Borrelidin : Cluster information
Compound
Entry name | Borrelidin |
---|---|
PKS Type | TypeI iterative |
Starter Unit | trans-cyclopentane-1,2-dicarboxylic acid (trans-1,2-CPDA) |
Chain Length | 9 |
Sugar Unit | none |
Classification | Other Macrocyclic Lactone |
Activity | Angiogenesis Inhibition Antibacterial Antiviral Antiproliferative Antiprotozoal |
Composition | C28H43NO6 |
Original source
Organism | Streptomyces parvulus |
---|---|
Strain | Tü4055 |
Contig | AJ580915 |
PKS/NRPS Module
Borre_00150 borA1 | 0 | ||
Borre_00160 borA2 | 1 | malonyl-CoA | |
Borre_00170 borA3 | 2 | malonyl-CoA | |
3 | methylmalonyl-CoA | ||
Borre_00180 borA4 | 4 | methylmalonyl-CoA | |
Borre_00190 borA5 | 5 | methylmalonyl-CoA | |
Borre_00200 borA6 | 6 | malonyl-CoA |
Reference
- Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase.
- Olano C, Wilkinson B, Moss SJ, Brana AF, Mendez C, Leadlay PF, Salas JA[PMID: 14651102]Chem Commun (Camb). (2003) 2780-2
- Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: cluster analysis and assignment of functions.
- Olano C, Wilkinson B, Sanchez C, Moss SJ, Sheridan R, Math V, Weston AJ, Brana AF, Martin CJ, Oliynyk M, Mendez C, Leadlay PF, Salas JA[PMID: 15112998]Chem Biol. 11 (2004) 87-97
- Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: insights into nitrile formation.
- Olano C, Moss SJ, Brana AF, Sheridan RM, Math V, Weston AJ, Mendez C, Leadlay PF, Wilkinson B, Salas JA[PMID: 15186422]Mol Microbiol. 52 (2004) 1745-56
- Stereoselectivity of isolated dehydratase domains of the borrelidin polyketide synthase: implications for cis double bond formation.
- Vergnolle O, Hahn F, Baerga-Ortiz A, Leadlay PF, Andexer JN[PMID: 21472957]Chembiochem. 12 (2011) 1011-4
- Identification of borrelidin binding site on threonyl-tRNA synthetase.
- Li M, Zhang J, Liu C, Fang B, Wang X, Xiang W[PMID: 25128830]Biochem Biophys Res Commun. 451 (2014) 485-90
- In vitro analysis of carboxyacyl substrate tolerance in the loading and first extension modules of borrelidin polyketide synthase.
- Hagen A, Poust S, de Rond T, Yuzawa S, Katz L, Adams PD, Petzold CJ, Keasling JD[PMID: 25188840]Biochemistry. 53 (2014) 5975-7
- Engineering a Polyketide Synthase for In Vitro Production of Adipic Acid.
- Hagen A, Poust S, Rond Td, Fortman JL, Katz L, Petzold CJ, Keasling JD[PMID: 26501439]ACS Synth Biol. 5 (2016) 21-7
- Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.
- Eng CH, Yuzawa S, Wang G, Baidoo EE, Katz L, Keasling JD[PMID: 26976746]Biochemistry. 55 (2016) 1677-80
Data download
History
- 2016-12-27[Update]
- 2016-01-27[Update]
- 2014-06-25[Update]
- 2013-05-28[Update]
- 2012-03-28[Release]