority Existing Chemicals due to concerns about their effects on human health and the environment.
Report Title
It is the title (chemicals name, etc.) of PEC Assessment Reports.
Details
When you click on "To NICNAS site", you can link to the page of “ Priority Existing Chemical assessments " published on the NICNAS website.
Japan Society for Occupational Health (JSOH)
JSOH: Occupational Exposure Limits(OELs)
Updated: 2019-06-04 (Issued 2018-09 (2018-2019))
Japan Society for Occupational Health (JSOH): "Recommendation of Occupational Exposure Limits" is a document published in the Journal of Occupational Health by JSOH for the purpose of preventing adverse health effects on workers caused by occupational exposure to chemical substances.
Substance Name
It is the substance name listed in "Recommendation of Occupational Exposure Limits" (Table I-1. Occupational exposure limits for chemical substances).
Occupational Exposure Limits
Occupational Exposure Limit-Mean (OEL-M) for mean concentration of a chemical substance is defined as the reference value to the mean exposure concentration at or below which adverse health effects caused by the substance do not appear in most workers working for 8 hours a day, 40 hours a week under a moderate work-load.
Occupational Exposure Limit-Ceiling (OEL-C) of occupational exposure to a chemical substance is defined as the reference value to the maximal exposure concentration of the substance during a working day at or below which adverse health effects do not appear in most workers.
Details
If you click on "Documentation in Japanese" or "TableI-3", you can see the information as follows.
Documentation in Japanese If you click on "Documentation in Japanese", you can see full Documentation.
TableI-3 Occupational exposure limits for dusts (Class of Dusts, OEL)
TableIII-2 Reference values corresponding to an individual excess lifetime risk of cancer
Remarks
Relevant information is indicated.
JSOH: Occupational Exposure Limits Based on Biological Monitoring
Updated: 2019-06-04 (Issued 2015-07 (2015-2016))
Japan Society for Occupational Health (JSOH): "Recommendation of Occupational Exposure Limits" is a document published in the Journal of Occupational Health by JSOH for the purpose of preventing adverse health effects on workers caused by occupational exposure to chemical substances.
Occupational Exposure Limits Based on Biological Monitoring (OEL-B) are defined as the reference values for data obtained by biological monitoring at or below (depending on the agents, above) which the adverse health effects do not appear in most workers who are exposed to the chemical substances.

If you click on "TableII-1" on the upper right of the OEL-B table in the "Comprehensive Information" view, you can see the details of "Occupational exposure limits based on biological monitoring (Substance, Assay material, Parameter, OEL-B, Sampling time)".
Substance Name
It is the substance name listed in "Recommendation of Occupational Exposure Limits" (Table II-1. Occupational exposure limits based on biological monitoring).
Details
If you click on "Documentation in Japanese", you can see full Documentation.
Remarks
Relevant information is indicated.
JSOH: Occupational Carcinogens
Updated: 2019-06-04 (Issued 2018-09 (2018-2019))
Japan Society for Occupational Health (JSOH): "Recommendation of Occupational Exposure Limits" is a document published in the Journal of Occupational Health by JSOH for the purpose of preventing adverse health effects on workers caused by occupational exposure to chemical substances.
Substance Name
It is the substance name listed in "Recommendation of Occupational Exposure Limits" (Table III-1. Occupational carcinogens).
Carcinogenicity classification
The definition of the "Group" is as follows.
Group 1 The agents which are carcinogenic to humans.
Group 2A The agents which are probably or possibly carcinogenic to humans (the agents with more sufficient evidence (probably carcinogenic to humans))
Group 2B The agents which are probably or possibly carcinogenic to humans (the agents with less (possibly carcinogenic to humans))
Details
If you click on "Documentation in Japanese", you can see full Documentation.
Remarks
Relevant information is indicated.
JSOH: Occupational Sensitizers
Updated: 2019-06-04 (Issued 2018-09 (2018-2019))
Japan Society for Occupational Health (JSOH): "Recommendation of Occupational Exposure Limits" is a document published in the Journal of Occupational Health by JSOH for the purpose of preventing adverse health effects on workers caused by occupational exposure to chemical substances.
Occupational sensitizers of the airway and skin are classified into three groups. A substance not being included in the list does not indicate that the substance is not a sensitizer.
Substance Name
It is the substance name listed in "Recommendation of Occupational Exposure Limits" (Table IV. Occupational sensitizers).
Airway
It is the classification for Airway Sensitizers. The definition of the "Group" is as follows.
Group 1 substances which induce allergic reactions in humans
Group 2 substances which probably induce allergic reactions in humans
Group 3 substances which are considered possibly to induce allergic reactions in humans based on animal experiments
Skin
It is the classification for Skin Sensitizers. The definition of the "Group" is as follows.
Group 1 substances which induce allergic reactions in humans
Group 2 substances which probably induce allergic reactions in humans
Group 3 substances which are considered possibly to induce allergic reactions in humans based on animal experiments
Details
If you click on "Documentation in Japanese" , you can see full Documentation.
Remarks
Relevant information is indicated.
JSOH: Reproductive Toxicants
Updated: 2019-06-04 (Issued 2018-09 (2018-2019))
Japan Society for Occupational Health (JSOH): "Recommendation of Occupational Exposure Limits" is a document published in the Journal of Occupational Health by JSOH for the purpose of preventing adverse health effects on workers caused by occupational exposure to chemical substances.
Substance Name
It is the substance name listed in "Recommendation of Occupational Exposure Limits" (Table V. Reproductive toxicants).
Reproductive Toxicants classification
Reproductive toxicity includes adverse effects on reproductive functions in males and females, as well as on the offspring. Effects on functions such as fertility, pregnancy, delivery, and lactation in women, and fertility/insemination in men are within the scope of the definition. Substances that have adverse effects on reproductive organs are also included within the classification criteria if it is suspected that the reproductive functions referred to above are affected. In the case of offspring, reproductive toxicity is defined as the effects on the development of the embryo/fetus including teratogenic insults by prenatal exposure to the substance and/or the effects on the infant by postnatal exposure via lactation due to transfer in breast milk. If effects on post-weaning growth, behavior, function, sexual maturation, carcinogenesis, accelerated aging, and other processes are clearly demonstrated in the offspring as a result of parental exposure, then such effects are considered as reproductive toxicity.

The definition of the "Group" is as follows.
Group 1 Substances known to cause reproductive toxicity in humans.
Group 2 Substances presumed to cause reproductive toxicity in humans.
Group 3 Substances suspected to cause reproductive toxicity in humans.
Details
If you click on "Summary" or "Documentation in Japanese", you can see the information as follows.
Summary If you click on "Summary", you can see brief summary of OEL Documentation.
Documentation in Japanese If you click on "Documentation in Japanese", you can see full Documentation.
Remarks
Relevant information is indicated.
Carcinogenicity Assessment
IARC: Carcinogenicity Assessment
Updated: 2019-07-31 (Original Data Last Updated 2019-07-16 Vol.1-124)
International Agency for Research on Cancer (IARC) : Carcinogenic Risks to Humans is a document published by the IARC, a member of the World Health Organization (WHO). This body researches the etiology of cancer in humans, the mechanisms of carcinogenicity and scientific methods of controlling carcinogenicity. Assessments of carcinogenicity consist of information on carcinogenicity classifications (Group 1, 2A, 2B, 3, 4) that are published in the IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Detailed information is published in the Monographs.

NITE-CHRIP provides information on the carcinogenicity classification of "IARC Monographs on the Evaluations of Carcinogenic Risks to Humans".
The Year means the year of publication in print. If published in electronic format only, this is stated as “ online”.
The outline of the "Category" is as follows.
1 Carcinogenic to humans.
2A Probably carcinogenic to humans.
2B Possibly carcinogenic to humans.
3 Not classifiable as to carcinogenicity in humans.
4 Probably not carcinogenic to humans.
US Environmental Protection Agency (EPA)
Updated: 2018-02-05 (Published 2018-8-30)
US Environmental Protection Agency (EPA) : This Carcinogen Risk Assessment is a classification and assessment of chemical substances published in the Integrated Risk Information System (IRIS). These assessments are based on the guidelines from 1986, 1996, 1999 and 2005.

NITE-CHRIP provides classification of carcinogenicity evaluated on the basis of guidelines presented in 1986, 1996, 1999, and 2005. The substances are classified as follows;
1986
A Human Carcinogen
B1 Probable human carcinogen - based on limited evidence of carcinogenicity in humans and sufficient evidence of carcinogenicity in animals
B2 Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals
C Possible Human Carcinogen
D Not Classifiable as to Human Carcinogenicity
E Evidence of Non-Carcinogenicity for Humans
1996
K/L Known/likely human carcinogen
CBD Carcinogenic potential cannot be determined
NL Not likely to be carcinogenic to humans
1999
CaH Carcinogenic to humans
L Likely to be carcinogenic to humans
S Suggestive evidence of carcinogenicity, but not sufficient to assess human carcinogenic potential
I Data are inadequate for an assessment of human carcinogenic potential
NL Not likely to be carcinogenic to humans
2005
CaH Carcinogenic to humans
L Likely to be carcinogenic to humans
S Suggestive evidence of carcinogenic potential
I Inadequate information to assess carcinogenic potential
NL Not likely to be carcinogenic to humans
US National Toxicology Program (NTP)
Updated: 2017-01-24 (Published 2016-11-03 14th Report)
US National Toxicology Program (NTP) : This Carcinogen Risk Assessment is implemented by the NTP, which was established with other national research organizations in the US such as the National Institute of Environmental Health Sciences (NIEHS), the National Institute for Occupational Safety and Health (NIOSH) and the National Center for Toxicological Research (NCTR) as its core members. The NTP coordinates toxicity test plans in the United States and to strengthen, etc., the scientific platforms for toxicological fields. Classifications and assessment reports on the carcinogenic substances are released by the NTP.

NITE-CHRIP provides information on the carcinogenicity classification of chemical substances published in the Report on Carcinogens.

The criteria for listing are as follows.
K Known to be Human Carcinogens
R Reasonably Anticipated to be Human Carcinogens
European Union (EU)
Updated: 2018-12-04 (Published 2018-10-05: ATP13)
European Union (EU) : This Carcinogen Risk Assessment involves the classification and labeling of dangerous substances based on Annex I of Council Directive 67 / 548 / EEC of June 27, 1967 on the Approximation of Laws, Regulations, and Administrative Provisions Relating to the Classification, Packaging and Labeling of Dangerous Substances.
Annex I of Council Directive 67 / 548 / EEC was included in Annex VI of CLP Regulation (EC)No. 1272/2008, which came into effect in January 2009.

NITE-CHRIP provides information on the carcinogenicity classification (Categories 1A, 1B and 2) published in Table 3 of Annex VI.

The outline of the "Category" is as follows.
Category 1A Substances known to have carcinogenic potential for humans;
Classification is largely based on human studies that establish a causal relationship between human exposure to a substance and the development of cancer.
Category 1B Substances presumed to have carcinogenic potential for humans;
Classification is largely based on experiments for which there is sufficient evidence to demonstrate animal carcinogenicity.
Category 2 Substances suspected human carcinogens;
The placing of a substance in Category 2 is done on the basis of evidence obtained from human and/or animal studies, but which is not sufficiently convincing to place the substance in Category 1A or 1B, based on strength of evidence together with additional considerations.
ICCA Safety Summary of Japan(JCIA BIGDr)
Updated: 2018-12-04
Safety Summaries (GPS/JIPS Safety Summaries) are intended to provide a summary of GPS/JIPS examination results (such as risk assessment result) of a chemical product a company makes and sells in a suitable format.
A list of the links to the GPS Safety Summaries created by Japanese companies on the website of International Council of Chemical Associations (ICCA) is provided. The links are listed by Substance Name, CAS Registry Number (CAS RN), or company name, to allow efficient access and search of the Safety Summaries created by Japanese companies.
Substance Name
It is the substance name of ICCA Safety of Japan(JCIA BIGDr).
Detail
If you click on “to JCIA BIGDr”, you can see the ICCA Safety Summary of Japan(JCIA BIGDr).
Test Data and Reports
Japan METI: Biodegradation and Bioconcentration Results
Updated: 2019-04-16 (Published 2018-08-31)
Japan METI: Biodegradation and Bioconcentration Results are the evaluation results of biodegradation and bioconcentration announced by the Ministry of Economy, Trade and Industry.
Chemical Substance Name
It is the chemical substance name which have been published by the Ministry of Economy, Trade and Industry or the name of tested chemical substance.
Result of Biodegradation
The published results and/or the judgment are displayed.
Result of Bioconcentration
The published results and/or the judgments are displayed.
Detail
Japan MHLW: Toxicity Test Results
Updated: 2018-01-30 (Published 2017-11)
As part of the Safety Inspections for Existing Chemical Substances carried out by the Ministry of Health, Labour and Welfare to promote chemical substance safety inspections, toxicity tests have been conducted mainly by the National Institute of Health Sciences. Japan also cooperates on the OECD : HPV (High Production Volume) Chemicals Programme.
Volume Number
The number shows the volume of the "Toxicity Testing Reports for Environmental Chemicals", published by the Chemicals Investigation Promoting Council, Japan, in which the targeted chemical substance is covered.
Tested Chemical Name
It is the name of the chemical substance whose test result was reported by the National Institute of Health Science.
Details
Japan MOE: Results of Eco-toxicity tests of chemicals
Updated: 2018-01-30 (Announced 2017-03)
The Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment (MOE) in Japan are the results of eco-toxicity tests conducted by the MOE to evaluate the risk posed by Existing Chemical Substances in relation to ecological systems by assessing the effect of such substances on aquatic organisms (algae, crustaceans, fish and benthonic organisms).

The tests conducted by the MOE are as follows: growth inhibition test (alga); acute immobilization test (Daphnia SP.); reproduction test (Daphnia manga); acute toxicity test (fish); prolonged toxicity test (fish); and early-life stage toxicity test (fish).
Chemical Substance Name
It is the name of the chemical substance whose test result was reported by the MOE.
Detail
ISHA: Carcinogenicity Test Results for Chemical Substances
Updated: 2018-03-20 (Issued 2017-08-28)
Carcinogenicity Tests are carried out by the Ministry of Health, Labour and Welfare (MHLW) in accordance with Article 57-5 of the Industrial Safety and Health Act. The test results are published on the "Workplace Safety Site", the homepage of the MHLW.
Chemical Name
It is the substance name published in the Carcinogenicity Test Results on the "Workplace Safety Site".
Summary
NITE-CHRIP links to the "Workplace Safety Site" and you can see the summary of Carcinogenicity Test Results (Inhalation test results or Oral test results).(in Japanese)
ISHA: Mutagenicity Test Results for Chemical Substances
Updated: 2016-04-07 (Confirmed 2015-10-01)
Mutagenicity Tests for Existing Chemical Substances are carried out by the Ministry of Health, Labour and Welfare (MHLW) in accordance with Article 57-5 of the Industrial Safety and Health Act. The test results are published on the "Workplace Safety Site", the homepage of the MHLW.

NITE-CHRIP provides chemical substance names for which test results have been released on the "Workplace Safety Site".
Chemical Name
It is the substance name published in the Mutagenicity Test Results on the "Workplace Safety Site". The substance at the end of the name is (Gas) has been tested by gas exposure method.
Test Result
Either of the followings is displayed.
Bacterial Test Negative, Positive, Negative/Positive (In case of both negative and positive results exist)
CHL/IU Test Negative, Positive, Equivocal (In case of the judgment is impossible)
Japan METI: Safety Test
Updated: 2015-12-17(Announced 2013-07-31)
Ministry of Economy, Trade and Industry (METI) Safety Test Results are the results of toxicity tests carried out by METI to gather safety data. The test results are reviewed by the Hazard Data Evaluation Committee, which was established by NITE.
Test Substance
The test substance name is displayed.
Study Type
The name of study type is displayed.
Detail
NITE: Toxicity and Eco-toxicity Test Results
Updated: 2016-05-31(Announced 2004-10-18)
NITE Toxicity and Eco-toxicity Tests are safety and toxicity tests carried out independently by NITE on existing chemical substances that have not been tested or evaluated with the Chemical Substances Toxicity Tests conducted by the Ministry of Health, Labour and Welfare or subjected to the eco-toxicity tests for chemicals conducted by Japan's Ministry of the Environment, etc. The test results are assessed by the Hazard Data Assessment Committee, which was established by NITE.
The test results are assessed by Hazard Data Assessment Committee, which was established by NITE.
Test Substance
The names of the substances, for which the toxicity test and the ecotoxicity test were carried out, are displayed.
Toxicity Test Results
If the toxicity tests for the corresponding chemical substance have been carried out, NITE-CHRIP links to the "CSCL Database : Japan CHEmicals Collaborative Knowledge database (J-CHECK)".
Ecotoxicological Test Results
If the ecotoxicological tests for the corresponding chemical substances have been carried out, NITE-CHRIP links to the "CSCL Database : Japan CHEmicals Collaborative Knowledge database (J-CHECK)".
US National Toxicology Program (NTP): Long-Term Study Reports & Abstracts
Updated: 2019-03-19 (Last Updated 2019-02-28)
The Long-Term Study Reports & Abstracts published by the US National Toxicology Program (NTP), which was established with other national research organizations in the United States such as the National Institute of Environmental Health Sciences (NIEHS), the National Institute for Occupational Safety and Health (NIOSH), and the National Center for Toxicological Research (NCTR) as its core members, are test reports on the long-term toxicity and carcinogenicity of chemical substances. The NTP was established to coordinate toxicity test plans in the United States and to strengthen, etc., the scientific platforms for toxicological fields.

Other NTP Reports (Short-Term Toxicity Studies, Genetically Modified Model Studies, Immunology Toxicity, Developmental, Special Drinking Water, Reproductive Assessment by Continuous Breeding, IEHS AIDS Therapeutics Toxicity Reports) are also published and available from the NTP site.
Report Title
The title (substance name etc.) of TR report is displayed.
Abstract
If you click on "to NTP site", you can link to the Abstract on the substance on the NTP website.
Full Text
If you click on "to NTP site", you can link to the Full Text on the substance on the NTP website.