Concanamycin A : Cluster information
Compound
| Entry name | Concanamycin A |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | malonyl-CoA |
| Chain Length | 14 |
| Sugar Unit | 4'-O-carbamoyl-2'-deoxyrhamnose |
| Classification | Other Macrocyclic Lactone |
| Activity | Antifungal Antiprotozoal Antitumor Antiviral |
| Composition | C46H75NO14 |
Original source
| Organism | Streptomyces neyagawaensis |
|---|---|
| Strain | ATCC 27449 (=NBRC 13477) |
| Contig | DQ149987 |
PKS/NRPS Module
| Conca_00040 conA | 0 |  | malonyl-CoA |
| 1 |  | malonyl-CoA | |
| Conca_00050 conB | 2 |  | methylmalonyl-CoA |
| 3 | | malonyl-CoA | |
| 4 | | methylmalonyl-CoA not conserved YASHS(S->A) | |
| Conca_00060 conC | 5 | | methylmalonyl-CoA |
| 6 | | methoxymalonyl-ACP | |
| 7 | | malonyl-CoA | |
| Conca_00070 conD | 8 | | methylmalonyl-CoA |
| 9 |  | methylmalonyl-CoA | |
| Conca_00080 conE | 10 | | ethylmalonyl-CoA |
| 11 | | methylmalonyl-CoA | |
| 12 | | methylmalonyl-CoA | |
| Conca_00090 conF | 13 |  | methoxymalonyl-ACP |
Reference
- Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.
- Haydock SF, Appleyard AN, Mironenko T, Lester J, Scott N, Leadlay PF[PMID: 16207901]Microbiology. 151 (2005) 3161-9
- Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.
- Eng CH, Yuzawa S, Wang G, Baidoo EE, Katz L, Keasling JD[PMID: 26976746]Biochemistry. 55 (2016) 1677-80
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Concanamycin A |
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History
- 2016-12-27[Update]
- 2014-06-25[Update]
- 2013-01-16[Update]
- 2012-10-02[Update]
- 2012-08-03[Update]
- 2012-03-28[Release]
